Clinical trials: Lumbar Back Pain
Low Back Pain, Shoulder Pain
An Efficacy and Safety Study of Tramadol Hydrochloride-Paracetamol in Treatment of Moderate to Severe Acute Neck-Shoulder Pain and Low Back Pain
The purpose of this study is to evaluate the efficacy and safety of tramadol hydrochloride-paracetamol tablets in treatment of moderate (medium level of seriousness) to severe (very serious) acute neck, shoulder and low back pain…
- Conditions
- Low Back Pain, Shoulder Pain, Neck Pain
- Trial name
- NCT01843660
- Testing
- Tramadol HCl-Paracetamol
- Volunteers
- 1,059 people
- Sponsor
- Xian-Janssen Pharmaceutical Ltd.
Low Back Pain, Pain
Care Management for the Effective Use of Opioids
The CAre Management for the Effective use of Opioids (CAMEO) trial is a 2-arm randomized clinical trial to compare the effectiveness of pharmacological vs. behavioral approaches for chronic lower back pain.
- Trial name
- CAMEO (NCT01236521)
- Testing
- Pharmacological (MED), Behavioral treatment (CBT)
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- VA Office of Research and Development
Lumbar Spinal Stenosis
Lumbar Stenosis Outcomes Research (LUSTOR)
The primary objective of the proposed pilot study is to determine the efficacy of pregabalin in prolonging the time to onset of pain and reducing the severity of pain associated with walking in patients with neurogenic…
- Trial name
- LUSTOR (NCT00638443)
- Testing
- Pregabalin, Diphenhydramine
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Rochester
Back Pain Lower Back Chronic
Safety of BTDS in Subjects With Low Back Pain: A 52-Week Extension Phase of BUP3015
The purpose of the extension phase is to evaluate the long-term safety and tolerability of buprenorphine transdermal system (BTDS).
- Trial name
- NCT01125917
- Testing
- Buprenorphine transdermal patch
- Where
- 84 sites in United States
- Volunteers
- 354 people
- Sponsor
- Purdue Pharma LP
Degenerative Lumbar Spine Causing Back and/or Leg Pain, Lumbar Spine Degeneration
A Prospective, Multicenter Observational Study on MAST™ (Minimal Access Spinal Technologies) Fusion Procedures for the Treatment of the Degenerative Lumbar Spine
The aim of the study is to observe and document surgical practice and evaluate patients' outcomes following a MAST™ single or double level instrumented fusion procedure using PLIF (Posterior Lumbar Interbody Fusion) or TLIF…
- Trial name
- MASTERS-D (NCT01143324)
- Testing
- MAST™ procedure
- Where
- 19 sites in Austria, Belgium and 12 more
- Volunteers
- 255 people
- Sponsor
- Medtronic Spinal and Biologics
Chronic Low Back Pain, Chronic Leg Pain
Comparison of the Effects of Two Spinal Cord Stimulation (SCS) Therapies on Subject Reported Pain (BENEFIT-02)
A BIOTRONIK wearable stimulator will be utilized in order to investigate the effects of two study spinal cord stimulation (SCS) therapies on subject reported pain and paresthesia perception observed over 12 days of study…
- Trial name
- NCT03594266
- Testing
- Therapy A spinal cord stimulation parameter set using BIO-RNA system and associated components, Therapy B spinal cord stimulation parameter set using BIO-RNA system and associated components
- Where
- 18 sites in United States
- Volunteers
- 136 people
- Sponsor
- Biotronik, Inc.
Low Back Pain
Comparison of Extensible and Inextensible Lumbosacral Orthoses for Lower Back Pain
This study is designed to discern if the use of a lumbosacral orthesis (LSO, also call a back support) improves the short-term outcome of lower back pain.
- Trial name
- LSO LBP (NCT01933399)
- Testing
- Inextensible LSO (stiff back support), Extensible LSO, a back support that is flexible, Standard of Care
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Medical University of South Carolina
Back Pain, Chronic Low Back Pain
Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System
The purpose of this investigation is to establish the safety and efficacy of the Biostat System when used for treatment of chronic low back (lumbar) pain due to symptomatic internal disc disruptions (IDD) by comparing safety and…
- Conditions
- Back Pain, Chronic Low Back Pain, Internal Disc Disruption, Degenerative Disc Disease
- Trial name
- NCT01011816
- Testing
- BIOSTAT BIOLOGX, Saline
- Where
- 20 sites in United States
- Volunteers
- 220 people
- Sponsor
- Spinal Restoration, Inc.
Chronic Low Back Pain
Placebo In Chronic Back Pain (Phase 2)
This study is designed to examine brain properties for placebo response in chronic back pain patients. The investigators have preliminary data indicating that, in blinded clinical trial studies with neutral instructions regarding…
- Trial name
- PICP2 (NCT02986334)
- Testing
- Naproxen, Omeprazole
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Apkar Apkarian
Chronic Low Back Pain
Stimgenics Open-Label, Post Market Study
The purpose of this investigational study is to study the effects of Stimgenics Spinal Cord Stimulation (SGX-SCS) in subjects with chronic, intractable pain of the trunk with lower limb pain, including unilateral or bilateral…
- Trial name
- SGX-SCS-RCT (NCT03606187)
- Testing
- Stimgenics SCS Programming Approach, Standard SCS Programming Approach
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Stimgenics LLC
Chronic Pain
Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid Function
Chronic Pain (CP) management has increasingly utilized long-term opioid analgesic therapy, a change associated with increased opioid abuse (via greater exposure in vulnerable individuals), non-pain health consequences (hormone…
- Trial name
- NCT02469077
- Testing
- 6 week aerobic exercise intervention, Morphine, naloxone
- Where
- 2 sites in United States
- Volunteers
- 117 people
- Sponsor
- Vanderbilt University Medical Center
Low Back Pain
Acute Low Back Pain. Topical Diclofenac and Oral Ibuprofen.
This is a randomized, double-blind placebo-controlled study comparing two different treatments for acute low back pain: oral ibuprofen and topical diclofenac.
- Trial name
- NCT04611529
- Testing
- Ibuprofen 400 mg, Topical diclofenac
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Montefiore Medical Center
Pain, Intractable, Breakthrough Pain
Patient Controlled Intrathecal Analgesia With Bupivacaine for Chronic Low Back Pain
The purpose of this study is to determine whether the local anesthetic bupivacaine delivered intrathecally in small doses via PTM self-administered boluses significantly improves the breakthrough pain and functional status of…
- Conditions
- Pain, Intractable, Breakthrough Pain, Chronic Pain
- Trial name
- NCT02886286
- Testing
- Bupivacaine, Opioid
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University Hospitals Cleveland Medical Center
Low Back Pain, Back Pain With Radiation
Evaluating the Role of Neuroinflammation in Low Back Pain
In this research, the study team will use brain imaging to evaluate the presence of neuroinflammation in the brains and spinal cords of patients with low back pain.
- Conditions
- Low Back Pain, Back Pain With Radiation, Back Pain Without Radiation, Back Pain Lower Back Chronic
- Trial name
- IGNITE (NCT03106740)
- Testing
- Minocycline Hydrochloride 100mg Capsule, Magnetic Resonance-Positron Emission Tomography Imaging
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Marco Loggia
Chronic Low Back Pain
Physical Activity Interventions To Heal Chronic Low Back Pain
This study will advance understanding on the mechanisms that mediate improved outcomes for chronic low back pain and provide specific directions for optimizing physical activity interventions for this population.
- Trial name
- PATH (NCT04678297)
- Testing
- Physical activity + emotion regulation intervention, Physical activity control intervention
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- University of Connecticut
Chronic Low Back Pain, Hip Ostearthritis
Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)
Back pain is a huge problem for millions of Americans, including nearly 11 million Veterans. Our older Veterans suffer the most. Citizens spend billions of dollars, yet consistently get poor results.
- Conditions
- Chronic Low Back Pain, Hip Ostearthritis, Myofascial Pain Syndrome, Fibromyalgia
- Trial name
- NCT02697435
- Testing
- Patient-Centered Care, Imaging-Directed Care
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Low Back Pain
Predicting Patients' Response to Spinal Manipulation
The purpose of this study is to compare the clinical effectiveness of two types of chiropractic spinal manipulation to conservative medical care for patients at least 55 years old with sub-acute or chronic LBP.
- Trial name
- NCT00285649
- Testing
- HVLA-SM, LVVA-SM, Usual Medical Care
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Palmer College of Chiropractic
Chronic Low-back Pain
VANISH for Chronic Low Back Pain
The program, called TMC-CP01, will use a combination of virtual reality, biofeedback, and psychological exercises to manage pain associated with Chronic Low Back Pain.
- Trial name
- VANISH (NCT04236804)
- Testing
- Flowly (TMC-CP01)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ajay Wasan, MD, Msc
Knee Injuries and Disorders, Ankle Injuries and Disorders
Prevention of Musculoskeletal Injuries in Slovenian Armed Forces
Physical readiness of military personnel is a cornerstone of any army, as soldiers are expected to meet high physical demands on a daily basis, and soldiers must complete one hour of physical conditioning each day.
- Conditions
- Knee Injuries and Disorders, Ankle Injuries and Disorders, Low Back Pain
- Trial name
- NCT03415464
- Testing
- Exercise
- Where
- Slovenia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana
Low Back Pain
Mechanisms of Specific Trunk Exercises in Low Back Pain
The research objective is to determine which physical therapy (PT) treatment is the most efficacious for patients with lower back pain (LBP), who have been subgrouped based on certain clinical features.
- Trial name
- NCT01362049
- Testing
- Physical Therapy rehabilitation: Stabilization exercises., Physical Therapy rehabilitation. Movement System Impairment (MSI) classification based exercise
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Vermont