Clinical trials: Low Dose
Platelet Dysfunction Due to Drugs
The Effects of loW Dose tIcagrelor on Platelet Function Testing in Patients With Stable Coronary arTery Disease
This study aims to assess the effects of low dose ticagrelor on platelet function testing in patients with stable coronary artery disease.
- Trial name
- TWIST (NCT04206176)
- Testing
- Ticagrelor
- Where
- Trinidad and Tobago
- Volunteers
- 25 people
- Sponsor
- The University of The West Indies
Ovarian Cancer, Hepatocellular Carcinoma
Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors
This study will assess the safety and efficacy of DPX-Survivac and low dose cyclophosphamide with pembrolizumab in subjects with selected advanced and recurrent solid tumours.
- Conditions
- Ovarian Cancer, Hepatocellular Carcinoma, Non-small Cell Lung Cancer, Bladder Cancer
- Trial name
- NCT03836352
- Testing
- DPX-Survivac, Cyclophosphamide, Pembrolizumab
- Where
- 23 sites in United States, Canada
- Volunteers
- 184 people
- Sponsor
- ImmunoVaccine Technologies, Inc. (IMV Inc.)
Prostate Cancer
Hypofractionated Proton Radiation Therapy for Low and Intermediate Risk Prostate Cancer
The purpose of this trial is to give a shorter course (5 ½-6 weeks) of proton radiation that has as little side effects on normal bladder and rectal tissues as the usual longer course (8 weeks) of proton radiation, without…
- Trial name
- PR07 (NCT01368055)
- Testing
- 70 Gy/CGE, 72.5 Gy/CGE
- Where
- United States
- Volunteers
- 361 people
- Sponsor
- University of Florida
COVID-19 Pneumonia
Chloroquine + Losartan Compared to Chloroquine Alone for the Treatment of COVID-19 Pneumonia
Study design Phase 2, double blinded, single-center, 1:1 randomized clinical trial of Chloroquine vs Chloroquine/losartan for the treatment of SARS-CoV-2 pneumonia in non-critically ill subjects
- Trial name
- NCT04428268
- Testing
- Chloroquine Phosphate Tablets
- Where
- Mexico
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Diabetic Foot, Arterial Occlusive Disease
Urokinase Therapy in Patients With Diabetic Foot Syndrome
The purpose of this study is to determine whether the additional therapy with low dose urokinase is more effective than only a conventional standard therapy concerning ulcer-healing, rate of major amputation and survival.
- Conditions
- Diabetic Foot, Arterial Occlusive Disease, Ischemia
- Trial name
- NCT00823225
- Testing
- standard therapy, Urokinase
- Where
- 6 sites in Germany
- Volunteers
- 5 people
- Sponsor
- medac GmbH
Follicular Lymphoma, Marginal Zone Lymphoma
A Study of Reduced Dose Radiation Therapy for People With B-Cell Lymphomas
The researchers are doing this study to find out whether a very low dose of radiation therapy (VLDRT) is an effective treatment for people with follicular lymphoma (FL) or marginal zone lymphoma (MZL) and works as well as the…
- Trial name
- NCT07029217
- Testing
- Radiation (Standard), Radiation (Very low dose)
- Where
- 7 sites in United States
- Volunteers
- 375 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Induction of Labor
Sequential Use of Foley's Catheter and Misoprostol Versus Misoprostol Alone for Induction of Labour: a Multicentre Randomised Controlled Trial
Evaluation of efficacy of inducing labour using a Foley's catheter and low dose oral misoprostol sequentially, in comparison with low dose oral misoprostol alone.
- Trial name
- NCT06249815
- Testing
- Misoprostol 200mcg Tab
- Where
- 2 sites in Kazakhstan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Kazakhstan's Medical University "KSPH"
Airway Obstruction
Comparison of High Dose and Low Dose Dexamethasone in Preventing Post-Extubation Airway Obstruction in Adults
The specific objectives were to determine whether high dose dexamethasone are more effective than low dose dexamethasone in the reduction or prevention of post-extubation airway obstruction among patients with a cuff leak volume…
- Trial name
- NCT00548483
- Testing
- dexamethasone (Oradexon, Nederland)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Mackay Memorial Hospital
Relapsing Remitting Multiple Sclerosis
Biological Activity and Safety of Low Dose IL2 in Relapsing Remitting Multiple Sclerosis
Interleukin-2 (IL-2) was initially discovered and used as a stimulator of effector T lymphocytes (Teffs), but is now viewed as a very promising immunoregulatory drug having the capacity to stimulate regulatory T cells (Tregs).
- Trial name
- MS-IL2 (NCT02424396)
- Testing
- IL2
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer
A Study of Radiation With Sorafenib in Advanced Cancer
The purpose of this study is to test the combination of radiation treatment and an anti-angiogenic drug called sorafenib (or BAY 43-9006 or Nexavar) to determine the effects of this combination on cancers but also on side effects…
- Trial name
- NCT00610246
- Testing
- Sorafenib
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto
Hypotension, Poor Peripheral Perfusion
Effect of Vasopressin on Tissue Oxygen Saturation in Cardiac Surgery Patients During Cardiopulmonary Bypass
The objective of this research is to compare the effect of a low dose Vasopressin infusion or placebo during cardiopulmonary bypass on vasopressor requirements, hemodynamics and tissue oxygen saturation and its recovery using…
- Trial name
- NCT01532505
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Mohamed Ismail
Bronchiectasis
Long-term Prognosis of Children With Bronchiectasis Treated With Low-dose Erythromycin Intervention
According to their compliance, the children were divided into two groups: low dose erythromycin treated group (erythromycin 3-5mg/kg.d orally for 6 months) and non-erythromycin treatment group.
- Trial name
- NCT03966066
- Testing
- erythromycin
- Volunteers
- 70 people
- Sponsor
- Beijing Children's Hospital
Pain, Postoperative
Low Dose Caudal VS Dorsal Penile Nerve Block for Postoperative Analgesia After Circumcision
in order to eliminate fear and anxiety. Regional techniques are more effective than systemic opioids, non steroidal anti-inflammatory drugs, and acetaminophen for postoperative analgesia in circumcision, The most preferred…
- Trial name
- NCT05342259
- Testing
- Caudal nerve block /neuroaxial, Dorsal penile nerve block, Combined caudal and dorsal penile nerve block
- Where
- Egypt
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Postoperative Pain, Back Pain Lower Back Chronic
Magnesium Sulfate Infusion on Postoperative Pain in Lumbar Surgery
Effective postoperative analgesia after lumbar spine surgery (e.g., laminectomy, vertebroplasty, lumbar stabilization) is associated with faster recovery and shorter hospital stay.
- Trial name
- NCT07418580
- Testing
- Magnesium sulfate, normal saline
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Parkinson Disease
Low-dose Carbon Monoxide (HBI-002) Trial to Evaluate Safety, Tolerability, PK, and Biomarkers in Parkinson's Disease
A phase 2a multicenter, randomized, double-blind, placebo-controlled multiple dose study to evaluate the safety, tolerability, pharmacokinetics, of HBI-002, an oral low-dose carbon monoxide (CO) liquid drug product, administered…
- Trial name
- LoCaMoTE-PD (NCT07005180)
- Testing
- HBI-002
- Where
- 8 sites in United States
- Volunteers
- 36 people
- Sponsor
- Hillhurst Biopharmaceuticals, Inc.
Myelodysplastic Syndrome, MDS
A Dose Range Finding Study of Lenalidomide in Non-5q Chromosome Deletion in Low and Intermediate Risk Myelodysplastic Syndrome (MDS) Patients
Revlimid® (Lenalidomide) is indicated for a type of blood cancer, myelodysplastic syndrome (MDS), at 10mg for a specific type of myelodysplastic syndrome with a genetic abnormality called "deletion 5q" in Low and Intermediate-1…
- Conditions
- Myelodysplastic Syndrome, MDS, Low to Intermediate-1 MDS, Non-deletion 5q
- Trial name
- NCT00699842
- Testing
- Lenalidomide
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Pneumonia, Viral, Cytokine Storm
Ultra Low Doses of Therapy With Radiation Applicated to COVID-19
The host response against the coronavirus 2 (SARS-CoV-2) appears to be mediated by a 'cytoquine storm' developing a systemic inflammatory mechanism and an acute respiratory distress syndrome (ARDS), in the form of a bilateral…
- Trial name
- ULTRA-COVID (NCT04394182)
- Testing
- Ultra-Low-dose radiotherapy, ventilatory support with oxygen therapy, Lopinavir/ritonavir
- Where
- 2 sites in Spain
- Volunteers
- 15 people
- Sponsor
- Fundacion GenesisCare
Postoperative Pain
Ketamine for Pain Relief in Bariatric Surgery
The surgical interventions for treating morbid obesity, i.e. bypass procedure and sleeve gastrectomy are collectively covered under the term 'bariatric surgery'.
- Trial name
- NCT03052673
- Testing
- Fentanyl, ketamine
- Where
- India
- Volunteers
- 76 people
- Sponsor
- Sir Ganga Ram Hospital
Depression, Major Depressive Disorder
Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive Symptoms
Ketamine has been shown to have an antidepressant effect when given intravenously in doses of 2mg/kg. Ketamine is used as a standard induction drug during general anesthesia.
- Trial name
- NCT02422303
- Testing
- ketamine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pneumonia, Neurological Dysphagia
Drug to Prevent Pneumonia in the Tube Fed
Background: Older people with neurological dysphagia are at risk of recurrent aspiration pneumonia. Angiotensin converting enzyme inhibitor (ACEI) has been shown to improve swallowing and cough reflexes which may protect…
- Trial name
- NCT02358642
- Testing
- Angiotensin converting enzyme inhibitor (Lisinopril)
- Where
- Hong Kong
- Volunteers
- 93 people
- Sponsor
- Chinese University of Hong Kong
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