Clinical trials: Lower Urinary Tract Symptoms
Bladder Outlet Obstruction and Detrusor Underactivity in Women With Severe Cystocele
BOO and DU and Their Clinical and Urodynamic Findings in Women With ≥Stage II Cystocele
Prevalence rates of bladder outlet obstruction (BOO) and detrusor underactivity (DU) and their related clinical and urodynamic findings in women with ≥ pelvic organ prolapse quantification stage II cystocele are important for…
- Trial name
- NCT03613324
- Testing
- Pad test
- Volunteers
- 455 people
- Sponsor
- National Taiwan University Hospital
Urinary Bladder, Overactive, Effect of Drug
Efficacy of Combined Pharmacotherapy Versus Solifenacin With Vaginal Estrogen Cream for Women With Detrusor Overactivity
To investigates the effects of combined pharmacotherapy with solifenacin and mirabegron versus solifenacin with vaginal estrogen cream in women with detrusor overactivity.
- Trial name
- NCT06197295
- Testing
- Solifenacin with vaginal estrogen cream, Combination pharmacotherapy
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Mackay Memorial Hospital
Superficial Bladder Cancer, Lower Urinary Tract Symptoms
Intravesical Natural Baobab Oil in the Management of BCG-induced Lower Urinary Tract Symptoms
Baobab oil is often used in traditional medicine as antipyretic, antioxidant, anti-inflammatory, analgesic and antimicrobial. It also regenerates the epithelial tissue in a short time improving tone and elasticity.
- Trial name
- Baobab (NCT01939756)
- Testing
- Intravesical baobab oil
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Savino M. Di Stasi
Overactive Bladder (OAB)
Transcutaneous Tibial Nerve Stimulation Therapy in Children With Overactive Bladder
Overactive bladder (OAB) is a syndrome characterized by urinary urgency, often accompanied by frequency and nocturia, with or without urge incontinence, without urinary tract infection or other clear pathological changes.
- Trial name
- NCT06765629
- Testing
- Non-invasive Percutaneous Tibial Nerve Stimulation (TTNS) group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Transcutaneous Electrical Nerve Stimulation, Urgent Urinary Incontinence
The Effectiveness of Parassacral Transcutaneous Stimulation Compared to Tibial Transcutaneous Stimulation, Home Protocol and Behavioral Therapy in the Treatment of Female Hyperative Bladder: Randomized Clinical Trial
Introduction: The overactive bladder is a highly prevalent condition, which negatively impacts the quality of life and daily activities of women.
- Conditions
- Transcutaneous Electrical Nerve Stimulation, Urgent Urinary Incontinence, Bladder Hyperactive, Women
- Trial name
- NCT04909047
- Testing
- parassacral transcutaneous electrostimulation
- Where
- 3 sites in Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centro de Atenção ao Assoalho Pélvico
Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia
Open-Label Extension Study of MCS-2 in the Treatment of Lower Urinary Tract Symptoms
This is an open-label extension study of another study protocol, MCS-2-TWN-a. Subjects who have completed the 12-week treatment and procedures under the protocol MCS-2-TWN-a will be eligible for this study.
- Trial name
- MCS-2-TWN-c (NCT01002274)
- Testing
- MCS-2
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Health Ever Bio-Tech Co., Ltd.
Mixed Urinary Incontinence, Stress Urinary Incontinence
The SLIM Study: Sling and Botox® Injection for Mixed Urinary Incontinence
This double-blind randomized controlled trial seeks to find a better treatment for women with mixed urinary incontinence (both stress and urgency incontinence).
- Conditions
- Mixed Urinary Incontinence, Stress Urinary Incontinence, Urgency Incontinence
- Trial name
- NCT02678377
- Testing
- OnabotulinumtoxinA (Botox ®) Injections, Saline Injections
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Northwestern University
Stress Urinary Incontinence
Durability Extension Study to Assess Clinical Activity and Safety of Enobosarm (GTx-024) in Stress Urinary Incontinence
The study will enroll only from the first 225 subjects who were randomly assigned to treatment in G201002 (irrespective of the treatment allocation, i.e., GTx-024 or placebo) and who have completed the 12-week treatment period…
- Trial name
- NCT03508648
- Testing
- GTx-024
- Where
- 46 sites in United States
- Sponsor
- GTx
Stress Urinary Incontinence
FEASIBILITY STUDY OF TELE-REHABILITATION IN WOMEN WITH STRESS URINARY INCONTINENCE
Tele-rehabilitation involves health care services, support and information provided remotely via digital communication and devices.
- Trial name
- NCT06241378
- Testing
- perineometer device for physiotherapy
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Benign Prostatic Hyperplasia
Transperineal Irreversible Electroporation for Benign Prostatic Hyperplasia
This clinical trial focuses on men with benign prostatic hyperplasia (BPH), a condition in which an enlarged prostate causes urinary problems.
- Trial name
- NCT06867315
- Testing
- Composite steep-pulse therapeutic device (CNP-III)
- Where
- 10 sites in China
- Volunteers
- 99 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Nocturia, Sleep Disorder
Effectiveness of Bryophyllum in Nocturia-Therapy
Night-time micturition, called nocturia, is a very common problem that unfavourably influences sleep- and life-qualities. The International Continence Society (ICS) defines nocturia as micturition once or several times during the…
- Trial name
- NCT04480658
- Testing
- Bryophyllum pinnatum 50 %, tablets into capsules (verum: 2x2capsules/day)
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Urinary Stress Incontinence
Study Comparing the Use of Laser and of Kinesiotherapy for the Treatment of Female Stress Urinary Incontinence
The purpose of this study is compare the effect of laser and of kinesiotherapy in the treatment of women with stress urinary incontinence
- Trial name
- NCT03301142
- Testing
- Laser, kinesiotherapy
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Overactive Bladder
Treatment of MEDITOXIN® in Female Patients With Idiopathic Overactive Bladder
To investigate the safety of MEDITOXIN in female subjects with idiopathic overactive bladder compared with BOTOX
- Trial name
- NCT03371342
- Testing
- Meditoxin, Botox
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Medy-Tox
Stress Urinary Incontinence
Feasibility of Resisted Expiratory Muscle Training for Females Assigned at Birth With Stress Urinary Incontinence: A Pilot Study
The goal of this randomized pilot study is to determine whether adding expiratory muscle strength training (EMST) to standard pelvic floor muscle training (PFMT) is feasible and may help improve stress urinary incontinence (SUI)…
- Trial name
- NCT07905586
- Testing
- Pelvic floor muscle training, Expiratory muscle strength training
- Volunteers
- 24 people
- Sponsor
- Thomas Jefferson University
Stress Urinary Incontinence
PelviSense, an Innovative, Non-invasive, Biofeedback Device for the Treatment of Stress Urinary Incontinence in Women
Background and purpose: The research team developed the PelviSense, a non-invasive biofeedback device paired with wearable EMG sensors for use as a PFMT adjunct.
- Trial name
- NCT06126757
- Testing
- PelviSense-assisted pelvic floor muscle training, Active Comparator
- Where
- Hong Kong
- Volunteers
- 132 people
- Sponsor
- The Hong Kong Polytechnic University
Spinal Cord Injuries, Urinary Bladder, Overactive
Prevention of Bladder Dysfunction in Acute Spinal Cord Injury
This study is a double blind, randomized, placebo controlled trial to explore the effect of early treatment with Onabotulinumtoxin A in patients with acute complete motor spinal cord injury (SCI) on the development of neurogenic…
- Trial name
- BOT-SCI (NCT01698138)
- Testing
- Onabotulinumtoxin A
- Where
- 2 sites in Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Overactive Bladder
A Single Dose Study of the Pharmacokinetics of Vibegron (MK-4618) in Participants With Renal Insufficiency (MK-4618-014)
This study will investigate the impact of impaired renal function on the plasma pharmacokinetics of vibegron (MK-4618) to guide use of vibegron in clinical trials in participants with overactive bladder and to guide…
- Trial name
- NCT01628042
- Testing
- Vibegron 100 mg
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Stress Urinary Incontinence
Comparison of Two Different Pelvic Floor Muscle Training Programs in Stress Urinary Incontinence
Pelvic floor muscle training (PFMT) is indicated as a first-line treatment for stress urinary incontinence. PFMT aims to improve pelvic floor muscle strength, endurance and relaxation ability or a combination of these.
- Trial name
- NCT05293886
- Testing
- Classical Pelvic Floor Muscle Training, Functional Pelvic Floor Muscle Training
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Hacettepe University
Urinary Incontinence, Stress
Outpatient and Home Pelvic Floor Training for Stress Urinary Incontinence
The objective of this study is to compare the effect of outpatient pelvic floor muscle training versus home pelvic floor muscle training in the treatment of stress urinary incontinence.
- Trial name
- NCT03058042
- Testing
- Exercises of the pelvic floor muscle at home, Exercises of the pelvic floor muscle in the outpatient
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- Federal University of São Paulo
Urinary Incontinence, Pelvic Floor Disorders
Home Biofeedback or Pelvic Floor Physical Therapy for Postpartum Urinary Incontinence.
Pelvic floor dysfunction is commonly seen in the postpartum women with symptoms including urinary urgency and frequency, urinary incontinence and fecal incontinence.
- Trial name
- NCT05194462
- Testing
- Pericoach® by Analytica, Pelvic Floor Physical Therapy
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)