Clinical trials: Lower Extremity Amputation, open to volunteers
Symptomatic Neuroma, Phantom Limb Pain After Amputation
Evaluation of RPNI for Symptomatic Neuromas in Lower Limb Amputees
This prospective, observational cohort study evaluates the long-term outcomes of Regenerative Peripheral Nerve Interface (RPNI) surgery in patients with major lower extremity amputations suffering from symptomatic neuromas.
- Conditions
- Symptomatic Neuroma, Phantom Limb Pain After Amputation, Residual Limb Pain, Neuropathic Pain
- Trial name
- RPNI-AMPUTEE (NCT07420192)
- Testing
- Regenerative Peripheral Nerve Interface (RPNI) Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Saglik Bilimleri Universitesi
Diabetes Mellitus
Assessing Diabetic Foot Ulcer Microcirculation With High-frequency Contrast Enhanced Ultrasound
The objective of this observational study is to investigate and validate the utility of high-frame-rate ultrasound imaging technology for dynamic observation of the blood perfusion process at the site of ulcer wounds in…
- Trial name
- NCT06309082
- Testing
- Amputation, Debridement
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Amputation
Pro APP Prosthetic Outcome Registry
A national, multi-center registry of patients using lower-limb prosthesis, their profiles and devices, and their long-term follow-up and clinical outcomes.
- Trial name
- NCT06210620
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Össur Iceland ehf
Prosthesis, Lower Limb Amputation Knee
Clinical and Functional Assessment of Patients With Transfemoral Amputation Treated With Osteointegrated Implant
Limb amputation is a traumatic event that significantly reduces the ability to perform daily activities, impairs mobility, and lowers quality of life.
- Conditions
- Prosthesis, Lower Limb Amputation Knee, Amputation; Traumatic, Leg, Lower
- Trial name
- OSTEO-OUTCOME (NCT06737770)
- Testing
- osseointegrated surgery for transfemoral amputation
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Ortopedico Rizzoli
Diabetic Foot Ulcer, Diabetes Complications
Characteristics of Diabetic Foot Ulcer Patients
This study examines the demographic, clinical, and laboratory characteristics of patients with diabetic foot ulcers admitted to 5 Azar Hospital, Gorgan, in 2024.
- Trial name
- NCT07188337
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- Golestan University of Medical sciences
Phantom Limb Pain
Home-based Rehabilitation Intervention for Phantom Limb Pain in Veterans With Lower Limb Amputations
Nearly 60-85% of Veterans with amputations experience pain at the location of the amputated limb called phantom limb pain (PLP).
- Trial name
- NCT06106984
- Testing
- Graded motor imagery mobile app
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Amputation
Effectiveness of Frontal Plane Adaptability in a Novel Foot Prosthesis
People with lower extremity amputation (LEA) have persistent problems with balance, falls, residual limb pain, functional mobility, cognitive attention during gait, and satisfaction with participation in daily activities, despite…
- Trial name
- NCT06214026
- Testing
- META-Arc foot locked, META-Arc foot unlocked
- Where
- 3 sites in United States
- Volunteers
- 96 people
- Sponsor
- University of Washington
Infections, Infected Wound
PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation
This is a Phase III clinical randomized control trial to investigate differences between patient with an infected nonunion treated by PO vs. IV antibiotics.
- Conditions
- Infections, Infected Wound, Nonunion of Fracture, Injury Leg
- Trial name
- POvIV2 (NCT05699174)
- Testing
- Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics
- Where
- 13 sites in United States
- Volunteers
- 250 people
- Sponsor
- Major Extremity Trauma Research Consortium
Amputation
Impact of Improving Footwear Options
Veterans with leg amputations have limited footwear options because their artificial feet do not change shapes for different shoes.
- Trial name
- NCT05601869
- Testing
- RECOVER Prosthetic Ankle-Feet System
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- VA Office of Research and Development
Anesthesia, Amputation; Traumatic, Leg, Lower
Anaesthetic Technique for Minor Lower Limb Amputation Surgery (ATLLAS)
Major lower limb amputation is recognised as a significant cause of morbidity and mortality. In the United Kingdom, 30-day in-hospital mortality is up to 8.7%.
- Trial name
- ATLLAS (NCT07244627)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University Hospitals of North Midlands NHS Trust
Lower Limb Amputation, Prosthesis User
Clinical and Psychological Adjustment of Patients With LLA: a Multidisciplinary Rehabilitative Intervention Project
Most of the limb amputation related to vascular disease is often secondary to a diagnosis of type 2 diabetes mellitus. The amputation involves significant motor, psychological, and social challenges for patients, with a major…
- Trial name
- AMPADinRehab (NCT06471855)
- Testing
- Multidisciplinary Conventional and Technology-based Rehabilitation, Multidisciplinary Conventional Rehabilitation
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Diabetic Foot Ulcers, Diabetes Mellitus
Assessment of Non Vascular Risk Factors for Severity of Diabetic Foot Ulcers (DFUs)
Diabetes mellitus is a chronic disease that occurs either when pancreas does not produce enough insulin or when the body can't use it effectively.
- Trial name
- DFUs (NCT07193992)
- Volunteers
- 100 people
- Sponsor
- Assiut University
Lower Limb Amputation Below Knee
Automatic Prosthetic Foot Stiffness Modulation to Improve Balance in the Real World
The goal of this clinical trial is to determine if automatic stiffness modulation improves balance control in ambulatory individuals with below-knee amputations in real-world conditions.
- Trial name
- NCT07791433
- Testing
- Fixed stiffness prosthesis, Automatic stiffness prosthesis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Amputation
Influence Of A Slope Adaptive Foot On Participation Of Veterans With Lower-Limb Amputations
Veterans with below-knee amputations are limited by prosthetic feet that cannot adapt to sloped and uneven terrain. This limitation results in reduced mobility, reduced balance confidence, and a higher risk of falls among some…
- Trial name
- NCT07266077
- Testing
- Fillauer Slope Adaptive Foot, Fillauer Motion Foot SLX
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Diabetic Foot Ulcer
Diabetes Related Foot Ulcers With Negative Pressure Wound Therapy
The goal of this study is to learn if the clinical effects of Negative Pressure Wound Therapy (NPWT) is better, worse or the same as standard wound care for patients with diabetic foot ulcers (DFUs).
- Trial name
- DIANE (NCT06721754)
- Testing
- Negative Pressure Wound Treatment
- Where
- 2 sites in Norway
- Volunteers
- 50 people
- Sponsor
- University Hospital, Akershus
Prosthesis User, Amputation
Prosthetic Limb Movement Feedback for Upper and Lower Extremity Amputees
To assess the functional characteristics and utility of upper and lower limb prosthetic devices (advanced bionic and current clinical standard-of-care) that incorporate physiologically relevant touch and/or movement feedback.
- Trial name
- NCT03135847
- Testing
- Tactor
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Traumatic Amputation of Lower Extremity
Improving Mobility and Function Following Transfemoral Amputation: A Novel Approach to Reverse Volumetric Muscle Loss
The purpose of this study is to investigate the relationship between thigh strength and walking ability and assess if using a blood pressure cuff on the leg improves strength and walking performance.
- Trial name
- NCT05929508
- Testing
- Ischemic Preconditioning
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Illinois Chicago
Limb Amputation, Extremity Amputation
Vascularized Composite Allotransplantation for Multiple Extremity Amputations
Limb transplantation surgery is the transfer of one or more limbs from a deceased human donor to a patient with single or multiple limb amputation.
- Trial name
- NCT01293214
- Testing
- Limb transplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Amputation, Gait Disorders, Neurologic
Usability of the Smart Hallway System in Clinical Setting
The aim of the study is to examine suitability of data and processed reports acquired from the Smart Hallway system for clinical settings in terms of user acceptability and accuracy for use in clinical practice.
- Trial name
- SmartHallway (NCT06645054)
- Testing
- Standard rehabilitation, Lower-limb prosthesis, Lower-limb orthosis
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Rehabilitation Institute, Republic of Slovenia
Perineural, Methylene Blue
Perineural Methylene Blue Infusion in Lower Limb Amputation Surgery
This prospective randomized controlled study will be conducted to evaluate the analgesic effect of continuous perineural infusion of methylene blue with bupivacaine on acute postoperative pain and to evaluate its preventive role…
- Conditions
- Perineural, Methylene Blue, Lower Limb Amputation
- Trial name
- NCT05830630
- Testing
- Bupivacaine methylene blue, bupivacaine saline
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Tanta University