Clinical trials: Low Energy Availability
Hypogonadotropic Hypogonadism
Low Energy Availability and Pituitary Function (LEAP Study)
The purpose of this study is to learn more about reproductive hormones and if they change in response to 5-days eating an individualized, standardized diet at two levels: energy balance and low energy intake.
- Trial name
- LEAP (NCT05808647)
- Testing
- 5-day controlled metabolic dietary intake
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Contraception, Bone Metabolism
Bone Metabolism in Premenopausal Exercising Women
The main goal of this study is to examine how sex hormones and low energy availability affect the concentrations of bone remodelling markers at rest and after a running protocol.
- Conditions
- Contraception, Bone Metabolism, Low Energy Availability, Eumenorrhea
- Trial name
- BeWOMEN (NCT06961773)
- Testing
- Low energy availability, High energy availability
- Where
- Spain
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universidad Politecnica de Madrid
Athlete, Relative Energy Deficiency in Sport
Preventing Athlete Under-fueling Through Nutrition.
The goal is to improve nutrition screening and support for Division III athletes. The study will use standard, low-risk nutrition screening methods, such as measuring height, weight, grip strength, and body composition, as well…
- Conditions
- Athlete, Relative Energy Deficiency in Sport, Low Energy Availability
- Trial name
- PERFORM (NCT07136038)
- Testing
- Low Energy Availability Screening and Nutrition Support
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Amenorrhea, Functional Hypothalamic Amenorrhea (FHA)
Effects of Resistance Training on Women With Functional Hypothalamic Amenorrhea
Functional hypothalamic amenorrhea (FHA) is a condition where women lose their menstrual periods, typically due to a combination of stress and insufficient calorie intake to fuel their daily physical activity (low energy…
- Conditions
- Amenorrhea, Functional Hypothalamic Amenorrhea (FHA), Low Energy Availability, Relative Energy Deficiency in Sport
- Trial name
- NCT07612735
- Testing
- Resistance Training Program
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Catholic University of Murcia
Healthy
Neurotransmitter Analysis, Stress, and Energy Availability in Athletes
The goal of this observational study is to examine if there is a correlation between energy deficiency, neurotransmitter levels, and exercise test performance among athletes in the Polish national rowing team.
- Trial name
- NCT06683625
- Testing
- 6K Max Effort Erg Test
- Where
- Poland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Relative Energy Deficiency in Sport
Impact Loading Effect on Bone Biomarkers in Female Runners
This study is a randomized, cross-over intervention study that will evaluate the effect of brief, high-impact loading exercises on biomarkers of bone metabolism in energy-restricted female runners.
- Trial name
- NCT05341700
- Testing
- Impact Load Exercises, No Impact Load Exercises
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Low Energy Availability, Cardiovascular Diseases
Low Energy Availability and Cardiovascular Disease
Low energy availability (LEA) signifies a condition where the body lacks sufficient energy to support essential physiological functions crucial for maintaining optimal health (1).
- Trial name
- NCT06615388
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Liverpool Hope University
Vascular Stiffness, Hypertension (HTN)
Low Energy Availability and Hypertension in Division I HBCU Athletes
Low energy availability (LEA) occurs when the body does not get enough calories to support both daily life and exercise. This can happen when athletes train hard but do not eat enough to match their energy needs.
- Conditions
- Vascular Stiffness, Hypertension (HTN), Nutritional Deficiency Related Cardiovascular Risk in Athletes
- Trial name
- CORE-DI (NCT07583940)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- North Carolina Agriculture & Technical State University
Diet; Deficiency, Exercise Intervention
Influence of Low Energy Availability on Skeletal Muscle and Cardiovascular Health
The project is designed as a randomized controlled intervention trial in which 60 young trained (n = 30) (Population A) and recreationally active (n = 30) women (Population B) with regular menstruation are divided into four…
- Trial name
- LEA (NCT04821076)
- Testing
- Diet intervention - caloric restriction, Exercise intervention, Diet intervention - Energy balance
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Low Energy Availability, Physical Performance
Characteristics of Performance in Collegiate Cheerleaders and Dancers
This study aims to investigate performance differences between collegiate cheerleaders and dancers classified as normal weight obese and those classified as normal weight lean.
- Conditions
- Low Energy Availability, Physical Performance, Nutrition
- Trial name
- NCT07378007
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Florida State University
Iron Deficiency, Iron Deficiency Anemia (IDA)
Collegiate Athlete Study
The purpose of this study is to determine what percentage of Black collegiate athletes have low energy availability. It will also determine the percentage of Black collegiate athletes who have iron deficiency, suboptimal or low…
- Conditions
- Iron Deficiency, Iron Deficiency Anemia (IDA), Vitamin D Deficiency, Vitamin D Insufficiency
- Trial name
- NCT07631312
- Testing
- Iron and Vitamin D Deficiencies Correction
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Morehouse School of Medicine
Body Weight Changes, Eating Disorder Symptom
Body Weight Regulation, Disordered Eating Behaviour, and Experiences of Sexual Harassment in Female Martial Art Athletes
Athletes in martial arts compete in categories separated by body weight, hence, many athletes need to adjust their habitual body weight during periods with competition preparation.
- Conditions
- Body Weight Changes, Eating Disorder Symptom, Sexual Harassment, Covid19
- Trial name
- FMAB (NCT04559542)
- Where
- Norway
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Relative Energy Deficiency in Sport
Unravelling Energy Issues Underpinning Low Energy Availability in High Performance Athletes
The goal of this clinical trial is to understand how the body responds to short-term, severe low energy availability (LEA) in healthy, weight-bearing endurance athletes aged 18-45 years old.
- Trial name
- NCT07026175
- Testing
- Diet-induced low energy availability, Exercise-induced low energy availability
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Australian Catholic University
Bone Density, Energy Availability
Low Energy Availability, Menstrual Irregularity, and Low Bone Mass
This study examines the role of energy availability on menstrual function and bone mass in female adolescent endurance athletes.
- Trial name
- NCT01059968
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Bone Resorption, Bone Atrophy
The Effects of Low Energy Availability and High Impact Jumping on Markers of Bone (re)Modelling in Females
Osteoporosis is worldwide health epidemic categorized by poor bone health, primarily diagnosed by low bone mineral density, and costs healthcare systems billions every year.
- Conditions
- Bone Resorption, Bone Atrophy, Energy Supply; Deficiency, Female Athlete Triad
- Trial name
- NCT04790019
- Testing
- Low energy availability, High impact jumping
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Eating Disorders
Triggers of Eating Disorders in Athletes
Over the past 30 years, a high prevalence of eating disorders in sports has been repeatedly documented, yet few preventive measures have been implemented.
- Trial name
- NCT06518954
- Testing
- Interview
- Where
- 2 sites in Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ostfold University College
Energy Balance, Energy Deficit
Impact of Diet-induced Change in Energy Balance on Metabolism in Endurance Athletes
Recent research has suggested that increasing levels of physical activity are associated with a reduction in the independent components that contribute to total energy expenditure (such as resting metabolic rate and non-exercise…
- Conditions
- Energy Balance, Energy Deficit, Low Energy Availability, Relative Energy Deficiency in Sport
- Trial name
- Carpe DIEM (NCT07122778)
- Testing
- Controlled energy-deficit diet, Habitual diet with surplus snacks
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Bath
Low Energy Availability, Relative Energy Deficiency in Sport
Energy Availability and Its Impact in Elite Triathletes
This study investigates how energy availability affects performance, injury risk, and training outcomes in elite triathletes. Over two competitive seasons (2026-2027), 40 elite and sub-elite triathletes will be monitored through…
- Trial name
- TriatLEA (NCT07232628)
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Low Energy Availability, Physical Performance
Body Composition and Lifestyle Factors in ROTC
This study aims to investigates the relationships between body composition, sleep, diet, and physical fitness in ROTC cadets. Further, it aims to evaluate the accuracy of body composition screening methods and identify lifestyle…
- Conditions
- Low Energy Availability, Physical Performance, Nutrition
- Trial name
- NCT07347522
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Florida State University
Resistance Exercise
Low Energy Availability and Recovery From Resistance Exercise
This research project will determine how restricting Calories to lose weight affects your ability to recover between weightlifting exercise sessions.
- Trial name
- LEAR (NCT06623747)
- Testing
- Diet
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Chaise Murphy