Clinical trials: Lower Extremity Pain
Varicose Veins
Evaluation of Endovenous Sclerotherapy for Treatment of Varicose Veins
The overall objective will be to evaluate clinical predictors of outcomes in patients who undergo endovenous sclerotherapy for the treatment of varicose veins.
- Trial name
- NCT00954980
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Lower Limb Spasticity
RELIEF Study: Lower Limb Pain Relief After Injection Cycles in Adults Suffering From Lower Limb Spasticity Following Stroke
The objective of this study is to demonstrate the effect of intramuscular BoNT-A injections in relieving pain, in a broad population of patients who suffer pain as the primary problem associated with spasticity.
- Trial name
- RELIEF (NCT02020980)
- Testing
- Botulinum toxin type A
- Where
- 28 sites in Spain
- Volunteers
- 186 people
- Sponsor
- Ipsen
Foot Orthoses, Fasciitis, Plantar
Customized Foot Orthoses on Muscle Activity During Standing and Gait in Plantar Heel Pain
The present study will use a randomized controlled trial (RCT) to determine the effectiveness of customized foot orthosis (CFO) for the treatment of patients with PHP.
- Trial name
- NCT06318910
- Testing
- orthotic wedge, CFO
- Where
- Thailand
- Volunteers
- 75 people
- Sponsor
- Mahidol University
Hip Injuries, Hip Dislocation
Does Limb Pre-Conditioning Reduce Pain After Hip Arthroscopy
The purpose of this study is to determine if the utilization of Ischemic Pre-Conditioning 24-hours prior to hip arthroscopy decreases patient's post-operative pain and opioid consumption.
- Conditions
- Hip Injuries, Hip Dislocation, Hip Fractures
- Trial name
- NCT04925791
- Testing
- standardized pre-conditioning treatment, Partial occlusion
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Lower Limb Injury
Multimodal Analgesia Versus Peripheral Nerve Block for Postoperative Pain Management After Lower Limb Injury Surgery
The purpose of this clinical trial is to understand the effectiveness of femoral nerve block, combined sciatic and femoral nerve block, lumbar plexus block, epidural block, and intravenous analgesia pump in the application of…
- Trial name
- NCT06779968
- Testing
- Femoral Nerve Block, Combined Sciatic and Femoral Nerve Block, Lumbar plexus block
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xiaguang Duan
Peripheral Artery Disease (PAD); Intermittent Claudication
Study of LLG783 in Patients With Peripheral Artery Disease (PAD) and Intermittent Claudication
This study is designed to determine whether LLG783 displays the clinical safety and efficacy profile, after multiple i.v. doses, to support further development in patients with PAD and intermittent claudication.
- Trial name
- PAD PoC (NCT03194776)
- Testing
- LLG783
- Where
- 8 sites in United States, Germany and 1 more
- Volunteers
- 46 people
- Sponsor
- Novartis Pharmaceuticals
Control of Frontal Plane Biomechanics, Patellofemoral Pain Syndrome
Impact of Hip Activation Compared to Hip Plus Balance Training on the Forward-Step-Down Test
The purpose of this research is to determine the impact of a hip activation home exercise program (HEP) compared to a hip activation + single leg balance HEP on performance of the Forward-Step-Down Test (FSDT) in healthy females.
- Trial name
- NCT06298903
- Testing
- Hip Activation, Hip activation + Single leg balance
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Amputation, Phantom Limb Pain
Neuromodulation in Lower Limb Amputees
The goal of this study is to investigate the role of transcutaneous spinal cord stimulation on spinal cord excitability in lower limb amputees.
- Conditions
- Amputation, Phantom Limb Pain, Hoffman's Reflex
- Trial name
- NCT04543786
- Testing
- Transcutaneous spinal cord stimulation
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- University of Pittsburgh
Low Back Pain, Leg Pain
Medtronic Closed-Loop Spinal Cord Stimulation System
The purpose of the study is to further understand the closed-loop feature in chronically implanted patients by characterizing the efficacy of the next generation, spinal cord stimulator.
- Conditions
- Low Back Pain, Leg Pain, Upper Limb Pain
- Trial name
- NCT05177354
- Testing
- Inceptiv
- Where
- 7 sites in Australia
- Volunteers
- 94 people
- Sponsor
- MedtronicNeuro
Chronic Pain
SCS as an Option for Chronic Low Back and/or Leg Pain Instead of Surgery
To evaluate the safety and effectiveness of Spinal Cord Stimulation (SCS) with multiple modalities compared to Conventional Medical Management (CMM) in patients with chronic low back and/or leg pain who have not undergone spinal…
- Trial name
- SOLIS (NCT04676022)
- Testing
- WaveWriter, Conventional Medical Managament
- Where
- 23 sites in United States
- Volunteers
- 241 people
- Sponsor
- Boston Scientific Corporation
Knee Osteoarthritis, Knee Injuries
Para-sartorial Compartment Block in Knee Surgery
Selective blockade of the saphenous nerve branches is among the regional anesthesia techniques in knee surgery. In this block, analgesia is provided without motor block and is an essential advantage in terms of early mobilization…
- Conditions
- Knee Osteoarthritis, Knee Injuries, Knee Disease, Knee Arthritis
- Trial name
- NCT05566561
- Testing
- Postoperative analgesia management
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Tibial Fractures, Anterior Knee Pain Syndrome
INfrapatellar Versus SUprapatellar Reamed Intramedullary Nailing for Fractures of the Tibia
This study will investigate the incidence and severity of anterior knee pain comparing two different approaches to tibial nail fixation; Infrapatellar versus percutaneous semi-extended suprapatellar incisions.
- Trial name
- INSURT (NCT02750072)
- Testing
- Infrapatellar Approach, Suprapatellar Approach
- Where
- 6 sites in Canada, Spain
- Volunteers
- 248 people
- Sponsor
- Fraser Orthopaedic Research Society
Acute Pain Management, Analgesic, Nonopioid
A Pilot Clinical Trial of Oral Ketamine for Acute Pain Management After Amputation Surgery
The purpose of this pilot study is to test the safety of oral ketamine to treat acute pain after amputation surgery. The objective of the proposed research is to conclusively determine if oral ketamine is a safe alternative…
- Conditions
- Acute Pain Management, Analgesic, Nonopioid, Amputation of Lower Extremity, All Causes
- Trial name
- NCT02341963
- Testing
- Oral Ketamine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Rush University Medical Center
Duration of Pain Relief
Effect of Dexamethasone on Duration of Lower Extremity Blocks With Bupivacaine in Subjects Having ACL Repair
Anterior cruciate ligament reapair is a painful procedure. Single shot femoral and sciatic nerve block only last 12-16 hrs. Since dexamethasone prolongs brachial plexus block, using it in lower extremity blocks will prolong the…
- Trial name
- NCT01756560
- Testing
- dexamethsone, Bupivacaine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Chicago
Anterior Cruciate Ligament Injuries
Perturbation Training vs Functional Activities on Pain, ROM, Balance, and Function Post-ACL
Anterior cruciate ligament (ACL) injuries are among the most common and functionally disabling knee injuries, particularly in physically active individuals.
- Trial name
- NCT07642752
- Testing
- Perturbation Training Group, Task-Oriented Functional Activities Group, Control Group (Standard Rehabilitation Protocol)
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Ankle Fractures, Anesthesia, Local
High Ankle Block in Ankle Fractures
The aim of the herein presented double-blinded is to compare the effectiveness of the high foot block against placebo infiltration in simple, uni- and bimalleolar ankle fractures.
- Trial name
- NCT04292691
- Testing
- 40ml of Ropivacaine 0.5% Injectable Solution, 40ml of Ringer's Lactate
- Volunteers
- 60 people
- Sponsor
- Ludwig-Maximilians - University of Munich
ACL - Anterior Cruciate Ligament Rupture, ACL Injuries
Non-Narcotic Pain Control After ACL Reconstruction
This is a double-blind randomized controlled trial of standard of care therapy, either oral ketorolac (experimental group) or oral oxycodone (control group) to demonstrate efficacy in reducing the percentage of narcotic doses…
- Trial name
- NCT06973785
- Testing
- dispense of study drug, Ketorolac
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Lower Extremity Problem, Prosthesis User
Transfemoral Powered Foot and Physical Therapy Study
Individuals living with Transfemoral Amputation, enrolled equally at the Veterans Affairs New York Harbor Healthcare System (VANYHHS) and Walter Reed National Military Medical Center (WRNMMC), will be fit with a powered…
- Trial name
- NCT03625921
- Testing
- Powered device with physical therapy, Powered device with standard of practice
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA New York Harbor Healthcare System
Sprains and Strains, Pain
A Study of the Efficacy and Safety of Tramadol HCl/Acetaminophen, Hydrocodone Bitartrate/Acetaminophen and Placebo in Patients With Pain From an Ankle Sprain With a Partial Torn Ligament
The purpose of this study is to explore the pain-relieving effects and safety of two analgesic treatment regimens as compared to placebo in patients experiencing acute musculoskeletal pain.
- Trial name
- NCT00236535
- Volunteers
- 603 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Lower Limb Amputation Above Knee, Lower Limb Amputation Below Knee
Pain in Trans Femoral and Trans Tibial Amputees
Phantom limb is difficult to manage and has a significant impact on the patient's quality of life. At present, the scientific evidence shows that the infusion of local anesthetics with epidural and perineural catheters in the…
- Trial name
- AMPUPHANTOM (NCT03789435)
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Istituto Ortopedico Rizzoli