Clinical trials: Lower Extremity
Ankle Sprains
Development of Chronic Ankle Instability After Acute Ankle Sprain
The goal of this observational prospective cohort study is to determine key clinical predictors for chronic ankle instability and return to sports in patients who suffered an acute ankle sprain.
- Trial name
- NCT05637008
- Where
- Belgium
- Volunteers
- 265 people
- Sponsor
- Universiteit Antwerpen
ACL Injury, ACL - Anterior Cruciate Ligament Rupture
The Rehabilitation Effect of Exercise Training in Cruciate Ligament Reconstruction Patients.
After anterior cruciate ligament (ACL) injury, the involved quadriceps may demonstrate weakness due to decrease in quadriceps activation.
- Conditions
- ACL Injury, ACL - Anterior Cruciate Ligament Rupture, ACL - Anterior Cruciate Ligament Deficiency
- Trial name
- NCT03359382
- Testing
- Resistance or home exercise combined with eccentric exercise
- Where
- Taiwan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Postoperative Pain, Pain
Comparison of Analgesic Efficacy of Intrathecal Bupivacaine Versus Bupivacaine Plus Dexmedetomidine in Patients Undergoing Orthopedic Surgeries.
Clinical Trial Overview: Intrathecal Bupivacaine vs. Bupivacaine + Dexmedetomidine Primary Objective Duration of Analgesia:** To compare the mean duration of postoperative pain relief between hyperbaric bupivacaine alone versus…
- Conditions
- Postoperative Pain, Pain, Orthopaedic Surgery, Anesthesia, Spinal
- Trial name
- NCT07866508
- Testing
- Dexmedetomidine plus Hyperbaric Bupivacaine, Hyperbaric bupivacaine % 0.5
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheikh Khalifa Bin Zayed Al Nahyan Combined Military Hospital Muzaffarabad
Magnetic Resonance Angiography, Peripheral Vascular Diseases
Magnevist (SH L 451A) Intra-individual Dose Comparison Study in Magnetic Resonance Angiography
The objective of the study was to compare the efficacy of Magnevist (SH L 451 A) at doses of 0.1 mmol/kg and 0.2 mmol/kg in contrast-enhanced 3D-Magnetic Resonance Angiography in three regions (abdominal, femoral, and leg…
- Conditions
- Magnetic Resonance Angiography, Peripheral Vascular Diseases, Peripheral Arterial Diseases
- Trial name
- NCT00652418
- Testing
- Gadopentetate dimeglumine (Magnevist, BAY86-4882, SH L 451A)
- Where
- 3 sites in Japan
- Volunteers
- 12 people
- Sponsor
- Bayer
Sprains and Strains, Pain
A Study of the Efficacy and Safety of Tramadol HCl/Acetaminophen, Hydrocodone Bitartrate/Acetaminophen and Placebo in Patients With Pain From an Ankle Sprain With a Partial Torn Ligament
The purpose of this study is to explore the pain-relieving effects and safety of two analgesic treatment regimens as compared to placebo in patients experiencing acute musculoskeletal pain.
- Trial name
- NCT00236535
- Volunteers
- 603 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Healthy Volunteers, Physical Fitness
Effects of Inertial Load of Water on Lower Limb Joint Moments During Landing and Cutting
This study examined whether a 10-week dynamic stability training program using water-filled equipment could improve joint control and postural stability during landing and directional changes.
- Conditions
- Healthy Volunteers, Physical Fitness, Lower Extremity
- Trial name
- NCT07117617
- Testing
- Dynamic Stability Training with Inertial load of water
- Where
- South Korea
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Ja Yeon Lee
Orthopedic Surgery
Melatonin for Prevention of Postoperative Delirium After Lower Limb Fracture Surgery in Elderly Patients
Postoperative delirium (POD) is one of the most frequent complications after surgery in elderly patients, affecting between 20 and 40% of patients older than 60 after major surgery.
- Trial name
- DELIRLESS (NCT04335968)
- Testing
- Melatonin 4 mg
- Where
- France
- Volunteers
- 357 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Melanoma (Skin), Sarcoma
Isolated Limb Infusion of Chemotherapy in Treating Patients With Melanoma or Soft Tissue Sarcoma of the Arm or Leg That Cannot Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Infusing chemotherapy to the tumor area only may kill more tumor cells and cause less damage to healthy…
- Trial name
- NCT00004250
- Testing
- dactinomycin, isolated limb perfusion, melphalan
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Can BFR Cycling Augment Strength and VO2peak
BFR Training on a Bike to Augment RC Strength, Leg Strength, and VO2 Peak
This study will investigate if subjects who bike at 40% of heart rate reserve (HRR) with blood flow restriction (BFR) applied to bilateral thighs for 10 minutes (at 80% limb occlusion pressure) will experience greater gains in 10…
- Trial name
- NCT05344391
- Testing
- BFR cycling, Cycling without BFR
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- George Fox University
Sports Physical Therapy
Accentuated Eccentric Loading Versus Flywheel Exercises in Footballers
In the field of football, the essence of the lower limb strength, power and general performance is greatly valued by any player who wants to perform exceptionally well in both the acceleration, jumping and general agility.
- Trial name
- NCT06985810
- Testing
- Accentuated Eccentric Loading training, Flywheel exercises
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Riphah International University
ECMO Treatment, ARDS
Hemodynamic Monitoring and Fluid Responsiveness in Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) - "HemodynamECMOnitoring-VV Study"
In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels.
- Conditions
- ECMO Treatment, ARDS, Pneumonia, Intensive Care
- Trial name
- NCT06593717
- Testing
- Transthoracic Echocardiography, Uncalibrated Pulse Contour Analysis, Transpulmonary Thermodilution/Calibrated Pulse Contour Analysis
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Vascular Disease，Peripheral
SPECTATOR: Perfusion Monitoring Before, During and After Lower Extremity Revascularization With Laser Speckle Contrast Imaging
This study aims to evaluate the feasibility of Laser Speckle Contrast Imaging for perioperative perfusion assessment of the lower extremity before, during, and after revascularization.
- Trial name
- SPECTATOR (NCT07558174)
- Testing
- Laser Speckle Contrast Imaging
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Anterior Cruciate Ligament Rupture
Anterior Cruciate Ligament (ACL) Revision Surgery: French National Study
This is a national multicentric study led by the French Arthroscopy Society (SFA) evaluating clinical practice in anterior cruciate ligament (ACL) revision surgery (epidemiological data, morphological data, operative data…
- Trial name
- NCT06379308
- Testing
- questionaries, datas of medical record
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Fractures, Hip, Local Anesthesia
Influence of Peri-operative Anesthetic and Analgesic Care on the Outcome of Patients Undergoing Hip Fracture Surgeries. A Prospective Study
The purpose of this voluntary research study is to clarify whether or not a single injection nerve block done before surgery and after surgery nerve block catheter can effectively enhance recovery in elderly hip fracture patients…
- Conditions
- Fractures, Hip, Local Anesthesia, Geriatric, Nerve Block
- Trial name
- NCT06925789
- Testing
- Ropivacaine
- Sponsor
- Milton S. Hershey Medical Center
Pelvic Fracture
Fragility Fractures of the Pelvis (FFP)
Prospective data will be collected in approximately 420 patients, above the age of 65, suffering from an FFP type fracture equal to or higher than type II, according to Rommens and Hofmann.
- Trial name
- NCT04182776
- Where
- 10 sites in United States, Canada and 5 more
- Volunteers
- 420 people
- Sponsor
- AO Innovation Translation Center
Peripheral Arterial Disease
Adapted Physical Activity in Patients With Lower Limb Peripheral Arterial Disease
The prevalence of peripheral arterial disease is 12.2% in France. Intermittent claudication is the most common symtom of this disease. During physical exercise, such as walking, blood oxygen (O2) requirements increase.
- Trial name
- ACTIV'AO (NCT04800276)
- Testing
- muscle strengthening targeted on ischemic areas, global muscle strenghtening
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier le Mans
Cerebral Palsy, Muscle Spasticity
Dysport® Pediatric Lower Limb Spasticity Study
The purpose of this research study is to determine whether Dysport® is effective in the treatment of increased stiffness of the calf muscles and to evaluate the safety of this treatment in children with Cerebral Palsy.
- Conditions
- Cerebral Palsy, Muscle Spasticity, Children
- Trial name
- NCT01249417
- Testing
- Botulinum toxin type A
- Where
- 29 sites in United States, Chile and 4 more
- Volunteers
- 241 people
- Sponsor
- Ipsen
Anesthesia, Spinal, Orthopedic Procedures
Comparison of Low-Dose Versus Standard-Dose Hyperbaric Bupivacaine in Spinal Anesthesia
The goal of this randomized controlled trial is to determine whether low-dose hyperbaric bupivacaine provides better hemodynamic stability and postoperative recovery compared with standard-dose hyperbaric bupivacaine in elderly…
- Conditions
- Anesthesia, Spinal, Orthopedic Procedures, Postoperative Recovery in Elderly Patients, Hemodynamics
- Trial name
- NCT07684989
- Testing
- Low-Dose Hyperbaric Bupivacaine, Standard-Dose Hyperbaric Bupivacaine
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Mayo Hospital Lahore
Diabete Type 2, Diabetic Foot
Turkish Validity-Reliability Study of the Diabetic Foot Self-Care Questionnaire
The aim of this study is to evaluate the translation, cross-cultural adaptation and psychometric properties of the Diabetic Foot Self-Care Questionnaire in patients with primary Type 2 Diabetes.
- Trial name
- NCT05404178
- Testing
- Type 2 diabetes group
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Harran University
Diabetic Foot Infection
PHOTOFINISH: a Clinical Study To Evaluate The Efficacy And Safety Of the System VULNOFAST® Plus/VULNOLIGHT® In Addition To The Usual Care (UC) Vs UC Alone For The Treatment Of Infected Diabetic Foot Ulcers
The aim of this randomised, open-label, multicentre clinical trial is to evaluate the superiority of the treatment which foresees the addition of the system VULNOFAST® plus / VULNOLIGHT® to the Usual Care, versus the treatment…
- Trial name
- PHOTOFINISH (NCT05613985)
- Testing
- Usual Care alone, System VULNOFAST® plus / VULNOLIGHT® in addition to Usual Care
- Where
- 7 sites in Italy
- Volunteers
- 78 people
- Sponsor
- L.Molteni & C. dei F.lli Alitti-Soc. di Esercizio S.p.A.