Clinical trials: Lower Respiratory Infection
Reflux Esophagitis
A Prospective Cohort Study on Endoscopic Features of Upper Gastrointestinal Tract at High Altitude (Zaduo County)
To prospectively enroll participants undergoing gastroscopy at Zaduo County People's Hospital and perform paired analyses with matched cases from Jilin Province.
- Trial name
- NCT07755384
- Testing
- Sedated gastroscopy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jilin University
LRTI, Sepsis
Prospective Study to Characterize Host-pathogen Related Factors in Hospitalized and ED Patients With LRTI and/or Sepsis
The TAILORED-Treatment consortium was established to develop new tools aimed to increase the effectiveness of antibiotic and antifungal therapy, reduce adverse events, and help limit the emergence of antimicrobial resistance in…
- Conditions
- LRTI, Sepsis, Fungal Infections, Bacteremia
- Trial name
- TailoredT (NCT02025699)
- Where
- Israel
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Respiratory Virus Infection
Epidemiology Of Respiratory Virus Infections In Children
This study aims to prospectively estimate the incidence of Respiratory virus (RV) infections in children with symptoms of an upper respiratory tract infection (URTI) or lower respiratory tract infection (LRTI) at St.
- Trial name
- NCT01167361
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- St. Jude Children's Research Hospital
Cystic Fibrosis, Pseudomonas Aeruginosa
Safety of AZLI in Children With Cystic Fibrosis (CF) and Chronic Pseudomonas Aeruginosa in the Lower Airways
This was an open-label, multicenter study in children ≤ 12 years of age with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa (PA) infection in the lower airways using three 28-day courses of Aztreonam for Inhalation…
- Trial name
- PALS (NCT01404234)
- Testing
- AZLI
- Where
- 29 sites in United States, France and 4 more
- Volunteers
- 61 people
- Sponsor
- Gilead Sciences
Pneumonia Childhood, Lower Respiratory Tract Infection
The Norwegian Antibiotics for Pneumonia in Children Study
This study evaluates the effect of amoxicillin in the treatment of lower airway infections in preschool children. Half of the patients will receive amoxicillin, while the other half will receive placebo.
- Trial name
- NAPiC (NCT03446534)
- Testing
- Amoxicillin
- Where
- 9 sites in Norway
- Volunteers
- 884 people
- Sponsor
- Oslo University Hospital
Lower Respiratory Tract Infection (LRTI), Pneumonia
Optimising Antibiotic Use for Paediatric Lower Respiratory Tract Infections in Africa
Lower respiratory tract infections (LRTIs) remain a leading cause of hospitalisation and death among young children in Africa. Although viral infections account for a substantial proportion of LRTIs, antibiotics are frequently…
- Conditions
- Lower Respiratory Tract Infection (LRTI), Pneumonia, Bronchopneumonia, Bronchiolitis
- Trial name
- BEACON (NCT07841691)
- Testing
- CRP- and PREPARE-guided Antibiotic Prescription
- Where
- South Africa
- Volunteers
- 400 people
- Sponsor
- University of Witwatersrand, South Africa
COVID - 19
Vitamin E Supplementation As Adjunctive Therapy To Lower Inflammation In COVID-19 Patients
Since the first reported case of the novel coronavirus (SARS-CoV-2) in humans at the end of 2019 in Wuhan, the virus had infected approximately 100 million individuals.
- Trial name
- VITEC (NCT07412574)
- Testing
- Patients were randomly assigned, under a double-blind design, α-Tocopherol group (n = 22)
- Where
- Mexico
- Volunteers
- 56 people
- Sponsor
- Universidad Veracruzana
Respiratory Tract Infections, Upper Respiratory Tract Infections
Smoking Ban and Paediatric Hospital Admissions for Respiratory Tract Infections in England
The purpose of this study is to investigate whether there has been a change in the number of hospital admissions for respiratory tract infections among children following the July 2007 introduction of a ban on smoking in public…
- Conditions
- Respiratory Tract Infections, Upper Respiratory Tract Infections, Lower Respiratory Tract Infections
- Trial name
- NCT01920165
- Testing
- Smoke-free legislation
- Where
- United Kingdom
- Volunteers
- 1,660,652 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Croup, Bronchiolitis
A Study Evaluating the Use of ResAppDx v2.0 as an Aid to Diagnose Respiratory Disease in Paediatric Patients in an Emergency Department
Aim of study is to demonstrate that the ResAppDx v2.0 algorithms provide an accurate diagnosis of paediatric respiratory disease in the study's clinical setting compared to a Clinical Adjudication Committee's (CAC) diagnosis; and…
- Conditions
- Croup, Bronchiolitis, Asthma in Children, Reactive Airway Disease
- Trial name
- NCT06156436
- Testing
- ResAppDx v.20
- Where
- 5 sites in United Kingdom
- Volunteers
- 75 people
- Sponsor
- ResApp Health Limited
Sore Throat, Dysuria
Digital Online Consultations - Effects on Antibiotic Prescribing and Health Care Utilization in Primary Care
BACKGROUND/SIGNIFICANCE: With developments in mobile health and the abundance of smartphones, online consultations have emerged as a popular form of primary care in Sweden.
- Conditions
- Sore Throat, Dysuria, Cough, Common Cold
- Trial name
- DOCACUP (NCT03474887)
- Testing
- Physical Consultation, Online Consultation
- Where
- Sweden
- Volunteers
- 4,057 people
- Sponsor
- Region Skane
Chronic or Recurrent Appendicitis
Laparoscopic Appendectomy for Chronic Right Lower Abdominal Pain
It is questionable whether elective appendectomy can effectively reduce pain in persistent or recurrent lower abdominal quadrant pain due to chronic appendicitis.
- Trial name
- NCT00413855
- Testing
- laparoscopic appendectomy or not (surgery)
- Volunteers
- 40 people
- Sponsor
- Maxima Medical Center
Respiratory Syncytial Virus (RSV)
Safety and Preliminary Immunogenicity of Recombinant RSV Vaccine （CHO Cell） in Adults Aged 18 Years and Older
This phase 1 study in China will evaluate the Safety and Preliminary Immunogenicity of Recombinant RSV Vaccine (CHO Cell) in Adults Aged 18 Years and Older
- Trial name
- NCT07807449
- Testing
- Recombinant RSV Vaccine (CHO Cell), Adjuvant Suspension, Recombinant RSV Vaccine (CHO Cell) with Adjuvant Suspension
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Yikang Biotech (Suzhou) Co., Ltd.
Bronchiolitis Acute, Lower Respiratory Tract and Lung Infections
Modern Technologies in Lower Respiratory Tract Infections in Children
Lower respiratory tract infections (LRTIs) are a significant cause of childhood morbidity and mortality globally, particularly in low-income countries.
- Conditions
- Bronchiolitis Acute, Lower Respiratory Tract and Lung Infections, Pediatric Lung Ultrasound, Tidal Volume
- Trial name
- MoT-LRTI (NCT07381790)
- Testing
- lung ultrasound, Tidal-flow volume loops
- Where
- 2 sites in Norway
- Volunteers
- 200 people
- Sponsor
- Helse Møre og Romsdal HF
Influenza, Otitis Media
Evaluation of Moderate to Severe Influenza Outcomes in Children
The purpose of this study was to determine whether moderate-severe endpoints (including high fever, lower respiratory tract disease, acute otitis media, or serious extra-pulmonary complications) were predictive of…
- Conditions
- Influenza, Otitis Media, Lower Resp Tract Infection, Encephalitic Infection
- Trial name
- M2SFlu (NCT02979626)
- Testing
- Respiratory nasal swab
- Where
- 2 sites in United States
- Volunteers
- 1,478 people
- Sponsor
- University of Colorado, Denver
Lower Respiratory Tract Infections
Rapid Diagnostic Supporting Antimicrobial Stewardship in Patients With Pneumonia
The purpose of this study is to determine whether or not the FilmArray Penumonia Panel adds value to patient care.
- Trial name
- NCT05937126
- Testing
- FilmArray Pneumonia Panel, Culture and antimicrobial susceptibility testing
- Where
- United States
- Volunteers
- 1,203 people
- Sponsor
- Mayo Clinic
Respiratory Syncytial Virus Lower Respiratory Tract Infection
Dose Ranging Study of ALX-0171 in Infants Hospitalized for Respiratory Syncytial Virus Lower Respiratory Tract Infection
The primary objective is to evaluate the anti-viral effect and safety of different doses of inhaled ALX-0171 in subjects hospitalized for Respiratory Syncytial Virus Lower Respiratory Tract Infection (RSV LRTI).
- Trial name
- Respire (NCT02979431)
- Testing
- ALX-0171 3.0 mg/kg, ALX-0171 6.0 mg/kg, ALX-0171 9.0 mg/kg
- Where
- 74 sites in Belgium, Bulgaria and 15 more
- Volunteers
- 180 people
- Sponsor
- Ablynx, a Sanofi company
Respiratory Syncytial Virus Infection
A One-Year Observation of Palivizumab in Infants at Risk for Respiratory Syncytial Virus Infection in Latin America
The study was designed to gather information regarding the use of palivizumab for the prophylaxis for respiratory syncytial virus (RSV) infection in high-risk infants in selected countries within Latin America.
- Trial name
- NCT01297504
- Where
- 24 sites in Argentina, Chile and 5 more
- Volunteers
- 464 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Pneumonia - Bacterial
Impact of BioFire FilmArray Pneumonia Panel vs Routine Diagnostics on Antimicrobial Outcomes (DOOR-MAT)
Multidrug-resistant bacterial infections are a growing global health concern. Hospital-acquired pneumonia is one of the most common infections occurring during hospitalization and can be associated with high mortality, reaching…
- Trial name
- NCT07585604
- Testing
- Multiplex PCR-based pneumonia panel (BIOFIRE® FILMARRAY® Pneumonia Panel)
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Respiratory Tract Infections
Optimal Collection of Specimens of the Lower Respiratory Tract
Respiratory tract infection is a serious condition causing 3 million deaths worldwide every year. Approximately 20-40% of patients with community-acquired pneumonia are hospitalised.
- Trial name
- NCT04595526
- Testing
- Forced expiratory technique and induced sputum, Tracheal suction
- Where
- Denmark
- Volunteers
- 280 people
- Sponsor
- University of Southern Denmark
Pneumonia, Viral, Ventilator Associated Pneumonia
Acyclovir in Ventilated Patients With Pneumonia and HSV-1 in BAL
Almost 90 out of 100 people carry herpes simplex viruses (HSV). Once a person has been infected with the herpes viruses, he or she can't get rid of them for the rest of her/his life.
- Conditions
- Pneumonia, Viral, Ventilator Associated Pneumonia, Community-acquired Pneumonia, Herpes Simplex
- Trial name
- HerpMV (NCT06134492)
- Testing
- Acyclovir
- Where
- 28 sites in Germany
- Volunteers
- 616 people
- Sponsor
- Jena University Hospital