Clinical trials: Low Flow, Low Gradient Aortic Stenosis
Amyloidosis Cardiac, Aortic Stenosis, Severe
Analysis of Calcium Score of Severe Aortic Stenosis in Patients With and Without Cardiac Amyloidosis (CAUSATIVE Study)
The concomitant presence of cardiac amyloidosis (CA) in patients with aortic stenosis (AS) may challenge the estimation of stenosis degree.
- Trial name
- CAUSATIVE (NCT06066632)
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- University Hospital of Ferrara
Aortic Valve Stenosis
accuRate Evaluation of Benefit With Optimal Medical Treatment With or Without Transcatheter Valve Repair of PARADOXical Low Flow Low Gradient Aortic Stenosis
Aim of this study is to evaluate whether microsurgical repair or replacement of the aortic valve is a treatment option for a subgroup of patients suffering from aortic Stenosis.
- Trial name
- REBOOT-PARADOX (NCT03863132)
- Testing
- TAVR
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- IHF GmbH - Institut für Herzinfarktforschung
Aortic Valve Stenosis
Low Flow Low Gradient Aortic Stenosis Relevance of the (re)Search for a Contractile Reserve
Investigators sought to demonstrate that the increase in the stroke volume during a dobutamine stress echocardiography might impact the prognosis of a patient addressed for a low flow low gradient suspected severe aortic valve…
- Trial name
- LOWAS (NCT02727504)
- Testing
- Electrocardiogram, 2D and 3D echocardiography, Dobutamine stress echocardiography
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Rennes University Hospital
Aortic Valve Stenosis
Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)
Low-flow, low-gradient (LF-LG) aortic stenosis (AS) may occur with depressed (i.e. Classical LF; CLF) or preserved (i.e. Paradoxical LF; PLF) LV ejection fraction (LVEF) and both situations are amongst the most challenging…
- Trial name
- NCT01835028
- Testing
- Echocardiography, Computed tomography, Magnetic resonance imaging
- Where
- 11 sites in United States, Austria and 4 more
- Volunteers
- 320 people
- Sponsor
- Laval University
Aortic Valve Stenosis, Valvular Stenosis
Diagnostic Impact of Low-dose Dobutamine Echocardiography in Low-flow Low-gradient Aortic Stenosis
When aortic valve-area is <1.0cm2 and transvalvular mean-gradient is >40mmHg, the diagnosis of severe aortic stenosis (AS) is straightforward.
- Conditions
- Aortic Valve Stenosis, Valvular Stenosis, Valvular Heart Disease
- Trial name
- DALLAS (NCT05015829)
- Testing
- Dobutamine Stress Echocardiography
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Odense University Hospital
Cardiovascular Abnormalities
Novel Echocardiographic and Invasive Haemodynamic Measurements in the Assessment of Patients Low Flow Low Gradient Aortic Stenosis Undergoing TAVI
In this study the investigators will assess a variety of novel markers of heart strength (contractility) and assess whether they can give a clearer indication of how well patients with weak hearts respond to the TAVI procedure.
- Trial name
- LFLG (NCT05196815)
- Testing
- Ultrasound, Catheters, Soft study wire
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Low Flow, Low Gradient Aortic Stenosis
Transcatheter Aortic Valve Replacement in Severe Low Flow, Low Gradient Aortic Stenosis
LOW-TAVR is a real-world, retrospective and prospective, multicenter Italian registry aimed at evaluating the characteristics and clinical outcomes of patients with severe low flow, low gradient aortic stenosis undergoing…
- Trial name
- LOW-TAVR (NCT06589063)
- Testing
- Transcatheter aortic valve replacement
- Where
- Italy
- Volunteers
- 1,350 people
- Sponsor
- University of Salerno
Aortic Valve Stenosis
CPX in Paradoxical Low Flow Aortic Stenosis
Severe aortic stenosis is a condition with poor life expectancy once it becomes symptomatic. There are no prospective studies illustrating the utility of cardiopulmonary stress (CPX) testing in diagnosing and prognosticating…
- Trial name
- NCT05481814
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Transthyretin Amyloid Cardiomyopathy, Aortic Stenosis
Dobutamine Stress Echocardiography in LF/LG Aortic Stenosis and Wild-type Transthyretin Amyloid Cardiomyopathy
The goal of this prospective clinical study is to improve the diagnosis of Low-flow low-gradient aortic stenosis (LF/LG AS), in patients with co-existing wild-type transthyretin cardiac amyloidosis (ATTRwt).
- Trial name
- DobAttrAS (NCT06372301)
- Testing
- Dobutamine stress echocardiography
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Steen Hvitfeldt Poulsen
Low-Flow, Low-Gradient Aortic Stenosis
Anatomic Stenosis Severity as a Prognostic Marker in Patients With Low-Flow Low-Gradient Aortic Stenosis Undergoing TAVI
The ATLAS TAVI Registry is a retrospective, investigator-initiated, multicenter registry including patients, who underwent Transcatheter Aortic Valve Implantation (TAVI) for classical or paradoxical low-flow, low-gradient aortic…
- Trial name
- ATLAS TAVI (NCT04914481)
- Where
- 11 sites in Canada, Denmark and 5 more
- Volunteers
- 1,500 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Aortic Valve Stenosis
Pressure Gradient vs. Flow Relationships in Patients With Symptomatic Valvular Aortic Stenosis
The objective of the present study is to investigate to hemodynamic profile at rest and during peak exercise of patients with suspected severe aortic stenosis and to compare flow- and pressure changes between high gradient…
- Trial name
- PREFLOW (NCT05580237)
- Testing
- Simultaneous right and left heart catheterization
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Aarhus University Hospital Skejby
Aortic Valve Stenosis
Volume Challenge Added to DSE in the Diagnosis of Severe LFLGAS
The aim of this study is to test the diagnostic added value of Volume Challenge (VC) to low-dose dobutamine stress echocardiography (LDDSE) in patients with a low-flow, low-gradient aortic stenosis (LFLGAS).
- Trial name
- FLOW-AS (NCT03617406)
- Testing
- Volume Challenge
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Moderate Aortic Stenosis
Comparison of Myval THV Series With Guideline-Directed Medical Therapy in Participants With Moderate Aortic Stenosis
The primary objective of this trial is to evaluate the safety and effectiveness of Meril's Myval THV series in comparison to Guideline-Directed Medical Therapy in participants with moderate aortic stenosis.
- Trial name
- NCT07532317
- Testing
- Transcatheter aortic valve Implantation
- Volunteers
- 778 people
- Sponsor
- Meril Life Sciences Pvt. Ltd.
Aortic Valve Stenosis
Aortic Stenosis Associated Left Ventricular Remodeling - An Investigation of Genetic and Gender Specific Differences in 170 Patients Undergoing Aortic Valve Replacement Surgery
The goal of this study is to investigate the genetic and gender specific differences, in patients with low flow low gradient aortic stenosis and high flow high gradient aortic stenosis.
- Trial name
- SALVAGE (NCT05696145)
- Volunteers
- 170 people
- Sponsor
- Lisa Gundestrup
Aortic Stenosis, Severe
Exercise CMR in (p)LF-LG AS
Patient with paradoxical or conventional low-flow low-gradient aortic stenosis on echocardiographic assessment will undergo physiological exercise-stress CMR in addition to guideline recommended surveys prior to TAVR.
- Trial name
- NCT06129799
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Göttingen