Clinical trials: Low Testosterone
Coronary Artery Disease
The Cardiac Benefit of Testosterone Replacement in Men With Low Testosterone Levels With Coronary Artery Disease After Successful Intervention of the Blockage or Narrowed Heart Artery
The purpose of the study is to find out if giving the study drug, Androgel (testosterone) as a testosterone replacement help bring the testosterone to an acceptable level and to find out if it will help improve heart condition in…
- Trial name
- NCT00413244
- Testing
- AndroGel 5 Grams
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Female Sexual Dysfunction, Postmenopausal Symptoms
Sexual Effects of Transdermal or Vaginal Testosterone
The aim of the study is to elucidate the role of testosterone treatment in postmenopausal women's sexual function and their therapeutic safety.
- Conditions
- Female Sexual Dysfunction, Postmenopausal Symptoms, Testosterone Deficiency, Testosterone Adverse Reaction
- Trial name
- NCT06794346
- Testing
- Transdermal testosterone, Vaginal testosterone gel
- Where
- Brazil
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Hypogonadism, Diabetes
Effects of Aromatase Inhibition Versus Testosterone in Older Men With Low Testosterone: Randomized-Controlled Trial.
Background: Men≥65 years often produce lower levels of testosterone, meaning there is less testosterone circulating to the tissues of the body.
- Conditions
- Hypogonadism, Diabetes, Sarcopenia, Osteoporosis
- Trial name
- NCT00104572
- Testing
- Androgel (Testosterone Gel), Anastrozole (Aromatase Inhibitor), Calcium Cardone 500mg with vitamin D 400 IU
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Endocrine Dysfunction, Trauma
Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy
The purpose of this study was to address 3 short term objectives; (1) Determine the effects of physiologic testosterone (T) therapy on neurological function and functional independence following traumatic brain injury (TBI) in…
- Conditions
- Endocrine Dysfunction, Trauma, Brain Injury
- Trial name
- NCT01201863
- Testing
- Androgel (Testosterone Gel)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Craig Hospital
Hypogonadism
Cardiovascular Outcomes of Low Testosterone
This study plans to learn more about heart and vascular aging in men. In some men as they get older, testosterone levels fall below the normal range for young men. Also, as men get older cardiovascular health worsens.
- Trial name
- CardioVOLT (NCT02758431)
- Testing
- Acyline, Testosterone Gel, Arimidex
- Where
- United States
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypogonadism, Male
A Comparison of Side Effects in Hypogonadal Men Treated With Natesto Versus Testosterone Injections
The purpose of this study is to evaluate changes in vascular parameters and the prevalence of side effects in subjects receiving 1 cc (200mg) every 2 weeks intramuscular (IM) of Testosterone Cypionate versus subjects receiving…
- Trial name
- NCT04439799
- Testing
- Testosterone Cypionate 200 Mg/ML, Intranasal Testosterone
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Miami
Sleep Apnea, Obstructive, Sleep Apnea
Sexual Dysfunction And Hypotestosteronemia In Patients With Obstructive Sleep Apnea Syndrome
Obstructive Sleep Apnea Syndrome (OSAS)is a common disease and is suspected to be associated with sexual dysfunction. Our purpose is to sudy the effect of CPAP (Continuous Positive Airway Pressure) treatment on patients' sexual…
- Conditions
- Sleep Apnea, Obstructive, Sleep Apnea, Hypotestosteronism
- Trial name
- NCT00832065
- Where
- 2 sites in United States
- Sponsor
- Lahey Clinic
Hypogonadism, Late Onset Hypogonadism
Study of DHT-Gel to Treat the Symptoms of Low Testosterone in Men 55-80
The purpose of this study is to evaluate whether DHT-Gel, when applied daily to the skin, can relieve the symptoms of low testosterone in men aged 55-80.
- Conditions
- Hypogonadism, Late Onset Hypogonadism, Low Testosterone
- Trial name
- NCT00163566
- Testing
- Dihydrotestosterone (0.7%) in hydroalcoholic gel
- Where
- 16 sites in United States
- Volunteers
- 128 people
- Sponsor
- ASCEND Therapeutics
Hypogonadism, Diabetes
Effect of Testosterone Gel Replacement on Fat Mass in Males With Low Testosterone Levels and Diabetes
The purpose of the study is to find out the effect of replacing testosterone in the form of a gel (Androgel®) on the amount of fat mass in males with low testosterone and diabetes.
- Trial name
- NCT00440440
- Testing
- Testosterone gel
- Where
- United States
- Sponsor
- Diabetes Center of the Southwest
Hypogonadism
Efficacy Study for Use of Dutasteride (Avodart) With Testosterone Replacement
This is a study using two FDA approved medications: Testosterone and the study medication, Dutasteride (Avodart 0.5mg/day). Half of the subjects will receive dutasteride and half will receive a placebo.
- Trial name
- DUT/T (NCT00752869)
- Testing
- dutasteride
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- The Miriam Hospital
Hypogonadism, Opioid-Related Disorders
Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration
The purpose of this randomized controlled clinical trial is to evaluate the effects of clomiphene citrate compared to placebo (substance without active medication) in men who are taking pain medication (opioids) for chronic pain…
- Conditions
- Hypogonadism, Opioid-Related Disorders, Male Infertility
- Trial name
- NCT01880086
- Testing
- Clomiphene citrate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Weill Medical College of Cornell University
Hypogonadism, Low Testosterone
A One Year Open Label Study for the Treatment of Hypogonadism (Low Testosterone) in Men Who Have Completed ZA-203
The purpose of this study is to determine the continued effects of Androxal on morning testosterone and reproductive status in men with secondary hypogonadism who have completed protocol ZA-203.
- Trial name
- NCT01386567
- Testing
- Androxal (enclomiphene citrate), Testim (topical testosterone)
- Where
- 8 sites in United States
- Volunteers
- 48 people
- Sponsor
- Repros Therapeutics Inc.
Hypogonadism
Cycled Testosterone Replacement Study
The purpose of this study is to determine whether testosterone (male hormone) therapy is effective if administered in a cyclic fashion (periodic dosing) compared to continuous dosing in men aged 60 to 85 years.
- Trial name
- NCT00957528
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Ketogenic Dieting
Low Carbohydrate High Fat Ketogenic vs. Non-ketogenic Diet
The aim of this paper was to investigate and compare the effects of two iso-energetic hypo-caloric ketogenic hyper-ketonemic and non-ketogenic low carbohydrate high fat high cholesterol diets on body-composition, muscle strength…
- Trial name
- LCHF (NCT04744558)
- Testing
- Low carb high fat ketogenic dieting, Low carb high fat non-ketogenic dieting
- Where
- Serbia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Testosterone Deficiency
Evaluation of Prealbumin Levels in Men With Low-T
This is a single-center study intended to evaluate prealbumin (transthyretin), a marker of anabolic metabolism, in men with androgen deficiency (Low-T).
- Trial name
- NCT03313635
- Testing
- Men presenting with low-T
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Beckman Coulter, Inc.
Male Infertility, Low Sperm Quality
A Clinical Trial to Evaluate the Effects of a Supplement on Markers of Male Fertility
This study will evaluate the effects of the WeNatal For Him supplement on markers of male fertility over a 3-month period. The trial is a single-arm, unblinded study enrolling 40 male participants who will take 3 capsules of the…
- Conditions
- Male Infertility, Low Sperm Quality, Low Testosterone, Low Energy
- Trial name
- NCT07740161
- Testing
- WeNatal For Him Supplement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- WeNatal
Hypogonadotropic Hypogonadism, Low Testosterone
Opioid Antagonism in Hypogonadotropic Hypogonadism
The goal of this study is to evaluate the effects of opioid antagonists on the hypothalamic-pituitary-gonadal axis in subjects with hypogonadotropic hypogonadism (HH).
- Trial name
- NCT04975334
- Testing
- Naloxone
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Stephanie B. Seminara, MD
Male Hypogonadism
Safety and Efficacy of Oral LPCN 1021 in Men With Low Testosterone or Hypogonadism
The purpose of this study is to determine the safety and efficacy of an oral testosterone undecanoate formulation for use as testosterone-replacement therapy in men with low testosterone.
- Trial name
- SOAR (NCT02081300)
- Testing
- Oral testosterone undecanoate, LPCN 1021, Topical testosterone gel 1.62 %
- Volunteers
- 315 people
- Sponsor
- Lipocine Inc.
Secondary Hypogonadism
A Randomized, Double Blind, Placebo-Controlled, Multi-Center Phase III Study in Men With Acquired Hypogonadotropic Hypogonadism to Compare Changes in Testosterone and Sperm Concentration Following Treatment With 12.5 mg or 25 mg Androxal or AndroGel 1.62%
This is a Randomized, Double Blind, Placebo-Controlled, Multi-Center Phase III Study in Men with Acquired Hypogonadotropic Hypogonadism to Compare Changes in Testosterone and Sperm Concentration Following Treatment with 12.5 mg…
- Trial name
- NCT01993225
- Testing
- Androxal 12.5 mg/25 mg, AndroGel 1.62%
- Where
- 9 sites in United States
- Volunteers
- 120 people
- Sponsor
- Repros Therapeutics Inc.
Hypoactive Sexual Desire Disorder
An Open-Label Study of 50 Mg Oral Testosterone Undecanoate (Kyztrex) in Menopausal Women with Low Testosterone and HSDD
This is an unblinded study to be conducted at a single research center, San Diego Sexual Medicine. Eligible subjects will receive 50 mg capsules of Kyzatrax® to be taken orally daily over a 3-month period.
- Trial name
- NCT06082817
- Testing
- Oral Testosterone Undecanoate
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- San Diego Sexual Medicine