Clinical trials: Low Dose
Contraception
Open-label Study to Evaluate the Efficacy and Safety of an Extended-cycle, Low Dose Combination Oral Contraceptive
This is an open-label, single treatment study. All subjects will receive one year of oral contraceptive therapy with DR-1011. Study participants will receive physical and gynecological exams, including Pap smear.
- Trial name
- NCT00196326
- Testing
- DR-1011
- Where
- 55 sites in United States
- Volunteers
- 2,235 people, healthy volunteers welcome
- Sponsor
- Duramed Research
Myopia
The Effects of Low Concentration Atropine on Pupil Size and Accommodation
The purpose of this study is to determine whether less frequent dosing of atropine drops may be as effective as daily dosing for the treatment of progressive myopia.
- Trial name
- NCT02870478
- Testing
- Atropine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Follicular Lymphoma
A Phase II Trial of Intermediate Radiation Dose For Lymphoma
The purpose of this study is to determine the optimal radiation dose fractionation regimen for low grade follicular lymphoma. It is hypothesized that the complete response rate with the use of 12 Gy in 6 daily fractions is 80%…
- Trial name
- NCT05284825
- Testing
- 12 Gy in 6 daily fractions
- Where
- Canada
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Opioid Use Disorder
Low-dose Versus a High-dose Sublingual Buprenorphine Induction
This study proposes to compare a low-dose versus a high-dose buprenorphine induction scheme in 40 fentanyl using people with Opioid Use Disorder (OUD).
- Trial name
- NCT05944952
- Testing
- buprenorphine/naloxone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Adrenal Sufficiency
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein
Males and females may exhibit different responses to testing of adrenal function. The hormones responsible for controlling adrenal function are ACTH (adrenocorticotropic hormone or corticotropin) and CRH (corticotropin-releasing…
- Trial name
- NCT00196001
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Self-administered Questionnaire to Patients
Gastroprotective Agent Utilization and Compliance in Patients > 60 Years Taking Low-dose Aspirin in France
The purpose of this study is to assess in general population low-dose aspirin and gastroprotective agent compliance and reasons for bad compliance
- Trial name
- NCT01238809
- Volunteers
- 7,300 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Neuromuscular Blockade
Low Dose of Sugammadex vs Neostigmine and Glycopyrrolate for the Reversal of Rocuronium
The aim of this study is to compare the use of a low dose sugammadex and neostigmine combined to glycopyrrolate to reverse a rocuronium induced moderate neuromuscular blockade.
- Trial name
- SUGANEO (NCT05718934)
- Testing
- Neostigmine and glycopyrrolate, Sugammadex
- Where
- Canada
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Sarcopenia
L1 M1 of LDCT for Low Muscle Mass Measurement
The first lumbar spine muscle index (L1 MI) on computed tomography (CT) obtained by measuring muscle surface at the first lumbar vertebrae (L1) level is an indicator of total skeletal mass in specific populations.
- Trial name
- NCT04547478
- Testing
- low dose chest CT(LDCT)
- Where
- Taiwan
- Volunteers
- 3,304 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Healthy Volunteers
A Study To Investigate The Elimination Of PF-06273588 From The Body Following A Single Low Dose.
To investigate the pharmacokinetics of PF-06273588 following administration of a micro-dose via both intravenous and oral routes.
- Trial name
- NCT01408355
- Testing
- PF-06273588
- Where
- United Kingdom
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Pfizer
Hypercholesterolemia
Statin Interchange by Pharmacist Collaborative Practice Agreement (CPA)
A group of ~ 225 patients were switched from atorvastatin to an equivalent statin either by their physicians usual management or by an collaborative pharmacist coordinated process.
- Trial name
- NCT01222182
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Spinal Anesthesia, Epidural; Anesthesia
Bupivacaine With Epidural Volume Extension
In this study the investigator will address the efficacy of using low dose bupivacaine spinal anesthesia (SA) in combination with epidural volume extension (EVE) for patients undergoing short obstetric procedures.
- Trial name
- NCT03110003
- Testing
- 10 mg Bupivacaine, 5 mg Bupivacaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Renal Insufficiency
Study to Assess Bemiparin Pharmacokinetics in Renal Insufficiency and in the Elderly
Open pharmacokinetic study with 5 parallel groups and two treatment phases (bemiparin 3,500 IU multiple dose and bemiparin 115 IU/kg single dose).
- Trial name
- NCT00413088
- Testing
- bemiparin
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rovi Pharmaceuticals Laboratories
Inflammatory Bowel Disease, Crohn's Disease
Low Dose Naltrexone in Symptomatic Inflammatory Bowel Disease
The investigators will be looking at the efficacy of the use of once daily use of low dose naltrexone (4.5mg) in subjects with symptomatic inflammatory bowel disease.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT01810185
- Testing
- Low dose naltrexone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Santa Barbara Cottage Hospital
Pharmacokinetics
Pharmacokinetic, Bioavailability, and Safety Study of COV155 Administered in Healthy Subjects Under Fed and Fasted Conditions
A single center, single dose, open-label, randomized, 3-period, 6-sequence, crossover study conducted in normal healthy subjects to evaluate the effect of a high- and low-fat meal on the pharmacokinetics (PK), bioavailability…
- Trial name
- NCT02561650
- Testing
- COV155
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mallinckrodt
Cesarean Section, Spinal Anesthesia
Low Dose Hyperbaric Bupivacaine and Dexmedetomidine as an Adjuvant, Caesarean Section
The aim of this study is to evaluate the effectiveness of low dose scheme with dexmedetomidine as an adjuvant. Taking in consideration optimum intraoperative surgical conditions, best post-operative pain free experience, and more…
- Conditions
- Cesarean Section, Spinal Anesthesia, Dexmedetomidine
- Trial name
- NCT03775655
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Platelet Reactivity
Low-dose of Ticagrelor and Standard-dose Clopidogrel on Platelet Effects in Chinese Patients With Stable CAD.
Ticagrelor has been demonstrated to provide a more rapid and more powerful inhibition of platelet aggregation compared with clopidogrel in coronary artery disease (CAD) patients.
- Trial name
- NCT03679091
- Testing
- low-dose ticagrelor, Clopidogrel
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Contraception
Open-Label Study to Evaluate the Safety and Efficacy of a Low-Dose 28-Day Oral Contraceptive
This is an open-label, single treatment study. All subjects will receive 6 months of oral contraceptive therapy with DR-1021. Study participants will receive physical and gynecological exams, including Pap smear.
- Trial name
- NCT00362479
- Testing
- DR-1021
- Where
- 85 sites in United States
- Volunteers
- 1,347 people, healthy volunteers welcome
- Sponsor
- Duramed Research
Post Operative Pain, Distal Radius Fracture
Low Dose Dexamethasone for Distal Radius Fractures
The addition of the steroid dexamethasone to a single injection of local anesthetic has been shown to significantly prolong the duration of peripheral nerve blockade compared to local anesthetic alone.
- Trial name
- NCT05274113
- Testing
- Dexamethasone 4mg, Ropivacaine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Infection, Human Immunodeficiency Virus
Bioavailability of BMS-626529 in Healthy Subjects From Prototype Low Dose Extended Release Formulations (Part 1) and Prototype Extended Release Multi-particulate Formulations (Part 2) of BMS-663068 Relative to 600 mg Extended Release Tablet
This 2-part study will determine the bioavailability of BMS-626529 in healthy subjects from prototype low dose extended release formulations (Part 1) of BMS-663068 and prototype extended release multi-particulate formulations…
- Trial name
- NCT02508064
- Testing
- BMS-663068
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Low-Dose High-Frequency CPR Training
Low-Dose, High-Frequency CPR Training in Pediatric Emergency Nurses
Life-threatening conditions such as respiratory failure, shock, and cardiac arrest require rapid recognition and timely intervention in pediatric emergency settings.
- Trial name
- LDHF CPR Peds (NCT07508085)
- Testing
- Low-Dose High-Frequency CPR Training, Massed CPR Training
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara University