Clinical trials: Lower Limb, open to volunteers
Sciatic Leg Pain, Hamstring Muscle Tightness
Acute Effects of Neurodynamics on Strength and Endurance in Athletes
This study explores the acute effects of neurodynamics, an intervention commonly used by physical therapist to improve nerve mobility and decrease pain, on the strength and muscular endurance in the athletic population.
- Conditions
- Sciatic Leg Pain, Hamstring Muscle Tightness, Hamstring Muscle Strain, Hamstring Muscle Strength
- Trial name
- NCT07721220
- Testing
- Sciatic Slider, Sciatic Tensioner, Mechanically loaded neurodynamic sciatic floss
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- High Point University
Cerebral Palsy
Effects of Mirror Therapy on Lower Extremity in CP Children
A non-progressive condition that harms the developing brain both during and after birth is cerebral palsy (CP). It is a multifaceted syndrome marked by abnormalities in movement and posture, along with concomitant sensory-motor…
- Trial name
- NCT06673823
- Testing
- Mirror therapy, conventional therapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Venous Leg Ulcer, Wound Heal
COMS for Chronic Ulcers Treatment
Chronic leg and foot ulcers are defined as wounds that fail to heal in a timely manner, typically persisting for over 4 to 8 weeks without substantial healing despite standard care.
- Conditions
- Venous Leg Ulcer, Wound Heal, Magnetic Field Exposure
- Trial name
- NAZARÉ (NCT06528873)
- Testing
- Concurrent optical and magnetic stimulation (COMS) treatment
- Where
- 10 sites in Austria, France and 2 more
- Volunteers
- 122 people
- Sponsor
- Sebastian Probst
Diplegic Cerebral Palsy
"Immediate Effect of DAFO on Gross Motor Function and Balance in Diplegic Cerebral Palsy
" Study will investigate the immediate effect of DAFO usage on balance and gross motor functions in individuals with spastic diplegic cerebral palsy.
- Trial name
- NCT06343688
- Testing
- "Assessment of Balance and Lower Extremity Gross Motor Function with and without DAFO"
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Amputation, Gait Disorders, Neurologic
Usability of the Smart Hallway System in Clinical Setting
The aim of the study is to examine suitability of data and processed reports acquired from the Smart Hallway system for clinical settings in terms of user acceptability and accuracy for use in clinical practice.
- Trial name
- SmartHallway (NCT06645054)
- Testing
- Standard rehabilitation, Lower-limb prosthesis, Lower-limb orthosis
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Rehabilitation Institute, Republic of Slovenia
Diabetic Foot Ulcers (DFU), Foot Ulcer Chronic
Evaluating the Durability of Closure for Diabetic Foot Ulcers Following a Randomized, Controlled, Modified Platform Trial.
Prospective long-term follow-up on durability of closure evaluated by photographic and thermal scanning.
- Conditions
- Diabetic Foot Ulcers (DFU), Foot Ulcer Chronic, Ulcer, Diabetic Foot Ulcer
- Trial name
- SCANX (NCT07360418)
- Testing
- Blue Drop Foot Scanner
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Applied Biologics, LLC
Femoral Fracture, Fragility Fracture
Essential Amino Acid Supplementation for Femoral Fragility Fractures
This trial will evaluate the impact of 4 weeks of postoperative essential amino acid (EAA)-based supplementation on muscle morphology after femoral fragility fracture.
- Conditions
- Femoral Fracture, Fragility Fracture, Muscle Atrophy
- Trial name
- NCT06050668
- Testing
- Essential Amino Acid Supplementation
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Michael C Willey
Healthy Subjects
Comparative Exercise-Induced Hypoalgesia in Upper and Lower Limbs: A Randomized Controlled Trial in Healthy Individuals
This randomized controlled trial with healthy subjects aims to compare exercise-induced hypoalgesia among three groups: one utilizing a lower limb cycle ergometer, another using an upper limb cycle ergometer, and a control group.
- Trial name
- NCT06283186
- Testing
- Aerobic exercise
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centro Universitario La Salle
Lymphedema, Genital Neoplasm
Lymphedema After Gyneco-oncologic Treatment
Trial developed to inventory the incidence of early and advanced stage lower limb lymphedema in patients diagnosed with and treated for gynaecologic cancer.
- Trial name
- Gynolymph (NCT05469945)
- Testing
- Compressive garments class II
- Where
- 2 sites in Belgium
- Volunteers
- 218 people
- Sponsor
- University Hospital, Ghent
Lower Extremity Lymphedema
Aerobic Exercise Effects in Lower Extremity Lymphedema
Lower extremity lymphedema negatively affects patients' functional status, quality of life, and activities of daily living. Complete decongestive therapy (CDT) is considered the gold-standard conservative treatment for patients…
- Trial name
- NCT07726277
- Testing
- aerobic exercise program, complet decongestive therapy
- Volunteers
- 50 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Anterior Cruciate Ligament Injuries
Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction
To evaluate the effect of graded exposure and mindfulness meditation after ACLR, the investigators will determine the effect of graded exposure and mindfulness meditation to 1) decrease self-reported injury-related fear and…
- Trial name
- NCT05949177
- Testing
- Graded Exposure and Mindfulness Meditation, Waitlist Control
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of North Carolina, Chapel Hill
Gait Rehabilitation
Feasibility and Effectiveness of Goal Driven Extended Reality for Lower Limb Rehabilitation
This pilot study will evaluate the feasibility and preliminary effectiveness of incorporating Extended Reality (XR) into the treatment of patients undergoing Lower Limb Rehabilitation (LLR) using the Vector Gait and Safety…
- Trial name
- NCT07043101
- Testing
- Extended Reality based Gait Rehabilitation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University at Albany
Hip Fractures, Venous Thromboembolism (VTE)
Delivery and Implementation of a Randomised Crossover Trial on Thrombosis
What is the Study About? The DIRECT study (Delivery and Implementation of a Randomised Crossover Trial on Thrombosis) is a large research project investigating the best way to prevent blood clots (thrombosis) in people who break…
- Trial name
- DIRECT (NCT06937372)
- Testing
- Patients in hospitals allocated to this arm will receive aspirin as their routine thromboprophylaxis after surgery., Low molecular weight heparin (LMWH)
- Where
- United Kingdom
- Volunteers
- 21,194 people
- Sponsor
- Queen Mary University of London
Venous Leg Ulcer, Chronic Non-Healing Cutaneous Wounds
LUT017 Gel for Venous Leg Ulcers and Chronic Non-Healing Skin Wounds in Adults
This research study is investigating a new topical medication called LUT017, which is being developed to help heal chronic skin wounds, particularly those known as venous leg ulcers (VLUs).
- Conditions
- Venous Leg Ulcer, Chronic Non-Healing Cutaneous Wounds, VLU
- Trial name
- NCT07463365
- Testing
- LUT017 gel
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Antoni Ribas
Peripheral Arterial Hemodynamics, Lower Extremity Blood Flow
Doppler Ultrasound Evaluation of the Effects of Exercise Combined With Kinesiology Taping on Local Hemodynamic Parameters
This study aims to evaluate the effects of exercise combined with kinesiology taping on local hemodynamic parameters in healthy university students.
- Trial name
- Kinesio tape (NCT07858851)
- Testing
- Kinesiology Taping, Ankle Pumping Exercise
- Where
- Taiwan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Diabetic Foot Ulcer, Venous Leg Ulcer
Real World Evidence with the Debritom+ TM Novel Micro Water Jet Technology At a Single Wound Center
Prospective, single-blinded, single-center, parallel group, randomized controlled trial (RCT) to assess rate and frequency of wound healing and associated financial savings, when using Medaxis debritom+ versus standard of care as…
- Conditions
- Diabetic Foot Ulcer, Venous Leg Ulcer, Surgical Wound Dehiscence, Traumatic Wounds
- Trial name
- EVIDENT (NCT04920253)
- Testing
- Study Device Debridement, SOC Debridement
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Medaxis, LLC
Myocardial Ischemia, Diabetes Complication
Evaluation of Perioperative Myocardial Injury in Patients Undergoing Below-Knee Lower Extremity Surgery
The aim of this observational study was to detect myocardial damage by monitoring high-sensitive troponin I levels in patients undergoing below-knee extremity surgery with peripheral nerve block.
- Trial name
- NCT07241572
- Testing
- high sensitive Troponin I
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Greater Trochanteric Pain Syndrome, Greater Trochanteric Pain Syndrome of Both Lower Limbs
ReneuRx™ (Nerve Selective Therapy) Utilized in Lateral Hip Pain
The goal of this clinical trial is to evaluate the safety and analgesic performance of the ReneuRx™ device in subjects with moderate to severe chronic lateral hip pain compared to subjects receiving treatment with corticosteroid…
- Conditions
- Greater Trochanteric Pain Syndrome, Greater Trochanteric Pain Syndrome of Both Lower Limbs, Lateral Hip Pain
- Trial name
- RENEU (NCT07568015)
- Testing
- Triamcinolone acetate, ReneuRx
- Where
- 11 sites in United States
- Volunteers
- 100 people
- Sponsor
- Brixton Biosciences, Inc.
Lymphedema, Lower Limb, Lymphedema
Detecting the Undetected: Heart Failure Screening at the Lymphoedema Point of Care
Heart failure affects more people than the four most common cancers combined. When identified early, management is more straightforward, preventing complications, hospitalisations, and fatalities.
- Conditions
- Lymphedema, Lower Limb, Lymphedema, Heart Failure, Heart Failure (for Example, Fluid Overload)
- Trial name
- NCT07498868
- Where
- United Kingdom
- Volunteers
- 618 people
- Sponsor
- Swansea Bay University Health Board
Diabetic Foot Ulcer, Diabetes Mellitus
Total Contact Soft Cast in Diabetic Foot Ulcers
To determine the effectiveness, compliance, patient tolerance, ease of use and safety of total contact soft cast in diabetic foot ulcers.
- Conditions
- Diabetic Foot Ulcer, Diabetes Mellitus, Foot Ulcer, Foot Ulcer, Diabetic
- Trial name
- NCT04210089
- Testing
- Total Contact Soft Cast, Cam Boot
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.