Clinical trials: Lower Extremity Ischemia
Stroke (CVA) or Transient Ischemic Attack
Effect of HABIT-ILE on Balance and Coordination Among Stroke Patients
Strokes frequently affect motor function, balance, and coordination, reducing independence. HABIT-ILE combines upper and lower limb exercises to improve coordination and balance.
- Trial name
- NCT07754110
- Testing
- Lower Extremity HABIT-ILE GROUP A, group B Conventional treatment ( Conventional Treatment
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
STEMI - ST Elevation Myocardial Infarction
Noninvasive Artificial Venous Stasis for Reperfusion in STEMI
This prospective, randomized study was designed to evaluate whether the noninvasive artificial venous stasis / RE-START procedure, administered prior to primary percutaneous coronary intervention, increases the frequency of…
- Trial name
- RE-START (NCT07689591)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Firat University
Stroke, Ischemic, Stroke Hemorrhagic
Evaluation of the Effectiveness and Safety of Keeogo™ Dermoskeleton in Subjects With Mobility Impairments Due to Stroke
A multi-site, interventional, non-comparative, single-arm trial to evaluate the safety of the Keeogo™ Dermoskeleton in subjects with hemiparesis due to ischemic or hemorrhagic stroke.
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Stroke, Hemiparesis
- Trial name
- NCT03986320
- Testing
- Keeogo™ Dermoskeleton
- Where
- 4 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- B-Temia, Inc.
Ischemic Ulcer
Side Effects of 4 Times Bone Marrow Mono Nuclear Transplantation in Patients With Ischemic Lower Limb
Critical limb ischemia (CLI) results from severe occlusive disease that impairs distal limb perfusion to the point where oxygen delivery is no longer adequate to meet the metabolic needs of the tissue, even under resting…
- Trial name
- NCT01480414
- Testing
- 4times injection, stem cell transplantation
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Royan Institute
Lower Extremity Ischemia
CRAIL - Controlled Reperfusion of the Acutely Ischemic Limb
The purpose of this study is to prove the findings of a preliminary study which strongly suggest the hypothesis that the result of conventional embolectomy for acute, severe lower-limb ischemia can be improved by controlled…
- Trial name
- CRAIL (NCT00567801)
- Testing
- conventional embolectomy/thrombectomy, embolectomy/thrombectomy with controlled reperfusion
- Where
- 23 sites in Austria, Germany
- Volunteers
- 250 people
- Sponsor
- University Hospital Freiburg
Peripheral Arterial Disease, Critical Lower Limb Ischemia
Safety and Feasibility of Surmodics SUNDANCE™ Drug Coated Balloon
To evaluate the safety and performance of the Sundance™ DCB in subjects with occlusive disease of the infrapopliteal arteries.
- Trial name
- SWING (NCT04107298)
- Testing
- SUNDANCE™ Drug Coated Balloon
- Where
- 8 sites in Australia, Austria and 3 more
- Volunteers
- 35 people
- Sponsor
- SurModics, Inc.
Lower Extremity Swelling Acute
Physician Clinical Trial Policy (CTP) Neurological Ischemia Lower Extremity Pain and Swelling
Physician Clinical Trial Policy (CTP) to evaluate the efficacy treatment of lower extremity pathologies derived from neurological ischemia disorders using the combination of Monochromatic Infrared Photo Energy (MIRE) and…
- Trial name
- DTSC (NCT01979367)
- Testing
- Anodyne
- Volunteers
- 1,000 people
- Sponsor
- American Association of Sensory Electrodiagnostic Medicine
Diabetic Foot, Critical Limb Ischemia
Umbilical Cord Mesenchymal Stem Cells Injection for Diabetic Foot
The purpose of this study is to determine whether umbilical cord Mesenchymal Stem Cells of treatment for diabetic foot is safe and effective in the management of diabetic foot ischemia, the therapeutic effect of stem cells is…
- Conditions
- Diabetic Foot, Critical Limb Ischemia, Mesenchymal Stem Cells, Umbilical Cord
- Trial name
- NCT01216865
- Testing
- umbilical cord mesenchymal stem cells, Standard Therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Qingdao University
Peripheral Vascular Disease
Efficacy/Safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease
Ecraprost in lipid emulsion is being developed for the treatment of Critical leg ischemia (CLI), which is the most severe form of peripheral arterial disease (PAD).
- Trial name
- NCT00059644
- Testing
- Ecraprost in lipid emulsion
- Where
- 27 sites in United States, United Kingdom
- Volunteers
- 560 people
- Sponsor
- Tanabe Pharma Corporation
Stroke
Comparative Effects of PNF and mCIMT on Lower Limb Function in Patient With Stroke
Stroke, which is frequently characterized by weakness, poor balance, and decreased mobility that impede independence in everyday activities, has been identified as a major cause of long-term impairment globally.
- Trial name
- NCT07331714
- Testing
- PNF, mCIMT
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Peripheral Vascular Diseases, Arterial Occlusive Diseases
Intra-arterial Stem Cell Therapy for Patients With Chronic Limb Ischemia (CLI)
The purposes of this study are to determine whether intra-arterial injection of autologous stem cells is effective in the treatment of chronic limb ischemia (CLI), to characterize stem cell dysfunction in patients with CLI, and…
- Conditions
- Peripheral Vascular Diseases, Arterial Occlusive Diseases, Leg Ulcer, Gangrene
- Trial name
- JUVENTAS (NCT00371371)
- Testing
- Bone marrow punction, BM-MNC infusion
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- UMC Utrecht
Peripheral Arterial Disease
Debulking Atherectomy Versus Stent Angioplasty for Limb Ischaemia of Diabetic Lower Limb Atherosclerosis-occlusive Disease.
In order to assessment the safety and efficacy of debulking atherectomy versus stent angioplasty for limb ischaemia of diabetic lower limb atherosclerosis-occlusive disease, we intend to conduct a prospective, multicenter…
- Trial name
- NCT05670171
- Testing
- Debulking Atherectomy, Stent Angioplasty
- Where
- 10 sites in China
- Volunteers
- 244 people
- Sponsor
- Xuanwu Hospital, Beijing
Compartment Syndrome of Leg
Diagnostic Value of Compression Ultrasound to Detect Acute Compartment Syndrome After Lower Limb Revascularisation
Acute compartment syndrome (ACS) after revascularization for acute limb ischemia is a potentially limb-threatening condition and requires urgent fasciotomy.
- Trial name
- NCT04806555
- Testing
- Compression ultrasound examination
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- Kantonsspital Aarau
Ischemic Cerebrovascular Accident
Long-Term Effects of Task-Oriented Lower Extremity Strengthening Training
Task-oriented exercises combined with strengthening have been shown effective in improving walking functions in patients with chronic stroke.
- Trial name
- NCT01934374
- Testing
- Task-Oriented Lower Extremity Strengthening Training
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Critical Limb Ischemia, Peripheral Vascular Disease
Study of Remodulin in Patients With Critical Limb Ischemia With No Planned Revascularization Procedures
The purpose of this study is to assess and compare the safety of continuous and daily subcutaneous Remodulin therapy in patients with critical limb ischemia (CLI) with no planned vascular interventional procedures; and to…
- Conditions
- Critical Limb Ischemia, Peripheral Vascular Disease, Foot Ulcers, Rest Leg Pain
- Trial name
- NCT00060996
- Testing
- Remodulin® (treprostinil sodium) Injection
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- United Therapeutics
Cardiogenic Shock, Cardiac Arrest
Lower Limb Surveillance During VA-ECLS
Temporary cardiac support by VA-ECLS can lead to lower limb ischemia. The aim of this study is to evaluate a multi-modal strategy (physical examination, NIRS monitoring and angiography through the reperfusion canula) of lower…
- Conditions
- Cardiogenic Shock, Cardiac Arrest, Lower Limb Ischemia
- Trial name
- NCT03910062
- Testing
- Lower limb angiography via the reperfusion cannula and NIRS monitoring
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Central Hospital, Nancy, France
Peripheral Vascular Disease, Ischemia
A Clinical Study Using Autologous Bone Marrow Stem Cell for Diabetes Related Vascular Complications
Stem cell therapy has been a new and effective therapy in recent years for diabetic foot.This study intends to establish an optimal clinical research program, and attempts to break the technical bottleneck in the stem cell…
- Conditions
- Peripheral Vascular Disease, Ischemia, Diabetic Foot
- Trial name
- NCT02796079
- Testing
- mesenchymal stem cells, saline
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Jie Shen
Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication
Continuous Compartment Pressure Monitoring for Compartment Syndrome in VA-ECMO Patients
Acute compartment syndrome (ACS) is a surgical emergency that can develop in patients on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication, Limb Ischemia, Limb Ischemia, Critical
- Trial name
- VA-ECMO (NCT05830721)
- Testing
- MY01 + Standard of Care, 14-Gauge Slit Catheter + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Johns Hopkins University
Diabetic Foot, Peripheral Arterial Disease
TEsting for Arterial Disease in Diabetes (TrEAD) Study
This study will focus on determining; How accurate the test is in detecting poor circulation How it's accuracy compares to other commonly used tests, and Whether test results are linked to the chance of ulcer healing or…
- Conditions
- Diabetic Foot, Peripheral Arterial Disease, Diabetic Foot Ulcer, Peripheral Vascular Diseases
- Trial name
- NCT04058626
- Testing
- Transcutaneous pressure of oxygen (TcPO2), Toe Brachial Pressure Index (TBPI), Podiatry Ankle Duplex scan (PAD-scan)
- Where
- 2 sites in United Kingdom
- Volunteers
- 305 people
- Sponsor
- Imperial College Healthcare NHS Trust
Ischemia
Treatment of Severe Limb Ischemia With Autologous Bonemarrow Derived Mononuclear Cells
The aim of the study is to investigate whether implantation of autologous bone marrow derived stem cells in ishemics limbs will improve vascularization
- Trial name
- DANCELL-CLI (NCT00442143)
- Testing
- Stem cell implantation
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital