Clinical trials: Lower Extremity Wound
Ankle Injuries
Percussive Therapy Reduced EMG Activity During Calf Raise in Limbs With and Without Chronic Ankle Instability
To examine the acute effect of percussive therapy on peak calf muscle activation during standing heel raise in subjects with and without chronic ankle instability (CAI).
- Trial name
- NCT06343207
- Testing
- Percussive massage gun therapy
- Where
- Czechia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Amputation, Traumatic, Traumatic Amputation of Lower Extremity
What is the Optimal Stiffness and Height of a Running-specific Prosthesis?
The proposed study aims to characterize the effects of running-specific leg prosthetic stiffness and height during on performance during running and sprinting to optimize running-specific prosthesis prescription.
- Conditions
- Amputation, Traumatic, Traumatic Amputation of Lower Extremity, Wounds and Injuries
- Trial name
- NCT02318979
- Testing
- Otto Bock prosthesis, Ossur prosthesis, Freedom Innovations prosthesis
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
Spinal Cord Injury
Safety Study of Outdoor and Indoor Mobility in People With Spinal Cord Injury (ROBOtics Spinal Cord Injury EKSO).
The aim of this study will be to evaluate the safety and the efficacy of a new robotic exoskeleton device in subjects with Spinal Cord Injury (SCI) and in subjects with other neurological disease with an impairment of lower limbs.
- Trial name
- ROBOSCIEKSO (NCT02065830)
- Testing
- EKSO
- Where
- 2 sites in Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Educational Problems, Simulation of Physical Illness
Learning Management of Open Fractures on Virtual Patient
A novel virtual world programme with over 240 multiple choice questions was developed to assess the competencies in managing an open fracture of the lower limb according to the British Orthopaedic Association Standards for Trauma…
- Conditions
- Educational Problems, Simulation of Physical Illness, Fractures, Bone, Emergencies
- Trial name
- NCT04605380
- Testing
- Virtual reality online world
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Lower Limb Amputation Above Knee (Injury)
The CYBERnetic Lower Limb Cocognitive Ortho-prosthesis Plus Plus, 1st Clinical Study (CLs++)
The aim of the study is to assess the efficacy and the usability of the cyberlegs ++ ortho prosthesis to improve the mobility and the quality of life in transfemoral amputees .
- Trial name
- NCT03376919
- Testing
- CLs++ gait training
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
ACL Injury, Kinesiotape
Kinesio Taping for the Knee and Ankle: Acute Impact on Balance, Proprioception, and ACL Risk
This study aims to evaluate and compare the acute effects of Kinesio taping applied to the knee and ankle on balance, proprioception, and anterior cruciate ligament (ACL) injury risk using the Landing Error Scoring System (LESS).
- Conditions
- ACL Injury, Kinesiotape, Balance, Proprioception
- Trial name
- ACL (NCT07138573)
- Testing
- Kinesio Taping (KT) applied to the knee then ankle, Kinesio Taping (KT) applied to the ankle then knee
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Tendinopathy
The Acute Effects of an Isometric Loading Intervention on Lower Extremity Landing Biomechanics in Individuals With Patellar Tendinopathy
The purpose of this study is to determine differences in lower extremity landing biomechanics and real-world physical activity between individuals with patellar tendinopathy compared to individuals without patellar…
- Trial name
- NCT03262181
- Testing
- Isometric Exercise
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Diabetic Foot, Resistance Exercise
Breathing-based Leg Resistance Exercise Improves Wound Healing, Blood Sugar and Quality of Life for Diabetic Foot Ulcers
The purpose of the study was designed leg resistance training combined with breathing approach, and evaluated its effect on wound healing, blood sugar control and quality of life in type 2 diabetic patients with foot ulcers.
- Conditions
- Diabetic Foot, Resistance Exercise, Wound Healing, Hyperglycemia
- Trial name
- NCT05110092
- Testing
- leg resistance combined with breathing exercise training
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Surgical Wound, Wound Heal
Evaluating the Outcomes for Incisional Application of Negative Pressure for Nontraumatic Amputations
The purpose of this study is to evaluate how well subjects heal after surgery who receive standard dressings or incisional negative pressure wound therapy for non-traumatic amputation sites.
- Conditions
- Surgical Wound, Wound Heal, Amputation
- Trial name
- NCT03250442
- Testing
- PrevenaTM Device, Standard Dry Dressing
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Musculoskeletal Pain, Autonomy
Translation and Validation of the Limbs, Pain, Autonomy, Depression, Anxiety and Quality of Life Scales in Albanian
The cross-cultural adaptation will be performed according to the internationally recommended methodology, using the following guidelines: translation, back-translation; revision by a committee, questionnaire diffusion and data…
- Conditions
- Musculoskeletal Pain, Autonomy, Healthy, Upper Limb Injury
- Trial name
- NCT06685094
- Where
- Spain
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Diabetic Foot Ulcers
A Pilot Study of the Provant Therapy System in Subjects With Diabetic Foot Ulcers
The objective of this study is to compare the reduction in wound surface areas between patients with diabetic ulcers utilizing Provant's pulsed radio frequency energy therapy (PRFE) as an adjunct to standardized basic wound care…
- Trial name
- NCT00761176
- Testing
- The Provant Therapy System
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Regenesis Biomedical, Inc.
Diabetic Ulcer
Evaluation of Topical Wound Oxygen (two2) Therapy
The purpose of this study is to evaluate the efficacy of the Topical Wound Oxygen (two2) therapy system on the healing of diabetic lower extremity ulcers.
- Trial name
- NCT00871312
- Testing
- Topical wound oxygen therapy
- Where
- 3 sites in United States, Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- AOTI Ltd.
Diabetic Foot Ulcer
Non-Invasive Testing to Evaluate Wound Healing in Diabetes
Normal group: We will collect normative data from healthy individuals to include baseline data, screening, and images. Up to 500 people will be enrolled and can include normal healthy volunteers, staff and students/trainees.
- Trial name
- NCT04232631
- Testing
- SnapshotNIR, Kent Imaging
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Treatment of Leg Ulcer, Sharp Debridement
Treatment of Chronic Leg Ulcer in Outpatient's Department and i Primary Care - Wound Size and Inflammation
The purpose of this study is to investigate the rate of wound healing using sharp debridement using curette and to compare between such intensive treatment at hospital and treatment in primary care.
- Conditions
- Treatment of Leg Ulcer, Sharp Debridement, Proinflammatory Cytokines
- Trial name
- NCT01249495
- Testing
- Sharp debridement
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Stroke, Walking, Difficulty
Agonist and Antagonist Muscle Activations in the Lower Limbs During Walking After Central Nervous System Injury
The retrospective study investigates the part of responsibility of neuromuscular disorders associated with chronic hemiparesis in walking impairment.
- Conditions
- Stroke, Walking, Difficulty, Spasticity/Paresis
- Trial name
- NEUROGAIT (NCT06107556)
- Testing
- Gait analysis
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Henri Mondor University Hospital
Peripheral Arterial Occlusive Disease Fontaine Stage IIa
Acute Local Metabolomic Alterations in Blood and Muscle Tissue in Intermittent Claudication
The most common clinical presentation of lower extremity arterial disease is intermittent claudication. Current understanding of the pathophysiology of intermittent claudication, as well as its treatment options are limited.
- Trial name
- NCT05111379
- Where
- Estonia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Landing Biomechanics, Fatigue
Risk Factors for Lower Extremity Overuse Injuries in Jump-landing Athletes
In this prospective study, male jump-landing athletes (volleyball and basketball) will be screened pre-season and followed for one consecutive season.
- Trial name
- NCT05161273
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Ghent
Burned
Isokinetic Training Versus Treadmill Training on Muscle Strength and Gait in Children With Lower Limb Burns
Burn wounds are one of the most complexes and dramatic of all injuries, it produces a direct local tissue destruction and damage.
- Trial name
- NCT06036082
- Testing
- Conventional physical therapy
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- South Valley University
Lower Limb Amputation Below Knee (Injury)
Human-Prosthetic Interaction: Brain & Technology After Lower-Limb Loss
This study evaluates brain neuroplasticity and functional performance in people with unilateral lower limb amputation.
- Trial name
- HumanIT (NCT05818410)
- Testing
- Prosthetic device (Lunaris), No prosthetic device, Prosthetic device (Sach foot)
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Lower Limb Injuries
Plyometric Training on Sand vs Firm Ground in Young Adults
Summary The purpose of this interventional study is to determine whether the type of training surface used during plyometric training influences neuromuscular performance, dynamic postural balance, and muscle soreness in young…
- Trial name
- PST-SF (NCT07489404)
- Testing
- Plyometric Training on Sand
- Where
- Tunisia
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Manouba