Clinical trials: Lower Urinary Tract Symptoms
Stress Urinary Incontinence
A Study of TAS-303 in Female Patients With Stress Urinary Incontinence
The purpose of this study is to evaluate pharmacological effect, safety and pharmacokinetic of TAS-303 in female patients with Stress Urinary Incontinence.
- Trial name
- NCT02562807
- Testing
- TAS-303 18mg single-dose, TAS-303 9mg single-dose
- Where
- Japan
- Volunteers
- 16 people
- Sponsor
- Taiho Pharmaceutical Co., Ltd.
Stress Urinary Incontinence
Comparison of the Viveve Treatment and Cryogen-Only Treatment Versus Sham Treatment for Stress Urinary Incontinence
This is a prospective, randomized, single-blind, study comparing both the Viveve Treatment (RF plus cryogen) and cryogen alone treatment versus sham treatment in patients with mild to moderate stress urinary incontinence.
- Trial name
- NCT04206085
- Testing
- Viveve - Active, Viveve - Cryogen-Alone
- Where
- 3 sites in Canada
- Volunteers
- 38 people
- Sponsor
- Viveve Inc.
Urge Urinary Incontinence
Post Approval Effectiveness and Durability Evaluation of the Altaviva™ Tibial Device
The purpose of this prospective, multicenter study is to assess the long-term safety and effectiveness of the Altaviva™ system for the treatment of UUI
- Trial name
- ENDURANCE™ (NCT07456865)
- Testing
- Altaviva™ system
- Where
- 19 sites in United States
- Volunteers
- 256 people
- Sponsor
- MedtronicNeuro
Urinary Incontinence, Stress, Mixed Incontinence
Treatment for Stress and Mixed Urinary Incontinence and Vaginal Vault Prolapse
The primary objective of this study is to further evaluate the safety and effectiveness of the use of a sling device in women for stress and mixed urinary incontinence as well as vaginal vault prolapse.
- Conditions
- Urinary Incontinence, Stress, Mixed Incontinence, Vaginal Vault Prolapse
- Trial name
- NCT00223106
- Testing
- Vaginal Sling
- Where
- United States
- Volunteers
- 467 people
- Sponsor
- Medtronic - MITG
Stress Urinary Incontinence
The Altis® Single Incision Sling System for Female Stress Urinary Incontinence Study
An international, multi-center, single arm, prospective clinical study designed to assess the safety and efficacy of the Coloplast Altis single incision sling system for females with stress urinary incontinence (SUI).
- Trial name
- NCT01272284
- Testing
- Altis® Single Incision Sling System (SIS)
- Where
- 17 sites in United States, Canada
- Volunteers
- 113 people
- Sponsor
- Coloplast A/S
Hyperplasia
Efficacy And Safety Study Of Naftopidil to Patients Treatment With LUTS
The purpose of this study is to evaluate the effectiveness and safety of Naftopidil and Tamsulosin in the treatment of lower urinary tract symptoms through a comparative study of patients with benign prostatic hyperplasia.
- Trial name
- NCT01203371
- Testing
- Naftopidil, Tamsulosin
- Where
- Brazil
- Sponsor
- Apsen Farmaceutica S.A.
Urinary Bladder, Overactive
Voiding Efficiency, a Predictor of Clean Intermittent Catheterization (CIC)
This study is a retrospective chart review of patients treated with onabotulinumtoxinA (BOTOX®) for idiopathic overactive bladder (OAB) and will determine voiding efficiency (VE) cutoff ratios that predict post-procedure urinary…
- Trial name
- NCT03043287
- Testing
- onabotulinumtoxinA
- Where
- 3 sites in United States
- Volunteers
- 420 people
- Sponsor
- Allergan
Urinary Bladder, Overactive
A Double-Blind, Paralleled Study Comparing Efficacy/Safety of Solifenacin to Tolterodine in Overactive Bladder Patients
To evaluate the efficacy and safety of solifenacin succinate (Vesicare) 5mg OD in subjects with overactive bladder compared to tolterodine wmg, bid
- Trial name
- NCT00368706
- Testing
- solifenacin succinate, tolterodine
- Where
- 4 sites in China
- Volunteers
- 246 people
- Sponsor
- Astellas Pharma Inc
Healthy Volunteer, Pharmacokinetics of YM178
A Study to Investigate the Food Effect on the Pharmacokinetics of YM178 in Healthy, Non-elderly Volunteers
The purpose of the study is to evaluate the effect of food intake on the pharmacokinetics of YM178 in healthy, non-elderly adult subjects.
- Trial name
- NCT00965926
- Testing
- YM178
- Where
- Japan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Overactive Bladder
To Evaluate the Efficacy and Safety of JLP-2002 on Symptoms of Overactive Bladder
Overactive bladder (OAB) is a clinical condition characterized by urgency (i.e., urinary urinary urinary urgency that is difficult to delay and unbearable) with or without urge incontinence, usually associated with frequency and…
- Trial name
- NCT04917315
- Testing
- JLP-2002 A mg
- Where
- South Korea
- Volunteers
- 210 people
- Sponsor
- Jeil Pharmaceutical Co., Ltd.
Urinary Bladder, Overactive
Study to Assess the Efficacy and Safety of the Beta-3 Agonist Mirabegron (YM178) in Patients With Symptoms of Overactive Bladder
The study is intended to test efficacy, safety and tolerability of two doses of Mirabegron against placebo and compare the efficacy and safety with active comparator in patients with symptoms of overactive bladder.
- Trial name
- SCORPIO (NCT00689104)
- Testing
- Mirabegron, Tolterodine
- Where
- 218 sites in Australia, Austria and 28 more
- Volunteers
- 2,336 people
- Sponsor
- Astellas Pharma Inc
Nocturia
Exploratory Study Evaluating the Effects of Darifenacin on Nocturia, Sleep and Daytime Wakefulness
The purpose of this study is to evaluate the efficacy of darifenacin in the treatment of moderate to severe nocturia in patients with overactive bladder and who do not have non-urologic causes of nocturia.
- Trial name
- NCT01018225
- Testing
- darifenacin
- Sponsor
- Cognitive Research Corporation
Benign Prostatic Hyperplasia
Observational Study to Evaluate Effect of Thrupas® Capsule on Cardiovascular System
To evaluate effect on cardiovascular system(blood pressure) when Thrupas® capsule is administered every day for 12 weeks in patients with Lower Urinary Tract Symptoms suggestive of Benign Prostatic Hyperplasia
- Trial name
- CV (NCT02029560)
- Where
- 4 sites in South Korea
- Volunteers
- 400 people
- Sponsor
- JW Pharmaceutical
Urinary Incontinence
Study of OnabotulinumtoxinA (BOTOX®) for Urinary Incontinence Due to Neurogenic Detrusor Overactivity in Pediatric Patients
This study will evaluate the 3 doses of onabotulinumtoxinA (botulinum toxin Type A) for the treatment of urinary incontinence due to neurogenic detrusor overactivity in pediatric participants between the ages of 5 to 17 years to…
- Trial name
- NCT01852045
- Testing
- OnabotulinumtoxinA
- Where
- 31 sites in United States, Belgium and 6 more
- Volunteers
- 114 people
- Sponsor
- Allergan
Lower Urinary Tract Symptoms (LUTS)
Establishing Normative Urodynamics Parameters for the Glean Urodynamics System in Healthy Adults
A prospective, open-label, single arm interventional trial to establish normative reference ranges for urodynamics parameters in healthy adult participants using using the Glean Urodynamics System.
- Trial name
- NCT07485205
- Testing
- Glean Urodynamics System
- Where
- 3 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Bright Uro
Stress Urinary Incontinence
A Phase 2a Study To Evaluate VMB-100 In Females With Stress Urinary Incontinence
The study drug VMB-100 is an mRNA encoding for IGF-1. It is administered by injection into the urethra sphincter, and taken up by the muscle cells.
- Trial name
- NCT06247241
- Testing
- VMB-100
- Sponsor
- Versameb AG
Nocturia
Multicenter Study to Investigate SER120 Nasal Spray Formulations in Patients With Nocturia
The purpose of this study is to investigate the efficacy and safety of SER120 nasal spray formulations in patients with nocturia for a total duration of 14 weeks.
- Trial name
- NCT01357356
- Testing
- SER120 (750 ng/day), SER120 (1000 ng/day), SER120 (1500 ng/day)
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Serenity Pharmaceuticals, Inc.
Overactive Bladder
A Study to Evaluate the Efficacy and Safety of DA-8010 in Patients With Overactive Bladder
This study will evaluate the efficacy and safety of DA-8010 in patients with overactive bladder for 12 weeks as double-blind, placebo-controlled and active-reference study, and also will evaluate the long-term safety of DA-8010…
- Trial name
- NCT05282069
- Testing
- DA-8010 2.5mg, DA-8010 5mg, Solifenacin 5mg
- Where
- South Korea
- Volunteers
- 607 people
- Sponsor
- Dong-A ST Co., Ltd.
Overactive Bladder (OAB)
Evaluation of a Non-Implanted Electrical Stimulation Device for Overactive Bladder (OAB)
A study to evaluate the safety and effectiveness of FemPulse System
- Trial name
- EVANESCE-II (NCT07195656)
- Testing
- Device Group, Medication Group
- Where
- 15 sites in United States
- Volunteers
- 151 people
- Sponsor
- FemPulse Corporation
Urinary Incontinence
Study of Pant Type Absorbing Urinary Incontinence Products
Pre-market feasibility clinical investigation designed to evaluate the clinical performance and safety of the investigational product in its intended target population
- Trial name
- NCT05031442
- Testing
- RH1 (low waist), Reference variant 1 (low waist), RC2 (high waist)
- Where
- 3 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Essity Hygiene and Health AB