Clinical trials: Lower Extremity Pain
Familial Mediterranean Fever
Magnetic Resonance (MR) Spectroscopy In Familial Mediterranean Fever (FMF) Patients
Familial Mediterranean fever (FMF) is an inherited disorder of unknown etiology, characterized by recurrent episodes of fever, peritonitis and/or pleuritis.
- Trial name
- NCT00658060
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Knee Osteoarthritis, Knee Pain Chronic
Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis
The objective of the study is to explore the effects of arm exercise (UE, arm ergometer) vs. leg exercise (LE, cycling ergometer) on exercise-induced hypoalgesia (EIH), central pain mechanisms and knee pain in people with knee…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Central Pain Syndrome
- Trial name
- NCT06105788
- Testing
- Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Lumbosacral Radicular Pain
Corticosteroid Lumbar Epidural Analgesia for Radicular Pain 2
This is a research study of SP-102, an experimental medication designed to relieve pain in patients with moderate to severe sciatica (pain in the lower back, hips, buttocks and legs).
- Trial name
- CLEAR 2 (NCT07579351)
- Testing
- SP-102, Dexamethasone Sodium Phosphate 10 MG/ML
- Volunteers
- 755 people
- Sponsor
- Semnur Pharmaceuticals, Inc.
Malleolus Fracture, Lateral
Comparing Function, Pain and Return to Work in Conservative Versus Surgical Treated Stable Lateral Malleolar Fractures
Ankle fractures are one of the most common fractures in adults resulting in hospital stays and inability to work. Instable or dislocated ankle fractures are mostly treated by surgery.
- Trial name
- NCT03587571
- Testing
- Surgical intervention
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Postoperative Pain
Intrathecal Pethidine Plus Dexamethasone for Distal Lower Orthopedic Surgeries
Bupivacaine is commonly used as a sole agent for spinal anesthesia unlike pethidine. Pethidine (meperidine) is a unique opioid. In addition to its analgesic activity, it also has significant local anesthetic activity.
- Trial name
- NCT05303311
- Testing
- Bupivacaine Hydrochloride, Pethidine plus Dexamethasone
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Plantar Fascitis
Investigation of the Efficacy of Myofascial Chain Release Techniques on Plantar Fasciitis
The primary aim of the study is to investigate the effectiveness of Myofascial Chain Release Techniques on pain, functional limitation and quality of life in patients with Plantar Fasciitis.
- Trial name
- NCT05479500
- Testing
- Myofascial Chain Release Techniques, Local Release Techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Istanbul Medeniyet University
Football Players
Effects of Windlass Versus Calcaneal Taping in Football Player With Plantar Fasciitis.
Plantar fasciitis is a prevalent ailment that affects the plantar fascia, a dense tissue strip that spans the underside of the foot, from the heel bone to the toes.
- Trial name
- NCT06637592
- Testing
- Calcaneal taping, Windlass taping
- Where
- 2 sites in Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Ankle Sprains
Balance and Proprioception Training Program in Patients With Chronic Ankle Sprains
To examine the effects of an individualized balance and proprioception training program on pain, function, and the risk of recurrent ankle sprains.
- Trial name
- NCT05920044
- Testing
- balance and proprioception training program., Usual care
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Ahram Canadian University
Femoral Fractures
Comparison of Spinal Anesthesia and Erector Spinae Plane Block in Critically Adult Patients Undergoing Femur Surgery
The goal of this observational study is to compare the regional anesthetic methods (not including general anesthesia) -spinal anesthesia, erector spinae plane (ESP) block- which are in routine practice in critically ill adult…
- Trial name
- NCT06652334
- Testing
- Spinal anesthesia, Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Duzce University
Patellofemoral Osteoarthritis
Proximal and Distal Therapeutic Approach in Pain and Lower Limb Kinematic in People With Patellofemoral Osteoarthritis
This is a crossover study that will investigate the immediate effects of a proximal therapeutic approach (SERF strap) and a distal one (foot orthoses) on knee pain intensity, global change, symptoms, ease of performance and…
- Trial name
- NCT04332900
- Testing
- Elastic hip strap, Insole
- Volunteers
- 30 people
- Sponsor
- Universidade Federal de Sao Carlos
Tibia Fracture, Femur Fracture
Bimodal Analgesia as Form of Pain Control Post Long Bone Fracture
The purpose of this prospective randomized study is to evaluate the risks and benefits of using bimodal analgesia, (i.e. Narcotics and NSAIDS) vs Narcotics alone post long bone fracture.
- Conditions
- Tibia Fracture, Femur Fracture, Humerus Fracture
- Trial name
- NCT00240396
- Testing
- Narcotics alone, Narcotics and NSAIDS
- Where
- United States
- Sponsor
- Beth Israel Deaconess Medical Center
Osteoarthritis, Knee, Exercise
The Effect of Contralateral Isokinetic Lower Extremity Exercises in Unilateral Painful Knee Osteoarthritis
Patients with unilateral knee pain due to knee osteoarthritis presenting to our clinic will be included in a 20-session treatment program, either on an outpatient basis or as inpatients at our clinic.
- Trial name
- NCT06675318
- Testing
- Cross training for quadriceps muscle of contralateral lower limb, Quadriceps isometric exercises, along with hot pack and TENS for painful knee
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Gazi University
Fracture of Lower Limb
Effects of Rhythmic Auditory Stimulation on Range of Motion in Post- Fracture Rehabilitation of Lower Limb
This study aims to investigate the effects of rhythmic auditory stimulation on pain levels and range of motion in children undergoing post-fracture rehabilitation of the lower limb.
- Trial name
- NCT07579520
- Testing
- Rhythmic Auditory Stimulation (RAS)
- Where
- Pakistan
- Volunteers
- 17 people
- Sponsor
- Riphah International University
Collum Femoris Fracture, Pericapsular Nerve Group Block
the Pericapsular Nerve Group (PENG) and Suprainguinal Fascia Iliaca Blocks (SIFIB) in Elderly Patients
This clinical trial aims to compare the effect of the pericapsular nerve group (PENG) and suprainguinal fascia iliaca blocks (SIFIB) on pain management in elderly patients with subtrochanteric femur fractures.
- Conditions
- Collum Femoris Fracture, Pericapsular Nerve Group Block, Suprainguinal Fascia Iliaca Block
- Trial name
- NCT06277648
- Testing
- PENG block, SIFIB
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Haseki Training and Research Hospital
Sciatica
Immediate and 1-week Efficacy of a Single Session of Sciatic Nerve Electrical Stimulation in the Management of Low-back Related Leg Pain
This clinical study focuses on people who experience long-term low-back related leg pain (commonly called sciatica). This type of pain is often associated with nerve irritation or compression in the lower spine and can cause…
- Trial name
- NCT07377357
- Testing
- Percutaneous Electrical Nerve Stimulation, Transcutaneous Electrical Nerve Stimulation, Real Dry Needling (without Percutaneous Electrical Nerve Stimulation)
- Where
- Spain
- Volunteers
- 88 people
- Sponsor
- Universidad Complutense de Madrid
Post Operative Analgesia
Comparison of Efficacy of Bupivacaine Alone vs. Bupivacaine-Tramadol in Lower Limb Surgery
This randomized controlled trial aims to compare the effectiveness of bupivacaine alone versus bupivacaine combined with tramadol for postoperative analgesia in patients undergoing lower limb surgeries under spinal anesthesia.
- Trial name
- BUP-TRA-PAIN (NCT07827352)
- Testing
- Bupivacain only, bupivacain-tramadol
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Farooq Hospital / Akhtar Saeed Medical college Rawalpindi
Ankle Sprain, Ankle (Ligaments); Instability (Old Injury)
Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy
Ankle arthroscopy is increasingly performed as a day-case procedure, making rapid recovery and efficient discharge critical. Anesthetic technique substantially influences postoperative recovery, yet high-quality evidence…
- Conditions
- Ankle Sprain, Ankle (Ligaments); Instability (Old Injury), Pain Management, ERAS
- Trial name
- NCT07460310
- Testing
- Total intravenous anesthesia combined with peripheral nerve block (TIVA + PNB) group, General anesthesia combined with peripheral nerve block (GA + PNB) group, Spinal anesthesia
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Flatfeet
Arthroereisis Versus Lateral Column Lengthening in the Treatment of Planovalgus Feet
There is no consensus on the surgical treatment of unremitting, painful flatfeet in children. Subtalar arthroereisis has gained notoriety although there is a paucity of literature on its biomechanical effects.
- Trial name
- NCT02055495
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Utah
Knee Arthropathy
Effect of NLR and MPV on Early Postoperative Outcome in Lower Extremity Arthroplasty Operations
In the planned study the investigators want to evaluate the relation between postoperative complications and minor/ major morbidities, mortality and Mean Platelet Volume (MPV) and Neutrophil/ lymphocyte (N/L) ratio.
- Trial name
- NCT03148951
- Where
- Turkey (Türkiye)
- Volunteers
- 754 people
- Sponsor
- Akdeniz University
Pes Planus
Exercises for Pes Planus
Pes planus is a musculoskeletal syndrome in which the medial longitudinal arch (MLA) of the foot is reduced or flattened. It results from a combination of static and dynamic abnormalities.
- Trial name
- NCT07123753
- Testing
- EXERCİSE
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Gaziantep Islam Science and Technology University