Clinical trials: Low Back Pain, Chronic
Low Back Pain
Auricular Vagus Nerve Stimulation for Chronic Pain
This proposal aims to investigate the treatment effect and underlying mechanism of transcutaneous acupuncture stimulation on chronic low back pain.
- Trial name
- NCT03959111
- Testing
- Stimulation at Location 1, Stimulation at Location 2
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Low Back Pain, Chronic Pain
Long-Term Safety and Tolerability Study of NKTR-181 in Subjects With Chronic Low Back Pain or Chronic Non-Cancer Pain
The purpose of this 52-week open label study is to determine the long-term safety of a new opioid molecule, NKTR-181, in patients with moderate to severe chronic low back pain or chronic non-cancer pain.
- Trial name
- SUMMIT-LTS (NCT02367820)
- Testing
- NKTR-181 BID tablets
- Where
- 56 sites in United States
- Volunteers
- 638 people
- Sponsor
- Nektar Therapeutics
Chronic Low Back Pain
Rage Against the Pain to Address Chronic Low Back Pain Among Veterans
Chronic low back pain is a leading cause of disability among Veterans. Yoga is recommended as a front-line treatment option for chronic low back pain and is available across the VA healthcare system; however, despite yoga being…
- Trial name
- RAP (NCT05103475)
- Testing
- Rage Against the Pain (RAP), Control
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Low Back Pain
A Phase 3 Study of Tanezumab for Chronic Low Back Pain
This study will investigate the efficacy and safety of tanezumab 5 mg and 10 mg administered by subcutaneous injection seven times at 8 week intervals (56 weeks).
- Trial name
- TANGO (NCT02528253)
- Testing
- Tanezumab 5 mg SC, Tanezumab 10 mg SC, Tramadol PR oral
- Where
- 262 sites in United States, Canada and 7 more
- Volunteers
- 1,832 people
- Sponsor
- Pfizer
Chronic Pain, Chronic Lower Back Pain
Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain
Effective control of chronic pain is a top priority in the United States, as approximately 10% of adults have severe chronic pain most of which is chronic lower back pain (CLBP).
- Conditions
- Chronic Pain, Chronic Lower Back Pain, Back Pain, Opioid Use
- Trial name
- NCT04156802
- Testing
- Real TBS to the mPFC, Real TBS to the MC
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Wake Forest University Health Sciences
Aging, Chronic Low-back Pain
Adaptability and Resilience in Aging Adults-2
Chronic low back pain is a major health concern among older adults and is associated with increased economic, functional, and psychological burden.
- Trial name
- ARIAA-2 (NCT04068922)
- Testing
- Resilience Intervention
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Florida
Non-specific Chronic Low Back Pain
An Interactive Gaming-based Intervention for Back Pain
This study aims to compare the outcomes of a traditional, exercise-based rehabilitation intervention for chronic low back pain with the outcomes achieved by combining a traditional intervention with adjunct therapy delivered…
- Trial name
- NCT02503410
- Testing
- Usual care, Interactive gaming
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Spaulding Rehabilitation Hospital
Chronic Low Back Pain
Internet-based Behavioral Pain Management
The purpose of the proposed project is to develop and test how well an internet-based behavioral pain self-management program, the Pain EASE program, can be used for treating low back pain in Veterans.
- Trial name
- NCT01918189
- Testing
- behavioral pain self-management intervention Pain EASE
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- VA Office of Research and Development
Low Back Pain
Effectiveness of Thoracic Facet Joint Nerve Blocks
1. To demonstrate whether: i. Facet joint nerve blocks have therapeutic value beyond the duration of local anesthetic effect. ii.
- Trial name
- NCT00355706
- Testing
- Thoracic facet joint nerve blocks
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Pain Management Center of Paducah
Osteoarthritis, Low Back Pain
An Efficacy and Safety Study of Fentanyl Transdermal Patch in Filipino Participants With Osteoarthritis and Chronic Low Back Pain
The purpose of this study is to evaluate the efficacy and safety of fentanyl among Filipino participants with osteoarthritis (disorder which is seen mostly in older persons in which the joints become painful and stiff) and…
- Trial name
- NCT01795898
- Testing
- Fentanyl
- Where
- Philippines
- Volunteers
- 237 people
- Sponsor
- Janssen Pharmaceutica
Chronic Low Back Pain
Phase 2 Chronic Low Back Pain Study
The primary purpose of this study was to evaluate the analgesic effect and safety of hydrocodone/acetaminophen extended release compared to placebo.
- Trial name
- NCT01364922
- Testing
- hydrocodone/acetaminophen extended release
- Where
- 17 sites in United States
- Volunteers
- 168 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Chronic Pain
SCS as an Option for Chronic Low Back and/or Leg Pain Instead of Surgery
To evaluate the safety and effectiveness of Spinal Cord Stimulation (SCS) with multiple modalities compared to Conventional Medical Management (CMM) in patients with chronic low back and/or leg pain who have not undergone spinal…
- Trial name
- SOLIS (NCT04676022)
- Testing
- WaveWriter, Conventional Medical Managament
- Where
- 23 sites in United States
- Volunteers
- 241 people
- Sponsor
- Boston Scientific Corporation
Low Back Pain
Efficacy and Safety of Hydrocodone Bitartrate Extended-Release Tablets for Moderate to Severe Chronic Low Back Pain
The primary objective of this study is to evaluate the efficacy of hydrocodone bitartrate extended-release tablets at doses of 30 to 90 mg every 12 hours compared with placebo in alleviating moderate to severe pain in patients…
- Trial name
- NCT01789970
- Testing
- Hydrocodone ER
- Where
- 87 sites in United States
- Volunteers
- 625 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Chronic Low Back Pain
ReActiv8 Implantable Neurostimulation System for Chronic Low Back Pain
The purpose of this trial is to evaluate the safety and efficacy of ReActiv8 for the treatment of adults with Chronic Low Back Pain when used in conjunction with medical management.
- Trial name
- ReActiv8-B (NCT02577354)
- Testing
- ReActiv8 Implantable Stimulation System (Patient Appropriate Stimulation), ReActiv8 Implantable Stimulation System (Low Stimulation)
- Where
- 26 sites in United States, Australia and 3 more
- Volunteers
- 204 people
- Sponsor
- Mainstay Medical
Chronic Low-back Pain
EaseVRx for the Reduction of Chronic Pain and Opioid Use
EaseVRx, a software-based virtual reality (VR) medical device, is intended to offer users a prescription pain management tool that manages the symptoms associated with chronic pain and reduces or eliminates the risk of opioid…
- Trial name
- NCT04139564
- Testing
- EaseVRx headset
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- AppliedVR Inc.
Low Back Pain
Targeted Interventions to Prevent Chronic Low Back Pain in High Risk Patients
Low back pain (LBP) is a common problem among US adults. Initial episodes tend to be self-limited ("acute"), but some people can progress to a state of persistent pain.
- Trial name
- TARGET (NCT02647658)
- Testing
- Guideline Based Care plus Psychologically Informed Physical Therapy, Guideline Based Care (GBC)
- Where
- 5 sites in United States
- Volunteers
- 2,300 people
- Sponsor
- University of Pittsburgh
Chronic Low Back Pain
Study of Basivertebral Nerve Ablation Treatment of Chronic Low Back Pain
Prospective, single arm, open label, multi-center study to evaluated the effectiveness of intraosseous basivertebral nerve radiofrequency ablation using the Intracept System.
- Trial name
- NCT03266107
- Testing
- Intracept
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Relievant Medsystems, Inc.
Back Pain Without Radiation
Duloxetine Versus Placebo in Chronic Low Back Pain
The primary purpose of your participation in this study is to help answer the following research question, and not to provide you treatment for your condition.
- Trial name
- NCT00424593
- Testing
- Duloxetine
- Where
- 17 sites in Brazil, France and 3 more
- Volunteers
- 236 people
- Sponsor
- Eli Lilly and Company
Low Back Pain
Efficacy and Cost: Benefit Ratio of 0, 1, and 2 Medial Branch Blocks for Lumbar Facet Joint Radiofrequency Denervation
Lumbar zygapophysial (facet) joint pain is a common cause of low back pain. Radiofrequency (RF) denervation is an effective and low risk treatment of chronic low back pain of suspected facet joint etiology.
- Trial name
- NCT00484159
- Testing
- Radiofrequency denervation of medial branches, 0.5% bupivacaine, 2% lidocaine
- Where
- 2 sites in United States
- Volunteers
- 151 people
- Sponsor
- Johns Hopkins University
Low Back Pain, Pain
D-cycloserine for the Treatment of Chronic, Refractory Low Back Pain
The purpose of this study is to evaluate the efficacy and safety of D-cycloserine versus placebo in relieving the signs and symptoms of patients with chronic lower back pain.
- Trial name
- NCT03535688
- Testing
- D-cycloserine
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Northwestern University