Clinical trials: Lower Extremity Pain
Chronic Low Back Pain (CLBP)
Movement Quality and Balance Improvement in People With Chronic Low Back Pain Following Trunk Muscle Training
The goal of this project is to assess if Chronic Low Back Pain (CLBP) participant's movement quality and balance variables can change after training that decreases their pain and disability.
- Trial name
- CLBP (NCT06944730)
- Testing
- Structural Exercise, Isolated Trunk Exercise, Back school
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Greater Trochanteric Pain Syndrome of Both Lower Limbs
Shock Wave Therapy Plus Exercise in GTPS
The aim of this randomized controlled study is to investigate if the sequential administration of focused shock wave therapy and of a rehabilitation program based on the strengthening of gluteal muscles is more effective than a…
- Trial name
- GTPSSWEX (NCT06248905)
- Testing
- Rehabilitation program based on the strengthening of gluteal muscles, Extracorporeal shock wave therapy
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Critical Limb Ischemia
Safety and Preliminary Efficacy of Allogeneic Endothelial Progenitor Cells (EPCs) in Patients With Critical Limb Ischemia
The purpose of this study is to determine if allogeneic Endothelial Progenitor Cells (EPCs) intravenous infusion to a subject with leg ulcer and/or gangrene due to poor blood flow will be safe and if it will relieve leg pain…
- Trial name
- NCT06359912
- Testing
- EPCs, Clinical standard treatment (CST)
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Allife Medical Science and Technology Co., Ltd.
Tibial Fractures, Leg Injuries
Light Therapy in the Treatment of Leg Pain
The purpose of this study is to apply Anodyne therapy to active duty soldiers, who have shin splints, to evaluate healing time and effectiveness.
- Trial name
- MilCAM (NCT00253981)
- Testing
- Monochromatic Near-Infrared Light Energy (MIRE)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Samueli Institute for Information Biology
Deep Vein Thrombosis (DVT)
Osteopathic Treatment and Deep Vein Thrombosis (DVT)
Osteopathic treatment will provide: 1. A significant reduction of pain and swelling of the affected DVT leg 2. An increase in the quality of life (QOL) for individuals with DVT of the leg 3.
- Trial name
- NCT02205294
- Testing
- Osteopathic Treatment
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Intractable Pain, Back Pain
Prometra's Utilization in Mitigating Pain II
Intrathecal infusion pumps are increasingly used to deliver analgesics for chronic intractable pain. The PUMP II trial is designed to evaluate the ongoing safety and efficacy of the new Prometra® Programmable Pump System for…
- Conditions
- Intractable Pain, Back Pain, Leg Pain, Arm Pain
- Trial name
- (PUMP 2) (NCT00866164)
- Testing
- Prometra Programmable Pump
- Sponsor
- Flowonix Medical
Leg Pain, Ulcer
Stem Cell Study for Patients With Leg Ulcer/Gangrene
The purpose of this study is to determine if stem cell therapy with one's own cells (autologous cells) delivered intramuscularly to one's leg with ulcer and/or gangrene due to poor blood flow will be safe and if it will relieve…
- Conditions
- Leg Pain, Ulcer, Gangrene, Ischemia
- Trial name
- NCT00221143
- Testing
- Autologous peripheral blood CD34 positive cell therapy
- Where
- 2 sites in Japan
- Volunteers
- 15 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Hip Fracture
Ultrasound Guided Femoral Nerve Block
The goal of the study is to evaluate whether pain control achieved by Ultrasound Guided Femoral Nerve Blockade (USFNB) is equal in efficacy to standard pain management practice of parenteral injection of opioid pain medication in…
- Trial name
- NCT02381717
- Testing
- ultra-sound guide, bupivacaine, morphine
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Beth Israel Deaconess Medical Center
Muscle Soreness
A Within-subject Study to Evaluate the Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Compared to Placebo in Subjects Experiencing Delayed Onset Muscle Soreness
This study will assess the analgesic efficacy of DSG 1% compared to placebo in the reduction of the pain associated with DOMS
- Trial name
- NCT02271854
- Testing
- Diclofenac sodium gel 1%
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Novartis
Medial Tibial Stress Syndrome
Effect of Shortwave Diathermy and Therapeutic Ultrasound on Medial Tibial Stress Syndrome Among Military Cadets
Medial tibial stress syndrome (MTSS) also known as shin splints or tibial periostitis is a common injury in athletes and soldiers/cadets with incidences ranging between 4% and 35% in these populations .
- Trial name
- NCT04292795
- Testing
- Therapeutic Ultrasound, Short wave diathermy
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Shifa Clinical Research Center
Phantom Limb Pain
Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain
After amputation of an arm or leg, up to 90% of subjects experience a "phantom limb", a phenomenon characterized by persistent feelings of the missing limb.
- Trial name
- NCT05296265
- Testing
- VR treatment for phantom limb pain
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- Albert Einstein Healthcare Network
Symptomatic Neuroma, Phantom Limb Pain After Amputation
Evaluation of RPNI for Symptomatic Neuromas in Lower Limb Amputees
This prospective, observational cohort study evaluates the long-term outcomes of Regenerative Peripheral Nerve Interface (RPNI) surgery in patients with major lower extremity amputations suffering from symptomatic neuromas.
- Conditions
- Symptomatic Neuroma, Phantom Limb Pain After Amputation, Residual Limb Pain, Neuropathic Pain
- Trial name
- RPNI-AMPUTEE (NCT07420192)
- Testing
- Regenerative Peripheral Nerve Interface (RPNI) Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Saglik Bilimleri Universitesi
Phantom Limb Pain
Study to Assess the Efficacy of Direct Observation and Mental Visualization of Foot Movements to Treat Bilateral Lower Limb Phantom Limb Pain
Because bilateral lower extremity amputees do not have an intact limb for use with the mirror, we are now proposing to conduct a pilot trial of two treatments for phantom limb pain (PLP) - direct observation of another person's…
- Trial name
- NCT00639431
- Testing
- direct observation, mental visualization
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Acute Achilles Tendon Rupture
Popliteal Nerve Block for Acute Achilles Tendon Rupture Repair Surgery
Achilles tendon rupture is common, yet the value of popliteal nerve block for postoperative pain control during surgical repair remains uncertain.
- Trial name
- NCT06886815
- Testing
- Popliteal Nerve Block
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Women's College Hospital
Sciatica, Sciatica Due to Intervertebral Disc Disorder
Transforaminal Epidural Injection in Acute Sciatica
Patients suffering from sciatica are treated conservatively for the first 8 weeks due to the favourable prognosis. This period is preferably extended up to 14-16 weeks after which patients may opt for surgery.
- Conditions
- Sciatica, Sciatica Due to Intervertebral Disc Disorder, Sciatic Radiculopathy
- Trial name
- TEIAS (NCT03924791)
- Testing
- Lidocaine, Methylprednisolone Acetate, Dexamethasone
- Where
- 2 sites in Netherlands
- Volunteers
- 142 people
- Sponsor
- C.L.A.Vleggeert-Lankamp
Failed Back Surgery Syndrome, Neuropathic Pain
The Pain Suppressive Effect of Alternative Spinal Cord Stimulation Frequencies
Electrical stimulation of the spinal cord (Spinal Cord Stimulation or SCS) for pain relief has been used for decades. It is used most commonly in patients with chronic neuropathic leg pain, after spinal surgery.
- Trial name
- HALO (NCT02112474)
- Testing
- Spinal Cord Stimulation, Group 1, Group 2
- Where
- 5 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Jennifer Breel
Femoral Neck Fractures
A Dose Finding Study for Pain Relief of a Broken Hip
Studies have suggested a link with effective pain relief and reduced illness and death in high risk patients. Ultrasound guided nerve blocks have been associated with an increased success rate and allow visualization of all the…
- Trial name
- NCT00926666
- Testing
- Levobupivacaine
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- NHS Greater Glasgow and Clyde
Diabetic Foot Ulcer Associated With Type II Diabetes Mellitus
Effect of Stress Ball Applied During Surgical Debridement/Dressing on Pain, Distress, and Physiological Parameters in Patients With Diabetic Foot Ulcers
Diabetes mellitus (DM) is a common metabolic disease characterized by hyperglycemia, resulting from a deficiency or insufficiency of insulin.
- Trial name
- NCT07119983
- Testing
- Stress ball
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Cukurova University
Morton Neuroma, Pes Planus
Comparison of the Effects of Morton's Neuroma on Foot Pressure Distribution and Gait Parameters in Pes Planus and Pes Cavus Patients
The aim of our study is to compare the effect of Morton's neuroma in feet with pes planus and pes cavus on foot pressure and temporal and spatial gait parameters.
- Conditions
- Morton Neuroma, Pes Planus, Pes Cavus
- Trial name
- NCT05012488
- Testing
- Comparison of gait and foot pressure
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Acibadem University
Lumbar Spinal Stenosis With Bilateral Lower Extremity Radiculopathy
Effect of Skin Stretching on Pain Reduction During Local Anesthetic Injections: A Randomized Clinical Study
The purpose of this study is to investigate the potential analgesic effect of skin stretching during local anesthetic injection in patients with chronic lumbar pain and bilateral lower extremity radiculopathy undergoing selective…
- Trial name
- NCT06976580
- Testing
- conventional local anesthetic injection, skin stetching technique for local anesthetic injection
- Where
- South Korea
- Volunteers
- 104 people
- Sponsor
- Yonsei University