Clinical trials: Loss of Smell
Specific Anosmias
Experiments to Test How and Why the Sense of Smell Differs Between People
The ability to smell varies greatly between different individuals. Some people are unable to detect an odor that most people can smell. It is not known what causes these individual differences.
- Trial name
- NCT00220038
- Testing
- smell tests
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
COVID-19
Validation of a Rapid Quantitative Test for Loss of Smell in COVID-19 Subjects
The purpose of this study is to evaluate the performance of a non-invasive olfactory device as a rapid indicator of COVID-19 in positive subjects.
- Trial name
- NCT04431908
- Testing
- olfactory device
- Where
- United States
- Volunteers
- 1,320 people
- Sponsor
- Yale University
Coronavirus Infection, Severe Acute Respiratory Syndrome
Study of the Pathogenesis of Olfactory Disorders in COVID-19
This study is a case-control study to characterize the molecular and cellular anomalies of the olfactory epithelium of COVID-19 patients with isolated anosmia, by comparison with the olfactory epithelium of non-infected subjects.
- Conditions
- Coronavirus Infection, Severe Acute Respiratory Syndrome, Sars-CoV2
- Trial name
- COVIDSMELL (NCT04366934)
- Testing
- Nasal swab, Taste and olfactory function evaluation
- Where
- 2 sites in France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Cancer, Sarcopenia
Personalized Cooking and Nutrition Guidance and Physical Activities Program to Reduce Muscle Loss in Advanced Cancer
People with advanced cancer often lose muscle over time. This can make them weaker, more tired, and reduce their quality of life. Many patients also struggle to eat because of changes in taste, smell, or appetite.
- Conditions
- Cancer, Sarcopenia, Muscle Mass Loss
- Trial name
- NCT07466862
- Testing
- Oncology Dietitian's Standard of Care, Personalized Culinary and Nutrition Therapy
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Gali Perel
Smell Loss
Preparation and Characterization Intranasal Film Loaded With Steroid as a Local Treatment of Anosmia in Compare to Insulin Intranasal Film
This study is a growing step of phase I study published on March 2021. The study was implicated on Minia university on small scale of patient (20) to investigate the impact of insulin as fast dissolving films for intranasal…
- Trial name
- NCT05328414
- Testing
- Prednisolone
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Deraya University
Hyposmia, Parkinson Disease
The Vietnamese Smell Identification Test in the Diagnosis of Parkinson's Disease
The goal of this observational study is to assess the value of the Vietnamese smell identification test (VSIT) in the diagnosis of Parkinson's disease, and compare it with the commonly used test in the world, Brisk smell…
- Trial name
- NCT05837637
- Testing
- The Vietnamese Smell Identification test (VSIT), the Brief Smell Identification test (BSIT)
- Where
- Vietnam
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
COVID-19
Qualitative and Quantitative Evaluation of Anosmia Over Time in Clinically Symptomatic Patients Tested for COVID-19 Infection
Loss of sense of smell and taste has been anecdotally reported during the covid-19 epidemic. The study investigators wanted to describe the prevalence of olfactory and gustatory dysfunction and assess the factors associated with…
- Trial name
- Anosmie-COVID (NCT04354857)
- Testing
- olfactory and gustatory tests
- Where
- France
- Volunteers
- 454 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Parkinson's Disease
A Study Assessing Change in Sense of Smell After Rasagiline Use in Parkinson's Patients
A decrease or loss of the sense of smell is very common in patients with Parkinson's Disease even in the earliest stages of the disease.
- Trial name
- PD-SOAR (NCT01007630)
- Testing
- Rasagiline
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- The Parkinson's Institute
Smell Dysfunction, Olfactory Disorder
Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)
Persistent smell loss that can include diminished or distorted smell function is a common symptom of long COVID syndrome. There are limited treatment options for long COVID-related smell loss.
- Conditions
- Smell Dysfunction, Olfactory Disorder, Long COVID
- Trial name
- NCT05855369
- Testing
- Trigeminal Nerve Stimulation (TNS), Active Smell Training (ST)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Medical University of South Carolina
Amyloidosis, Cardiac Amyloidosis
Study of Olfactory Disorders in Patients With Cardiac Amyloidosis
Amyloidosis is a disease caused by the continuous accumulation of fibrillary proteins in the extracellular matrix causing the architecture of different organs to be disrupted. The prevalence of the disease increases with age.
- Conditions
- Amyloidosis, Cardiac Amyloidosis, Olfactory Loss, Hyposmia
- Trial name
- AMYLODOR (NCT04661800)
- Testing
- Sniffin's stick test
- Where
- France
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sequelae of; Infection, Post Infection Glomerulonephritis
Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2
Post-acute sequelae of SARS-CoV-2 infection can cause multiple system function disorders, and complicated symptoms last for an extended period.
- Conditions
- Sequelae of; Infection, Post Infection Glomerulonephritis, Post-Infectious Peripheral Neuralgia, Post-Infectious Disorder (Disorder)
- Trial name
- sequelae (NCT04846010)
- Testing
- PurWet, FurFat, PurApo
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- All Natural Medicine Clinic, LLC
Schizophrenia
What the Nose Knows: Hedonic Capacity, Psychosocial Interventions and Outcomes in Schizophrenia
This project proposes to conduct the first study of the predictive utility of olfactory hedonic measurement for targeted psychosocial rehabilitation in schizophrenia.
- Trial name
- NCT05282186
- Testing
- Cognitive Enhancement Therapy, Social Skills Training
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Beth Israel Deaconess Medical Center
Anosmia, Parosmia
Multimodal Chewing Gum Flavour Training to Aid Flavour Perception Recovery - a Pilot Study.
Olfactory training is developed for people who have partly or completely lost their sense of smell (olfactory dysfunction). Participants expose themselves to odours twice daily for usually 12 weeks or longer.
- Conditions
- Anosmia, Parosmia, Phantosmia, Dysgeusia
- Trial name
- FITS (NCT07498062)
- Testing
- Flavour impairment training using chewing gum group (FIT), Olfactory training group (OT), Waiting list control group
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Smell Disorder, Taste Disorders
Taste and Smell Impairment in Critically Ill COVID-19 Patients
Evaluating the smell and taste perceptions of patients hospitalized in the intensive care unit with suspicion of Coronavirus disease-19 diagnosis with a survey study
- Conditions
- Smell Disorder, Taste Disorders, Coronavirus Infection
- Trial name
- NCT04532632
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Pinar Ay Sayin
Testicular Cancer
Taste, Smell and Chemotherapy (TASTY)
Taste and smell abnormalities are common in cancer patients undergoing chemotherapy, with a prevalence ranging from 46% to 77% for taste changes, and 35% to 75% for smell changes.
- Trial name
- TASTY (NCT01641172)
- Testing
- Dexa scan, audiogram, measurement of heart rate variability and baroreflex sensitivity
- Where
- Netherlands
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Anosmia
Efficacy of Platelet-rich Plasma in Management of Anosmia
Olfactory dysfunction is a prevalent disorder that affects up to 20% of the general population and has significant effects on a person's quality of life as well as increased morbidity and mortality (Croy I et al., 2014;Nordin S…
- Trial name
- NCT06930248
- Testing
- Platelet rich plasma injection
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Traumatic Olfactory Nerve Injury With Anosmia (Diagnosis), Effect of Drug
The Effect of Platelet-rich Plasma Nasal Injection in the Treatment of Traumatic Olfactory Dysfunction
The purpose of this study is to explore the efficacy of injecting high-concentration platelet plasma combined with hyaluronic acid into the nasal olfactory mucosa in the treatment of traumatic anosmia.
- Trial name
- PRP (NCT06290219)
- Testing
- platelet-rich plasma combined with hyaluronic acid, Zinc Gluconate 10 MG Oral Tablet, 4 bottles of phenyl ethyl alcohol, lemon, eucalyptus, and clove oil
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taichung Veterans General Hospital
Anosmia, Covid19
Olfactory Disfunction and Co-ultraPEALut
Olfactory dysfunction is common among patients with Corona-Virus-Infection-Disease (COVID)-19, and up to 30% of patients may report persistent disorders of smell or taste as a long-term sequelae.
- Conditions
- Anosmia, Covid19, Hyposmia, Parosmia
- Trial name
- NCT04853836
- Testing
- co-ultraPEALut, Olfactory Rehab, PEA-LUT 1 sachet
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Acromegaly, Olfactory Disorder
Olfactory Function and Olfactory Bulb Volume in Acromegaly Patients
A prospective, controlled, single blinded study was planned. 20 patients with Acromegaly (Acromegaly Group) and 20 healthy subjects (Control Group) were planned to include in the study.
- Trial name
- NCT04138537
- Testing
- OB volume, CCCRC test
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Olfaction
A Clinical Trial to Study the Effects on the Olfaction Capacity of an Individual Undergoing Skull Base Surgeries Using Cautery vs Scalpel .
Olfaction is a prominent entity that determines a person's quality of life. During human evolution, olfaction has played an essential role in determining safe food, assessing threats, and developing social relationships.
- Trial name
- NCT07385911
- Testing
- Scalpel, Cautery
- Where
- India
- Volunteers
- 80 people
- Sponsor
- All India Institute of Medical Sciences, Jodhpur