Clinical trials: Low-dose Radiotherapy
Non-Small-Cell Lung Carcinoma
Trial to Evaluate Radiotherapy With or Without CBDCA in Elderly Patients With Non-Small Cell Lung Cancer (JCOG0301)
The purpose of this study is to evaluate whether radiotherapy with carboplatin will result in longer survival than radiotherapy alone in elderly patients with unresectable stage III NSCLC.
- Trial name
- NCT00132665
- Testing
- A: Radiotherapy alone, B: CBDCA and Radiotherapy
- Where
- 37 sites in Japan
- Volunteers
- 200 people
- Sponsor
- Japan Clinical Oncology Group
Covid19
Low Dose Lung Radiotherapy to Treat COVID-19 Pneumonia
The purpose of this study is to document the feasibility and tolerability of low dose thoracic radiotherapy in patients with WHO level 5 COVID 19 infections.
- Trial name
- NCT04572412
- Testing
- Low dose Radiotherapy
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- Lancashire Teaching Hospitals NHS Foundation Trust
Parkinson's Disease
Radiation Therapy (RT) for Parkinson's Disease (PD)
The purpose of this study is to investigate the use of ultra-low, anti-inflammatory doses of radiation therapy (RT) for the treatment of Parkinson's Disease (PD).
- Trial name
- NCT07218952
- Testing
- Radiation therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Alzheimer Disease
The Safety and Scientific Validity of Low-dose Whole Brain Radiotherapy in Alzheimer's Disease.
Alzheimer's disease is the most frequent neurocognitive disorder associated with dementia, with a constantly increasing prevalence associated with an aging population.
- Trial name
- NCT04203121
- Testing
- low dose whole brain radiation to treat Alzheimer disease
- Where
- South Korea
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kyung Hee University Hospital at Gangdong
Lung Cancers, Radiation Treatment for Tumors
Spatial Fragmentation Combined With Low-dose Radiotherapy for Immunotherapy Combined With Chemotherapy-resistant Locally Advanced or Advanced Non-small Cell Lung Cancer
The purpose of this study was to evaluate the effect of immunotherapy combined with spatial fractionation radiotherapy and low dose radiotherapy on the prognosis of patients with advanced lung cancer under specific dose regimens…
- Trial name
- NCT06775678
- Testing
- Spatially Fractionated Radiation Therapy Combined With Low-dose Radiotherapy, Conventional fractionated radiotherapy
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Lung Cancer, Non-small Cell Lung Cancer
Low-Dose Radiation + SBRT + Tislelizumab Plus Platinum-based Chemotherapy in Stage ⅡA-ⅢB Non-small Cell Lung Cancer
This phase II study aims to evaluate the efficacy and safety of low-dose radiation + SBRT + Tislelizumab plus platinum-based chemotherapy as neoadjuvant therapy for stage II-III non-small cell lung cancer.
- Trial name
- NCT06877299
- Testing
- Low-Dose Radiation(LDRT) + Stereotactic body radiotherapy (SBRT)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sichuan University
Lung Cancer
Rh-Endostatin Combined With CCRT(50 Gy) Followed by Durvalumab Maintenance for the Treatment of Specific Phase III NSCLC
A Study to Assess the Effects of Durvalumab following Rh-Endostatin combined with reduced-dose CCRT(50 Gy) in Patients with Stage III Unresectable Non-Small Cell Lung Cancer who can not tolerate 60 Gy irradiation.
- Trial name
- RELIEF (NCT04613284)
- Testing
- Recombinant human endostatin (Endostar), Thoracic irradiation of 50 Gy with 3DCRT or IMRT
- Volunteers
- 97 people
- Sponsor
- Shanghai Chest Hospital
DLBCL - Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma
Low Dose Radiation as Bridging Therapy in Relapsed B-Cell Non-Hodgkin Lymphoma
The goal of this clinical trial is to learn about treatment for people with B-cell lymphoma that did not respond to treatment or that has gotten worse after treatment.
- Conditions
- DLBCL - Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Follicular Lymphoma, Mediastinal Large B-cell Lymphoma
- Trial name
- NCT05621096
- Testing
- Bridging radiation therapy, Liso-cel, Post-infusion radiation
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Nebraska
Recurrent Glioblastoma
A Phase III Study of Re-Irradiation in Recurrent Glioblastoma
The investigators hope to improve overall median survival of patients with recurrent Glioblastoma by investigating continuous low-dose daily Temozolomide plus or minus five treatments of re-irradiation.
- Trial name
- NCT01830101
- Testing
- TMZ plus concurrent re-irradiation, Temozolomide
- Where
- Canada
- Sponsor
- AHS Cancer Control Alberta
Lung Nodules
DeepPriorCBCT for Low Dose Lung CBCT Reconstruction
The goal of this clinical trial is to learn if the DeepPriorCBCT model ensure high-quality CBCT image while reducing CBCT radiation dose.
- Trial name
- NCT07035977
- Testing
- Participants will receive a 1/6 views undersampling lung CBCT scan.
- Where
- 5 sites in China
- Volunteers
- 138 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Myeloid Malignancies, Acute Myelogenous Leukemia
Fludarabine and Busulfan vs. Fludarabine, Busulfan and Total Body Irradiation
This is a single institution study of fludarabine and busulfan versus fludarabine, busulfan and low dose total body irradiation in patients undergoing allogeneic stem cell transplantation.
- Conditions
- Myeloid Malignancies, Acute Myelogenous Leukemia, Chronic Myelogenous Leukemia, Myeloproliferative Disorders
- Trial name
- FLUBUTBI (NCT01366612)
- Testing
- Fludarabine and Busulfan plus/minus Total Body Irradiation (low dose), Fludarabine and Busulfan + Low Dose Total Body Irradiation (LD TBI)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Hackensack Meridian Health
Hidradenitis Suppurativa, Hidradenitis
Low Dose Radiotherapy for Advanced Hidradenitis Suppurativa
To establish the safety of radiotherapy in the treatment of advanced hidradenitis suppurativa. Patients will receive radiotherapy treatment over one week and then they will be followed for the next three months.
- Trial name
- RTHS (NCT03040804)
- Testing
- Low dose Radiotherapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Montefiore Medical Center
Neoplasms, Secondary Malignant Neoplasm
Abscopal Effect from the Low-dose Radiotherapy in Polymetastatic Cancer Patients Receiving Stereotactic Radiotherapy
Recently, MD Anderson Cancer Center reported the phase II trial to investigate high-dose radiotherapy (HDRT, 20-70 Gy) and low-dose radiotherapy (LDRT, 1-10 Gy) for metastatic cancer patients who had undergone immunotherapy.
- Trial name
- KROG22-11 (NCT05733156)
- Testing
- SBRT + LDRT
- Where
- 2 sites in South Korea
- Volunteers
- 52 people
- Sponsor
- Soonchunhyang University Hospital
Radiotherapy, Radiotherapy Side Effect
Pulsed Low Dose Rate Radiation Therapy for Gastric Cancer Patients With Peritoneal Metastasis
This phase II trial studies the side effects and response of pulsed low dose rate radiation therapy in treating gastric cancer patients with peritoneal metastasis.
- Conditions
- Radiotherapy, Radiotherapy Side Effect, Stomach Neoplasms
- Trial name
- NCT03061162
- Testing
- pulsed low dose rate radiation therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yang Yang
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Evaluating a Decreased Dose of Radiation Therapy to the Elective Neck for the Treatment of HPV-Related Oropharyngeal Cancer, ENLIGHT Trial
This clinical trial evaluates how decreasing the dose of radiation to the elective neck (areas of lymph nodes not directly involved in the cancer) impacts treatment outcomes in patients with human papillomavirus (HPV)-related…
- Trial name
- NCT07178301
- Testing
- Computed Tomography, Nasopharyngeal Laryngoscopy, Positron Emission Tomography
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Northwestern University
Liver Metastases, Non-Small Cell Lung Cancer
Intestinal Low-Dose Radiotherapy Combined With Immune Checkpoint Inhibitors in Solid Tumors With Liver Metastases
This study aims to evaluate the effectiveness and safety of combining low-dose radiotherapy to the intestines with immune checkpoint inhibitors (ICIs) in patients with liver metastases from solid tumors.
- Conditions
- Liver Metastases, Non-Small Cell Lung Cancer, Colorectal Cancer (Diagnosis), Pancreatic Cancer Metastatic
- Trial name
- ILDR-ICI-LM (NCT07875465)
- Testing
- Intestinal Low-Dose Radiotherapy (ILDR), PD-1/PD-L1 inhibitors, Combined Chemotherapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Bing Xia
Squamous Cell Carcinoma
Paclitaxel, Carboplatin And Low Dose Radiation As Induction Therapy In Locally Advanced Head And Neck Cancer
This study is being performed utilizing two cycles of Paclitaxel and Carboplatin, plus low doses radiation as initial therapy prior to other treatment (surgery or radiation).
- Trial name
- NCT00176267
- Testing
- Radiotherapy, Paclitaxel, Carboplatin
- Volunteers
- 26 people
- Sponsor
- Susanne Arnold
Head and Neck Cancer
Neoadjuvant Radiotherapy Plus Targeted Therapy and Immunotherapy vs. Targeted Therapy Plus Immunotherapy in Resectable HNSCC
This study compares the efficacy of neoadjuvant low-dose radiotherapy plus targeted-immunotherapy versus targeted-immunotherapy alone in resectable HNSCC patients.
- Trial name
- NCT06804850
- Testing
- Tislelizumab, Afatinib, Low dose radiotherapy
- Sponsor
- West China Hospital
DS Stage I Plasma Cell Myeloma, DS Stage II Plasma Cell Myeloma
Bortezomib, Melphalan, and Total-Body Irradiation Before Stem Cell Transplant in Treating Patients With Multiple Myeloma
This phase I/II trial studies the side effects and best dose of bortezomib when given together with melphalan, and total-body irradiation before stem cell transplant and to see how well it works in treating patients with multiple…
- Conditions
- DS Stage I Plasma Cell Myeloma, DS Stage II Plasma Cell Myeloma, DS Stage III Plasma Cell Myeloma, Refractory Plasma Cell Myeloma
- Trial name
- NCT01936090
- Testing
- Bortezomib, Total-Body Irradiation, Melphalan
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Mayo Clinic
Solid Tumor, Adult
RACIN in Patients With Advanced TIL-negative Solid Tumors
Subjects with locally advanced or metastatic incurable Tumor Infiltrating Lymphocytes (TIL)-negative solid tumors who are not eligible for, declined or failed standard therapy will be treated with a combination nivolumab…
- Trial name
- RACIN (NCT03728179)
- Testing
- Low dose irradiation + Nivolumab + Ipilimumab or Cyclophosphamide + Aspirin/Celecoxib
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois