Clinical trials: Lower Urinary Tract Injury
Pelvic Organ Prolapse, Urinary Incontinence
Chlorhexidine vs. Iodine for Vaginal Preparation in Urogynecologic Procedures
This is a randomized controlled trial to determine if there is a difference between chlorhexidine gluconate and povidone iodine vaginal preparations for urogynecological surgery post operative infections.
- Conditions
- Pelvic Organ Prolapse, Urinary Incontinence, Pelvic Floor Disorders, Gynecologic Disease
- Trial name
- CLNUP (NCT04048356)
- Testing
- Vaginal scrub, to be applied vaginally and perineally immediately prior to surgery.
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Spinal Cord Injuries, Lower Urinary Tract Symptoms
Efficacy of Electrical Pudendal Nerve Stimulation for Neurogenic Lower Urinary Tract Dysfunction
The main goal to treat early NLUTS is to relieve lower urinary tract syndrome and prevent from late complications. The present study is to evaluate the efficacy of electrical pudendal nerve stimulation (EPNS) and…
- Conditions
- Spinal Cord Injuries, Lower Urinary Tract Symptoms, Dysuria, Incontinence
- Trial name
- NCT02554201
- Testing
- Electrical pudendal nerve stimulation, Transvaginal electrical stimulation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Neurogenic Lower Urinary Tract Dysfunction
Somatosensory Evoked Potentials From the Lower Urinary Tract
Spinal cord injury and other systemic neurological diseases (Multiple Sclerosis, Parkinson's disease) affect the integrity of lower urinary tract (LUT) function, leading to neurogenic lower urinary tract dysfunction (NLUTD).
- Trial name
- NCT02449512
- Where
- Switzerland
- Sponsor
- Swiss Paraplegic Research, Nottwil
Spinal Cord Injuries, Neurogenic Lower Urinary Tract Dysfunction
Time Needed to Perform Intermittent Catheterization in Adults With Spinal Cord Injuries
This study investigates the burden of intermittent catheterization in adult individuals with neurogenic lower urinary tract dysfunction (NLUTD) following spinal cord injury (SCI).
- Trial name
- NCT05003999
- Testing
- HPC - SpeediCath ®, Non-HPC - Self-Cath ®
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Andrei Krassioukov
Mild Cognitive Impairment, Spinal Cord Injuries
Effects of Antimuscarinics on Cognition in Spinal Cord Injury
Prospective evaluation of the cognitive function of in-house patients suffering from an acute traumatic spinal cord injury before and three months after the initiation of antimuscarinic treatment.
- Trial name
- NCT01600404
- Testing
- antimuscarinic treatment
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Urinary Bladder, Neurogenic
Ambulatory Closed-loop Stimulation for Bladder Control
Individuals with spinal cord injury (SCI) develop neurogenic detrusor overactivity (NDO), resulting in urinary incontinence, decreased bladder capacity, and reduced quality of life.
- Trial name
- NCT05740527
- Testing
- Noninvasive electrical stimulation of genital nerves
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- MetroHealth Medical Center
Spinal Cord Injuries, Neurogenic Lower Urinary Tract Dysfunction
Patient and Caregiver Perspectives on Intravesical Instillations for Urinary Symptoms
The goal of this observational qualitative study is to learn about the experiences and perspectives of patients with neurogenic lower urinary tract dysfunction (NLUTD) and their caregivers regarding different types of…
- Conditions
- Spinal Cord Injuries, Neurogenic Lower Urinary Tract Dysfunction, Neurogenic Bladder
- Trial name
- NCT07390591
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medstar Health Research Institute
Overactive Bladder, Urinary Incontinence
Botulinum-A Toxin Injection for Detrusor Hyperreflexia in Spinal Cord Injury: A Non-Surgical Approach.
The purpose of the study is to determine whether Botulinum-A toxin injected in the bladder muscle will help prevent the frequency and degree of urinary incontinence in Spinal Cord Injured and Multiple Sclerosis patients.
- Trial name
- NCT00262496
- Testing
- Botox
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Urinary Incontinence, Spinal Cord Injury
Lumbar to Sacral Ventral Nerve Re-Routing
To assess the level of improvement in voiding function after lumbar to sacral ventral nerve re-routing procedure in Spinal Cord Injury and spina bifida patients
- Conditions
- Urinary Incontinence, Spinal Cord Injury, Spina Bifida
- Trial name
- NCT00378664
- Testing
- lumbar to sacral ventral nerve re-routing procedure
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Kenneth Peters, MD
Bladder Outlet Obstruction, Multiple Sclerosis
GentleCath™ for Men Intermittent Catheter With FeelClean™ Technology
Male self catherterisng observational study.
- Conditions
- Bladder Outlet Obstruction, Multiple Sclerosis, Cauda Equina Syndrome, Enlarged Prostate With Lower Urinary Tract Symptoms
- Trial name
- NCT05470751
- Testing
- Intermittent self-catheterisation
- Where
- 16 sites in United States, France and 1 more
- Volunteers
- 72 people
- Sponsor
- ConvaTec Inc.
Overactive Bladder
OnabotulinumtoxinA (onaBoNT-A) Versus Oral Oxybutynin ER
Overactive bladder is a condition associated with symptoms of feeling the urge to urinate, urinating often, and may or may not be accompanied by leakage of urine.
- Trial name
- NCT01050114
- Testing
- onaBoNT-A, Oxybutynin ER
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Christopher Patrick Smith
Spinal Cord Injuries, Neurogenic Bladder Disorder
Medico-economical Impact of the Brindley Neurosurgical Technique in France
Bladder dysfunction is a major problem in patients with complete spinal cord lesions. For patients presenting incontinence or risk for kidney, two major conventional alternatives are possible : conservative therapies (muscarinic…
- Conditions
- Spinal Cord Injuries, Neurogenic Bladder Disorder, Paraplegia, Quadriplegia
- Trial name
- BRINDLEY (NCT00221767)
- Testing
- Brindley technique (bladder system)
- Where
- France
- Volunteers
- 53 people
- Sponsor
- University Hospital, Bordeaux
Overuse Injury, Urinary Incontinence
Prevention and Treatment of Injuries and Urinary Incontinence Among Norwegian Rhythmic Gymnasts
Overuse injuries are common among competitive Norwegian rhythmic gymnasts with a mean weekly prevalence of 37% [95% CI: 36 - 39%] and incidence of 4.2 new overuse injuries [95% CI: 3.6 - 4.9] per gymnast per year (Gram, M.…
- Trial name
- NCT05506579
- Testing
- Exercises for knees, lower back, hip/groin and pelvic floor muscles in an expanded warm up program
- Where
- Norway
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Spinal Cord Injury, Urinary Incontinence
Two Devices for Reflex Voiding Following Spinal Cord Injury
The purpose of this investigation is to evaluate methods in spinal cord injured individuals to improve reflex urination. Anal dilation will be investigated to reduce high urethral resistance and a vibrator on the patient's bottom…
- Trial name
- NCT00662207
- Testing
- Vibrator, Anal dilator
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- US Department of Veterans Affairs
Neurogenic Lower Urinary Tract Dysfunction, Multiple Sclerosis
Supraspinal Control of Lower Urinary Tract Function in Healthy Controls and Patients With Bladder Dysfunction
The purpose of this study is to provide profound insight into the supraspinal neuronal mechanisms and networks responsible for lower urinary tract (LUT) control and to verify, amend or adjust neuronal circuitry models established…
- Conditions
- Neurogenic Lower Urinary Tract Dysfunction, Multiple Sclerosis, Overactive Bladder, Spinal Cord Injury
- Trial name
- NCT01768910
- Testing
- fMRI, bladder filling, bladder cooling
- Where
- 2 sites in Switzerland
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Urinary Incontinence, Overactive Bladder
Dysport® Treatment of Urinary Incontinence in Adults Subjects With Neurogenic Detrusor Overactivity (NDO) Due to Spinal Cord Injury or Multiple Sclerosis - Study 1
The purpose of this study is to provide confirmatory evidence of the safety and efficacy of two Dysport® (AbobotulinumtoxinA) doses (600 units [U] and 800 U), compared to placebo in reducing urinary incontinence (UI) in adult…
- Trial name
- CONTENT1 (NCT02660138)
- Testing
- Botulinum toxin type A
- Where
- 81 sites in United States, Canada and 8 more
- Volunteers
- 227 people
- Sponsor
- Ipsen
Spinal Cord Injuries (SCI), Neurogenic Lower Urinary Tract Dysfunction
Radio-frequency (RF) Bladder Monitor
The goal of this pilot feasibility study is to evaluate a wearable microwave (MW)-based bladder monitoring system in adult volunteers and those with spinal cord injury (SCI) who use self-catheterization for bladder management.
- Conditions
- Spinal Cord Injuries (SCI), Neurogenic Lower Urinary Tract Dysfunction, Neurogenic Bladder (NB)
- Trial name
- NCT07639541
- Testing
- Wearable microwave Bladder Monitoring System
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pelvic Floor Disorders, Sport Injury
Quality and Behavior of Pelvic Floor in Runner Women
The main objective is to analyze the relationship between the PF muscles and the other variables along the different tasks of daily life and during the race.
- Conditions
- Pelvic Floor Disorders, Sport Injury, Stress Urinary Incontinence
- Trial name
- NCT03934996
- Testing
- Runners with educational training
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Malaga
Overactive Bladder
A Long-term Follow-up Study of Botulinum Toxin Type A in Patients With Overactive Bladder as a Result of Spinal Injury or Multiple Sclerosis
The purpose of this study is to assess the long-term safety and effectiveness of botulinum toxin type A on patients with overactive bladder as a result of spinal cord injury or multiple sclerosis.
- Trial name
- NCT00876447
- Testing
- Botulinum Toxin Type A 300U, Botulinum Toxin Type A 200U
- Where
- 22 sites in United States, Australia and 20 more
- Volunteers
- 397 people
- Sponsor
- Allergan
Neurogenic Bladder Dysfunction
Chronic Electrical Stimulation to Reduce Bladder Hyperreflexia
Bladder spasms after spinal cord injury (SCI) can result in incontinence, urinary tract infections, kidney damage, trigger dangerous increases in blood pressure and decrease independence and quality of life.
- Trial name
- NCT03472599
- Testing
- Genital Nerve Stimulation
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development