Clinical trials: Lumbar Discogenic Pain
Degenerative Disc Disease, Disc Degeneration
ASCEND: A Clinical Trial to Evaluate the Safety and Effectiveness of VIA Disc NP, a Supplement for Degenerated Intervertebral Discs
VIA Disc NP is an off-the-shelf minimally processed human nucleus pulposus tissue allograft intended to supplement degenerated intervertebral discs.
- Conditions
- Degenerative Disc Disease, Disc Degeneration, Lumbar Discogenic Pain
- Trial name
- ASCEND (NCT06615505)
- Testing
- VIA Disc NP
- Where
- 5 sites in Australia
- Volunteers
- 121 people
- Sponsor
- VIVEX Biologics, Inc.
Discogenic Low Back Pain
McKenzie Extension Protocol Versus Core Stability Exercises Combined With Spinal Decompression in Discogenic Lumbar Radiculopathy
The pathophysiology arises from structural and biochemical degeneration within the intervertebral disc rather than direct nerve root compression alone.
- Trial name
- D-MECS (NCT07730502)
- Testing
- McKenzie Extension Protocol, Core stability Exercise, Spinal decompression, Moist heat, interferential current
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Ibadat International University, Islamabad
Low Back Pain
Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain
To demonstrate clinically significant improvements or lack thereof in the caudal epidural patients with our without steroids. To evaluate differences in outcomes in patients receiving steroids compared to those patients…
- Trial name
- NCT00370799
- Testing
- Caudal epidural injection, Caudal Epidural Injection with generic Celestone, Caudal Epidural Injection with Celestone
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Pain Management Center of Paducah
Degenerative Disc Disease, Discogenic Low Back Pain
A Comparative Study Between Mechanical and a Viscoelastic Disc Prosthesis in the Lumbar Spine
TDR implants for the lumbar spine are currently most 2- or 3-piece devices with a purely mechanical function that provide/restore mobility.
- Trial name
- NCT03716947
- Testing
- Device: ZACK, Device: ORBIT, Device: SASCA
- Where
- Sweden
- Volunteers
- 246 people
- Sponsor
- Karolinska Institutet
Degenerative Disc Disease, Chronic Lower Back Pain
Intervertebral DXM Gel Injection in Adults With Painful Lumbar Degenerative Disc Disease
The purpose of this study is to assess the safety and the efficacy of an hydrogel (double cross-link microgel - DXM) injection into the intervertebral disc (IVD) space in patients with painful lumbar degenerative disc disease…
- Conditions
- Degenerative Disc Disease, Chronic Lower Back Pain, Discogenic Pain, Intervertebral Disc Degeneration
- Trial name
- DXM gel (NCT04727385)
- Testing
- Double Crosslink Microgel
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Gelmetix
Low Back Pain, Chronic Low-back Pain
AuriculoTherapy NeuroImaging
This is a clinical study of patients who have low back pain (for at least 6 months). The goal is to understand, with brain imaging, how auriculotherapy (an acupuncture-like stimulation of the ear) may work to relieve pain.
- Conditions
- Low Back Pain, Chronic Low-back Pain, Back Pain, Low, Lumbar Disc Disease
- Trial name
- ATNI (NCT06825390)
- Testing
- Cryo-auriculotherapy, Experimental auricular stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Keith M Vogt
Back Pain
Safety and Efficacy of the TransDiscal System Versus Medical Management in Treating Chronic Discogenic Low Back Pain
The primary objective of this randomized controlled trial is to evaluate the safety and efficacy of the TransDiscal System (TDS) in treating discogenic pain of the lumbar spine using a modified disc biacuplasty procedure.
- Trial name
- COLD (NCT01263054)
- Testing
- TransDiscal System, Medical Management
- Where
- 9 sites in United States
- Volunteers
- 67 people
- Sponsor
- Halyard Health
Lumbar Disc Herniation
Tramadol vs.Tramadol With Paracetamol
This study focused on to determine postoperative analgesic efficacy of tramadol compared to tramadol with addition of paracetamol after a lumbar disc surgery.
- Trial name
- NCT03482492
- Testing
- Tramadol, Paracetamol
- Volunteers
- 60 people
- Sponsor
- Yeditepe University Hospital
Discogenic Low Back Pain, Intervertebral Disc Degeneration
RenewDisc Trial: Endoscopic Discectomy and Autologous Stem Cell Therapy for Discogenic Low Back Pain
he RenewDisc Trial is a prospective observational clinical study evaluating outcomes in patients with confirmed discogenic low back pain who undergo standard clinical care using endoscopic spine procedures.
- Conditions
- Discogenic Low Back Pain, Intervertebral Disc Degeneration, Lumbar Disc Disease, Chronic Low Back Pain
- Trial name
- RENEWDISC (NCT07338877)
- Where
- Slovakia
- Volunteers
- 120 people
- Sponsor
- EPC Education s.r.o.
Low Back Pain
Lumbar Fusion or Non-operative Care for Treatment of Presumed Discogenic Pain
Title and abstract 1 a. Title: Lumbar fusion or non-operative care for treatment of presumed discogenic pain. A randomized study. 1 b. Structured summary: Authors: B. Nyström, B. Schillberg, E. Svensson, T. Stiles.
- Trial name
- NCT02695576
- Testing
- Lumbar Fusion Surgery, Physiotherapy, Cognitive behavioral therapy
- Volunteers
- 74 people
- Sponsor
- Spinal Surgery Clinic, Strängnäs
Sciatica Due to Intervertebral Disc Disorder
Two-leg Rotation and Sciatica
this study including the application of a specific technique of Mulligan mobilization calles 2 leg rotation on patients having lumbar discogenic lesion with sciatica.
- Trial name
- (MWM) (NCT07444125)
- Testing
- standard physical therapy, 2 leg rotation
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- University of Hail
Degenerative Disc Disease
Safety and Preliminary Efficacy Study of Mesenchymal Precursor Cells (MPCs) in Subjects With Lumbar Back Pain
The purpose of this study is to compare two doses of immunoselected, culture-expanded, nucleated, allogeneic adult MPCs when combined with hyaluronic acid to two control intradiscal injections in subjects with chronic low back…
- Trial name
- NCT01290367
- Testing
- Single Dose MPCs Injection, Single injection of saline solution, Single injection of hyaluronic acid
- Where
- 14 sites in United States, Australia
- Volunteers
- 100 people
- Sponsor
- Mesoblast, Ltd.
Degenerative Disc Disease
AMG0103 in Subjects With Chronic Discogenic Lumbar Back Pain
This clinical trial evaluate the safety, tolerability and exploratory efficacy of targeted single injection of AMG0103 in subject with chronic discogenic lumbar back pain
- Trial name
- NCT03263611
- Testing
- AMG0103
- Where
- 6 sites in United States
- Volunteers
- 25 people
- Sponsor
- AnGes, Inc.
Degeneration of Lumbar Intervertebral Disc
RCT Study of the Gelstix™ Device to Treat Chronic Discogenic Low Back Pain GelStix Study
Degenerative Disc Disease is one of the most common spinal pathologies, affecting up to 10-15 % of adults. The purpose of this study is to evaluate the efficacy of treatment with the GelStix™ device in a patient population with…
- Trial name
- GelStix (NCT02763956)
- Testing
- GelStix™ Nucleus Augmentation Device
- Where
- 2 sites in Netherlands, Switzerland
- Volunteers
- 72 people
- Sponsor
- Ospedale Regionale di Lugano
Low Back Pain, Disk Prolapse
Effects of Sustained Natural Apophyseal Glides in Combination With McKenzie Extension Protocol in the Management of Discogenic Low Back Pain
Lumbar degenerative disc disease and discogenic low back pain is comparatively common and disabling musculoskeletal condition. McKenzie's extension protocol is considered to be the gold standard physical therapy treatment for…
- Conditions
- Low Back Pain, Disk Prolapse, Disk Herniated Lumbar, Sciatic Radiculopathy
- Trial name
- NCT05314049
- Testing
- Mckenzie Extension Protocol, Lumbar SNAGs, inferential therapy
- Volunteers
- 44 people
- Sponsor
- Foundation University Islamabad
Lumbar Radiculopathy, Discogenic Lumbosacral Radiculopathy
Effect of Trans-spinal Electromagnetic Neuromodulation in Treatment of Patients With Discogenic Lumbosacral Radiculopathy
Purposes of the study To investigate the effect of adding Trans-spinal Electromagnetic Neuromodulation to conventional physical therapy in patients with Discogenic Lumbosacral Radiculopathy
- Trial name
- NCT07743424
- Testing
- Trans-spinal Electromagnetic Neuromodulation, Conventional physical therapy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Yara Aboelazm Abd Elaziz Mohamed
Lumbar Radiculopathy
Low Level LASER Therapy With and Without Proprioceptive Stimulation Among Discogenic Lumbar Radiculopathy Patients
The aim of this study is to evaluate the effects of low level laser therapy with and without proprioceptive stimulation on somatosensation, pain and gait parameters in patients with discogenic lumbar radiculopathy.
- Trial name
- NCT05953727
- Testing
- Low level laser therapy with proprioceptive stimulation, Low level laser therapy without proprioceptive stimulation
- Where
- 2 sites in Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Degenerative Disc Disease, Low Back Pain
Lumbar Transforaminal Anterior Epidural Steroid Injections in Discogenic Low Back Pain
Modic changes have been associated with low back pain in many clinical studies and are often considered a part of the disc degeneration process. Modic type 1 change is considered an inflammatory process.
- Trial name
- NCT04930211
- Testing
- Dexamethasone-Lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Marmara University
Lumbar Radiculopathy
Effect of Transfer of Energy Capacitive and Resistive on Chronic Discogenic Sciatica
The goal of this clinical trial is to evaluate the effect of Transfer of Energy Capacitive and Resistive (TECAR) on pain, functional disability and electrophysiological parameters in adults with chronic discogenic sciatica .
- Trial name
- NCT07841405
- Testing
- Transfer of Energy Capacitive and Resistive (TECAR) therapy, conventional physical therapy program
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University
Lumbar Discogenic Pain
The Safety/Efficacy Study of Human Umbilical Cord Mesenchymal Stem Cells Therapy (19#iSCLife®-LDP) for Lumbar Discogenic Pain
This experimental use umbilical cord mesenchymal stem cells in treatment of the early stage of lumbar discogenic pain (endogenous pain of the disc) to evaluate its safety and efficacy.
- Trial name
- NCT04104412
- Testing
- human umbilical cord mesenchymal stem cell
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Sclnow Biotechnology Co., Ltd.