Clinical trials: Lower Resp Tract Infection
Respiratory Viral Infections, Respiratory Syncytial Virus Infections
Safety and Tolerability Study to Evaluate MEDI-534 in Children 6 to < 24 Months of Age
The overall objective of the MEDI-534 clinical development program is to evaluate the safety, efficacy and tolerability of MEDI-534 for the prevention of serious RSV and PIV3 disease in young infants.
- Conditions
- Respiratory Viral Infections, Respiratory Syncytial Virus Infections, Parainfluenza Virus 3, Human
- Trial name
- CP149 (NCT00493285)
- Testing
- MEDI-534
- Where
- 30 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Lower Tract Respiratory Infection
Wood Stove Interventions and Child Respiratory Health
Acute lower respiratory tract infections (LRTIs) account for more than 27% of all hospitalizations among US children under five years of age, with recurrent LRTIs in children a recognized risk factor for asthma.
- Trial name
- KidsAIR (NCT02240134)
- Testing
- Education Intervention (Tx1), Air Filtration Unit Treatment (Tx2)
- Where
- United States
- Volunteers
- 523 people, healthy volunteers welcome
- Sponsor
- University of Montana
Pneumonia, Bronchiolitis
Neutrophil Monocyte Lymphocyte Ratios in Pediatric Chest Infections
This prospective cohort study aims to evaluate neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and neutrophil-to-monocyte ratio in children with lobar pneumonia, bronchiolitis, and bronchopneumonia compared with…
- Trial name
- NCT07888049
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Prematurity, RSV
The Impact of a Short Intervention During RSV Prophylaxis on Influenza Vaccination Rate.
Premature infants (born before 34 wk) are routinely vaccinated against RSV but vaccination rate against influenza are low in spite of national programs.
- Conditions
- Prematurity, RSV, Influenza, Upper Respiratory Tract Infection
- Trial name
- NCT01985620
- Testing
- Educational intervention
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Laryngeal Masks, Pharyngitis
Postoperative Sore Throat in Children: Comparison Between Two Supraglottic Devices, Ambu® AuraOnce™ Laryngeal Mask Airway (LMA) and I-Gel®.
Sore throat is minor but well recognized complaint after receiving general anaesthesia. It is rated as 8th most undesirable outcome in postoperative period.It not only affects the patient's satisfaction but also can affect…
- Conditions
- Laryngeal Masks, Pharyngitis, Minors, Anesthesia
- Trial name
- NCT03140228
- Testing
- I-Gel, LMA
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Rhinovirus
The Rhinovirus Hospitalization and Investigation of Nasal-airway Omics (RHINO) Study
The goal of this study is to determine the burden of Rhinoviruses (RVs) as a cause of acute, severe, respiratory illnesses leading to hospitalization.
- Trial name
- NCT07342582
- Testing
- Nasal Swab Healthy Surveillance, Nasal Swab Sick Samples, Nasal Swab Hospitalized Cohort
- Where
- United States
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Respiratory Syncytial Virus Infections
A Study on the Immune Response, Safety and the Occurrence of Respiratory Syncytial Virus (RSV)-Associated Respiratory Tract Illness After Administration of RSV OA Vaccine in Adults 60 Years and Older
The purpose of the current study is to evaluate the immune response of the RSVPreF3 OA investigational vaccine in older adults (OA) at least (>=) 60 years of age (YOA) in China compared to OA in the same age range to be enrolled…
- Trial name
- NCT06551181
- Testing
- RSVPreF3 OA investigational vaccine
- Where
- 40 sites in China, Finland and 5 more
- Volunteers
- 2,620 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COVID-19 Lower Respiratory Infection, SARS-CoV2 Infection
Osteopathic Manipulative Therapy Effects on Prolonged Post-COVID Olfactory Dysfunction
The goal of this project is to determine the efficacy of a treatment method that increase a participants sense of smell after suffering from COVID-19 related decline in smell.
- Trial name
- NCT05112887
- Testing
- Osteopathic Manipulative Therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ohio University
Respiratory Syncytial Virus Infections
A Study in India on the Immune Response and Safety of a Respiratory Syncytial Virus (RSV) Older Adults (OA) Vaccine When Given to Older Adults 60 Years of Age and Above and Adults 50-59 Years of Age at Increased Risk (AIR) of Respiratory Syncytial Virus Lower Respiratory Tract Disease (RSV-LRTD)
The purpose of the study is to evaluate the immunogenicity and safety of a single dose of investigational RSVPreF3 OA vaccine in Indian older adults 60 years of age (YOA) and above and Indian adults 50-59 YOA at increased risk of…
- Trial name
- NCT06614725
- Testing
- RSVPreF3 OA investigational vaccine
- Where
- 14 sites in India
- Volunteers
- 751 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Young Adults, Influenza Vaccines
Characterizing the Human Airway Immune Response to FluMist Vaccination
The goal of this clinical trial is to measure the immune response in the blood, nose, and lungs after participants receive either the FDA-approved inactivated influenza vaccine or the FDA-approved intranasal FluMist vaccine.
- Conditions
- Healthy Young Adults, Influenza Vaccines, Influenza Vaccine Response
- Trial name
- EVax-3 (NCT07177417)
- Testing
- FluMist, inactivated influenza vaccine, bronchoscopy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Upper Respiratory Infections, Lower Respiratory Tract Infections
Nutritional Intervention and Respiratory Infections in Older Subjects
Poor Ecuadorian older people suffer from chronic dietary deficiencies of zinc, iron, copper, vitamins C, B6, B12, D, and folic acid.
- Trial name
- NCT01971112
- Testing
- Multivitamins and minerals
- Where
- Ecuador
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Corporacion Ecuatoriana de Biotecnologia
Pneumonia, Diarrhea
Vitamin A and Zinc: Prevention of Pneumonia (VAZPOP) Study
Children with malnutrition are often low in some nutrients, like zinc or vitamin A, that could help them fight off infections like pneumonia.
- Conditions
- Pneumonia, Diarrhea, Acute Upper Respiratory Tract Infections
- Trial name
- NCT00228254
- Testing
- Zinc (12.5 mg/day), vitamin A 10,000 IU per week
- Where
- 2 sites in United States, Ecuador
- Volunteers
- 2,582 people, healthy volunteers welcome
- Sponsor
- Tufts University
Acute Respiratory Infection, Asthma Exacerbations
Reusable Face Masks to Reduce Risk of Viral Respiratory Infections and Asthma Exacerbations
REMASK trial is a Trial within Cohort study (TwiCs), nested within the COVIDENCE UK longitudinal study. It has been designed to determine whether the offer of a free reusable, elastomeric face mask to adults with asthma and other…
- Trial name
- REMASK (NCT06885229)
- Testing
- FloMask - reuseable face mask
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen Mary University of London
COVID-19, SARS-CoV-2
COVID-19 Pandemic Response Network
Coronavirus Disease 19 (COVID-19) represents an unprecedented challenge to the operations and population health management efforts of health care systems around the world.
- Conditions
- COVID-19, SARS-CoV-2, Coronavirus, Influenza -Like Illness
- Trial name
- NCT04320862
- Where
- United States
- Volunteers
- 9,207 people, healthy volunteers welcome
- Sponsor
- Duke University
Upper Respiratory Tract Infections, Rhinopharyngitis
Effect of the Consumption of a Fermented Milk on Common Infections in Adults Submitted to Multi-stressor Situation
This multicentric, randomized, double-blind and controlled study aims to examine the effect of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel® = tested product) on the incidence of…
- Conditions
- Upper Respiratory Tract Infections, Rhinopharyngitis, Sore Throat, Sinusitis
- Trial name
- NCT01315418
- Testing
- 1-Fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel®), 2-Non fermented dairy product (control)
- Where
- France
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Respiratory Tract Infections, Upper Respiratory Tract Infections
Smoking Ban and Paediatric Hospital Admissions for Respiratory Tract Infections in England
The purpose of this study is to investigate whether there has been a change in the number of hospital admissions for respiratory tract infections among children following the July 2007 introduction of a ban on smoking in public…
- Conditions
- Respiratory Tract Infections, Upper Respiratory Tract Infections, Lower Respiratory Tract Infections
- Trial name
- NCT01920165
- Testing
- Smoke-free legislation
- Where
- United Kingdom
- Volunteers
- 1,660,652 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
RSV Infections, Lower Respiratory Tract Infections
Real-World Effectiveness of Nirsevimab Against RSV-Related and All-Cause Respiratory Tract Infections in Chinese Infants
A multicenter, retrospective cohort study based on clinical data from seven tertiary hospitals in China will be undertaken. The study aims to evaluate the real-world effectiveness of Nirsevimab in preventing Respiratory Syncytial…
- Trial name
- NCT07382219
- Testing
- Nirsevimab
- Where
- 7 sites in China
- Volunteers
- 816 people, healthy volunteers welcome
- Sponsor
- Han Tongyan
Covid19, COVID-19 Pneumonia
NAC for Attenuation of COVID-19 Symptomatology
The objective of this study is to determine whether oral NAC is effective at attenuating COVID-19 disease symptom severity and duration of symptoms.
- Conditions
- Covid19, COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Lower Respiratory Infection
- Trial name
- NACinCOVID2 (NCT05074121)
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Sepsis, Septic Shock
Molecular Diagnosis and Risk Stratification of Sepsis in India
Background: Globally, sepsis is common with an estimated population incidence of 437 cases per 100, 000 person-years and acute mortality of 26%, one of the few major medical conditions whose incidence and resulting mortality…
- Conditions
- Sepsis, Septic Shock, Sepsis Syndrome
- Trial name
- MARS-India (NCT03727243)
- Where
- India
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Respiratory Syncytial Virus Infections
Efficacy Study of GSK's Investigational Respiratory Syncytial Virus (RSV) Vaccine in Adults Aged 60 Years and Above
This study will evaluate the efficacy of the RSVPreF3 OA investigational vaccine in preventing Lower Respiratory Tract Disease (LRTD) caused by RSV in adults ≥60 years of age following a single dose of the RSVPreF3 OA vaccine and…
- Trial name
- NCT04886596
- Testing
- RSVPreF3 OA vaccine
- Where
- 277 sites in United States, Australia and 15 more
- Volunteers
- 26,675 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline