Clinical trials: Low; Birthweight
Feeding; Difficult, Newborn, Necrotizing Enterocolitis
A Multi-strain Synbiotic Versus a Multi-strain Probiotic in Premature Infants
The aims are to 1) compare two probiotic treatments (multi-strain synbiotic vs. multi-strain probiotic) on bifidobacteria fecal colonization counts at 1, 2, 3, and 4 weeks of life, 34 weeks corrected gestation age (CGA) ; 2)…
- Trial name
- NCT01337921
- Testing
- Multi-strain Probiotic
- Sponsor
- University of Nebraska
Liver Diseases
Half-life of Plasma Phytosterols in Preterm Infants on Parenteral Nutrition
The purpose of this study is to determine plasma phytosterols half-lives in preterm infants who received intravenous soy oil-based lipid emulsions.
- Trial name
- NCT02758834
- Volunteers
- 45 people
- Sponsor
- Università Politecnica delle Marche
Brain Injuries, Cerebral Palsy
Magnesium Sulfate to Prevent Brain Injury in Premature Infants
Premature infants are at risk for acute brain injuries and long-term developmental problems such as cerebral palsy (CP). Research suggests that high levels of magnesium at and around the time of birth may decrease the risk of…
- Trial name
- NCT00065949
- Testing
- magnesium sulfate
- Where
- United States
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Premature Birth, Late-onset Invasive Infection
Speed of Increasing Milk Feeds Trial
Survival of preterm infants has increased greatly over the years, so a major aim now is to improve the long term outlook for these babies and to avoid serious complications.
- Conditions
- Premature Birth, Late-onset Invasive Infection, Necrotizing Enterocolitis
- Trial name
- SIFT (NCT01727609)
- Testing
- Milk feed (breast milk or formula milk)
- Where
- 57 sites in Ireland, United Kingdom
- Volunteers
- 2,804 people
- Sponsor
- University of Oxford
Malaria, Malaria in Pregnancy
A Randomized Controlled Trial for Intermittent Preventive Treatment in Pregnancy With Fansidar in Solomon Islands
The purpose of this study is to assess the effectiveness of intermittent preventive treatment in pregnancy (IPTp) with Sulphadoxine-pyrimethamine compared to chloroquine prophylaxis in Honiara, Solomon Islands for prevention of…
- Trial name
- IPTpRCT (NCT00964691)
- Testing
- Sulphadoxine-pyrimethamine, Chloroquine prophylaxis
- Where
- Solomon Islands
- Volunteers
- 2,504 people, healthy volunteers welcome
- Sponsor
- Ministry of Health and Medical Services, Solomon Islands
Infant, Low Birth Weight
Multiple Micronutrient Supplementation (MMS) Evaluation Among Bangladeshi Pregnant Women
Maternal nutrition profoundly affects foetal growth, development, and subsequent infant birth weight. Babies with low birth weight (LBW) have an elevated risk of death in infancy and later childhood.
- Trial name
- NCT05108454
- Testing
- Multiple micronutrient supplementation
- Where
- Bangladesh
- Volunteers
- 4,500 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Overweight, Pregnancy
A Low Glycemic Load Diet During Pregnancy in Overweight Women
This study will compare the effects of a low glycemic load versus standard diet for pregnancy on outcomes related to risk for obesity, diabetes, and heart disease in both mother and infant.
- Trial name
- NCT00364403
- Testing
- Low glycemic load, Low fat diet
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boston Children's Hospital
Bronchopulmonary Dysplasia, Very Low Birth Weight
Preterm Infant Inhaled Albuterol Dosing
The purpose of this study is to help determine the best dose of inhaled albuterol sulfate in premature babies at risk of developing bronchopulmonary dysplasia (BPD).
- Trial name
- NCT02447250
- Testing
- Varied albuterol dose response
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Oregon Health and Science University
Growth Retardation
The Effects of Time Points to Cease Parenteral Nutrition and IGF-1 on Very Low Birth Weight Infants
This study aims to estimate short-term and long-term effects of time points to cease parenteral nutrition on very preterm infants, such as growth; to estimate the role of insulin-like growth factor 1 in the growth.
- Trial name
- NCT06071403
- Testing
- (enteral feeding volume/ total fluid volume)*100%
- Where
- China
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Peking University
Low Birthweight, Preterm Birth
Enhancing Nutrition and Antenatal Infection Treatment for Maternal and Child Health in Ethiopia
The ENAT study will test the impact of packages of antenatal interventions to enhance maternal nutrition and manage pregnancy infections on the outcomes of infant birth size, gestational length, and infant growth in the first 6…
- Conditions
- Low Birthweight, Preterm Birth, Maternal; Malnutrition, Affecting Fetus, Sexually Transmitted Diseases
- Trial name
- ENAT (NCT04171388)
- Testing
- Azithromycin 500 mg, Multiple Micronutrient or Fortified Balanced Energy Protein Supplement, Enhanced Infection Management Package (EIMP)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Infant, Newborn, Diseases, Infant, Extremely Low Birth Weight
Transfusion of Prematures Trial
The objective of the TOP trial is to determine whether higher hemoglobin thresholds for transfusing ELBW infants resulting in higher hemoglobin levels lead to improvement in the primary outcome of survival and rates of…
- Conditions
- Infant, Newborn, Diseases, Infant, Extremely Low Birth Weight, Infant, Small for Gestational Age, Bronchopulmonary Dysplasia (BPD)
- Trial name
- TOP (NCT01702805)
- Testing
- Liberal Cell Transfusion, Restricted red cell transfusion
- Where
- 20 sites in United States
- Volunteers
- 1,824 people
- Sponsor
- NICHD Neonatal Research Network
Human Immunodeficiency Virus, Acquired Immune Deficiency Syndrome
Mentor Mothers: A Sustainable Family Intervention in South African Townships
The purpose of this study is to test a mother-to-mother intervention during pregnancy and after delivery with Mothers Living with HIV (MLH)in South Africa.
- Conditions
- Human Immunodeficiency Virus, Acquired Immune Deficiency Syndrome, Tuberculosis
- Trial name
- NCT00972699
- Testing
- Peer support and mentoring
- Where
- South Africa
- Volunteers
- 1,200 people
- Sponsor
- University of California, Los Angeles
Endothelial Dysfunction, Sublingual Capillary Glycocalyx and Density
Prematurity as Predictor of Children's Cardiovascular-renal Health
Extreme preterm birth interferes with the development of the cardiovascular system. Both macro- as well as microvasculature undergoes extensive, organ specific maturation.
- Conditions
- Endothelial Dysfunction, Sublingual Capillary Glycocalyx and Density, Visual Disturbances and Blindness, Ventricular Dysfunction, Left
- Trial name
- PREMATCH (NCT02147457)
- Where
- Belgium
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Patent Ductus Arteriosus
Comparative Study of Efficacy and Safety of Oral Ibuprofen and Intravenous Ibuprofen in Closure of Patent Ductus Arteriosus in Very Low Birth Weight Infants
it is a prospective randomized simple-blinded pilot trial with the principal aim to compare efficacy and tolerance between oral ibuprofen and intravenous ibuprofen in early curative closure of PDA in very low birth weight…
- Trial name
- NCT00642330
- Testing
- oral ibuprofen, intravenous ibuprofen
- Where
- Tunisia
- Volunteers
- 62 people
- Sponsor
- Hopital La Rabta
Very Low Birth Weight Infants
Cognitive and Behavioral Outcomes of School-aged Children Who Were Born Preterm
This study evaluates the cognitive and behavioral outcomes including image findings of school-aged children who were born preterm compared with who were born term gestational age.
- Trial name
- NCT02741934
- Where
- South Korea
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
ELBW - Extremely Low Birth Weight Infant, IVH- Intraventricular Hemorrhage
The Impact of Continuous Transcutaneous CO2 (TCCO2) Monitoring in Extremely Low Birth Weight (ELBW) Infants
An observational study comparing outcomes of Extremely Low Birth Weight (ELBW) infants that were monitored with non-invasive Transcutaneous CO2 (TCCO2) monitor to infants that were not monitored by TCCO2 monitor.
- Trial name
- NCT03477708
- Where
- Israel
- Volunteers
- 166 people
- Sponsor
- Rambam Health Care Campus
Pregnancy, Premature Birth
A Trial of Micronutrients and Adverse Pregnancy Outcomes
The purpose of this study is to examine the efficacy of multivitamin supplementation on fetal loss, low birth weight and severe preterm birth in healthy (HIV negative) women.
- Conditions
- Pregnancy, Premature Birth, Infant, Low Birth Weight, Pregnancy Outcomes
- Trial name
- NCT00197548
- Testing
- Multivitamins-vitamins B-complex, C, and E
- Volunteers
- 8,468 people
- Sponsor
- Harvard School of Public Health (HSPH)
Low-Birth-Weight Infant, Tuberculosis
IMPAACT P1106: Pharmacokinetic Characteristics of Antiretrovirals and Tuberculosis Medicines in Low Birth Weight Infants
P1106 is Phase IV prospective pharmacokinetic (PK) study of low birth weight infants who are receiving or will be receiving as part of clinical care nevirapine (NVP) prophylaxis, tuberculosis (TB) prophylaxis or treatment and/or…
- Conditions
- Low-Birth-Weight Infant, Tuberculosis, HIV
- Trial name
- NCT02383849
- Where
- 2 sites in South Africa
- Volunteers
- 124 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Neonatal Hypothermia
Effect of a Servo-control System on Heat Loss in Very Low Birth Weight Infants at Birth
Hypothermia in preterm infants during the immediate postnatal phase is associated with morbidity and mortality and remains an unresolved, worldwide challenge.
- Trial name
- SCOPRI (NCT03844204)
- Testing
- Thermal servo-controlled system
- Where
- Italy
- Volunteers
- 440 people
- Sponsor
- University Hospital Padova
Trophic Feeding, Very Low Birth Weight Baby
Effect of Oral Colostrum Applications Every 2 Hours and 4 Hours In Order to Achieve Trophic Feeding in Preterm Infants
The goal of this clinical trial is aims to evaluate the effects of applying colostrum orally every 4 and 2 hours in order to achieve trophic feeding in preterm infants.
- Conditions
- Trophic Feeding, Very Low Birth Weight Baby, Preterm
- Trial name
- NCT06379178
- Testing
- Oral colostrum application 2 hours, Oral colostrum application 4 hours
- Where
- Indonesia
- Volunteers
- 47 people
- Sponsor
- Gadjah Mada University