Clinical trials: Lower Back Pain Chronic
Low Back Pain
Study on the Safety and Effectiveness of Switching Between Two Forms of Tapentadol in Patients With Chronic Low Back Pain
The objective of this study is to test the idea that the immediate-release (IR) form of tapentadol (CG5503) can be directly converted into an approximately equivalent total daily dose (TDD) of the extended-release (ER) form, and…
- Trial name
- NCT00594516
- Testing
- tapentadol (CG5503) Immediate Release IR, tapentadol (CG5503) Extended Release (ER), tapentadol (CG5503) Immediate Release (IR)
- Volunteers
- 117 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Low Back Pain
Effect of Peripheral Magnetic Stimulation in Patients With Chronic Lower Back Pain
The aim of this study is to analyze the effect of Repeated Peripheral Magnetic Stimulation (rPMS) in patients with chronic low back pain. This is a controlled, randomized, multicenter clinical trial (Brazil x Portugal).
- Trial name
- PEMS-CLBP (NCT07243548)
- Testing
- rPMS Intervention, rPMS Controle
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Inês Gomes
Lower Back Pain
Restorative Exercise for Strength Training and Operational Resilience (RESTORE) for Chronic or Recurrent Low Back Pain
The purpose of the study is to learn about the effect of integrative therapies on chronic or recurrent low back pain. The intervention called RESTORE (Restorative Exercises for Strength Training and Operational Resilience) is…
- Trial name
- RESTORE (NCT02132910)
- Testing
- RESTORE Intervention
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Low Back Pain
An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Severe Chronic Low Back Pain
The purpose of this study is to evaluate the efficacy and safety of Transdermal Therapeutic System (TTS)-fentanyl patch (transdermal patch containing a drug that is put on the skin so the drug will enter the body through the…
- Trial name
- NCT01774903
- Testing
- TTS-fentanyl
- Where
- Thailand
- Volunteers
- 45 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Low Back Pain
Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® Disc Augmentation System: A Pilot Study
The purpose of this study is to assess the safety of the Biostat Disc Augmentation System for the treatment of chronic low-back (lumbar) pain due to symptomatic internal disc disruptions (IDD) and to obtain preliminary efficacy…
- Trial name
- NCT00693784
- Testing
- Biostat® Disc Augmentation System
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Spinal Restoration, Inc.
Chronic Low Back Pain
Yoga for Veterans With CLBP
Chronic low back pain (CLBP) is a prevalent condition among VA patients, but many current treatment options have limited effectiveness.
- Trial name
- NCT02524158
- Testing
- Yoga Therapy for CLBP
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- VA Office of Research and Development
Pain, Chronic, Pain, Back
Ultra-high Frequency (500 KHz) Spinal Cord Stimulation for Treatment of Chronic Back Pain or Lower Limb Pain
This study is a prospective, single-arm, open label, single center to confirm the effectiveness and safety of an ultra-high frequency (500 KHz) spinal cord stimulation in patients with chronic back pain or lower limb pain.
- Conditions
- Pain, Chronic, Pain, Back, Pain, Radiating
- Trial name
- NCT03543085
- Testing
- GiMer Medical MN 1000 External Stimulator
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- GiMer Medical
Complex Regional Pain Syndrome (CRPS)
TARGET Post-Approval Study
The purpose of this prospective, multicenter, single arm post-approval study is to demonstrate continued safety of the Axium and Proclaim Neurostimulator System for dorsal root ganglion (DRG) stimulation.
- Trial name
- TARGET PAS (NCT02800863)
- Testing
- Dorsal Root Ganglion (DRG) Stimulation (Axium™ Neurostimulator System), Dorsal Root Ganglion (DRG) Stimulation (Proclaim™ Neurostimulator System)
- Where
- 44 sites in United States
- Volunteers
- 426 people
- Sponsor
- Abbott Medical Devices
Low Back Pain, Radiating Pain
Effect of Nitrous Oxide in Treating Neuropathic Pain: A Study in Chronic Low Back Pain Patients
Epidural injection will be completed under fluoroscopy and all patients will receive 1-4 mg of Midazolam for relaxation before procedure and, if needed, 50-100 mcg of Fentanyl intravenous (IV).
- Trial name
- NCT01172600
- Testing
- Entonox, Oxygen
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- The Cleveland Clinic
Low Back Pain
Trial of Scrambler Therapy or Sham Treatment for Low Back Pain
This pilot study will evaluate Scrambler therapy and Sham treatment on levels of low back pain, pain sensitivity and mRNA expression of pain sensitivity candidate genes.
- Trial name
- NCT01896687
- Testing
- Scrambler
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Virginia Commonwealth University
Back Pain, Chronic Pain
Effectiveness of Precision Spinal Cord Stimulation With Artisan Paddle Electrode
The primary objective of this study is to evaluate the acute and chronic efficacy of spinal cord stimulation using the Precision implantable neurostimulation device with the Artisan paddle electrode in patients with Failed Back…
- Conditions
- Back Pain, Chronic Pain, Pain in Leg, Unspecified
- Trial name
- NCT00386724
- Testing
- Precision Spinal Cord Stimulation System, Artisan Surgical Lead
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Boston Scientific Corporation
Low Back Pain
Spinal Manipulation Services vs. Prescription Drug Therapy for Long-term Care
Our overall objective is to assess the value of Spinal Manipulation Services as compared to Prescription Drug Therapy for long-term management of chronic Law back Pain (LBP).
- Trial name
- NCT03669354
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Southern California University of Health Sciences
Low Back Pain
Imaging Study of Chronic Low Back Pain in Patients Taking Pain Medication
Duloxetine has recently been shown to be effective in reducing the pain in chronic pain patients. Duloxetine is known to exert a central mechanism, however the precise human brain structures responsible for mediating its…
- Trial name
- NCT00388414
- Testing
- duloxetine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Stanford University
Non-specific Chronic Low Back Pain
An Interactive Gaming-based Intervention for Back Pain
This study aims to compare the outcomes of a traditional, exercise-based rehabilitation intervention for chronic low back pain with the outcomes achieved by combining a traditional intervention with adjunct therapy delivered…
- Trial name
- NCT02503410
- Testing
- Usual care, Interactive gaming
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Spaulding Rehabilitation Hospital
Mechanical Low Back Pain, Chronic Low Back Pain
Spinal Control During Functional Activities to Improve Low Back Pain Outcomes
Exercise is one of the primary interventions used with people with chronic, mechanical low back pain. It is unknown, however, which exercise is best for which person, which exercises a person will adhere to and for how long, and…
- Trial name
- LBP (NCT02027623)
- Testing
- Motor skill training, Strength and flexibility exercise
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Washington University School of Medicine
Chronic Low Back Pain
Management of Chronic Low Back Pain in Older Adults Using Auricular Point Acupressure
Almost one-third (30%) of persons 60 years and older suffer from cLBP and cause a significant negative impact on individuals and society in the U.S.
- Trial name
- NCT03589703
- Testing
- Target ear points related to chronic low back pain (T-APA), Non-Target ear Points not related to chronic low back pain (NT-APA), Enhanced Educational Control Group (CG-2)
- Where
- 2 sites in United States
- Volunteers
- 272 people
- Sponsor
- The University of Texas Health Science Center, Houston
Low Back Pain, Osteoarthritis
Long-term Open-Label Safety Study to Evaluate EN3409
The purpose of the long-terms study is to evaluate the safety, tolerability, and analgesic efficacy of EN3409 in subjects with moderate to severe chronic pain requiring continuous around-the-clock opioid analgesia for an extended…
- Conditions
- Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01755546
- Testing
- EN3409
- Where
- 57 sites in United States
- Volunteers
- 304 people
- Sponsor
- BioDelivery Sciences International
Chronic Low-back Pain
Virtual Reality Guided Acupuncture Imagery Treatment for Chronic Low Back Pain
Testing the effect of Virtual Reality - guided imagery acupuncture
- Trial name
- NCT06814470
- Testing
- Virtual reality guided imagery acupuncture treatment (VRGAIT), Virtual reality guided imagery acupuncture treatment control
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Massachusetts General Hospital
Chronic Low Back Pain
Bright Light Treatment At Home To Manage Chronic Pain In U.S. Veterans
Nearly 50% of U.S. veterans report they experience pain on a regular basis. This chronic pain often co-occurs with other disorders including post-traumatic stress disorder (PTSD), depression, anxiety and insomnia.
- Trial name
- NCT02373189
- Testing
- Bright light
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Rush University Medical Center
Low Back Pain
The Glucosamine-study: The Effect of Glucosamine in Treatment of Chronic Low Back Pain
Low back pain (LBP) is the most frequent cause of sick leave and disability pension, and degenerative and osteoarthritic (OA) changes is a significant cause of pain and disability.
- Trial name
- NCT00404079
- Testing
- Glucosamine sulphate
- Where
- Norway
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital