Clinical trials: Lower Limb Surgery
Lower Limb Surgery, Pain
Role of Perineural Catheter in Pain Control and Opioid Consumption After Major Amputation of Lower Limb
The goal of this randomized controlled clinical trial is to evaluate the effectiveness of postoperative bupivacaine infusion through a perineural catheter in managing postoperative pain and to determine the opioid consumption…
- Conditions
- Lower Limb Surgery, Pain, Phantom Limb Pain After Amputation, Stump Pain
- Trial name
- NCT07896798
- Testing
- Bupivacaine Infusion, Opioid Infusion, Saline
- Volunteers
- 96 people
- Sponsor
- Aga Khan University
Amputation, Amputation of Lower Limb
Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain
The goal of this Registry is to see how the device is used when freezing nerves during an amputation procedure.
- Conditions
- Amputation, Amputation of Lower Limb, Amputation of Upper Limb, Amputation, Limb Loss
- Trial name
- VANISH (NCT06908538)
- Testing
- cryoablation
- Where
- 6 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- AtriCure, Inc.
Lower Limb Surgeries
Effect of Height Based vs Conventional Dose of Spinal Anesthesia in Lower Limb Surgeries
This study aim is to compare height based dose of spinal anesthesia vs conventional dose. Hypothesis is height based dose has less hemodynamics changes compared to conventional dosing.
- Trial name
- NCT07751835
- Testing
- Height based dose of hyperbaric bupivacaine 0.5%
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Liaquat National Hospital & Medical College
Epidural Dosage of Lidocaine Bupivacaine in Lower Limb Surgeries
Comparison of Different Epidural Lidocaine-Bupivacaine Mixtures for Lower Limb Surgeries
This randomized controlled trial will evaluate different epidural lidocaine-bupivacaine mixtures in patients undergoing lower limb surgery at a tertiary care hospital in Karachi, Pakistan.
- Trial name
- LBM-LLS (NCT07648784)
- Testing
- Lidocaine-Bupivacaine Epidural Mixture (High-dose Lidocaine)
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Shaheed Mohtarma Benazir Bhutto Institue of Trauma
Acute Postoperative Pain, Lower Limb Surgery
Tapentadol vs Pregabalin for Postoperative Pain in Lower Limb Surgery
This pilot randomised controlled trial compared 72-hour oral premedication with tapentadol (50 mg every 12 hours) versus pregabalin (75 mg every 24 hours) for preventing acute postoperative pain in 46 patients undergoing elective…
- Trial name
- NCT07587645
- Testing
- Tapentadol, Pregabalin
- Where
- Mexico
- Volunteers
- 46 people
- Sponsor
- ISSSTE Hospital Regional "Gral. Ignacio Zaragoza"
Reconstructive Surgery Using Pedicled Perforating or Free Perforating Flaps, Pelvic Eschar
Study and Modeling of Perforator Flap Vascularization
The aim of reconstructive surgery is to restore physical integrity altered by trauma, congenital malformations or cancerous pathologies.
- Conditions
- Reconstructive Surgery Using Pedicled Perforating or Free Perforating Flaps, Pelvic Eschar, Traumatic Pathology of the Lower and/or Upper Limb
- Trial name
- EMoVaLP (NCT07084740)
- Testing
- PeriCam and PeriFlux measurements
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Tizanididne, Levobupicaine
Comparison of Analgesic Efficacy of Intrathecal Levobupivacaine With and Without Oral Tizanidine in Lower Limb Surgeries: A Prospective Randomized Study
Tizanidine, alpha-2 adrenergic receptor agonist, provides analgesic and hemodynamic benefits, which could enhance the efficacy of local anaesthetics.
- Conditions
- Tizanididne, Levobupicaine, Lower Limb Surgery, Pain, Chronic
- Trial name
- NCT07310628
- Testing
- Tizanidine
- Where
- India
- Volunteers
- 64 people
- Sponsor
- All India Institute of Medical Sciences
Lower Limb Orthopedic Surgery
Intravenous Dexmedetomidine Versus Midazolam in Preventing Shivering in Trauma Patients Undergoing Lower Limb Orthopedic Surgery Under Spinal Anesthesia
Shivering is a common and significant complication following spinal anesthesia, with a reported incidence of 40-60% especially in trauma patients due to pain, stress response, blood loss, and disrupted thermoregulation.
- Trial name
- NCT07300826
- Testing
- Dexmedetomidine, Midazolam
- Volunteers
- 100 people
- Sponsor
- Assiut University
Patients Undergoing Lower Limb Surgery
Comparative Study of the Effects of Two Local Anesthetics Administered Intrathecally: 0.5% Levobupivacaine and Ropivacaine 0.5%
This is a Biomedical Research, prospective, randomized, double blind, controlled monocentric, phase IV comparison of the effects of two local anesthetics intrathecally: 0.5% levobupivacaine and ropivacaine 0.5%.
- Trial name
- ROPI-LEVO (NCT01935596)
- Testing
- ropivacaïne, lévobupivacaïne
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Stellate Ganglion Block, Arteriovenous Fistula
Stellate Ganglion Block for Preserving Arteriovenous Fistula in Hemodialysis Patients Undergoing Major Lower Limb Orthopedic Surgery
The aim of this study is to evaluate the role of stellate ganglion blockade (SGB) for preserving arteriovenous fistula in hemodialysis patients undergoing major lower limb orthopedic surgery.
- Conditions
- Stellate Ganglion Block, Arteriovenous Fistula, Hemodialysis, Major Lower Limb Orthopedic Surgery
- Trial name
- NCT06300658
- Testing
- Stellate ganglion block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Aswan University
Lower Limb Surgery
Comparsion Between Intrathecal Fentanyl and Intravenous Nalbuphine as a Postoperative Analgesia in Lower Limb Surgeries
Postoperative pain management has been a major challenge and there has been great interest about it ., there have been persistent efforts to bring out the best possible analgesic technique with the least side effects.
- Trial name
- NCT06720506
- Testing
- fentanyl, Nalbuphine
- Volunteers
- 100 people
- Sponsor
- Assiut University
Lower Limb Surgeries
Epidural Nalbuphine Versus Dexmedetomidine as Adjuvants to Bupivacaine in Lower Limb Surgeries
Combined spinal epidural anesthesia (CSE) with bupivacaine alone is not sufficient to cover pain sequel during lower limb surgeries.
- Trial name
- NCT05041270
- Testing
- normal saline, Dexmedetomidine, Nalbuphine
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Zagazig University
Hip Fractures, Elderly Patients
Comparison of Phenylephrine and Ephedrine in the Treatment of Hemodynamic Disorders After Spinal Anesthesia in the Elderly
Spinal anesthesia is often used for lower limb surgery in elderly. Hypotension is a side effect of spinal block. In this study, intravenous ephedrine and phenylephrine will be compared with each other to prevent spinal…
- Conditions
- Hip Fractures, Elderly Patients, Spinal Anesthesia, Lower Limb Surgery
- Trial name
- HypoGer (NCT03858465)
- Testing
- Ephedrine, Phenylephrine
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Warsaw
Mastectomy, Upper Limb Amputation Below Elbow
Cryoanalgesia to Prevent Acute and Chronic Pain Following Surgery: A Randomized, Double-Masked, Sham-Controlled Study
The ultimate objective of the proposed line of research is to determine if cryoanalgesia is an effective adjunctive treatment for pain in the period immediately following various painful surgical procedures; and, if this…
- Conditions
- Mastectomy, Upper Limb Amputation Below Elbow, Upper Limb Amputation Above Elbow, Lower Limb Amputation Below Knee
- Trial name
- NCT03578237
- Testing
- Cryoneurolysis (active)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of California, San Diego
Efficacy of Erector Spinae Plane Block in Lower Limb Surgery in Pediatric
Erector Spinae Plane Block in Pediatric Lower Limb Surgery
Anesthesia will be induced in all patients using Fentanyl 1µg,propofol 2mg/kg and cisatracurium 0.15 mg/kg IV to facilitate endotracheal intubation, maintenance of anaesthesia afterward will be achieved by isoflurane1.5-2% in…
- Trial name
- NCT05369455
- Testing
- erector spinae plane block, ultrasound guided caudal block
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tanta University
Lower Limb Surgery
Retrospective Foot and Ankle Data Collection
A retrospective post-market data collection study of the following implant devices : DARCO™ Headed Cannulated Screw ORTHOLOC™ 3Di Recon-Midfoot/Flatfoot System ORTHOLOCTM 3Di 2 Foot Reconstruction System: CROSSCHECK™ Module
- Trial name
- NCT05234801
- Testing
- DARCO™ Headed Cannulated Screw, ORTHOLOC™ 3Di Recon-Midfoot/Flatfoot System, ORTHOLOCTM 3Di 2 Foot Reconstruction System: CROSSCHECK™ Module
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Short Duration Lower Limb Surgery Via Spinal Anaesthesia
Spinal Anaesthesia With Chloroprocaine HCl 1% for Elective Lower Limb Procedures of Short Duration.
This study evaluate the effect of 3 doses of Chloroprocaine HCl 1% (30, 40 and 50 mg) for spinal anaesthesia in adult patients undergoing short duration elective surgery of the lower limb.
- Trial name
- NCT02481505
- Testing
- Chloroprocaine HCl 1%
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Sintetica SA
Patients Scheduled for Iliac Crest Bone Graft Harvest During Upper or Lower Limb Surgery
Ultrasound TFP (Transversalis Fascia Plane) for Analgesia After Iliac Crest Bone Graft Harvest
Iliac crest bone graft harvest is associated with acute pain that can lead to chronic postoperative pain. Local anesthetic infiltration and regional anesthesia could be of interest to reduce opioid consumption during and after…
- Trial name
- TFP (NCT02398474)
- Testing
- TFP block ropivacaine, ropivacaine infiltration of the iliac crest bone
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Rennes University Hospital
Lower Limb Surgery
Minimum Effective Dose of 0.5% Bupivacaine for Ultrasound-guided Spinal Anesthesia Using Taylor's Approach
This study aims to determine the minimum effective dose of bupivacaine 0.5% in 90% of patients undergoing lower limb surgery with ultrasound-guided spinal anesthesia using Taylor's approach.
- Trial name
- MEDBST (NCT03899038)
- Testing
- spinal anesthesia
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Huazhong University of Science and Technology
Lower Limb Vascular Surgery - Femoral Artery Endarteriectomy
Prediction of Femoral Revascularization Quality Using the Somatic NIRS Signal
Despite effective femoral artery endarteriectomy, patients with occlusive arteritis may need complementary stenting of revascularization procedures within the 2 years after the primary surgery because of a poor blood supply in…
- Trial name
- TEA-NIRS (NCT02337920)
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Caen