Clinical trials: Low and Intermediate Risk Prostate Cancer
PROSTATE CANCER
Two-fraction Versus Five-fraction Stereotactic Radiotherapy for Localized Prostate Cancer
The goal of this clinical trial is to compare two dose schedules of stereotactic radiation therapy in patients with localized prostate cancer.
- Trial name
- SABR-Dual (NCT06027892)
- Testing
- Two-fraction stereotactic radiotherapy, Five-fraction stereotactic radiotherapy
- Where
- Israel
- Volunteers
- 562 people
- Sponsor
- Rabin Medical Center
Prostate Cancer
Safety and Efficacy Study of Dose-escalated Hypofractionated Radiotherapy For Prostate Cancer
The purpose of this study is to determine the safety and efficacy of a short course of radiotherapy (40 Gy / 5 fractions / 29 days) for the treatment of low- and intermediate-risk prostate cancer.
- Trial name
- PHART6 (NCT01146340)
- Testing
- Hypofractionated radiotherapy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prostate Cancer
Study of POMELLA™ Extract to Treat Prostate Cancer
This is a randomized, two-arm, placebo controlled trial to evaluate benefit of treatment using POMELLA™ extract on mechanisms known to drive prostate cancer.
- Trial name
- NCT01100866
- Testing
- POMELLA™ (pomegranate extract)
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Vancouver Coastal Health
Prostate Cancer
Hypofractionated SBRT For Prostate Cancer
The purpose of this study is to determine, in both low-risk and intermediate-risk cohorts, the rates of acute and late grade 3 or higher gastrointestinal and genitourinary toxicity observed during a 24 month follow up and to…
- Trial name
- NCT00977860
- Testing
- Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- Adam Olson
Prostate Cancer
Circulating Tumor Cells in Prostate Cancer Patients
The purpose of this study is to determine if a non-invasive cancer treatment, high-dose stereotactic body radiotherapy (SBRT), is associated with changes in circulating tumor cells counts in patients with low- and…
- Trial name
- NCT01414712
- Testing
- Blood Drawing
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Texas Southwestern Medical Center
Prostate Cancer, Prostatic Cancer
CyberKnife Radiosurgery for Organ-Confined Prostate Cancer: Homogenous Dose Distribution
The purpose of this study is to determine the effects of CyberKnife radiosurgery in patients with early stage organ-confined prostate cancer.
- Conditions
- Prostate Cancer, Prostatic Cancer, Prostate Neoplasms, Prostatic Neoplasms
- Trial name
- NCT00643994
- Testing
- CyberKnife Stereotactic Radiosurgery
- Where
- 23 sites in United States
- Volunteers
- 379 people
- Sponsor
- Accuray Incorporated
Low or Intermediate Risk Prostate Cancer
Advanced Imaging for Radiotherapy Treatment Planning and Guidance for Low-Intermediate Risk Prostate Cancer (Margin)
The integration of magnetic resonance imaging (MRI) in the treatment planning process for prostate cancer will reduce uncertainties in delineation of the prostate gland, and will enable delineation of the urethra, penile bulb…
- Trial name
- NCT00890006
- Testing
- Advanced imaging for radiotherapy planning and guidance
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- University Health Network, Toronto
Intermediate Risk Prostate Cancer, Castration-resistant Prostate Cancer
VAccination in Early and ADvanced Prostate caNCEr
This is a clinical trial of a new treatment for prostate cancer that is a type of vaccine that could be a new way to treat cancer.
- Trial name
- ADVANCE (NCT03815942)
- Testing
- ChAdOx1-MVA 5T4 vaccine, Nivolumab Infusion [Opdivo]
- Where
- 2 sites in United Kingdom
- Volunteers
- 23 people
- Sponsor
- University of Oxford
Prostate Cancer Stage I
Targeted Microwave Focal Therapy
Focal therapy (FT) for prostate cancer (PCa) is an interesting therapeutic option for localized disease with a favorable low- to intermediate-risk profile.
- Trial name
- NCT04627896
- Testing
- Katty focal therapy
- Where
- Italy
- Volunteers
- 11 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Prostate Cancer
Hypofractionated Proton Radiation Therapy for Low and Intermediate Risk Prostate Cancer
The purpose of this trial is to give a shorter course (5 ½-6 weeks) of proton radiation that has as little side effects on normal bladder and rectal tissues as the usual longer course (8 weeks) of proton radiation, without…
- Trial name
- PR07 (NCT01368055)
- Testing
- 70 Gy/CGE, 72.5 Gy/CGE
- Where
- United States
- Volunteers
- 361 people
- Sponsor
- University of Florida
Prostate Cancer, Lower Urinary Tract Symptoms (LUTS)
Concomitant Trans-Perineal Prostate Biopsy and Ablation (Bioblation) for Prostate Cancer
This prospective study aims to validate the clinical outcomes of performing a concomitant trans-perineal prostate biopsy and laser ablation (termed "Bioblation") during a single session.
- Conditions
- Prostate Cancer, Lower Urinary Tract Symptoms (LUTS), Benign Prostatic Hyperplasia
- Trial name
- Bioblation (NCT07526675)
- Testing
- Bioblation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Prostate Adenocarcinoma, Stage I Prostate Cancer
Stereotactic Body Radiation Therapy in Treating Patients With Low- and Intermediate-Risk Prostate Cancer
This clinical trial studies stereotactic body radiation therapy in treating patients with low- and intermediate-risk prostate cancer.
- Trial name
- NCT01737151
- Testing
- stereotactic body radiation therapy, four fraction split-course SBRT
- Where
- 3 sites in United States
- Volunteers
- 19 people
- Sponsor
- Virginia Commonwealth University
Prostate Cancer
CyberKnife Stereotactic Radiosurgery for Low and Intermediate Risk Prostate Cancer
The purpose of this study is to determine the side effects and how effective CyberKnife stereotactic ablative body radiation (SABR) is in patients with prostate cancer.
- Trial name
- NCT02070952
- Testing
- CyberKnife Stereotactic Ablative Body Radiation Therapy
- Where
- United States
- Volunteers
- 167 people
- Sponsor
- Riverside Community Hospital, California
Localized Prostate Cancer, Low Risk Prostate Cancer
The PRECISION Study: 3 Fractions of Prostate SBRT and RayPilot HypoCath Image Guidance
The investigators want to investigate whether it is possible to reduce the number of curative radiotherapy doses from 5 to only 3 for men with localized early prostate cancer.
- Conditions
- Localized Prostate Cancer, Low Risk Prostate Cancer, Intermediate Risk Prostate Cancer
- Trial name
- PRECISION (NCT06117059)
- Testing
- 3 fractions of prostate SBRT
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- NHS Lothian
Prostate Cancer
Identification of Clinically Insignificant or Significant Prostate Cancer With the miR Scientific Sentinel™ Platform
In this non-interventional study, men being seen by urologists in the course of their normal practice that present with clinical suspicion of prostate cancer (based on DRE, elevated Prostate Specific Antigen (PSA), and/or family…
- Trial name
- NCT04100811
- Where
- 3 sites in United States
- Volunteers
- 2,019 people
- Sponsor
- miR Scientific LLC
Macroscopic Tumor Visualized at MRI, Tumor Size Allowing Partial Prostate Treatment Volume
Stereotactic Focal Radiotherapy as an Alternative Treatment to Active Surveillance for Low and Intermediate Risk Prostate Cancer
*Rationale : Active surveillance of prostate cancer helps to avoid the morbidity associated with curative radical prostatectomy /radiotherapy in patients with early stage disease.
- Conditions
- Macroscopic Tumor Visualized at MRI, Tumor Size Allowing Partial Prostate Treatment Volume, CAPRA SCORE ≤5
- Trial name
- TOPPGUN-RS (NCT07152067)
- Testing
- Stereotactic Body Radiation Therapy (SBRT)
- Where
- 2 sites in Belgium
- Volunteers
- 146 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Prostate Cancer
Prostate Advances in Comparative Evidence
This study is an international multicentre randomised study of low, intermediate, and high risk prostate cancer and is composed of three parallel randomisation schemes based on applicability of surgery as a treatment for the…
- Trial name
- PACE (NCT01584258)
- Testing
- Prostatectomy, Conventionally Fractionated Prostate Radiotherapy, Prostate SBRT
- Where
- 68 sites in Canada, Ireland and 2 more
- Volunteers
- 2,205 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Prostate Cancer
Safety and Efficacy of Two-step Radical Prostatectomy
The goal of this observational study is to learn about the safety and efficacy of two-step radical prostatectomy in the treatment of low- to intermediate-risk prostate cancer patient with enlarged prostate and severe benign…
- Trial name
- NCT05722392
- Testing
- Two-step Radical Prostatectomy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University
Prostate Neoplasms
Evaluation of Truebeam for Low-Intermediate Risk Prostate Cancer
The primary safety purpose of this study is to estimate the rates of immediate and long-term high grade (grade 3-5) gastrointestinal and genitourinary side effects during the five years after TrueBeam stereotactic body…
- Trial name
- NCT01581749
- Testing
- "TrueBeam" stereotactic body radiosurgery
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Albert DeNittis
Prostate Cancer
Feasibility Trial of Single-Dose Radiotherapy for Localized Low and Intermediate Risk Prostate Cancer
The goal of this study is to assess the feasibility of high-dose radiotherapy (Single-Dose Radiotherapy, SDRT) of 24 Gy in patients with localized low and intermediate risk prostate cancer using a special system of internal and…
- Trial name
- FAST-ONE (NCT07112781)
- Testing
- Single Dose Radiotherapy
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Branch Office of "Hadassah Medical Ltd"