Clinical trials: Lower Extremity Function
Prostheses and Implants
Advanced Prosthetic Devices for Lower Limb Amputees
Lower limb amputation is an emerging global health concern. Currently, there are over 1.6 million amputees in the U.S. and around 6000 new amputations are recorded per annum in the UK.
- Trial name
- NCT04197011
- Testing
- prosthetic device
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Peripheral Artery Disease
Vorapaxar and Lower Extremity Bypass Grafts
There are no medical therapies indicated for reduction of limb ischemic events. Studies of dual-antiplatelet therapy with aspirin and clopidogrel versus aspirin alone (CASPAR) as well as studies of systemic anticoagulation (WAVE)…
- Trial name
- NCT02975583
- Testing
- Vorapaxar
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
Being Between 40-80 Years Old, Being Diagnosed With Haemiplegia
The Relationship Between Lower Limb Functionality, Foot Joint Position Sensation and Balance in Haemiplegic Patients
Stroke is defined as a neurological disorder resulting from acute focal damage to the central nervous system caused by vascular factors, which may include cerebral infarction, intracerebral haemorrhage and subarachnoid…
- Conditions
- Being Between 40-80 Years Old, Being Diagnosed With Haemiplegia, Getting 20 Points or More in the Mini Mental Test, Volunteering to Participate in the Study
- Trial name
- NCT06043960
- Testing
- Humac Norm İsokinetic Machine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Sprain of Ankle
TAASS-Traumeel Ointment and Gel Compared With a Topical NSAID in Athletes With Acute Ankle Sprain
The objective of this study is to determine the efficacy of Traumeel S (both ointment and gel) compared to another antiinflammatory drug called Diclofenac in patients with a sprained ankle.
- Trial name
- TAASS (NCT01066520)
- Testing
- Traumeel S ointment, Traumeel S gel, Diclofenac gel
- Where
- Spain
- Volunteers
- 449 people
- Sponsor
- Biologische Heilmittel Heel GmbH
Unstable Strength Training, Balance Assessment
To Design an Experimental Intervention, 62 Youth Volleyball Players Were Divided Into an Experimental Group and a Control Group and Underwent 10 Weeks of Non-stationary Strength Training Versus Traditional Strength Training: Compared the Effects of Non-stationary Strength Training on the Athletes
Purpose: Volleyball has a high influence in the world, and there are many professional volleyball players and a large number of volleyball fans in all countries.
- Trial name
- FMS、YBT、ST (NCT06831721)
- Testing
- Unstable Strength Training
- Where
- China
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Muscle Architecture
Motor Imagery and Muscle Architecture
The aim of this study is to examine the effects of plyometric training on biceps femoris longus (BFl) and vastus lateralis (VL) muscle architecture in healthy football players.
- Trial name
- NCT05558033
- Testing
- Plyometric Exercise, Football Training
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Anesthesia, Hip Fractures
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
The ANDES Platform Trial is a pragmatic, multicenter, adaptive randomized controlled platform trial in patients aged 65 years or older undergoing surgery for hip fracture.
- Conditions
- Anesthesia, Hip Fractures, Dementia, Cognitive Impairment
- Trial name
- ANDES platform (NCT06452147)
- Testing
- Nerve block, Standard anesthesia care, Bupivacaine liposome
- Where
- 13 sites in China
- Volunteers
- 1,860 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Hip Fractures
Trigen InterTAN vs Sliding Hip Screw RCT
The purpose of this study is to compare the Trigen InterTAN Intramedullary nail to Sliding Hip Screws in AO/OTA 31-A1 and A2 intertrochanteric hip fractures.
- Trial name
- NCT03065101
- Testing
- Trigen Intertan, Post-Surgery Follow Up, Sliding Hip Screw
- Where
- 5 sites in United Kingdom
- Volunteers
- 34 people
- Sponsor
- Smith & Nephew Orthopaedics AG
Heart Failure With Preserved Ejection Fraction
Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction
The objective of this pilot study is to establish evidence to support the validity of HT in improving skeletal muscle function and physical capacity of patients with HFpEF.
- Trial name
- NCT06388226
- Testing
- Leg heat therapy
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Indiana University
Kidney Diseases, Kidney Failure, Chronic
Effect of Remote Ischaemic Preconditioning on Renal Function in Patients Undergoing Living Donor Kidney Transplantation
The purpose of this study was to investigate whether lower limb ischaemic preconditioning can improve renal function in patients undergoing living donor kidney transplantation
- Conditions
- Kidney Diseases, Kidney Failure, Chronic, Kidney Failure, Renal Insufficiency
- Trial name
- NCT01289548
- Testing
- remote ischaemic preconditioning
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huazhong University of Science and Technology
Children, Cerebral Palsy
Reliability and Validity of Strength Measurements of the Lower Limbs in Children With Bilateral Spastic Cerebral Palsy.
Specific musculo-tendinous adaptations in children with cerebral palsy (CP) have an influence on muscle strength and consequently on functional behavior and participation.
- Conditions
- Children, Cerebral Palsy, Muscle Weakness
- Trial name
- NCT03818152
- Testing
- Functional strength assessment
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- University Ghent
Stroke
Comparative Effects of Backward Treadmill Walking and Lower Extremity Cross Training Among Stroke Patients
Stroke is one of the high rated neurological disorders, induced by disruption of brain's blood flow. Stroke can alter the level of consciousness, motor and cognitive skills, sensory perception and language; it all depends on the…
- Trial name
- NCT05834192
- Testing
- Backward treadmill walking, Lower extremity cross training
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Diabetic Neuropathies
Effect of Customized Software for Foot-related Exercises (SOPeD) for Prevention and Treatment in People With Diabetic Neuropathy
The main objective of this trial is to investigate the effect of a customized foot-related exercises software (SOPeD) in diabetic neuropathy status, functional outcomes and gait biomechanics in people with diabetic neuropathy.
- Trial name
- FOCA-I (NCT04011267)
- Testing
- Physical therapy by foot-ankle segmental and functional exercises
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- University of Sao Paulo General Hospital
Anterior Cruciate Ligament Rupture
Arthroscopic ACL Reconstruction: Quadriceps Tendon vs Hamstring Tendon Autograft - A Prospective RCT
A prospective randomized controlled trial comparing functional outcomes of arthroscopic anterior cruciate ligament reconstruction using quadriceps tendon autograft versus hamstring tendon autograft at SMS Medical College, Jaipur.
- Trial name
- NCT07470944
- Testing
- Arthroscopic ACL Reconstruction
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Sawai Mansingh Medical College
Osteo Arthritis Knee
Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis:
The overall goal of this pilot randomized trial is to obtain necessary prerequisite data to conduct a randomized controlled intervention to test the effect of vitamin K supplementation on knee osteoarthritis progression and…
- Trial name
- NCT05505552
- Testing
- Vitamin K
- Where
- 3 sites in United States
- Volunteers
- 37 people
- Sponsor
- Tufts University
Peripheral Arterial Disease
Shear Stress in the Arteries of the Lower Limbs During Exercise in Patients With Peripheral Arterial Disease
The aim of the study will be to evaluate shear stress and blood flow parameters in lower limb arteries during arm cycle ergometer exercise in participants with peripheral artery disease.
- Trial name
- NCT06068504
- Testing
- Arm-cranking exercise, Heating
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- University of Nove de Julho
Stroke, CVA (Cerebrovascular Accident)
Effects of Dry Needling on Spasticity, Functions, Balance and Independence Level in Patients With Stroke
The aim of this study is to investigate the effects of dry needling method in addition to neurodevelopmental therapy on spasticity, upper and lower extremity functions, balance and independence level in patients with stroke who…
- Trial name
- NCT03863678
- Testing
- Neurodevelopemental therapy (NDT), Neurodevelopemental therapy (NDT) and dry needling
- Where
- Cyprus
- Volunteers
- 42 people
- Sponsor
- Eastern Mediterranean University
Achilles Tendinopathy (AT)
Lower-Extremity Kinetic Chain Exercise Program for Achilles Tendinopathy
Achilles tendinopathy is a common condition that causes pain, stiffness, and reduced function of the Achilles tendon. It can affect both physically active individuals and the general adult population, often making everyday…
- Trial name
- LEKC-AT (NCT07730866)
- Testing
- Lower-Extremity Kinetic Chain Exercise Program, Conventional Exercise Program
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- May University in Cairo
Incomplete Spinal Cord Injury (SCI)
Effect of Antigravity Treadmill Training on Cardiorespiratory Fitness and Lower Limb Function in Incomplete Spinal Cord Injury
This study aims to investigate the effect of locomotor training using an antigravity treadmill on cardiorespiratory fitness and lower limb function in patients with incomplete spinal cord injury.
- Trial name
- Antigravity (NCT07653529)
- Testing
- Antigravity Treadmill for gait training, gait training and balance exercise
- Volunteers
- 60 people
- Sponsor
- Middle East University
Stroke
rTMS Study to Improve Functional Performance for Patients With Stroke
To use repetitive transcranial magnetic stimulation (rTMS) to treat stroke patients is getting a popular idea. Previous studies seemed to support its effects on facilitating motor recovery after stroke.
- Trial name
- NCT02006875
- Testing
- rTMS
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University WanFang Hospital