Clinical trials: Lower Extremity Ischemia
Ischemic Stroke
Effectiveness of Theta Burst Stimulation For Upper and Lower Extremity Recovery in Stroke
This single-center, single-blind, randomized, sham-controlled clinical trial will include 60 patients aged >45 years who are within 3 months of a first-ever middle cerebral artery ischemic stroke.
- Trial name
- NCT07834333
- Testing
- Continuous Theta Burst Stimulation (cTBS), Intermittent Theta Burst Stimulation (iTBS)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Diabetic Foot, Peripheral Arterial Disease
Microwave Radiometry Thermometry for the Diagnosis of Critical Limb Ischemia in Diabetic Patients
Diagnosis of vascular involvement in diabetic foot disease remains challenging. Differential diagnosis between pure neuropathic or neuro-ischemic diabetic foot requires a combination of clinical examination, medical history and…
- Conditions
- Diabetic Foot, Peripheral Arterial Disease, Ischaemic Neuropathy
- Trial name
- NCT03002116
- Testing
- Tissue thermometry using non-invasive microwave radiometry device
- Where
- 3 sites in Greece, United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Attikon Hospital
Peripheral Arterial Disease, Critical Limb Ischemia
Use of Thermal Imaging Camera to Assess Perfusion Before and After Vascular Intervention
This is a preliminary prospective observational study measuring change in lower extremity temperature in response to revascularization procedure.
- Conditions
- Peripheral Arterial Disease, Critical Limb Ischemia, Critical Lower Limb Ischemia
- Trial name
- TIC (NCT06544135)
- Testing
- FLIR One Pro LT
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- University Hospitals Cleveland Medical Center
Peripheral Vascular Disease
Safety/Feasibility Study of HBOC-201 in Amputation at/Below Knee From Critical Lower Limb Ischemia
The purpose of this study is to assess the safety and feasibility of HBOC-201 in increasing adequate wound healing in patients with severe peripheral vascular disease who are undergoing lower limb amputation.
- Trial name
- NCT00300040
- Testing
- Hemoglobin glutamer 250 - bovine, 6% Hydroxyethylstarch
- Where
- 5 sites in South Africa, United Kingdom
- Volunteers
- 16 people
- Sponsor
- Biopure Corporation
Apoplexy, Femoral Neck Fracture
Epidemiology of Aeromedical Evacuation
Increasing air travel has resulted in a significant increase in aeromedical evacuation over the past decade. However there is only a small amount of epidemiological data available on the diagnosis, costs and transport…
- Conditions
- Apoplexy, Femoral Neck Fracture, Myocardial Infarction, Subarachnoid Hemorrhage
- Trial name
- NCT01071382
- Volunteers
- 504 people
- Sponsor
- Ruhr University of Bochum
Peripheral Arterial Disease, Peripheral Vascular Disease
Safety Study of MultiGeneAngio in Patients With Chronic Critical Limb Ischemia
The purpose of this study is to evaluate the safety and activity of two doses of MultiGeneAngio, a cell therapy product produced from the patient's own cells, as potential treatment for patients with chronic critical limb…
- Conditions
- Peripheral Arterial Disease, Peripheral Vascular Disease, Critical Limb Ischemia
- Trial name
- NCT00956332
- Testing
- MultiGeneAngio
- Where
- 7 sites in Israel
- Volunteers
- 28 people
- Sponsor
- MultiGene Vascular Systems Ltd.
Critical Limb-Threatening Ischemia, Critical Limb Ischemia
Evaluation of the MAGNITUDE® Bioresorbable Drug-Eluting Scaffold in the Treatment of Patients With Below the Knee Disease in Australia
The objective of this prospective, multi-center, clinical investigation is to evaluate the MAGNITUDE BRS System for the planned treatment of narrowed infrapopliteal lesions.
- Conditions
- Critical Limb-Threatening Ischemia, Critical Limb Ischemia, Critical Lower Limb Ischemia
- Trial name
- MAGNITUDE-BTK (NCT06075940)
- Testing
- MAGNITUDE BRS
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- R3 Vascular Inc.
Stroke, Acute
Rehabilitative BCI in Acute Ischemic Stroke
In order to explore the role and expound the mechanism of rehabilitative brain computer interface (BCI)-based training (referred to as the Walk Again Neurorehabilitation protocol) in neurofunctional reconstruction in acute phase…
- Trial name
- NCT04704427
- Testing
- Non-invasive BCI training, Traditional Physiotherapy protocol
- Volunteers
- 40 people
- Sponsor
- Xuanwu Hospital, Beijing
Peripheral Vascular Diseases
Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia
To compare the outcome of bypass surgery and plaque excision for treatment of critical limb ischemia in the lower limbs
- Trial name
- PROOF (NCT00504088)
- Testing
- Bypass, Silverhawk Plaque Excision
- Where
- 31 sites in United States
- Sponsor
- FoxHollow Technologies
Cardiogenic Shock
Passive Leg Raising for Predicting Fluid Responsiveness in VA-ECMO Assisted Patients
Peripheral Veno-Arterial Extra Corporeal Membrane Oxygenation (VA ECMO) is a temporary assistance that provides a mechanical circulatory support in patients victim of cardiogenic shock (CS) or refractory cardiac arrest.
- Trial name
- PARANOVA (NCT04984603)
- Testing
- PLR in patients under VA-ECMO
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Critical Limb Ischemia, Arterial Occlusive Disease
Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia
The hypothesis behind the trial is the concept that Pregabalin is effective in reducing pain at rest in lower limb ischemia, and the study evaluates active treatment or placebo added to the regular pain regimens for these…
- Conditions
- Critical Limb Ischemia, Arterial Occlusive Disease, Pain, Ischemia
- Trial name
- NCT00403780
- Testing
- pregabalin
- Where
- 3 sites in Sweden
- Volunteers
- 18 people
- Sponsor
- Karolinska Institutet
Compartment Syndrome Nontraumatic Lower Extremity
The Effects of Prolonged Head-Down Tilt Lithotomy Position on Lower Limb Haemodynamics
During certain bowel surgeries for cancer (colorectal surgery), individuals frequently have to be placed in a head-down position to enable surgeons have optimal access to the cancer site.
- Trial name
- HELP (NCT06036641)
- Testing
- NIRS monitoring, Laser Doppler flowmetry, Inflammatory and Oxidative stress biomarkers
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Portsmouth
Critical Limb Ischemia, Ischemia
VEGF Gene Transfer for Critical Limb Ischemia
The purpose of this gene therapy study is to evaluate the safety and efficacy of intramuscular gene transfer using Vascular Endothelial Growth Factor (VEGF) or placebo in patients with moderate to high-risk Critical Limb Ischemia…
- Conditions
- Critical Limb Ischemia, Ischemia, Leg Ulcer
- Trial name
- NCT00304837
- Testing
- pVGI.1 (VEGF-2)
- Where
- 3 sites in United States
- Sponsor
- Losordo, Douglas, M.D.
Ischemic Wound of the Lower Limb, Necrotic Arterial Wounds
Randomized Controlled Trial on the Use of Flammacerium in Necrotic Arterial Wounds of the Lower Limb Versus Standard Treatment
Ischemia of an area may lead to a necrotic wound. In lower limb, it especially happens in diabetic or artheriopatic patients. It can lead to an amputation need. Revascularization procedure cannot be provide in all cases.
- Trial name
- Flammacérium (NCT02385903)
- Testing
- Flammacerium, Standard dressing procedure
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Atherosclerosis, Ischemia
Clinical Of Chocolate Balloon Dilatation Versus Plain Balloon Dilatation to Treat Arteriosclerosis Occlusive Disease of Lower Extremity
This is a Prospective randomized controlled study to evaluate the difference of safety，effectiveness between chocolate balloon and plain balloon dilatation in treatment of infrapopliteal artery lesions.
- Trial name
- NCT05158283
- Testing
- chocolate balloon, plain balloon
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Xuanwu Hospital, Beijing
Diabetic Foot, Lower Limb Ischemia
Stem Cell Therapy for Patients With Vascular Occlusive Diseases Such as Diabetic Foot
Mesenchymal stem cells with multidirectional differentiation potential,autologous stem cell transplantation into ischemic foot, make its differentiation to form new blood capillary, improve and restore the local blood flow.
- Trial name
- NCT02304588
- Testing
- Mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Ischemic Heart Disease, Cardiac Valve Disease
Passive Leg Raising Test to Predict Hypotension During Induction of Anesthesia in Patients Undergoing Cardiac Surgery
Hypotension frequently occurs during anesthesia induction. Preload decrease by anesthetics was often considered as one of main causes for this hypotension. However, the studies on this topic have been lacking.
- Trial name
- NCT01144546
- Testing
- passive leg raising (45 degree leg elevation for 1-2 min)
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Seoul National University Hospital
Subacute Stroke, Ischemic Stroke
Segmental Vibrator With NMES on Lower Limb Function in Subacute Stroke
Stroke is one of the world's leading causes of death and disability. It can cause a variety of motor disorders, such as apraxia, sensory deficits, abnormal muscle tone, inadequate weight transfer, lack of fine motor skills…
- Trial name
- NCT06927206
- Testing
- Experimental Group A: Segmental vibrator only on dorsiflexor, Experimental Group B: Segmental vibrator + Electrical stimulation on dorsiflexors
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Peripheral Artery Disease Without Critical Limb Ischemia
Non-Healing Ulcers Without Critical Limb Ischemia
Background: Lower limb arterial revascularization procedures, either percutaneously or surgically performed, are an established treatment modality of ischemic foot ulcers, especially in the setting of a critical limb ischemia.
- Trial name
- NEWLI (NCT01666093)
- Testing
- Angioplasty of the lower limbs vessels
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Diabetic Foot, Gangrene; Limb
MetaMet: Bone Cutter Versus Bone Saw for Ray Amputation
Toe amputation is a commonly performed operation for infection and/or ischaemia (tissue death due to lack of blood flow). However, a large number of patients having this surgery ultimately require further amputation due to poor…
- Conditions
- Diabetic Foot, Gangrene; Limb, Wound Infection, Wound Healing Delayed
- Trial name
- MetaMet (NCT05804565)
- Testing
- Bone Saw, Bone Cutter
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- University College Hospital Galway