Clinical trials: Loss of Smell
Olfaction Disorders, Sinusitis
Trial of Directed High-dose Nasal Steroids on Residual Smell Loss in Sinus Patients After Sinus Surgery
The purpose of this study is to determine if a trial of directed high-dose nasal steroids improves residual smell loss in patients with chronic rhinosinusitis following sinus surgery.
- Conditions
- Olfaction Disorders, Sinusitis, Paranasal Sinus Diseases
- Trial name
- NCT01814618
- Testing
- Budesonide Respules
- Where
- United States
- Sponsor
- University of North Carolina, Chapel Hill
Parosmia
Stellate Ganglion Block With Lidocaine for the Treatment of COVID-19-Induced Parosmia
Chronic olfactory dysfunction, both hyposmia and parosmia, from the COVID-19 pandemic is a growing public health crisis, affecting up to 1.2 million people in the United States.
- Trial name
- Stella (NCT06055270)
- Testing
- Stellate Ganglion Block
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Anosmia, COVID-19
Effectiveness and Safety of Platelet Rich Plasma (PRP) on Persistent Olfactory Dysfunction Related to COVID-19
Olfactory dysfunction (OD) is a well know symptom of coronavirus disease 2019 (COVID-19), accounting for 48 to 85% of patients. In 1 to 10% of cases, patients develop a chronic olfactory dysfunction (COD,) lasting more than 6…
- Trial name
- NCT05226546
- Testing
- Platelet rich plasma (PRP), olfactory training
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Anosmia, Ageusia
Efficacy of Photobiomodulation in the Rehabilitation of Olfactory Dysfunctions Induced by Long COVID-19
On January 30, 2020, the WHO (World Health Organization) declared the new coronavirus pandemic as the sixth public health emergency of international concern.
- Conditions
- Anosmia, Ageusia, COVID-19, Rehabilitation
- Trial name
- NCT06423495
- Testing
- low-intensity laser treatment
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gaffree & Guinle Universitary Hospital
Olfactory Impairment
Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT): Open Label
Smell dysfunction significantly impacts quality of life and safety, with limited effective treatments. This open-label study evaluates the preliminary efficacy of combining non-invasive trigeminal nerve stimulation (TNS) with…
- Trial name
- SCENT-OL (NCT07689773)
- Testing
- Trigeminal Nerve Stimulation-enhanced Smell Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
Anosmia, Covid19
COVID-19 in Patients With Anosmia in Egypt
The study aims to test the frequency of severe acute respiratory syndrome new corona virus SARS-CoV-2 or other respiratory viruses in patients presenting with anosmia or dysgeusia to Ain Shams University Hospitals, Cairo, Egypt.
- Conditions
- Anosmia, Covid19, Dysgeusia
- Trial name
- NCT04473157
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Ain Shams University
Olfactory Disorder
cAMP (Cyclic Adenosine Monophosphate) Levels in the Nose
The purpose of this study is to determine the normal distribution of nasal tissue cathelicidin antimicrobial peptides (cAMP) levels in subjects with normal smell and subjects with smell dysfunction.
- Trial name
- NCT01332825
- Testing
- saline nasal irrigation
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Washington
Obesity & Overweight, Insulin Resistance Syndrome
SENSILINS: Impact of Cephalic Phase Insulin Release Induced by an Environmental Food Odor Stimulus on Glucose Homeostasis According to Insulin Sensitivity Level
This single-center, randomized, single-blind, 2-period crossover interventional study will evaluate whether exposure to a pleasant food odor 10 minutes before a 75 g oral glucose tolerance test (OGTT) modifies glucose homeostasis…
- Trial name
- SENSILNS (NCT07638111)
- Testing
- Pleasant Food Odor Stimulation, Control Environmental Condition
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Obesity, Overweight
The Effects of GLP-1 Receptor Agonists on Chemosensory Function and Ingestive Behavior
The goal of this study is to explore whether of GLP-1 receptor agonist use is associated with differences in taste, smell, food preferences, appetite, food cravings, and responses to food cues in adults.
- Conditions
- Obesity, Overweight, Taste Perception, Olfaction
- Trial name
- NCT07611201
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Purdue University
Anosmia, Head Trauma
NAC for Head Trauma-induced Anosmia
This study will compare administration of N-Acetyl Cysteine (NAC) versus placebo for the treatment of olfactory loss due to head injury.
- Trial name
- NCT03680911
- Testing
- N Acetyl Cysteine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Miami
Anosmia
Coronavirus Smell Therapy for Anosmia Recovery
As the COVID-19 pandemic spread around the world, anosmia and dysgeusia were quickly recognized as two of the key presenting symptoms.
- Trial name
- Co-STAR (NCT04422275)
- Testing
- Budesonide, High-Concentration Essential Oil, Low-Concentration Essential Oil
- Where
- United States
- Sponsor
- Washington University School of Medicine
Anosmia
Does Cardiopulmonary Bypass Change Olfaction?
The loss of the sense of smell, anosmia, can have profound effects on the lives of those who suffer from it. In our clinical practice, we have encountered several patients complaining of anosmia after recently undergoing surgery…
- Trial name
- Anosmia (NCT02179554)
- Where
- United Kingdom
- Sponsor
- Manchester University NHS Foundation Trust
Post-viral Anosmia, Post-traumatic Anosmia
Self-assessment of Olfactory Disorders for French Speaking Patients
Sense of smell disorders are common and are said to affect up to 20% of the general population. They are often disabling and have a real impact on the quality of life.
- Conditions
- Post-viral Anosmia, Post-traumatic Anosmia, Chronic Rhinosinusitis, Idiopathic Anosmia
- Trial name
- VIF-DOR (NCT04705805)
- Testing
- Self-assessment of olfactory disorders through two questionnaires.
- Where
- France
- Volunteers
- 135 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Sinusitis
Effects of Anti-IgE Antibody Omalizumab on Patients With Chronic Sinusitis
We propose to study the effects of Xolair on patients with chronic sinusitis with or without nasal polyps. Because of the similarities between the inflammatory processes found in asthmas and rhinitis to those found in chronic…
- Trial name
- NCT00603785
- Testing
- Xolair
- Sponsor
- University of California, San Francisco
Olfactory Disorder, Anosmia
Smell Changes & Efficacy of Nasal Theophylline
This study evaluates the efficacy and safety of nasal theophylline irrigation in treating smell loss related to a viral respiratory infection.
- Conditions
- Olfactory Disorder, Anosmia, Viral Infection, Theophylline Causing Adverse Effects in Therapeutic Use
- Trial name
- SCENT (NCT03990766)
- Testing
- Theophylline, Saline Nasal
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Washington University School of Medicine
Cognitive Function
Sensory Enrichment for Older Adults
This study evaluates the efficacy of multi-odorant enrichment on cognitive skills, olfactory function, and quality of life.
- Trial name
- NCT03914989
- Testing
- olfactory enrichment (essential oils)
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Idiopathic Anosmia, Idiopathic Hyposmia
Alpha-synuclein Rt-quic and Neurologic Symptoms in Persons With idiOpathic anosMiA
Test of early warning signs and RT-QuIC in patients with idiopathic olfactory dysfunction
- Conditions
- Idiopathic Anosmia, Idiopathic Hyposmia, Idiopathic Olfactory Dysfunction
- Trial name
- AROMA (NCT05740683)
- Testing
- RT-QuiC
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Danish Dementia Research Centre
Perception, Self
Comparing the Olfactory Perception of a Fragrance-Loaded SpECs Over Time
The human olfactory system plays a crucial role in sensory perception, influencing emotional states, memory, and interpersonal interactions(1).
- Trial name
- NCT07383337
- Testing
- Fragrance
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons in Ireland - Medical University of Bahrain
Olfactory Disorder, Olfaction Disorders
"Platelet Rich Plasma for the Management of Post-Viral Olfactory Dysfunction.
SARS COV-19 has resulted in prolonged olfactory dysfunction in many patients. The investigators aim to compare the effect of topical platelet-rich plasma (test) vs saline (placebo) in patients with covid-related post-viral…
- Trial name
- NCT05666492
- Testing
- Platelet rich plasma, Saline
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Thomas Jefferson University
Traumatic Anosmia
The Effect of Oral Theophylline on Traumatic Anosmia
This study aimed to improve the treatment outcomes of patients with post-traumatic anosmia through medication and olfactory training.
- Trial name
- theophylline (NCT07171021)
- Testing
- Theophylline 200 mg, olfactory training
- Where
- Taiwan
- Volunteers
- 158 people
- Sponsor
- Taichung Veterans General Hospital