Clinical trials: Lower Extremity
Bony Weight Bearing Disorder
Safety of Immediate Weight-Bearing as Tolerated After Well-Reduced Geriatric Hip
Purpose: Proximal femur fracture is a major traumatic injury in elderly populations; however, practical postoperative weight-bearing protocols are lacking.
- Trial name
- NCT06199739
- Testing
- Early-Weight bearing
- Where
- Taiwan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Knee Injuries, Proprioceptive Disorders
A Validation Study of Force Sense Measurement
The term proprioception was first introduced by Sherrington in 1906, who described it as a type of feedback from the limbs to the central nervous system.
- Trial name
- NCT03852199
- Testing
- Test protocol for proprioceptive force sense in case group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Acute Compartment Syndrome
The Use of Near Infrared Spectroscopy in the Diagnosis of Acute Compartment Syndrome in Injured Soldiers
The purpose of this study is to define the reliability and accuracy of Near Infrared Spectroscopy (NIRS) in the detection of intra-compartmental tissue perfusion in injured and noninjured extremities over time.
- Trial name
- NCT01123798
- Testing
- near-infrared spectroscopy
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- J&M Shuler
ACL Injury, ACL Sprain
Isoinertial Rehabilitation in Recovering Hamstring Strength Following Surgical Anterior Cruciate Ligament Reconstruction
The present experimental study aims to evaluate the effectiveness and tolerability of isoinertial strength training of the hamstrings using machines in patients with ACL-R during the intermediate post-intervention phases.
- Conditions
- ACL Injury, ACL Sprain, ACL Tear, Anterior Cruciate Ligament Rupture
- Trial name
- NCT06063915
- Testing
- Isoinertial training, Strength Training
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Università degli studi di Roma Foro Italico
Lymphedema, Secondary, Lymphedema of Leg
Secondary Lymphedema Due to Human Adjuvant Disease
This observational, descriptive, retrospective study the clinical and imaging findings of 10 lower legs of 5 patients with previous history of injection of modeling substances for cosmetic purposes at buttocks and hips ande…
- Conditions
- Lymphedema, Secondary, Lymphedema of Leg, Granuloma, Foreign-Body
- Trial name
- NCT04588493
- Testing
- Lower extremity Lymphoscintigraphy
- Where
- Mexico
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Hospital Angeles del Pedregal
Knee Injuries
Electrostimulation in Anterior Cruciate Ligament Reconstruction
The anterior cruciate ligament (ACL) is frequently injured, and it is the structure of the athlete´s knee which has the highest prevalence of reconstruction.
- Trial name
- NCT01633047
- Testing
- electrical stimulation, physical therapy exercises
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Lower Extremity Muscular Power Performance Output
The Immediate and 24-hour Effects of Body Tempering Versus Foam Rolling on Lower Extremity Muscular Power During the Vertical Jump and Standing Long Jump Tests
The goal of this clinical trial is to examine the effects of body tempering on healthy volunteers between the ages of 18-39. The main question it aims to answer is will the intervention have an impact on immediate or 24-hour…
- Trial name
- NCT06646926
- Testing
- Body tempering, Foam rolling self-myofascial release
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Near-Infrared Spectroscopy
Comparison of Intercostal and Quadriceps Femoris Muscle Oxygenation in Women and Men
The differences in physiological responses due to gender during exercise tests have recently begun to be investigated. The oxygen use of respiratory muscles and lower extremity muscles may differ during upper and lower extremity…
- Trial name
- NCT06896838
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Tibial Fractures, Malleolar Fractures
Intramedullary Nailing of Tibia Fractures
Currently, the treatment of choice for tibial fracture is intramedullary nailing. This procedure has been shown to have low rates of infection, high rates of bone healing, and a faster return to weight bearing and activity in…
- Trial name
- NCT01797640
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Utah
Stress, Job, PTSD
The Sequestration of Holistic Stress Management Techniques for Adults
This remote study is intended to assist the population with access to cost-effective pastoral counseling for stress management in the workplace and every day life.
- Conditions
- Stress, Job, PTSD, Hypervigilance, Hyperthyroidism
- Trial name
- NCT06098755
- Testing
- Holistic Medicine (HM)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Goddess Zena I. Jones
Adult-acquired Flatfoot Disorder (AAFD)
Weightbearing Assessment of Tarsal Instability
The purpose of this study is to compare the average joint motion and joint axis orientation of the hindfoot bones between patients diagnosed with adult-acquired flatfoot disorder (AAFD) and a control group of patients without…
- Trial name
- WBCT (NCT01868789)
- Testing
- Weightbearing CT
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Orthopedic Foot and Ankle Center, Ohio
Periodic Leg Movements, Excessive, Sleep-Related
Effect of Acute Exercise on Sleep Patterns in Patients With PLMS, Using a Wearable Device, Compared With a Control Group ( SONEX )
The effects of chronic exercise on health promotion, improvement of quality of life, and reduction of the risk of developing chronic diseases such as obesity, diabetes mellitus, cardiovascular diseases, depression, and cancer are…
- Trial name
- SONEX (NCT07382206)
- Testing
- cardiopulmonary exercise test (CPET), Cardiopulmonary Exercise Test (CPET) - Twice
- Where
- Brazil
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Post Induction Hypotension
Effects of Esketamine and Bilateral Lower Limb Elevation on Hemodynamic Stability During Induction of General Anesthesia in Elderly Patients Undergoing Thoracic Surgery
Video-assisted thoracoscopic surgery (VATS) is widely used in thoracic surgery due to small incisions, low stress response, and high patient tolerance.
- Trial name
- NCT07374458
- Testing
- Esketamine, Bilateral Lower Limb Elevation
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Healthy Adolescents
Comparison of Upper and Lower Extremity Isometrics on Cognition in Healthy Adolescents
This study aims to compare the effects of upper and lower-extremity isometrics on cognition in healthy adolescents.
- Trial name
- NCT06047743
- Testing
- Alternating unilateral Isometric Handgrip Exercise, Dominant knee extension Isometric Exercise
- Where
- Pakistan
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Amputation
Quantification of Motor Compensation Following Biomechanical, Proprioceptive and Physiological Alterations Post-lower Limb Amputation.
Lower limb amputation causes segmental loss that alters locomotor organization. The human body, designed to function in a multisegmental manner, must adapt to this new configuration where segments are missing, depending on the…
- Trial name
- QAMPA (NCT06780943)
- Testing
- Biomechanics, Physiological, Proprioceptive
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Coordination and Balance Disturbances, Healthy
Effect of Lower Extremity Joint Manipulation on a Lower Extremity Somatosensory Illusion
The purpose of this study is to examine the influence of extremity manipulation on individual's center of pressure after they adapt to an ankle based illusion.
- Trial name
- NCT05226715
- Testing
- chiropractic manual therapy
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Parker University
Healthy Volunteers
To studyJUV-161 Administered to Healthy Volunteers Undergoing Unilateral Lower Limb Immobilization (ULLI)
This is a double-blind, placebo-controlled, randomized study of 96 days total duration to assess the effect of JUV-161 on muscle disuse atrophy.
- Trial name
- NCT07397468
- Testing
- JUV-161
- Where
- 2 sites in New Zealand
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Juvena Therapeutics
Genetic Predisposition to Disease, Inflammation
Gene Expression in Chronic Venous Leg Ulcers
Chronic Venous Disease (CVD) is a widespread clinical condition widely spread in the western countries that may negatively impact the quality of life (QoL) of affected patients.
- Conditions
- Genetic Predisposition to Disease, Inflammation, Venous Leg Ulcer
- Trial name
- GECVELUS (NCT05134597)
- Testing
- Genetic assessment
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Healthy Volunteers
Effects of tDCS on Anaerobic Power of Lower Limb Muscles
Anaerobic power and capacity are essential in many human activities, especially during sports practice that demand a high strength and power of the limbs.
- Trial name
- NCT04467476
- Testing
- Transcranial direct current stimulation
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Piauí
Hyperthermia, Weather; Heat
Mitigating Heat-induced Physiological Strain and Discomfort in Older Adults Via Lower Limb Immersion and Neck Cooling
The incidence and severity of hot weather and extreme heat events (heat waves) is increasing. As such, there is an urgent need to develop heat-alleviation strategies that can provide targeted protection for older adults who are…
- Conditions
- Hyperthermia, Weather; Heat, Heat Stress, Heat Syncope
- Trial name
- NCT05601713
- Testing
- No cooling (control), Lower limb immersion, Lower limb immersion + neck cooling
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Ottawa