Clinical trials: Low Anterior Resection
TME, Rectal Cancer Surgery
REsults of LOw Anterior Resections With or Without Preventive Stoma in Nonemergency Department
The purpose of this multicenter randomized non-inferiority trial is to evaluate the safety of low anterior resection for rectal cancer performed with versus without a diverting stoma in patients with a low predicted risk of…
- Conditions
- TME, Rectal Cancer Surgery, Low Rectal Cancer, Middle Rectal Cancer
- Trial name
- RELOAD (NCT07463261)
- Testing
- Without a preventive stoma, With a preventive stoma
- Where
- 7 sites in Russia
- Volunteers
- 442 people
- Sponsor
- ANO Scientific and Practical Club for the Development of Modern Medical Technologies
Rectal Cancer, Low Anterior Resection Syndrome
Rectal Cancer Survivorship: Impact of Low Anterior Resection Syndrome (LARS) on the Quality of Life
Quality of life and risk factors for developing major LARS are explored. Therapeutic options were explored in the cohort experiencing major LARS
- Trial name
- NCT06059170
- Testing
- LARS score/ EORTC QLQ C30
- Where
- Belgium
- Volunteers
- 187 people
- Sponsor
- University Hospital, Ghent
Fecal Incontinence
PRP Injection Into Anal Sphincters for Fecal Incontinence
The treatment of fecal incontinence after low anterior resection is problematic, and not always able to increase quality of life.
- Trial name
- NCT04063293
- Testing
- Platelet Rich Plasma
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul Medipol University Hospital
Low Anterior Resection Syndrome, Malignant Anal Neoplasm
Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study
This phase II trial studies how well sacral nerve stimulation works in treating low anterior resection syndrome or fecal incontinence (the body's passage of stool without control) in patients with rectal cancer that has spread to…
- Conditions
- Low Anterior Resection Syndrome, Malignant Anal Neoplasm, Malignant Bladder Neoplasm, Malignant Cervical Neoplasm
- Trial name
- NCT04066894
- Testing
- Explantation, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Low Anterior Resection Syndrome, Sacral Neuromodulation - Interstim Therapy
Effectiveness of Sacral Neuromodulation in Low Anterior Resection Syndrome
Low anterior resection syndrome (LARS) is a complex disorder suffered by patients who undergo rectal resection mainly due to rectal cancer.
- Conditions
- Low Anterior Resection Syndrome, Sacral Neuromodulation - Interstim Therapy, Rectal Cancer
- Trial name
- SANLARS (NCT03598231)
- Testing
- Sacral neuromodulation
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Low Anterior Resection Syndrome, Rectal Cancer
Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome
The study is a multicentre randomized controlled trial with the objective to compare the effect of transanal irrigation with glycerol suppositories in patients suffering from major Low Anterior Resection Syndrome (LARS).
- Trial name
- NCT04087421
- Testing
- Qufora Irrisedo Cone System, Glycerol "OBA"
- Where
- Denmark
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Low Anterior Resection Syndrome
Transanal Irrigation - Best Treatment Possibility for Low Anterior Resection Syndrome? Multicenter, Randomized Clinical Trial
Introduction: About 50% of patients who undergo rectal resection (mostly as a treatment for rectal cancer) suffer from various and partly severe functional problems, despite the preservation of the anal fold.
- Trial name
- NCT05920681
- Testing
- Transanal irrigation, Best supportive care
- Where
- Lithuania
- Volunteers
- 40 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Loop Ileostomy
Fortune of Temporary Ileostomies in Patients After Rectal Cancer Surgery
The risk factors for stoma reversal failure have been rarely studied, which is probably one of the worst scenarios for a case who has a sphincter preserving procedure for a rectal cancer and is expecting to have regular bowel…
- Trial name
- NCT02532478
- Volunteers
- 160 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Rectal Neoplasm
Knowledge-enhanced Digital Intervention to Prevent Low Anterior Resection Syndrome
Low anterior resection syndrome refers to changes in bowel habits such as frequent defecation, urgent defecation, and fecal incontinence, which result in decreased bowel function.
- Trial name
- NCT07041515
- Testing
- Mobile app, standard
- Volunteers
- 320 people
- Sponsor
- National Cancer Center, Korea
Rectal Cancer, Gut Microbiomes
Autologous Probiotics in Patients With Defunctioning Ileostomy Following LAR for Rectal Cancer
Rectal cancer patients who received low anterior resection combined with ileostomy may effectively reduce the probability of anastomotic leakage after surgery.
- Conditions
- Rectal Cancer, Gut Microbiomes, Autologous Probiotic Transplantation, Defunctioning Ileostomy
- Trial name
- NCT07366047
- Testing
- Autologous Probiotics
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Colorectal Cancer, Rectal Tumors
Reconstruction Techniques and Vascular Approach After Laparoscopic Left Hemicolectomy and Rectum Low Anterior Resection
This is an interventional, controlled and randomized single-center clinical trial with patients diagnosed with colorectal cancer that will undergo laparoscopic left hemicolectomy or laparoscopic low anterior resection for rectal…
- Trial name
- TAHR (NCT02746224)
- Testing
- Initially dissection of inferior mesenteric vein, Initially dissection of inferior mesenteric artery, Latero-terminal colorectal anastomosis
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Colorectal Cancer, Low Anterior Resection Syndrome
Effect of Exercise on Bowel Function in Colorectal Cancer Survivors
The survival rate of colorectal cancer patients is increasing due to the development of medical technology. However, many colorectal cancer survivors (CRCs) have bowel dysfunction unlike other cancer survivors.
- Trial name
- NCT05420870
- Testing
- exercise
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Rectal Cancer
Mucosal Flap Reinforced Colorectal Anastomosis and Trans-Anal Vacuum Drainage: A Feasibility Study
Background: Dehiscence of colorectal anastomosis is a serious complication associated with increased mortality and impaired functional and oncological outcomes.
- Trial name
- Endodrain (NCT04735107)
- Testing
- colorectal anastomosis reinforcement and trans-anal drainage
- Where
- Slovakia
- Volunteers
- 50 people
- Sponsor
- Comenius University
Anterior Resection Syndrome
Low Anterior Resection Syndrome and Rectal Irrigation Study
Prospective study assessing treatment acceptability and the impact of rectal irrigation on patients with low anterior resection syndrome (LARS) in terms of quality of life and bowel function.
- Trial name
- LARRIS (NCT04246775)
- Testing
- Peristeen
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Cardiff and Vale University Health Board
Rectal Disorders, Low Anterior Resection Syndrome
Impact of Early Postoperative Treatment With Posterior Tibial Nerve Stimulation on the Incidence and Duration of Low Anterior Rectal Resection Syndrome
The treatment of rectal cancer is currently based on surgical resection of the rectum with total excision of the mesorectum, associated with neoadjuvant radiochemotherapy.
- Conditions
- Rectal Disorders, Low Anterior Resection Syndrome, Low Anterior Resection
- Trial name
- LARS (NCT05368168)
- Testing
- Posterior tibial nerve stimulation (PTNS)
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Innovacion en Cirugía Vigo
Low Anterior Resection Syndrome, Rectal Cancer
Bowel Dysfunction 3 Years After Anterior Resection a in a Swedish National Cohort
The primary objectives are to evaluate the prevalence of LARS and Quality of Life in rectal cancer patients 3 years after anterior resection, to investigate if anastomotic technique is a risk factor for major LARS and to study…
- Trial name
- NCT04591821
- Where
- Sweden
- Volunteers
- 1,200 people
- Sponsor
- Region Skane
Low Anterior Resection Syndrome, Rectal Cancer
Transanal Irrigation for the Management of LARS
This study aims to evaluate the impact of Transanal irrigation (TAI) on the quality of life and low anterior resection symptoms (LARS) in Canadian rectal cancer survivors living with minor to major LARS.
- Trial name
- TAI-LARS (NCT05007015)
- Testing
- Transanal Irrigation
- Where
- 8 sites in Canada
- Volunteers
- 66 people
- Sponsor
- Jewish General Hospital
Cancer of Rectum
Peritoneal Microdialysis in Patients Undergoing Low Anterior Resection (LAR) for Recto-sigmoid Cancer
Anastomotic leakage is a serious complication after LAR with high morbidity and mortality rates. Early diagnosis and treatment is mandatory.
- Trial name
- NCT00271986
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
Rectal Cancer
Comparison of Low and High Ligation in the Rectal Cancer
The purpose of this study is to evaluate the defecatory function when nerve fibers around the inferior mesenteric artery(IMA) and left colic artery(LCA) are preserved(so called low ligation ) or not(high ligation) in the…
- Trial name
- NCT00701012
- Testing
- preservation of nerve fibers around IMA, resection of nerve fibers around IMA
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Wakayama Medical University
Ileostomy - Stoma
Early Closure of Protective Ileostomy in Rectal Cancer Patients
The aim of the study was to compare the restoration of the GI tract by the closure of protective ileostomy after low anterior resection for rectal cancer after 14 days and more than 3 months.
- Trial name
- ECPIS (NCT02997267)
- Testing
- Closure of the ileostomy
- Where
- Poland
- Volunteers
- 58 people
- Sponsor
- Stanley Dudrick's Memorial Hospital