Clinical trials: Lumbar Disc Disease
Intervertebral Disc Compression, Muscle Atrophy
50% Body Weight Reverses Stature, Lumbar Disc Expansion and Vertebral Compliance by Hyper-Buoyancy Floatation.
Study with the aim to see the effect on a space ground analogue , Hyper-Buoyancy Floatation (HBF) on lumbar column and the effect of a supplementary 50% of an axial load.
- Conditions
- Intervertebral Disc Compression, Muscle Atrophy, Spine Injury
- Trial name
- NCT05590754
- Testing
- Hyper-buoyancy Floatation (HBF), Axial Load after 4h of HBF
- Where
- 2 sites in Spain, United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Madrid
Degenerative Disc Disease, Isthmic-lytic Spondylolisthesis
Efficacy of Using Solum IV and BMC With GFC in TLIF
The purpose of this study is to examine the efficacy of using Solum IV and bone marrow concentrate with general fluid concentrate in Transforaminal Lumbar Interbody Fusion (TLIF).
- Conditions
- Degenerative Disc Disease, Isthmic-lytic Spondylolisthesis, Degenerative Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT03223701
- Testing
- Solum IV, Bone Marrow Concentrate with general fluid concentrate (GFC) in Transforaminal Lumbar Interbody Fusion
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Seton Healthcare Family
Lumbar Disc Herniation, Low Back Pain
Comparison Of Early Mobilization And Electrical Stimulation On Functional Recovery After Lumbar Disc Herniation Surgery
This randomized controlled trial aims to compare the effectiveness of early mobilization alone versus early mobilization combined with electrical stimulation on functional recovery following lumbar disc herniation surgery.
- Conditions
- Lumbar Disc Herniation, Low Back Pain, Postoperative Rehabilitation
- Trial name
- EMES-LDH (NCT07575477)
- Testing
- Early Mobilization Program, Electrical Stimulation (NMES/TENS)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Medipol University Hospital
Spine Health, Spine Injuries and Disorders
Occupational Exposure to Whole Body Vibration Among U.S. Military Veterans: Acute and Chronic Contributions to Musculoskeletal Disorders and Spine-Area Pain
Significance to VA: There is a lack of prospective longitudinal studies investigating the relationship between risk factors to Veterans and development and progression of musculoskeletal (MSK) spine injury and pain.
- Conditions
- Spine Health, Spine Injuries and Disorders, Spine Degeneration, Whole Body Vibration
- Trial name
- NCT07367139
- Testing
- Water
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Milwaukee VA Medical Center
Intervertebral Disc Herniation
Preoperative Estimation Of Disc Herniation Recurrence In Patients With Lumbar Disc Herniation
This study will be conducted at Research Institute of Traumatology and Orthopedics (NRITO) n.a. Ya.L.Tsivyan, Novosibirsk, Russia.
- Trial name
- NCT04254250
- Testing
- Preoperative risk estimation of disc herniation recurrence
- Where
- 2 sites in Russia
- Volunteers
- 386 people
- Sponsor
- Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
Lomber Disc Herniation
Effectiveness of High Intensity Laser Therapy in Management of Lumbar Disc Herniation
Chronic lumbar radiculopathy is a multifactorial condition typically caused by lumbar disc herniation, where degenerative changes lead to nerve root compression, resulting in radiating pain, sensory disturbances, and motor…
- Trial name
- NCT07550569
- Testing
- Hiltherapy, physiotherapy
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Baskent University
Degenerative Disc Disease
Pivotal Study of rhBMP-2/ACS/LT-CAGE® Device for Anterior Lumbar Interbody Fusion in Patients With Symptomatic Degenerative Disc Disease
This study is designed to assess the safety and effectiveness of the rhBMP-2/ACS/LT-CAGE® device as compared to the LT-CAGE® device with autogenous bone in patients with symptomatic degenerative disc disease using an open…
- Trial name
- NCT01491386
- Testing
- rhBMP-2/ACS/LT-CAGE® Device, Autogenous Bone/LT-CAGE® Device
- Volunteers
- 279 people
- Sponsor
- Medtronic Spinal and Biologics
Lumbar Disc Herniations
Detection of Bacteria in Herniated Nucleus Material in Lumbar Disc Herniations by Culture and PCR
The aim is to investigate if herniated nucleus material in lumbar disc herniations is infected with bacteria, and if so, to determine their prevalence (control group), and to determine if patients with pre-existing Modic changes…
- Trial name
- NCT02385968
- Where
- Denmark
- Volunteers
- 5 people
- Sponsor
- Spine Centre of Southern Denmark
Disc Degeneration
Comparaison of Interbody Bone Fusion Between Two Osteoinductive Bioactive Bone Substitutes After Anterior Lumbar Interbody Arthrodesis in Degenerative Lumbar Disc Surgery in Adults
Disc degeneration is a progressive deterioration process of the intervertebral disc, which can manifest as significant low back pain and a loss of mobility that interferes with daily activities.
- Trial name
- FUSALIF (NCT07044206)
- Testing
- Use of bone substitute during intervertebral fusion surgery
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Degeneration Disc Intervertebral
Effect of Abaloparatide on Lumbar Disc Degeneration
Low back pain is a major public health issue as the leading cause of disability globally. Degeneration of intervertebral disc (IVD) disorder is once source of low back pain.
- Trial name
- NCT03708926
- Testing
- Abaloparatide
- Where
- United States
- Sponsor
- Johns Hopkins University
Vibration, Lumbar Disc Herniation
IASTM and Vibration Effects on Pain, Functionality, and Kinesiophobia in Lumbar Disc Herniation
The aim of this study is to investigate the effects of Instrument-Assisted Soft Tissue Mobilization and vibration massage therapy on pain, functionality, and kinesiophobia in individuals with lumbar disc herniation.
- Conditions
- Vibration, Lumbar Disc Herniation, Soft Tissue Mobilization
- Trial name
- NCT07293676
- Testing
- Exercise, IASTM, Percussion massage therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Low Back Pain, Disc, Herniated
Motor Control Mechanisms by CNS of Tuina in Patients With Lumbar Disk Herniation
Lumbar disk herniation (LDH)is a prevalent health problem around the world. It can cause symptoms of low back pain, numbness or weakness.The understanding of low back pain in traditional Chinese medicine(TCM) theory"unbalanced…
- Trial name
- NCT03475095
- Testing
- Tuina
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Disc Degenerative Disease
Clinical Trial of YH14618 in Patients With Degenerative Disc Disease
Research Hypothesis: There will be a greater proportion of VAS responders defined as those who achieve ≥ 50% reduction from baseline in VAS for low back pain at week 12 following intradiscal injection of YH14618 compared to…
- Trial name
- NCT02320019
- Testing
- YH14618
- Where
- South Korea
- Volunteers
- 326 people
- Sponsor
- Yuhan Corporation
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Clinical Effect of Preventive Use of Tylenol on Fever After Removal of Drainage Tube in Lumbar Fusion Surgery
This study evaluates the influence of Non-steroidal Anti-inflammatory Drugs on preventing fever after the removal of drainage tube in the patients who suffered lumbar fusion surgery, if the outcome turn out positive, the…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Radiculopathy
- Trial name
- NCT04042948
- Testing
- Tylenol
- Where
- China
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Lumbar Herniated Intervertebral Disc
Biportal Endoscopic Discectomy Versus Microdiscectomy: RCT, Non-inferiority Trial
This study is to compare the clinical outcome between the biportal endoscopic discectomy and microdiscectomy in herniated intervertebral disc of lumbar spine
- Trial name
- BESS (NCT03924700)
- Testing
- Biportal endoscopy, Microdiscectomy
- Where
- 2 sites in South Korea
- Volunteers
- 64 people
- Sponsor
- Seoul National University Hospital
Lumbar Disc Herniation Surgery, Disc Herniation
Return to Activity After Surgery for Lumbar Disc Herniation
RCT investigating postoperative activity restriction after lumbar discectomy in patients treated with annular closure.
- Trial name
- NCT07667348
- Testing
- Postoperative therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Intrinsic Therapeutics
Prolapsed Intervertebral Disc
Effects of Lumbar Traction on the Straight Leg Raise Test and Pain
Disc prolapse causes impairment of function by nerve root compression compelling the patient to seek medical advice for low backache.
- Trial name
- NCT04728685
- Testing
- Mechanical Traction
- Where
- Saudi Arabia
- Volunteers
- 45 people
- Sponsor
- King Saud University
Lumbar Disc Disease, Low Back Pain
Clinical and MRI Findings in Lumbar Disc Disease
Low back pain related to lumbar disc disease is a very common condition. Doctors frequently use Magnetic Resonance Imaging (MRI) to look at the spine and diagnose these problems.
- Conditions
- Lumbar Disc Disease, Low Back Pain, Lumbar Disc Herniation, Lumbosacral Radiculopathy
- Trial name
- NCT07516613
- Volunteers
- 96 people
- Sponsor
- Assiut University
Lumbar Disc Herniation, Lumbar Radiculopathy
Effects of SNAGS With and Without Pilates in Lumbar Disc Bulge Patients
The aim of this study is to compare the effects of Sustained Natural Apophyseal Glides with and without Pilates on pain, range of motion and disability in patients with lumbar Disc Bulge.
- Trial name
- NCT06076408
- Testing
- SNAGS with Pilates, SNAGS
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Degenerative Lumbar Disc Disease
Advanced XLIF Monitoring Multicenter Study
The objective of this study is to evaluate the utility of localized stimulation of the lumbosacral nerve roots during XLIF through correlation of observed changes in the response latency, amplitude, waveform morphology, and/or…
- Trial name
- NCT02272140
- Where
- 12 sites in United States
- Volunteers
- 324 people
- Sponsor
- NuVasive