Clinical trials: Low Blood Pressure
Orthopedic Disorder, Hemodynamic Instability
Hypotension Prediction Index Based Perioperative Protocolized Hemodynamic Management in Geriatric Orthopedic Surgery
Blood pressure optimization has been considered as a crucial factor to avoid perioperative vital organ hypoperfusion, and perioperative hypotension has been addressed as a risk factor for complications and adverse clinical…
- Trial name
- NCT05274412
- Testing
- hypotension prediction index(HPI), ordinary goal-directed hemodynamic therapy
- Where
- Taiwan
- Volunteers
- 280 people
- Sponsor
- National Taiwan University Hospital
Hypotension, Heart Failure
Dapagliflozin on Hypotensive Heart Failure Patients After Sacubitril/Valsartan Therapy
The DAPA-HF trial demonstrated that dapagliflozin was able to reduce the risk of worsening heart failure events and cardiovascular death comparing to placebo in patients with reduced ejection fraction further to standard of care.
- Trial name
- NCT04575675
- Testing
- Dapagliflozin, Sacubitril-Valsartan, Beta blocker
- Where
- Taiwan
- Volunteers
- 78 people
- Sponsor
- Cheng-Hsin General Hospital
Meningioma
Magnesium and Intraoperative Blood Loss in Meningioma Surgery
Meningioma is the most common central nervous system tumor and craniotomy with tumor removal was associated with moderate blood loss and blood transfusion.
- Trial name
- NCT03558516
- Testing
- Magnesium group, Normal saline group
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Post Induction Hypotension, Postoperative Morbidity
Preoperative Carotid Doppler Ultrasound Parameters for Prediction of Post-Induction Hypotension in Elective Non-Cardiac Surgery
This prospective observational study aims to evaluate the predictive value of preoperative carotid Doppler ultrasound parameters, including carotid velocity-time integral (carotid VTI) and corrected carotid flow time (ccFT), for…
- Trial name
- NCT07488182
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Necmettin Erbakan University
Multiple System Atrophy, MSA - Multiple System Atrophy
Study to Evaluate Investigational Allogeneic Cell Therapy Product hOMSC300 for Treatment of Early to Moderate Stage Multiple System Atrophy (MSA)
Purpose of this phase 1 study is to assess the safety of intrathecal administration of allogeneic human oral mucosa stem cells (hOMSCs) in patients suffering from early to moderate stage Multiple System Atrophy (MSA)
- Trial name
- NCT05698017
- Testing
- hOMSC300
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Cytora Ltd.
Hypotension
Washington Study of AxoTrack-Guided Central Venous Cannulation
Undifferentiated hypotension is a medical emergency where a patient's blood pressure drops to critical levels due to several possible reasons.
- Trial name
- WASHCAN (NCT03027323)
- Testing
- AxoTrack System
- Where
- United States
- Sponsor
- University of Washington
Pre-eclampsia, Pre-Eclampsia, Severe
Prevalence of Blood Pressure Complications During Cesarean Section in Pre-eclamptic Patients (HOPE)
Preeclampsia (PE) is an obstetric placental vascular pathology with a prevalence of 2 to 5% of pregnant women. It is defined by learned societies by the association of high blood pressure (BP≥140/90mmHg) and proteinuria \&gt…
- Trial name
- HOPE (NCT06588023)
- Testing
- Observational study to evaluate professional practices
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Intradialytic Hypotension, Hemodialysis-Induced Symptoms
Timing of Intradialytic Exercise and Its Impact on Intradialytic Hypotension
The objective of this study is to compare the rate of low blood pressure events (Intradialytic Hypotension: IDH) when intradialytic exercise is performed in the first half of the hemodialysis (HD) session as compared to that when…
- Trial name
- NCT03504943
- Testing
- Early Intradialytic Exercise, Late Intradialytic Exercise
- Where
- 3 sites in Canada
- Volunteers
- 112 people
- Sponsor
- University of Manitoba
Hypertension
Beach Tennis And Hypertension Study
The purpose of the present study was to evaluate the effect of a beach tennis session on 24-hour ambulatory blood pressure in adults with hypertension.
- Trial name
- BAH (NCT03909308)
- Testing
- Beach Tennis session
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cerebral Oxygen Saturation, Postoperative Cognitive Function
Effect of Cerebral Oxygen Saturation Monitoring on POCD of Elderly Patients Undergoing Shoulder Arthroscopy
To observe whether adjusting the level of intraoperative controlled hypotension through cerebral oxygen saturation monitoring can improve postoperative cognitive function(POCD) and reduce postoperative neurological complications…
- Trial name
- NCT05615480
- Testing
- Controlled hypotension guided by cerebral oxygen saturation monitoring
- Volunteers
- 400 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Heart Failure With Reduced Ejection Fraction, Hypotension
Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension
The evidence-based pharmacologic treatments available for patients with heart failure with reduced ejection fraction (HFrEF) has been established over the last few decades of cardiovascular research.
- Conditions
- Heart Failure With Reduced Ejection Fraction, Hypotension, LV Dysfunction
- Trial name
- MIDOH-HF-P (NCT06405555)
- Testing
- Midodrine Oral Tablet
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Protamine Allergy, Protamine Adverse Reaction
Serum Tryptase Levels During Cardiac Surgery, Diagnosis and Treatment Decisions for Allergic Reactions
The investigators aim to assess tryptase test efficacy for measuring the allergic response to protamine during cardiac bypass surgery.
- Trial name
- NCT02644785
- Testing
- protamine
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Mustafa Kemal University
Hypertension
Clinical Trial to Assess the Effects of Low-fat Dairy on Systolic Blood Pressure
The purpose of this study is to determine if increased consumption of low-fat dairy can reduce blood pressure and improve endothelial function in men and women with pre or stage-1 hypertension.
- Trial name
- NCT01463085
- Testing
- Low-fat dairy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Dairy Research Institute
Hypertension
The Effect of a Low Sodium-High Potassium Salt on Blood Pressure in Vietnamese Adults
The purpose of this study was to investigate the effects of low-sodium, high-potassium condiments and salt on blood pressure in untreated (pre)hypertensive Vietnamese adults.
- Trial name
- NCT02016404
- Testing
- Low-sodium, high-potassium salt, Regular salt
- Where
- Vietnam
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Cardiac Surgery Patients
HPI for Prevention of Hypotension During Cardiac Surgery
Hypotension prediction index (HPI) was applied in various types of non-cardiac surgery with convincing benefits of preventing hypotensive events and clinical sequelae.
- Trial name
- NCT06137547
- Testing
- Hypotension prediction index (HPI)
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Mackay Memorial Hospital
Hyperprolactinemia, Spontaneous Intracranial Hypotension
Pituitary Function and Spontaneous Intracranial Hypotension
Previous research has identified spontaneous cerebral spinal fluid leakage as a cause for spontaneous intracranial hypotension, leading to positional headache patterns.
- Trial name
- NCT02603549
- Testing
- Pituitary panel will be drawn pre-op and post-op for all patients.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cedars-Sinai Medical Center
Hypotension, Orthostatic
Orthostatic Hypotension in Rehabilitation Patients
The purpose of this study is to determine the prevalence and clinical course of orthostatic hypotension (OH) on a rehabilitation and nursing home unit during their inpatient stay and to initiate a standardized, interdisciplinary…
- Trial name
- NCT00117585
- Testing
- Treatment Phase 1, Treatment Phase 2, Treatment Phase 3
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- VA Office of Research and Development
Total Knee Arthroplasty
Low Versus High Pressure Suction Drainage After Total Knee Arthroplasty
Principal hypothesis: A low suction drainage (-50 mmHg) reduce a 25% the blood loss with respect a standard closed drainage (-700 mmHg) following total knee arthroplasty.
- Trial name
- NCT00866268
- Testing
- low pressure suction drainage, High pressure suction drainage
- Where
- 2 sites in Spain
- Volunteers
- 169 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Ischemic Stroke, High Blood Pressure
Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED)
ENCHANTED is an independent, investigator initiated, international collaborative, quasi-factorial randomised controlled trial involving a package of 2 linked comparative randomised treatment arms, which aims to address 4 key…
- Trial name
- ENCHANTED (NCT01422616)
- Testing
- Low-dose rtPA, Standard-dose rtPA, Intensive blood pressure (BP) lowering
- Where
- Australia
- Volunteers
- 4,587 people
- Sponsor
- The George Institute
Symptomatic Neurogenic Orthostatic Hypotension, MSA - Multiple System Atrophy
Phase 3 Efficacy and Durability of Ampreloxetine for the Treatment of Symptomatic nOH in Participants With Multiple System Atrophy
This is a Phase 3, multi-center, randomized withdrawal study to evaluate the efficacy and durability of ampreloxetine in participants with MSA and symptomatic nOH after 20 weeks of treatment.
- Trial name
- CYPRESS (NCT05696717)
- Testing
- Ampreloxetine
- Where
- 79 sites in United States, Argentina and 18 more
- Volunteers
- 102 people
- Sponsor
- Theravance Biopharma