Clinical trials: Lower Extremity Artery Disease
Peripheral Arterial Disease (PAD)
Post-marketing Study in Femoral Popliteal Artery of Drug Coated Balloon Used for Treatment of Lower Limb Ischemia
The objective of this prospective, multi-center, single arm study is to obtain further data on the safety and performance of the Drug-coated Balloon catheters in the treatment of the Superficial Femoral Artery (SFA) and Popliteal…
- Trial name
- UltraFuture I (NCT05498740)
- Testing
- Drug eluting Balloon
- Where
- 24 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhejiang Zylox Medical Device Co., Ltd.
Combined Anticoagulation and Antithrombotic Therapy, PAD - Peripheral Arterial Disease
Effectiveness of Combined Anticoagulation and Antithrombotic Therapy vs Antithrombotic Therapy Alone After Lower Extremity Revascularization for Peripheral Arterial Disease
EFFECTIVENESS OF COMBINED ANTICOAGULATION AND ANTITHROMBOTIC THERAPY VS ANTITHROMBOTIC THERAPY ALONE AFTER LOWER EXTREMITY REVASCULARIZATION FOR PERIPHERAL ARTERIAL DISEASE.
- Trial name
- NCT04994223
- Testing
- Rivaroxaban 10 MG Oral Tablet [Xarelto]
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi
Chronic Limb Threatening Ischemia
Multimodal Noninvasive Assessment of Peripheral Circulation in Chronic Limb-threatening Ischemia
Assessment of a novel diagnostic method for screening and diagnosing chronic limb-threatening ischemia (CLTI). Using hyperspectral and thermal imaging, the perfusion and oxygenation in the lower limbs will be studied in healthy…
- Trial name
- NCT05786001
- Where
- Finland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tampere University
Type 2 Diabetes, Peripheral Vascular Disorder Due to Diabetes Mellitus
Efficacy and Safety of Liraglutide in Type 2 Diabetes With Lower Extremity Arterial Disease
Diabetic lower extremity arterial disease ( DLEAD ), is a common complication of type 2 diabetes. However, DLEAD remains less studied than other diabetic vascular complications; and only few randomised controlled trials (RCTs)…
- Trial name
- NCT04146155
- Testing
- Liraglutide+standard-of-care treatment, standard-of-care treatment
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Arteriopathy
Effect of a Neuromuscular Electrical Stimulation Program on Walking Capacity in Peripheral Artery Disease Patients
Lower extremity peripheral arterial disease (LEPAD) is a highly prevalent chronic disease. Cardiovascular mortality of LEPAD patients at five years ranges between 18 to 30%.
- Trial name
- ELECTROPAD (NCT03795103)
- Testing
- neuromuscular electrical stimulator, Walking sessions, Advices
- Where
- 5 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Peripheral Arterial Disease
Using SnapshotNIR With Provocative Leg Maneuver for PAD Assessment
The objective of this trial is to determine if Near-infrared spectroscopy (NIRS) can accurately evaluate the degree of Peripheral Arterial Disease (PAD) during a Provocative Elevation Maneuver of the Lower Extremity (PEMLE) test…
- Trial name
- NCT06237621
- Testing
- SnapshotNIR imaging
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kent Imaging Inc
Peripheral Artery Disease, Peripheral Vascular Diseases
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease
Peripheral artery disease (PAD) is associated with elevated oxidative stress, and oxidative stress has been implicated as the cause of reduced endothelial reactivity in individuals with PAD.
- Conditions
- Peripheral Artery Disease, Peripheral Vascular Diseases, Peripheral Arterial Disease, Peripheral Arterial Occlusive Disease
- Trial name
- NCT06319339
- Testing
- Vumerity
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Peripheral Arterial Disease
Functional MRI of the Lower Extremities
In this project, the investigators propose to use high-resolution magnetic resonance imaging (MRI) to measure blood perfusion in different groups of calf muscle.
- Trial name
- NCT03423316
- Testing
- Supervised exercise therapy
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Near-Infrared Spectroscopy, Iliac Artery Stenosis
NIRS and Exercise Intensity in Patients With FLIA
The research objectives of this project are to increase the understanding of pathophysiology and performance limitations related to sport-related flow limitation in the iliac artery (FLIA) using non-invasive measurement of muscle…
- Conditions
- Near-Infrared Spectroscopy, Iliac Artery Stenosis, Iliac Artery Disease, Iliac Artery Occlusion
- Trial name
- NCT05229250
- Testing
- Cycling test, Occlusion tests, NIRS during cycling
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center
Peripheral Artery Disease
Optical Imaging Measurement of Intravascular Solution Efficacy Trial
Iodinated contrast is the current gold standard for infrainguinal angiography imaging in patients without renal insufficiency and has also been used with intravascular Optical Coherence Tomography (iOCT) to improve image quality…
- Trial name
- OPTIMISE (NCT01743872)
- Testing
- Contrast Injection, Dextran Injection, CO2 Injection
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Hemorrhage, Hypovolemic Shock
Efficacy of Prehospital Tourniquet Models for Arterial Occlusion in Upper and Lower Limbs
The goal of this clinical trial is to compare the occlusive capability and mechanical behavior of different commercially available pre-hospital tourniquet models and the results of their application on upper and lower limbs, in…
- Conditions
- Hemorrhage, Hypovolemic Shock, Tourniquets
- Trial name
- TQ-BR (NCT06725602)
- Testing
- TQ - Proximal Application ("high and tight"), TQ - Controlled application (2-3 inches)
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
COPD, Healthy
Femoral Artery Blood Flow During Rest and One-leg Knee Extensor Exercise in Patients With COPD
Doppler ultrasound is generally considered to provide reliable femoral blood flow measurements between rest and exercise, and the blood flow response to exercise is widely believed to be reduced in patients with chronic…
- Conditions
- COPD, Healthy, Chronic Obstructive Pulmonary Disease
- Trial name
- COPD-DOPPLER (NCT06135701)
- Testing
- One-legged knee-extensor exercise with Doppler measurements
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Diabetic Angiopathies, Diabetes Mellitus, Type 2
Assessment of Metabolic Profiles of Lower Extremity Arterial Disease in Patiens Withe Type 2 Diabetes
The prevalence of lower extremity arterial disease (LEAD) in patients with diabetes increases significantly and are characterized with obvious arteriosclerosis that are caused by multiple metabolic disorders.
- Trial name
- NCT05068895
- Testing
- liquid chromatography-mass spectrometry
- Where
- China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Zhiming Zhu
Peripheral Arterial Disease
Ultrasound Evaluation of Lower Extremity Arteries After Topical Nitroglycerin Administration
There have not been any published studies showing the use of topical nitroglycerin on the dilatory effect on the posterior tibial or dorsalis pedis arteries.
- Trial name
- NCT04155476
- Testing
- Nitroglycerin Topical Product
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Deborah Heart and Lung Center
Diabetic Foot, Diabetes
Predictors of Skin Temperature, Plantar Pressure and Ulceration in Diabetic Foot Patients.
Diabetes is a chronic disease with increasing prevalence worldwide with a high burden to individuals and the society and it is expected to be the 7th leading cause of death in 2030.
- Trial name
- NCT03254095
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Critical Limb Ischaemia, Claudication
Peripheral Vascular Disease and Nerve Stimulation
A study to see what effect the geko™ device has on blood flow in patients with lower limb vascular disease.
- Conditions
- Critical Limb Ischaemia, Claudication, Ulcers, Varicose Veins
- Trial name
- CCLINS (NCT01942941)
- Testing
- geko™ electrical stimulation
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Peripheral Artery Disease
Vorapaxar and Lower Extremity Bypass Grafts
There are no medical therapies indicated for reduction of limb ischemic events. Studies of dual-antiplatelet therapy with aspirin and clopidogrel versus aspirin alone (CASPAR) as well as studies of systemic anticoagulation (WAVE)…
- Trial name
- NCT02975583
- Testing
- Vorapaxar
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
WOUNDS
Efficacy Study of Ultrasound-Assisted Debridement to Influence Wound Healing
The UltraHeal Study is a randomized controlled trial to compare healing response of low frequency contact ultrasonic-assisted debridement in addition to best practice wound care to best practice wound care alone in a Vascular…
- Trial name
- UltraHeal (NCT01973361)
- Testing
- Ultrasound debridement, Best practice wound care
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Peripheral Artery Disease, Diabetes Mellitus
The Application of Digital Infrared Thermal Imaging in Peripheral Artery Disease of the Lower Extremities
Peripheral artery disease (PAD) is highly prevalent. It occurs most often in the lower extremities. Symptoms include intermittent claudication, ischemic pain, ulceration and necrosis. Amputation may be necessary in severe cases.
- Trial name
- NCT02783677
- Testing
- Percutaneous balloon angioplasty
- Where
- Taiwan
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Ischemia Reperfusion Injury, Peripheral Artery Disease
Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion
In this study, we are trying to see if vitamin B6 can minimize the amplified blood pressure response to exercise following ischemia-reperfusion injury.
- Trial name
- NCT06369350
- Testing
- Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center