Clinical trials: Low Voltage Areas
Atrial Fibrillation
Consistency of LGE-MRI Fibrosis and EAM Low-voltage Area
This study aims to: 1. Assess the consistency of LGE-MRI bi-atrial fibrosis and electroanatomical mapping of bi-atrial low voltage region 2.
- Trial name
- NCT06552845
- Testing
- LGE-MRI Scan
- Where
- China
- Volunteers
- 50 people
- Sponsor
- China National Center for Cardiovascular Diseases
Atrial Fibrillation
CPVI Alone Versus CPVI Plus Low-Voltage Areas Ablation During SR Versus CPVI Plus Low-Voltage Areas Ablation During AF for the Treatment of CAF
The primary objective of this investigation is to compare the efficacy of Three different AF ablation strategies in patients with Persistent atrial fibrillation: CPVI plus Low-Voltage Areas ablation during sinus rhythm Versus.
- Trial name
- NCT06499818
- Testing
- STABLE-SR, STABLE-AF, CPVI
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Yantai Yuhuangding Hospital
Atrial Fibrillation (AF), Atrial Fibrillation Mechanisms
Substrate Remodelling and Targeted Ablation in AF
Atrial fibrillation (AF) is the most common heart rhythm disorder, affecting millions worldwide and causing symptoms such as palpitations, fatigue and breathlessness.
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Mechanisms, Catheter Ablation, Low Voltage Areas
- Trial name
- STRATA-AF (NCT07047235)
- Testing
- Pulmonary vein reisolation, Ganglionic plexi ablation, Substrate ablation
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Barts & The London NHS Trust
Atrial Fibrillation
Does VoltagE Guided Additional Ablation Improve Procedural Outcome of Atrial Fibrillation Ablation?
This study is designed to investigate whether pulmonary vein isolation(PVI) plus stepwise additional ablation approach based on the degree of low voltage area versus PVI only can improve procedure outcome in persistent atrial…
- Trial name
- NCT03377751
- Testing
- Additional posterior wall isolation, Voltage-guided substrate homogenization, PVI only group
- Where
- 3 sites in South Korea
- Volunteers
- 20 people
- Sponsor
- Korea University Guro Hospital
Atrial Fibrillation (AF)
Low-VOLTage Area-Guided Catheter Ablation and SVC Isolation for Persistent Atrial Fibrillation Using a Balloon-in-Basket Pulsed Field Ablation Catheter
The primary objective of this study is to determine whether low-voltage areas (LVA)-guided catheter ablation combined with superior vena cava (SVC) isolation and pulmonary vein isolation (PVI), performed using the…
- Trial name
- LowVOLT-AF (NCT07587541)
- Testing
- Volt™ Pulsed Field Ablation System
- Volunteers
- 618 people
- Sponsor
- University of Luebeck
Paroxysmal Atrial Fibrillation
Additional Low Voltage Area Ablation in Older Patients With Paroxysmal Atrial Fibrillation
The primary objective of this investigation is to compare the efficacy of two different AF ablation strategies in older patients with paroxysmal AF: Pulmonary vein isolation alone versus additional low-voltage substrate…
- Trial name
- STABLE-SR-III (NCT03462628)
- Testing
- CPVI plus low-voltage substrate modification, CPVI alone
- Where
- China
- Volunteers
- 438 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Atrial Fibrillation (AF)
Circumferential Pulmonary Vein Isolation Plus Transition Zone Modification in Atrial Fibrillation Patients Without Low-Voltage Areas
This study investigates two treatments for atrial fibrillation (AF) patients without low-voltage-areas (LVAs). It aims to determine whether adding transition zone modification (TZM) to the pulmonary vein isolation (PVI) improves…
- Trial name
- PVI-TZM-AF (NCT06930599)
- Testing
- Pulmonary vein isolation plus transition zone modification, Pulmonary vein isolation alone
- Volunteers
- 162 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Persistent Atrial Fibrillation, Catheter Ablation
Persistent Atrial Fibrillation Without the Evidence of Low-voltage Areas
An effective therapy of persistent atrial fibrillation beyond pulmonary vein isolation remains unsatisfactory. Targeting endocardial low-voltage areas represents an approach of substrate modification.
- Conditions
- Persistent Atrial Fibrillation, Catheter Ablation, Low Voltage Areas
- Trial name
- NCT06124690
- Testing
- Catheter ablation
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Robert Bosch Medical Center
Cardiovascular Diseases, Atrial Fibrillation, Persistent
Low-voltage Areas Defragmentation in Sinus Rhythm for Radiofrequency Ablation of Persistent Atrial Fibrillation
This is a study evaluating the value of defragmentation of sinus rhythmic low voltage areas in addition to isolation of pulmonary veins in the removal of recurrent atrial fibrillation.
- Trial name
- SCAR-AF (NCT04045067)
- Testing
- Isolation of pulmonary veins, Ablation by radiofrequency of low-voltage areas
- Where
- 9 sites in France
- Volunteers
- 212 people
- Sponsor
- French Cardiology Society
Atrial Fibrillation
Ablation of Fibrotic Areas in Patients With Persistent Atrial Fibrillation.
Brief summary: The objective of this study is to compare two different ablation strategies in participants with persistent atrial fibrillation and fibrotic areas in the left atrium.
- Trial name
- IDEAL-AF (NCT04377594)
- Testing
- Radio frequency ablation
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska University Hospital