Clinical trials: Lower Extremity Pain
Musculoskeletal Injury, Pediatrics
Topical Diclofenac vs.Oral Ibuprofen for MSK Pain in Children
The TOP-MAP pilot trial has multiple goals. The first goal of this pilot clinical trial is to find out if it will be possible to carry out a study at multiple pediatric emergency department sites (Peds ED) comparing Non-Steroidal…
- Conditions
- Musculoskeletal Injury, Pediatrics, Sprain and Strain of Ankle, Sprain Knee
- Trial name
- TOP-MAP (NCT07145645)
- Testing
- Voltaren Topical Gel, Ibuprofen Oral Suspension 100 mg/5mL, ORA-Blend Oral Suspension
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Knee Injuries
Impact of a Bike Fitting Assessment and Interventions by a Physiotherapist in Recreational Cyclists With Knee Pain.
Background Cycling is a very popular activity and has various health benefits. Knee pain is very common among recreational cyclists and often limits cyclists to perform their sport.
- Trial name
- NCT05713656
- Testing
- Physiotherapy care
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Pediatric Obesity, Lower Extremity Biomechanics
Training Induced Reduction of Lower-limb Joint Loads During Locomotion in Obese Children
Childhood obesity is one of the most critical and accelerating health challenges throughout the world. It is a major risk factor for developing varus/valgus misalignments of the knee joint.
- Trial name
- NCT02545764
- Testing
- Strength and neuromuscular exercise programme
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- St. Pölten University of Applied Sciences
Myofascial Trigger Point Pain, Myofascial Pain Syndrome
Dry Needling and Functional Improvement
Dry Needling (DN) is a skilled intervention that uses acupuncture filiform needles that are inserted into myofascial trigger points or other tissues underneath the skin.
- Trial name
- DN (NCT02838394)
- Testing
- Dry needling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham Young University
Lumbosacral Radicular Pain
Corticosteroid Lumbar Epidural Analgesia for Radicular Pain 2
This is a research study of SP-102, an experimental medication designed to relieve pain in patients with moderate to severe sciatica (pain in the lower back, hips, buttocks and legs).
- Trial name
- CLEAR 2 (NCT07579351)
- Testing
- SP-102, Dexamethasone Sodium Phosphate 10 MG/ML
- Volunteers
- 755 people
- Sponsor
- Semnur Pharmaceuticals, Inc.
Non-specific Low Back Pain (NSLBP)
Mulligan Mobilization Techniques for Non-Specific Low Back Pain
This study aims to compare the effectiveness of two different Mulligan mobilization techniques in patients with non-specific low back pain.
- Trial name
- NCT07181395
- Testing
- Hip Internal Rotation Mulligan Mobilization, Straight Leg Raise Mulligan Mobilization, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Pain, Hip Fractures
Comparison Effects of Two Regional Anesthetic Technique on Pain During High Risk Hip Fracture Surgery
In this study, our is to compare effect of lumbosacral plexus and sacral plexus + suprainguinal fascia iliaca plane block on perioperative pain via analgesia nociceptive index monitor on high-risk patients undergoing hip fracture…
- Conditions
- Pain, Hip Fractures, Perioperative Analgesia
- Trial name
- NCT05862922
- Testing
- Analgesia Nosiception İndex Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Restless Leg Syndrome
Investigation of Efficacy of incobotulinumtoxinA (Xeomin) in Relieving Symptoms of Restless Leg Syndrome.
The purpose of this research study is to compare the safety and effectiveness of local injections of botulinum toxin A (Xeomin®) to an inactive test substance (placebo) in a medical condition called Restless Leg Syndrome.
- Trial name
- NCT01931878
- Testing
- incobotulinumtoxinA
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Yale University
Tibial Plateau Fracture
Continuous Femoral Nerve Block With a Tibial Plateau Fracture
The primary purpose of the proposed study is to compare postoperative pain scores and total opioid consumption between two groups randomized to either receive or not receive a femoral nerve block for pain control following…
- Trial name
- NCT02168959
- Testing
- bupivacaine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Utah
Flexibility
Effect of Opposite Leg Position on Hamstring Flexibility in Patients With Mechanical Low Back Pain
PURPOSE: this study aimed to investigate the effect of opposite knee position on hamstring flexibility BACKGROUND Hamstrings tightness is one of the most common findings in patients with LBP.
- Trial name
- NCT04082013
- Testing
- Hamstring Flexibility
- Where
- Egypt
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Cairo University
Phantom Limb Pain (PLP), Primary/Secondary Scar Hyperalgesia
A Trial of Lidocaine Patch for Lower Limb Amputation Pain
Phantom limb pain (PLP) and scar hyperalgesia (SH) are frequent problems after amputation; in particular most persons who undergo limb amputation will experience phantom pain.
- Trial name
- NCT02696720
- Testing
- Lidocaine
- Where
- 2 sites in Belgium
- Sponsor
- Brugmann University Hospital
Hip Fractures, Postoperative Pain
Evaluation of the Effectiviness of Two Different Bupivacaine Concentrations of the Pericapsular Nerve Group (PENG) Block
The use of regional anaesthesia techniques as part of multimodal analgesia in hip surgeries improves postoperative analgesia. PENG (Pericapsular nerve group) block is an effective motor sparing analgesia technique used in hip…
- Trial name
- PENG (NCT05921110)
- Testing
- Pericapsular nerve group block 0,25%, Pericapsular nerve group block 0,16%
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Ilker Ital
Motor Complete Spinal Cord Injury
The Effects of Passive Gait Training in Complete Motor Spinal Cord Injury (SCI)
The purpose of this study is to determine whether a three times per week, 2 month robotic assisted treadmill gait training program, will beneficially affect the fitness, physical and psychological well-being, and the vascular and…
- Trial name
- NCT01349478
- Testing
- LOKOMAT
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Dr. Gabriel Zeilig
Neuropathic Pain, Lower Limb Amputation
Pre-emptive Analgesia With Qutenza in Lower Limb Amputation
Neuropathic (nerve pain) following amputation of a limb is very common, affecting 60-80% of patients (Sherman et al, 1984). It can prolong their recovery making it difficult to fit protheses and mobilise.
- Trial name
- NCT01748435
- Testing
- Qutenza
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- NHS Greater Glasgow and Clyde
Pain, Postoperative, ACL Injury
Effectiveness of iPACK on Postoperative Pain From Hamstring Autograft Following ACL Repair
Patients undergoing ACL repair with hamstring autograft frequently develop significant post operative pain at the hamstring grafting site.
- Conditions
- Pain, Postoperative, ACL Injury, Anesthesia, Local, Opioid Use
- Trial name
- NCT05080348
- Testing
- Ropivacaine iPACK Injection, Normal Saline iPACK Injection
- Volunteers
- 40 people
- Sponsor
- Brenton Alexander
ACL - Anterior Cruciate Ligament Rupture, ACL Injuries
Non-Narcotic Pain Control After ACL Reconstruction
This is a double-blind randomized controlled trial of standard of care therapy, either oral ketorolac (experimental group) or oral oxycodone (control group) to demonstrate efficacy in reducing the percentage of narcotic doses…
- Trial name
- NCT06973785
- Testing
- dispense of study drug, Ketorolac
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Back Pain, Lower Extremity Pain
The Feasibility of Using Neuroscience Education in Adults Over 65 Years Old With Chronic Low Back and/or Lower Extremity Pain
This is a pilot study to determine if neuroscience education is acceptable to adults over 65 and if it can have an impact on pain, pain beliefs and gait speed
- Trial name
- NCT02449876
- Testing
- Neuroscience Education
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- State University of New York - Upstate Medical University
Postoperative Pain
Peripheral Nerve Blocks for Major Lower Extremity Amputations
This study will be a double-blinded randomized controlled trial analyzing all patients who will undergo major lower extremity amputations by the vascular surgery service at University of California, San Francisco (UCSF) Fresno…
- Trial name
- NCT03174782
- Testing
- Bupivacaine, Saline Solution
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Lumbar Radiculopathy, Low Back Pain
Spinal Mobilization With Leg Movement Versus Neurodynamic Mobilization in Lumbar Radiculopathy
Low back pain with lumbar radiculopathy is a common condition that significantly affects functional ability and quality of life. Manual therapy is widely used as a first-line treatment to reduce pain and improve mobility.
- Trial name
- NCT07524686
- Testing
- Spinal Mobilization With Leg Movement, Neurodynamic Mobilization
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Deraya University
Chronic, Intractable Back Pain and/or Leg Pain
Clinical Trial of MED HF10™ Spinal Cord Stimulation for the Treatment of Chronic Pain
This is a single-center, prospective, non-randomized exploratory study in subjects with chronic, intractable back pain and/or leg pain per the center's routine practice.
- Trial name
- MED (NCT06897280)
- Testing
- SCS Device Program Setting
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Nevro Corp