Clinical trials: Lumbar Back Pain
Chronic Low-back Pain
Multidisciplinary Digital Therapeutics of Chronic Lower Back Pain Versus Usual Care
This randomized controlled pilot study will be evaluating an app, MORT-LBP app (ETH-02K), owned by EverEx, Inc., to examine safety and efficacy in individuals with chronic lower back pain.
- Trial name
- NCT05940025
- Testing
- MORT-LBP, treatment as usual (TAU)
- Where
- 2 sites in South Korea
- Volunteers
- 46 people
- Sponsor
- EverEx Inc.
Low Back Pain
Evaluation of the Effect of Lumbar Belt on Spinal Mobility in Subjects With and Without Low Back Pain
Low back pain (LBP) is a common condition worldwide as the lifetime prevalence is up to 80%. It is defined as pain in the lumbosacral region in which the etiological causes are most often mechanical, and it is therefore defined…
- Trial name
- LombaMob (NCT05600543)
- Testing
- Lumbar belt, Lombaskin lumbar belt and the Lyne Up percko postural T-shirt.
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Thuasne
Low Back Pain
Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) for Uncontrolled Moderate - Severe Low Back Pain
The primary objective is to assess the efficacy of oxycodone/naloxone (OXN) for the management of opioid-induced constipation (OIC) compared to oxycodone controlled-release tablets (OXY) in subjects with moderate to severe low…
- Trial name
- NCT01427270
- Testing
- Oxycodone/Naloxone controlled-release, Oxycodone HCl controlled-release
- Where
- 194 sites in United States, Czechia and 2 more
- Volunteers
- 455 people
- Sponsor
- Purdue Pharma LP
Low Back Pain, Sciatica
BOL-DP-o-04 in Patients With Low Back Pain and Sciatica
The study is aimed to evaluate the pain-relieving effect of BOL-DP-o-04, in addition to SOC, on Low Back Pain and Sciatica.
- Trial name
- NCT04145310
- Testing
- BOL-DP-o-04 + SCO
- Where
- Israel
- Volunteers
- 26 people
- Sponsor
- Breath of Life International Pharma Ltd
Chronic Low-back Pain, Chronic Leg Pain
A First in Human Feasibility Study to Evaluate the Safety and Effectiveness of the BIOTRONIK Prospera SCS System with HomeStream Remote Management
The BENEFIT-03 Clinical Study is a first in human, prospective, multi-center, single-arm, interventional feasibility study to be conducted in Australia.
- Trial name
- NCT04683718
- Testing
- Permanent implant of a BIOTRONIK Prospera SCS (Spinal Cord Stimulation) System with HomeStream Remote Management
- Where
- 5 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Biotronik, Inc.
Low Back Pain
Clinical Efficacy and Safety of Axiom Worldwide DRX9000 Axial Decompression System for Treatment of Low Back Pain
This study will document efficacy and safety of the Axiom Worldwide DRX9000™ for treatment of low back pain (LBP) in a prospective, randomized, crossover, multicenter trial utilizing a standardized clinical research multimodal…
- Trial name
- NCT00469118
- Testing
- DRX9000™
- Where
- United States
- Sponsor
- NEMA Research, Inc.
Acute Low-back Pain
Efficacy and Safety of Etoricoxib/Cyanocobalamin Versus Etoricoxib for Acute Low Back Pain
Phase III longitudinal, multicenter, randomized, double-blind clinical trial. The aim of this study is to evaluate the efficacy and safety of the Fixed-Dose Combination of Etoricoxib/Cyanocobalamin Versus Etoricoxib in Patients…
- Trial name
- NCT06517823
- Testing
- Etoricoxib + Cyanocobalamin fixed dose, Etoricoxib fixed dose
- Where
- Mexico
- Volunteers
- 190 people
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Chronic Non-specific Low Back Pain
Comparison of VER-01 to Opioids in Patients With Chronic Non-specific Low Back Pain
Randomized, open-label, parallel-group phase III trial to prove an additional benefit of the full-spectrum cannabis extract VER-01 over opioids in patients with chronic non-specific low back pain for whom drug treatment is…
- Trial name
- ELEVATE (NCT05610813)
- Testing
- VER-01, Opioid therapy
- Where
- 2 sites in Germany
- Volunteers
- 384 people
- Sponsor
- Vertanical GmbH
Low Back Pain
The Intracept Global Registry ( TIGR ) - Pilot Study
The Intracept Global Registry is a prospective, noninterventional, observational global post market independent data collection of the ongoing effectiveness, safety, and satisfaction outcomes for patients treated with the…
- Trial name
- NCT04449835
- Testing
- Intracept Procedure
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Relievant Medsystems, Inc.
Chronic Pain, Low Back Pain
A Prospective, Multi-site, Randomized, Sham-Controlled, Double-Blind Trial With One-Way Crossover Designed to Assess the Effectiveness and Safety of the Gimer NeuroBlock SCS Trialing System for the Treatment of Chronic Back Pain and/or Lower Limb Pain
This study is a prospective, multi-site, randomized, shamcontrolled, double-blind trial with one-way crossover designed to assess the effectiveness and safety of the Gimer NeuroBlock SCS Trialing System for the treatment of…
- Conditions
- Chronic Pain, Low Back Pain, Lower Limb Pain
- Trial name
- NCT04693650
- Testing
- NeuroBlock UHF stimulation
- Where
- 4 sites in Taiwan
- Volunteers
- 22 people
- Sponsor
- GiMer Medical
Pain, Pain, Chronic
Long Term Use of a High Energy Pulsed Heating Device in the Management of Chronic Pain
The purpose of this study is to evaluate the Soovu Labs pain Relief System in a group of users that represent people most likely to purchase and use the units. This study is called an In Home Users Trial (IHUT).
- Conditions
- Pain, Pain, Chronic, Pain, Back
- Trial name
- NCT04407884
- Testing
- Soovu Labs Inc. Pain Relief System
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Soovu Labs Inc.
Degenerative Disc Disease
Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain
This is a prospective, multicenter, randomized, double-blind, placebo-controlled Phase 3 study designed to evaluate the safety and efficacy of Mesoblast's rexlemestrocel-L alone or combined with hyaluronic acid (HA) in…
- Trial name
- MSB-DR003 (NCT02412735)
- Testing
- Rexlemestrocel-L, Rexlemestrocel-L + HA Mixture
- Where
- 48 sites in United States, Australia
- Volunteers
- 404 people
- Sponsor
- Mesoblast, Ltd.
Low Back Pain
Assessing the Impact of the Axomove Therapy Medical Device on Low Back Pain Patients
An evaluation study of the impact of the Axomove Therapy® medical device on subacute or chronic low back pain patients leaving rehabilitation centres to facilitate self-rehabilitation.
- Trial name
- AVA-PREPA (NCT05910463)
- Testing
- AXOMOVE Therapy Medical Device
- Where
- France
- Volunteers
- 190 people
- Sponsor
- Axomove
Chronic Low Back Pain, Leg Pain
MIS MiLIF Versus Open
This study is being undertaken to compare the clinical outcomes of patients that have unilateral posterolateral lumbar interbody fusion using a traditional open approach versus the MiLIF procedure based on the MiCOR Precision…
- Trial name
- NCT00792129
- Testing
- The Atavi System
- Where
- 9 sites in United States
- Volunteers
- 113 people
- Sponsor
- Zimmer Biomet
Chronic Low-back Pain, Degenerative Disc Disease
Safety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back Pain
The brief purpose of this research study is to learn about the safety, tolerability, and efficacy of paraspinal intramuscular injection of CELZ-201-DDT in patients with chronic lower back pain.
- Trial name
- ADAPT (NCT06053242)
- Testing
- CELZ-201-DDT
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Creative Medical Technology Holdings Inc
Low Back Pain
Long Term Safety Study of Tanezumab in Chronic Low Back Pain
The purpose of this study is to investigate the safety and efficacy of tanezumab for chronic low back pain. Patients who were randomized and treated with study medication in a previous chronic low back pain "parent" study will be…
- Trial name
- NCT00924664
- Testing
- Tanezumab 20 mg, Tanezumab 10 mg
- Where
- 149 sites in United States
- Volunteers
- 849 people
- Sponsor
- Pfizer
Low Back Pain
Efficacy Safety of a Combination Thiocolchicoside+Ketoprofen Compared to Thiocolchicoside Twice a Day for 7 Days in Patients Suffering From Acute Non Specific Low Back Pain
Primary Objective : To demonstrate the superiority of the oral fixed - combination of a muscle relaxant, thiocolchicoside (TCC) to a non steroidal anti-inflammatory drug, ketoprofen, over oral TCC, on average pain within the last…
- Trial name
- TIOKET (NCT00679146)
- Testing
- Thiocolchicoside+Ketoprofen, Thiocolchicoside
- Where
- 6 sites in Brazil, Colombia and 4 more
- Volunteers
- 334 people
- Sponsor
- Sanofi
Lumbar Degenerative Disc Disease
TRIUMPH Lumbar Artificial Disc IDE: A Pilot Study
The purpose of this investigation is to evaluate the safety and effectiveness of the TRIUMPH® Lumbar Artificial Disc for the treatment of patients who are suffering from Degenerative Disc Disease (DDD) at one level from L1 to S1.
- Trial name
- NCT01198470
- Testing
- TRIUMPH® Lumbar Artificial Disc
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Globus Medical Inc
Discogenic Pain
Study Investigating STA363 Compared to Placebo in Patients With Chronic Discogenic Low Back Pain
This is a phase IIb, prospective, multi-country, multicenter, randomized, double-blind, placebo-controlled, parallel group study to investigate the efficacy, safety and transformation of NP following single intradiscal injection…
- Trial name
- STA-02 (NCT04673461)
- Testing
- STA363 containing 90 mg (60 mg/mL) lactic acid, STA363 containing 180 mg (120 mg/mL) lactic acid
- Where
- 17 sites in Netherlands, Russia and 1 more
- Volunteers
- 110 people
- Sponsor
- Stayble Therapeutics
Chronic Lower Back Pain, Chronic Pain
Buprenorphine (CAM2038) in Subjects With a Recent History of Moderate to Severe Chronic Low Back Pain
This is a Phase III, placebo-controlled, multicenter study with an enriched-enrollment withdrawal (EEW) design to evaluate the efficacy and safety of CAM2038 in opioid-experienced subjects with moderate to severe CLBP that…
- Trial name
- CAM2038 (NCT02946073)
- Testing
- buprenorphine
- Where
- 69 sites in United States
- Volunteers
- 1,053 people
- Sponsor
- Braeburn Pharmaceuticals