Clinical trials: Lumbar Back Pain
Chronic Low-back Pain
Development and Feasibility of Mindfulness Based Pain Reduction
This is a development study with clinical outcomes. The investigators aim to develop and test an 8-week MBPR (Mindfulness-Based Pain Reduction) program, which draws on intervention work and clinical experience in the…
- Trial name
- MBPR (NCT04980612)
- Testing
- Mindfulness Based Pain Reduction, Mindfulness Based Stress Reduction
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of California, San Francisco
Pain, Osteoarthritis
An Open-label Extension Study With Flexible Dosing of Extended-release (ER) Tapentadol (CG5503) to Treat Patients With Moderate to Severe Chronic Pain
The purpose of the study is to assess the long-term safety profile of Tapentadol (CG5503) extended release (ER) at dosages ranging from 100 to 250 mg twice a day in treating patients with moderate to severe chronic pain over a…
- Conditions
- Pain, Osteoarthritis, Low Back Pain
- Trial name
- NCT00487435
- Testing
- Tapentadol (CG5503) Extended Release (ER)
- Where
- 148 sites in United States, Australia and 2 more
- Volunteers
- 1,166 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Chronic Low Back Pain
Rage Against the Pain to Address Chronic Low Back Pain Among Veterans
Chronic low back pain is a leading cause of disability among Veterans. Yoga is recommended as a front-line treatment option for chronic low back pain and is available across the VA healthcare system; however, despite yoga being…
- Trial name
- RAP (NCT05103475)
- Testing
- Rage Against the Pain (RAP), Control
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Lower Back Pain
Assessment of Chiropractic Treatment for Low Back Pain and Smoking Cessation in Military Active Duty Personnel.
The purpose of this study is to evaluate the effectiveness of chiropractic manipulative therapy for pain management and improved function in active duty service members with low back pain that do not require surgery.
- Trial name
- NCT01692275
- Testing
- Medical Care + Chiropractic Care, Conventional Medical Care Only
- Where
- 3 sites in United States
- Volunteers
- 750 people
- Sponsor
- RAND
Acute Pain, Low Back Pain, Mechanical
Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain
This is a study of adults with acute low back pain flare-up at risk of becoming chronic and disabling. The study tests how well spinal manipulation and guided selfcare work compared to standard medical care.
- Trial name
- PACBACK (NCT03581123)
- Testing
- Supported-Self Management (SSM), Spinal Manipulation Therapy (SMT), SMT + SSM
- Where
- 3 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- University of Minnesota
Chronic Low Back Pain, Chronic Neck Pain
Overcoming Pain Through Yoga in the Military
Our primary aim is to assess the feasibility of conducting yoga research among active-duty military personnel with Chronic Low Back Pain (CLBP) and/or Chronic Neck Pain (CNP).
- Trial name
- OPTYM (NCT03504085)
- Testing
- Yoga: Active Hatha, Yoga: Restorative
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- University of California, San Diego
Low Back Pain, Patient Acceptance of Health Care
Veterans Response to Dosage in Chiropractic Therapy
This study evaluates how Veterans with chronic low back pain (cLBP) respond to varying doses of chiropractic therapy and how health services utilization are impacted as a result. There are 2 phases in this study.
- Conditions
- Low Back Pain, Patient Acceptance of Health Care, Veterans Health
- Trial name
- VERDICT (NCT04087291)
- Testing
- Chiropractic Care
- Where
- 4 sites in United States
- Volunteers
- 766 people
- Sponsor
- Palmer College of Chiropractic
Major Depressive Disorder, Back Pain
Duloxetine Treatment of Major Depression and Chronic Low Back Pain For Older Adults
The following primary hypotheses will be tested: 1. During Step 1: Major Depressive Disorder (MDD) or Chronic Low Back Pain (CLBP) in < 40% of the initial 60 subjects treated with duloxetine (DUL) + Clinical Management(CM) during…
- Conditions
- Major Depressive Disorder, Back Pain, Aged
- Trial name
- ACHIEVE2 (NCT00696293)
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Chronic Low Back Pain
Transcranial Alternating Current Stimulation in Back Pain- Pilot Sudy
Chronic pain is a severe disabling problem within society, affecting 25-30% of the United States population.. Transcranial alternating current stimulation (tACS) has the potential to provide a treatment option that is safe…
- Trial name
- BPS (NCT03243084)
- Testing
- XCSITE100 Stimulator tACS
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of North Carolina, Chapel Hill
Low Back Pain, Sciatica
Integrated Supported Biopsychosocial Self-Management for Back Related Leg Pain
Guidelines advocate several complementary modalities as alternatives to drugs and other invasive treatments for chronic low back pain (LBP) conditions.
- Conditions
- Low Back Pain, Sciatica, Back Related Leg Pain, Pain, Chronic
- Trial name
- SUPPORT (NCT05022121)
- Testing
- Supported Biopsychosocial Self-Management (SBSM), Medical Care
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Low Back Pain, Chronic Pain
Optimize Low Back Pain
The objective of this study is to improve health care for patients with chronic LBP and increase the likelihood that patients obtain outcomes that matter most to them.
- Trial name
- OPTIMIZE (NCT03859713)
- Testing
- Physical Therapy, Cognitive Behavioral Therapy, Mindfulness
- Where
- 3 sites in United States
- Volunteers
- 749 people
- Sponsor
- University of Utah
Chronic Pain, Back Pain
Assess the Effectiveness of Pulse RadioFrequency in Patients With Chronic Lumbar Radicular Pain
Pulsed RadioFrequency (PRF) is a relatively new technique derived from a well established and proven intervention, thermal radiofrequency (RF). Both procedures are used in the treatment of chronic pain.
- Trial name
- NCT01117870
- Testing
- Pulsed Radiofrequency
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- McMaster University
Chronic Low-back Pain
A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 in Participants With Chronic Low Back Pain
The main purpose of this study is to assess whether LY3857210 is safe and efficacious in relieving chronic low back pain (CLBP).
- Trial name
- NCT05630196
- Testing
- LY3857210
- Where
- 30 sites in United States, Puerto Rico
- Volunteers
- 138 people
- Sponsor
- Eli Lilly and Company
Low Back Pain
Effectiveness of Percutaneous Lumbar Epidural Adhesiolysis and Neurolysis on Low Back Pain
Clinically significant improvements in the percutaneous adhesiolysis patients with hypertonic neurolysis compared to those patients randomized to the control group who did not receive adhesiolysis and hypertonic saline…
- Trial name
- NCT00370994
- Testing
- Caudal epidural injection, Percutaneous adhesiolysis
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Pain Management Center of Paducah
Sacroiliac Joint Complex, Low Back Pain
Conventional vs Bipolar SIJ RFA for Treatment of Sacroiliac Joint Pain
Specific Aims The sacroiliac joint complex (SIJC) is a diathrodial, synovial joint and posterior ligamentous network that receives both anterior innervation from the lumbosacral plexus as well as posterior sensory innervation via…
- Trial name
- NCT05409443
- Testing
- Nimbus Sacroiliac Joint Radiofrequency Ablation (N-SIJRFA), Conventional Sacroiliac Joint Radiofrequency Ablation (C-SIJRFA)
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Acute Low Back Pain
Nonivamide/Nicoboxil Ointment in Acute Low Back Pain
The aim of this study is to assess the efficacy and tolerability of Nicoboxil/Nonivamide ointment in comparison to Nicoboxil, Nonivamide, and placebo ointments for the treatment of acute low back pain.
- Trial name
- NCT01708915
- Testing
- nicoboxil, nonivamide + nicoboxil (Finalgon), nonivamide
- Where
- 37 sites in Germany
- Volunteers
- 805 people
- Sponsor
- Boehringer Ingelheim
Low Back Pain
Effect of Lumbar Bracing on Spinal Function
A recent province-wide survey (Alberta, Canada) suggests that clinicians' beliefs about soft lumbar bracing for low back pain (LBP) vary substantially.
- Trial name
- NCT02251106
- Testing
- Lumbar corset (Quickdraw, Aspen Medical Products)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Pain, Low Back Pain
Efficacy and Safety Study of Buprenorphine HCl Buccal Film in Subjects With Low Back Pain
The purpose of this study is to determine whether buprenorphine hydrochloride (HCl) buccal film is effective and safe in the treatment of chronic low back pain (CLBP).
- Trial name
- NCT01256450
- Testing
- Buprenorphine
- Where
- 24 sites in United States
- Volunteers
- 334 people
- Sponsor
- BioDelivery Sciences International
Low Back Pain
Chiropractic Manipulation and Medical Care for Low Back Pain
The investigators will be comparing the effectiveness of two types of chiropractic manipulation and standard medical care for patients with a recent onset of low back pain.
- Trial name
- NCT01211613
- Testing
- Manual Manipulation, Mechanically-assisted manipulation, Standard Medical Care
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of Pittsburgh
Low Back Pain
The Back Exercises to Neutralize Disability Study
A pilot randomized control trial (RCT) to generate effect sizes on the effects of blood flow restricted exercise on trunk extensor cross-sectional area (primary outcome), strength and endurance, whole body and regional lean mass…
- Trial name
- BEND (NCT02308189)
- Testing
- Exercise with blood flow restriction, Exercise
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Ohio University