Clinical trials: Lorazepam
Stress Disorders, Post-Traumatic
Computational Assessment of GABA Receptor Modulation in PTSD
A substantial majority of Veterans with posttraumatic stress disorder (PTSD) continue to suffer even with the best current medications.
- Trial name
- NCT06852469
- Testing
- Lorazepam 1 mg tablet
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Status Epilepticus, Convulsions
Intranasal Lorazepam Versus Intramuscular Paraldehyde in Paediatric Convulsions
The purpose of this study is to evaluate intranasal lorazepam in paediatric status epilepticus. This is a potentially, more effective, safer and cheaper treatment for a common paediatric medical emergency compared to our present…
- Trial name
- NCT00116064
- Testing
- intranasal lorazepam, intramuscular paraldehyde
- Where
- Malawi
- Volunteers
- 156 people
- Sponsor
- Kamuzu University of Health Sciences
Healthy
Phase 1 Study to Characterize the Safety and Pharmacokinetics of Single Intravenous Dose of Lorazepam in Healthy Japanese Adult Subjects
The purpose of this study is to evaluate safety, tolerability and pharmacokinetics of 2-mg lorazepam intravenous administration in healthy Japanese adult subjects.
- Trial name
- NCT01994668
- Testing
- Lorazepam
- Where
- Japan
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Pfizer
Schizophrenia, Psychotic Disorders
A Study of Risperidone in Combination With Lorazepam Compared With Standard Therapy for Emergency Treatment of Schizophrenic Patients
The purpose of the study is to show that risperidone (an antipsychotic medication) combined with lorazepam (an anti-anxiety medication) is more effective than conventional therapy administered by intramuscular injection for…
- Conditions
- Schizophrenia, Psychotic Disorders, Emergency Treatment
- Trial name
- NCT00249171
- Testing
- risperidone
- Volunteers
- 226 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Peripheral Vertigo.
Promethazine vs. Lorazepam for Treatment of Vertigo
This study was a prospective, randomized, double-blind, parallel group clinical trial designed to compare the efficacy of intravenous (IV) promethazine and lorazepam for the treatment of peripheral vertigo in Emergency Department…
- Trial name
- NCT01827293
- Testing
- Promethazine, Lorazepam
- Where
- Iran
- Volunteers
- 210 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Anxiety Disorders, Generalized Anxiety Disorder
Lorazepam-Induced Toxicity in the Aged
This study will compare the effects of an acute dose of lorazepam to a placebo in elderly patients with generalized anxiety disorder (GAD).
- Trial name
- NCT00044642
- Testing
- Lorazepam
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Claustrophobia
Premedication for Claustrophobic Patients for MRI Scan
Claustrophobia is an irrational fear of restriction and suffocation. It is a specific phobia, according to DSM 5. Claustrophobic patients may fear that restriction of their limbs will hinder their ability to move quickly towards…
- Trial name
- NCT05876117
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Salem Anaesthesia Pain Clinic
Status Epilepticus
Phase III Randomized Study of Diazepam Vs Lorazepam Vs Placebo for Prehospital Treatment of Status Epilepticus
OBJECTIVES: I. Compare the efficacy, onset of clinical anticonvulsant activity, and complications of diazepam and lorazepam given intravenously as prehospital therapy to patients in status epilepticus. II.
- Trial name
- NCT00004297
- Testing
- diazepam, lorazepam
- Volunteers
- 210 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Anxiety Disorder
GEM 1.5 mg b.i.d. to 4.5 mg b.i.d. Versus Lorazepam in GAD (0777-026)
This study will determine the effectiveness of MK0777 GEM versus Lorazepam in the treatment of patients with generalized anxiety disorder.
- Trial name
- NCT00546624
- Testing
- MK0777
- Volunteers
- 38 people
- Sponsor
- Merck Sharp & Dohme LLC
Nausea, Vomiting
Randomized Trial of the Effectiveness of Topical "ABH Gel" vs. Placebo in Cancer Patients With Nausea
This randomized clinical trial studies ABH (lorazepam, diphenhydramine hydrochloride, and haloperidol) gel in patients with nausea. ABH gel, when absorbed into the skin, may be an effective treatment for nausea and vomiting.
- Trial name
- NCT01556932
- Testing
- ABH gel
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Virginia Commonwealth University
Anxiety
Effect of A Single Dose of Lorazepam on Salivary Cortisol Response in Children Undergoing Digestive Endoscopy:
The purpose of this study is to determine the effect of a single dose of Lorazepam on salivary cortisol in children undergoing digestive endoscopy. To do so, the patients will be randomized in three groups.
- Trial name
- Endo-Lora (NCT03180632)
- Testing
- Lorazepam
- Where
- Canada
- Volunteers
- 98 people
- Sponsor
- St. Justine's Hospital
Patient Satisfaction for Bronchoscopy
Effect of Additive Lorazepam on Patient Satisfaction as a Premedication in Diagnostic Flexible Bronchoscopy
Many patients undergoing flexible bronchoscopy (FB) experience anxiety and discomfort during the procedure. The investigators want to evaluate whether an additional Lorazepam premedication would improve patient satisfaction for…
- Trial name
- NCT01121055
- Testing
- Lorazepam, Control
- Where
- South Korea
- Volunteers
- 372 people
- Sponsor
- Seoul National University Hospital
Nausea, Vomiting
Diphenhydramine, Lorazepam, and Dexamethasone in Treating Nausea and Vomiting Caused By Chemotherapy
RATIONALE: Diphenhydramine, lorazepam, and dexamethasone may help lessen or prevent nausea and vomiting in patients treated with chemotherapy.
- Conditions
- Nausea, Vomiting, Unspecified Childhood Solid Tumor, Protocol Specific
- Trial name
- NCT00429702
- Testing
- Decadron®, Benadryl®, Ativan®
- Where
- 7 sites in United States, Puerto Rico
- Volunteers
- 7 people
- Sponsor
- University of South Florida
Pain, IUD
Prescribing Lorazepam for IUD Insertion: Pilot Feasibility Study
The objective of this pilot study is to discuss the feasibility of prescribing lorazepam prior to IUD insertion and of measuring effect of lorazepam on anxiety and pain with Intrauterine Device (IUD) insertion.
- Trial name
- NCT06496854
- Testing
- Lorazepam 1 mg, Ibuprofen 800 mg
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Lorazepam, Neuroimaging
Lorazepam Effects on Neuroimaging Measures
This within-subject, double blind, randomized controlled study will investigate the effects of a widely used benzodiazepine (BZD), lorazepam, on various neuroimaging measures.
- Trial name
- NCT04671836
- Testing
- Lorazepam 1Mg Tablet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Transient Insomnia
SM-1 vs 2 Comparators and Placebo in Participants With a History of Transient Insomnia.
The purpose of this study is to investigate the effectiveness, safety and tolerability of a combination drug product (SM-1) containing diphenhydramine, zolpidem and lorazepam, in adult participants who sometimes have difficulty…
- Trial name
- NCT03331042
- Testing
- SM-1, D+Z, D+L
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- Sequential Medicine Ltd
Alcohol Withdrawal, Alcohol Withdrawal Delirium
Phenobarbital vs Ativan for Alcohol Withdrawal in the Intensive Care Unit
Our aim is to compare outcomes of patients with benzodiazepine-refractory alcohol withdrawal syndrome who are treated with either a phenobarbital-based or a lorazepam based protocol.
- Trial name
- PARTI (NCT04156464)
- Testing
- Phenobarbital, Lorazepam
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- OSF Healthcare System
Anxiety Disorders
Clinical Study Assessing a New Scale to Measure Onset of Action in Generalized Anxiety Disorder
The study is to assess the performance characteristics of a new measure to assess onset of efficacy in a GAD patient population.
- Trial name
- NCT00715039
- Testing
- lorazepam, paroxetine
- Where
- 15 sites in United States
- Volunteers
- 169 people
- Sponsor
- Pfizer
Healthy
Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers
RATIONALE: Lorazepam, diphenhydramine hydrochloride, and haloperidol gel, when absorbed into the skin, may be an effective treatment for nausea and vomiting.PURPOSE: This clinical trial studies lorazepam, diphenhydramine…
- Trial name
- NCT01204255
- Testing
- lorazepam, diphenhydramine hydrochloride, haloperidol
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Agitation,Psychomotor, Haloperidol Causing Adverse Effects in Therapeutic Use
Inhaled Loxapine vs Intramuscular (IM) Haloperidol + Lorazepam for Agitation
The primary objective of this study is to determine the noninferiority of inhaled loxapine compared to intramuscular haloperidol/lorazepam on agitation reduction at 120 minutes.
- Conditions
- Agitation,Psychomotor, Haloperidol Causing Adverse Effects in Therapeutic Use, Lorazepam Causing Adverse Effects in Therapeutic Use, Loxapine Causing Adverse Effects in Therapeutic Use
- Trial name
- loxapine (NCT03110900)
- Testing
- Haloperidol + lorazepam, Loxapine
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Arkansas