Clinical trials: Lorazepam
Schizophrenia, Schizoaffective Disorder
Intramuscular (IM) Olanzapine Versus IM Haloperidol Plus Lorazepam for Acute Agitation in Schizophrenia
The aim of this study was to compare the efficacy and safety of intramuscular 10 mg olanzapine versus intramuscular 5 mg haloperidol plus lorazepam 2 mg in the treatment of acute agitated schizophrenic patients of Taiwanese…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Agitation
- Trial name
- NCT00797277
- Testing
- IM olanzapine, IM haloperidol plus lorazepam
- Where
- Taiwan
- Volunteers
- 67 people
- Sponsor
- National Taiwan University Hospital
Status Epilepticus
Lorazepam for the Treatment of Status Epilepticus in Children
The purpose of this study is to gather the data to: 1) determine the best dose, and 2) evaluate its effectiveness and safety in stopping seizures.
- Trial name
- NCT00114569
- Testing
- lorazepam
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Anticholinergics Toxicity
Treatment of Adolescent Antimuscarinic (Anticholinergic) Toxidrome
Overdose of xenobiotics (antihistamines, antipsychotics, or Jimson Weed) with resulting antimuscarinic toxidrome is a common scenario in medical toxicology.
- Trial name
- TAAT (NCT03090620)
- Testing
- Physostigmine, Lorazepam
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Status Epilepticus, Convulsions
Randomized Trial Comparing 3 Routes of Delivering Lorazepam to Children.
This study aims to address the hypothesis that Lorazepam (an anticonvulsant) is as effective when given via the intranasal or buccal route as the intravenous route in terminating convulsions in children.
- Trial name
- NCT00343096
- Testing
- Lorazepam
- Where
- Malawi
- Volunteers
- 800 people
- Sponsor
- Kamuzu University of Health Sciences
Seizures
Seizure Therapy With Intravenous Levetiracetam and Lorazepam
The overarching aim of STILL is assessment of IV LEV in the management of seizures in the ED setting. The main study endpoints are considered in the two patient groups of interest (SE and non-SE): For non-SE patients, STILL will…
- Trial name
- STILL (NCT00465244)
- Testing
- Levetiracetam 1 g IV + Lorazepam 2 mg IV
- Sponsor
- Massachusetts General Hospital
Healthy Volunteer
A Sedation/Cognition/Electroencephalogram (EEG) Study Using AZD7325 and Comparator.
The purpose of the study is to determine the effects of the compound AZD7325 as compared to lorazepam on sleepiness, concentration and brain activity.
- Trial name
- NCT00720421
- Testing
- AZD7325, Lorazepam
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Major Depressive Disorder
A Study of the Effect of LY2216684 on Lorazepam
The purpose of this study is to determine how much lorazepam gets into the blood and how long it takes the body to get rid of it when given together with LY2216684.
- Trial name
- NCT01275144
- Testing
- LY2216684, Lorazepam
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Reflex Epilepsy, Photosensitive
PF-06372865 in Subjects With Photosensitive Epilepsy
PF-06372865 in subjects with photosensitive epilepsy
- Trial name
- NCT02564029
- Testing
- PF-06372865, Lorazepam
- Where
- 16 sites in United States
- Volunteers
- 7 people
- Sponsor
- Pfizer
Oral Sedation and Cervical Dilator Pain
Oral Sedation During Cervical Dilator Placement
This will be a randomized, double-blind, placebo-controlled trial involving 2 arms. It will be comparing the effects of placebo compared to 1 mg oral lorazepam/5 mg oral oxycodone on pain scores during cervical dilator placement…
- Trial name
- OSDI (NCT03202550)
- Testing
- Oxycodone and Lorazepam (Active Comparator)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Johns Hopkins University
Alcohol Withdrawal
A Comparison of Lorazepam and Diazepam in the Treatment of Alcohol Withdrawal
The purpose of this study is to compare the efficacy of two commonly used medications in the treatment of alcohol withdrawal, diazepam and lorazepam.
- Trial name
- NCT00523185
- Testing
- Lorazepam, Diazepam
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Stanford University
Depressive Disorder and Anxiety Disorders
A Study To Investigate Effects Of GSK561679 On Brain Activation During Emotional Processing In Healthy Volunteers
This study will be conducted in healthy volunteers to investigate the effect of single dose GSK561679 on the changes of brain activation, as it compares to an active comparator, lorazepam.
- Trial name
- NCT00513565
- Testing
- single dose
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Alcoholism
Comparing Gabapentin and Lorazepam for Treating Alcohol Withdrawal
This study will evaluate a safe and useful medication for outpatient detoxification that is as effective as benzodiazepines in the short-term, and more effective in the protracted withdrawal period.
- Trial name
- NCT00011297
- Testing
- gabapentin (Neurontin), lorazepam (Ativan)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Hypothermia, Cardiac Arrest
Therapeutic Hypothermia With Propofol in Survival and Neurological Prognoses After Cardiac Arrest
Therapeutic hypothermia has been proven to significantly improve the survival and neurological prognoses in patients resuscitated from cardiac arrest.
- Trial name
- NCT02367755
- Testing
- Propofol, Lorazepam
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Far Eastern Memorial Hospital
Pain, Anxiety
The Use of Clonidine in Pain and Anxiety Associated With Acute Burn Injury in Children
Some of the children who suffer acute burn injury do not have adequate pain and anxiety management with the current regimen of scheduled opiates (morphine) and benzodiazepines (lorazepam).
- Trial name
- clonidine (NCT00580151)
- Testing
- clonidine
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Chronic Kidney Disease (CKD)
Lorazepam and the Risk of Serious Adverse Events
This is a population-based cohort study assessing whether initiating a new outpatient prescription of a higher dose of lorazepam (>1-4 mg/day) compared to a lower dose (0.5-1 mg/day) in older adults with low kidney function (an…
- Trial name
- NCT07179978
- Testing
- Lorazepam
- Where
- Canada
- Volunteers
- 12,308 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Oxytocin, Lorazepam, Anti-Anxiety Agents, Physiological Effects of Drugs
Effects of Oxytocin and Lorazepam on Fear-related Intra-amygdalar Activity
High-potency benzodiazepines have strong anxiolytic effects accompanied by significant adverse effects including impaired cognitive function, drowsiness, dizziness and impaired motoric abilities.
- Trial name
- NCT03829839
- Testing
- Oxytocin, Lorazepam 1 mg
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Benzodiazepine Dependence
Gabapentin Treatment of Benzodiazepine Dependence
Benzodiazepine dependence is a growing public health problem for which very few evidenced-based treatment approaches are available.
- Trial name
- NCT01893632
- Testing
- gabapentin
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Status Epilepticus
Lorazepam for the Treatment of Status Epilepticus or Repetitive Status Epilepticus in Japan
The purpose of this study is to determine the efficacy, safety and pharmacokinetics of Lorazepam on Japanese patients with Status Epilepticus or Repetitive Status Eplilepticus.
- Trial name
- NCT02239380
- Testing
- Lorazepam
- Where
- 20 sites in Japan
- Volunteers
- 26 people
- Sponsor
- Pfizer