Clinical trials: Low-Level Light Therapy
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Minoxidil With or Without Low-Level Red-Light Therapy for Improving Chemotherapy-Induced Alopecia in Breast Cancer Patients
This phase II trial compares the safety and effectiveness of topical minoxidil alone to topical minoxidil in combination with low-level red-light therapy for improving chemotherapy-induced hair loss or thinning (alopecia).
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8
- Trial name
- NCT07594678
- Testing
- Electronic Health Record Review, Minoxidil, Revian RED LED-light cap
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Postoperative Facial Nerve Dysfunction
Comparison of Two Photobiomodulation Systems for Facial Nerve Dysfunction Following TMJ Surgery
This randomized clinical trial compared two photobiomodulation systems for the management of postoperative facial nerve dysfunction following temporomandibular joint surgery.
- Trial name
- NCT07771933
- Testing
- GRR Laser Photobiomodulation System, SiroLaser Advance Plus
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ankara University
Neuropathy, Neuropathy, Diabetic
Photobiomodulation Therapy and Nerve Density for Patients With Diabetic or Chemotherapy-associated Neuropathy
This study seeks to determine if photobiomodulation (PBM, or low level laser light) affects the growth and distribution of nerves int he skin.
- Conditions
- Neuropathy, Neuropathy, Diabetic, Neuropathy Toxic
- Trial name
- NCT03195868
- Testing
- Realief Therapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Minnesota
Head and Neck Cancer, Lymphedema of the Head and Neck
Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema
The U.S. Food and Drug Administration approved photobiomodulation therapy (PBMT) as a treatment for breast cancer-related arm lymphedema (BCRL) in 2006. The investigators conducted two pilot clinical trials.
- Trial name
- NCT06837480
- Testing
- LTU-904 Portable Laser Therapy Unit (active laser device)
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Myopia
Effectiveness and Safety of Repeated Low-Level Red-Light Therapy on Myopia Control Among Children and Adolescents
Myopia has become one of the leading causes of visual impairment globally and brings a heavy burden on the society. Therefore, preventing and controlling the progression of myopia has become an urgent public health issue that…
- Trial name
- NCT05871840
- Testing
- Repeated Low-Level Red-Light (RLRL) Therapy
- Volunteers
- 360 people
- Sponsor
- Shenzhen Hospital (Guangming), University of Chinese Academy of Sciences
Bell's Palsy
Photobiomodulation Therapy for Idiopathic Facial Paralysis
Objective: Bell's palsy is characterized by acute, unilateral onset that compromises function and esthetics, exerting a considerable impact on the social, professional, and psychological aspects of the lives of affected…
- Trial name
- NCT05585346
- Testing
- MLS laser, Oral vitamin B1
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Beijing Tongren Hospital
Transitional Cell Cancer of Renal Pelvis and Ureter
ENdoluminal LIGHT ActivatED Treatment of Upper Tract Urothelial Cancer (ENLIGHTED) Study
This is a phase 3, open label, single arm study of padeliporfin in the treatment of Upper Tract Urothelial Carcinoma (UTUC). The ENLIGHTED study will recruit patients with low-grade non-invasive upper tract urothelial carcinoma…
- Trial name
- UCM301 (NCT04620239)
- Testing
- padeliporfin VTP
- Where
- 18 sites in United States, France and 3 more
- Volunteers
- 89 people
- Sponsor
- Steba Biotech S.A.
Lateral Epicondylitis
Effects of Photobiomodulation Therapy Combined With Static Magnetic Field in Patients With Lateral Epicondylitis
Lateral epicondylitis (LE) is one of the most frequently encountered lesions affecting the upper extremity and is the most common cause of elbow pain in adults.
- Trial name
- NCT04829734
- Testing
- Active PBMT-sMF
- Where
- 2 sites in Brazil
- Volunteers
- 50 people
- Sponsor
- University of Nove de Julho
Pelvic Pain, Levator Ani Syndrome
Photobiomodulation for Myofascial Pelvic Pain
The goal of this clinical trial is to evaluate the efficacy of photobiomodulation of the pelvic floor muscles in female Veterans with chronic pelvic pain.
- Conditions
- Pelvic Pain, Levator Ani Syndrome, Spastic Pelvic Floor Syndrome, Chronic Pelvic Pain Syndrome
- Trial name
- PMPP (NCT05926752)
- Testing
- SoLá therapy, Pelvic floor physical therapy
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Orlando VA Medical Center
Orthodontic Treatment Acceleration, Photobiomodulation Therapy
Photobiomodulation Therapy (PBMT) for Accelerating Maxillary Canine Movement Using Two Wavelengths (650 nm and 976 nm): A Split-Mouth Randomized Controlled Clinical Trial
movement using low-level laser therapy with different wavelengths. Participants will receive laser application during orthodontic treatment, and the rate of canine movement will be measured and compared between the study groups.
- Trial name
- PBMT-CAN (NCT07597304)
- Testing
- 650 nm Photobiomodulation Therapy, 976 nm Photobiomodulation Therapy
- Where
- Iraq
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kufa University
Skeletal Muscle Performance
Photobiomodulation Therapy Combined With Static Magnetic Field on the Subsequent Performance
There is evidence about the effects of photobiomodulation therapy (PBMT) alone and combined with static magnetic field (PBMT-sMF) on skeletal muscle fatigue, physical performance and post-exercise recovery in different types of…
- Trial name
- NCT04934709
- Testing
- Active PBMT-sMF
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Myopia, Amblyopia
Myopia Control With Three Lever Irradiance of PBM Therapy in Children and Adults
Photobiomodulation therapy, that is, Low-level red-light technology provides a new and innovative myopia control approach. This strategy enables relatively high energies of light to be delivered at much shorter durations of…
- Conditions
- Myopia, Amblyopia, Refractive Error - Myopia Axial, Ametropia
- Trial name
- MCPT (NCT05957458)
- Testing
- Airdoc device of red light for Myopia
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Beijing Airdoc Technology Co., Ltd.
Chronic Pain
Whole-Body Photobiomodulation and Chronic Pain Trial
Chronic pain is a common long-term condition that can affect any area throughout the body. Individuals suffering with chronic pain often have associated fatigue, sleep and mood disturbances.
- Trial name
- NCT05069363
- Testing
- Whole-Body Photobiomodulation Therapy
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Head and Neck Cancer, Trismus
Photobiomodulation and Sonophoresis Improving Jaw Mobility and Quality of Life Among Head and Neck Cancer Survivors
Head and neck cancer originate from the several different anatomical subsites especially the squamous cell carcinoma. This involves mainly Oropharynx, Hypopharynx, and Larynx.
- Trial name
- NCT04082793
- Testing
- Photobiomodulation therapy with mandibular exercises, Sonophoresis with mandibular exercises
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Asir John Samuel
Phototherapy, Low-level Laser Therapy
Local and Systemic Effects of Photobiomodulation Therapy on Muscle Performance and Recovery Post-exercise.
Recent studies with photobiomodulation therapy have shown positive results in delaying skeletal muscle fatigue and improving performance through levels of biochemical markers and variables related to exercise when this therapy…
- Conditions
- Phototherapy, Low-level Laser Therapy, Systemic
- Trial name
- NCT03695458
- Testing
- Phototherapy
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Low Level Laser Therapy, Acne Vulgaris
Low Level Laser Versus Polarized Light in the Treatment of Acne Vulgaris
The present study is designed to compare clinically the therapeutic applications between low level laser therapy (excimer laser) and non-laser polarized light (Bioptron prol) in the treatment of Acne vulgaris.
- Trial name
- NCT06867276
- Testing
- Excimer laser, Bioptron Pro 1
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Malnutrition, Child
Use of Low-level Laser Therapy on Children Aged One to Five Years With Energy-protein Malnutrition
Malnutrition is a clinical-social disease caused by multiple prenatal, intrauterine and postnatal factors as well as social, political and cultural determinants (distal causes).
- Trial name
- NCT03355313
- Testing
- Low level Light therapy
- Where
- 2 sites in Brazil
- Volunteers
- 50 people
- Sponsor
- University of Nove de Julho
Temporomandibular Joint Disorder
Effect of Photobiomodulation in Patients With Temporomandibular Dysfunction Refractory to Botulinum Toxin Treatment.
The objective of this preliminary research was to identify the effect of low-level laser photobiomodulation therapy (LLLT-PBMT) in patients with myofascial temporomandibular disorders (TMDs), refractory to botulinum toxin (BTX)…
- Trial name
- NCT06915064
- Testing
- Low- level laser- photobiomodulation therapy
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- University of Coimbra
Dry Eye, Dry Eye After LASIK-Laser in Situ Keratomileusis
Combined Treatment With Pulsed Light and Photobiomodulation Before Laser Refractive Surgery
Laser corneal refractive surgery is a widely adopted approach for correcting refractive errors, but postoperative dry eye remains a common side effect.
- Trial name
- TEBELID (NCT05803798)
- Testing
- IPL+LLLT
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Chronic Obstructive Pulmonary Disease (COPD)
PBMT Associated With a Pulmonary Rehabilitation Program on the Functional Capacity of Patients With COPD
This study aims to evaluate the effectiveness of photobiomodulation therapy (PBMT) as an adjunct to the pulmonary rehabilitation program on the functional capacity of patients with COPD.
- Trial name
- NCT07878884
- Testing
- Intervention Group, control group
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre