Clinical trials: Lumbosacral Radiculopathy
Pain, Neuropathic
Efficacy Study in Lumbosacral Radiculopathy
This study will be a double-blind, placebo-controlled, parallel group study. After enrolment and initial assessments, subjects will receive 35 days of study medication.
- Trial name
- NCT01110057
- Testing
- GS856553
- Where
- 17 sites in Denmark, France and 3 more
- Volunteers
- 142 people
- Sponsor
- GlaxoSmithKline
Pain, Chronic
Evaluation of the Effect of Caudal Epidural Pulsed Radiofrequency Stimulation on Chronic Pain
Postlumbar surgery syndrome (PLSS; failed back syndrome) is characterized by persistent pain in the lower back or lower extremities after spinal surgery. It occurs in 10-40% of patients who undergo a back surgery.
- Trial name
- NCT05062993
- Testing
- caudal epidural pulse radio frequency
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Diskapi Teaching and Research Hospital
Sciatica, Lumbosacral Radiculopathy
A Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radiculopathy
The primary objectives of this clinical trial are to investigate the pharmacokinetics and safety of MDT-15 pellets in escalating sequential doses administered to different cohorts.
- Trial name
- NCT01917825
- Testing
- MDT-15
- Where
- 6 sites in United States
- Volunteers
- 54 people
- Sponsor
- Medtronic Spinal and Biologics
Lower Back Pain, Lumbosacral Radiculopathy
Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy
This is a research study to find out if Qutenza 8% capsaicin topical system is safe and effective when treating subjects with lower back pain (LBP) that is caused by damage at or near the nerve's root in the lower back leg…
- Trial name
- NCT06540456
- Testing
- Qutenza® 8% Capsaicin Topical System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical University of South Carolina
Lumbosacral Radiculopathy
A Long-term, 3-Year, Follow-up Study for Patients Completing the KS-GIG-001-01 Study
This is a long-term, 3-year, follow-up study for patients completing the KS-GIG-001-01 Study
- Trial name
- NCT05613569
- Testing
- KLS-2031
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Kolon Life Science
Radiculopathy Lumbar, Degenerative Lumbar Disc Disease
Post-market Safety and Effectiveness of the CORUS-LX System in Improving Lumbar Interbody Fusion Outcomes
The goal of this clinical trial is to assess the safety and effectiveness of the study device, CORUS-LX, as an adjunct to lumbar interbody fusion, when used in combination with pedicle screw and rod constructs for the treatment…
- Trial name
- ILIF (NCT07222787)
- Testing
- Supplemental Posterior Fusion with Study Device, Supplemental Posterior Fusion with Standard Technique
- Where
- 12 sites in United States
- Volunteers
- 250 people
- Sponsor
- Providence Medical Technology, Inc.
Lumbosacral Radicular Syndrome
PRF Treatment for Patients With Chronic Lumbosacral Radicular Pain Compared to Conventional Medical Management
The purpose of the study is to evaluate the effect of PRF treatment adjacent to the lumbar dorsal root ganglion (DRG) of L5 or S1 in patients with a chronic lumbosacral radicular syndrome (LRS).
- Trial name
- NCT00991237
- Testing
- Pulsed Radiofrequency
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Pain, Acute
Low Dose Lignocaine Injections as a Treatment Option for Acute Lumbosacral Radiculopathy
Low back pain is one of the most common ailments that plagues patients, with nearly 80% of the population developing some form of back pain in their lifetime.
- Trial name
- NCT04215757
- Testing
- peripheral nerve block
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences, Rishikesh
Cervical Lordosis Rehabilitation
Does Improvement Towards a Normal Cervical Sagittal Configuration Aid in the Management of Lumbosacral Radiculopathy
A randomized controlled study with six months follow-up will be conducted to investigate the effects of sagittal head posture correction on 3D spinal posture parameters, back and leg pain, disability, and S1 nerve root function…
- Trial name
- NCT05553002
- Testing
- Deneroll cervical extension traction, Traditional treatment
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Radicular Pain, Lumbar Surgery
Return to Work After Lumbar Surgery: a Nationwide Survey of Spinal Surgeons' Practices
This national cross-sectional survey investigates the current practices and perceptions of Belgian spinal surgeons regarding return to work (RTW) after lumbar surgery for radicular pain.
- Conditions
- Radicular Pain, Lumbar Surgery, Radicular Pain Related to Lumbosacral Disc Disease, Fusion of Spine, Lumbar Region
- Trial name
- NCT07193758
- Where
- Belgium
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Radiculopathy Lumbar, Radiculopathy, Lumbosacral Region
Radiofrequency for Chronic Radicular Lumbar Pain: Geriatric vs. Young Patients
This study aims to evaluate the treatment response and lumbar magnetic resonance imaging (MRI) findings of patients who have undergone pulsed radiofrequency therapy for chronic radicular lumbar pain at the dorsal root ganglia.
- Conditions
- Radiculopathy Lumbar, Radiculopathy, Lumbosacral Region, Chronic Pain
- Trial name
- NCT06903949
- Testing
- Lumbar Dorsal Root Ganglia Pulsed Radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Ankara Etlik City Hospital
Lumbar Radiculopathy
Pulsed Radiofrequency in Chronic Lumbosacral Radicular Pain
To evaluate the efficacy of usage of High-voltage pulsed radiofrequency on DRG in comparison to standard-voltage pulsed radiofrequency intervention in patients with chronic lumbosacral radicular pain
- Trial name
- NCT05713032
- Testing
- Pulsed radiofrequency on lumbar dorsal root ganglion
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Alexandria University
Compression of Spinal Nerve Root, Spinal Disorder
Soleus H-Reflex in Different Sitting Postures
The purpose of this study was to examine the effect of prolonged sitting duration and three different sitting postures (erect, slumped, and slouched sitting postures) on spinal nerve root function by measuring the soleus (SOL)…
- Conditions
- Compression of Spinal Nerve Root, Spinal Disorder, Low Back Pain
- Trial name
- NCT01744899
- Testing
- Sitting posture
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Lumbosacral Radiculopathy
Effects of Mackenzie Extension and William Flexion Exercises in Lumbo-sarcal Radiculopathy
Lumbosacral radiculopathy (LR) is among most common disorder caused due to irritation or compression of nerve pathway leading to symptoms of pain, numbness and tingling sensations along the nerve root.
- Trial name
- NCT05654428
- Testing
- Mckenzie Extension Exercises, William Flexion Exercises
- Where
- Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Neuro Counsel Hospital, Pakistan
Herniated Lumbar Disc
High Power Laser Therapy for Herniated Disc and Lumbosacral Radiculopathy
To determine the effect of high-power laser therapy on the size of herniated disc and functional outcome in patients with lumbosacral radiculopathy.
- Trial name
- NCT06831227
- Testing
- High power Laser Therapy, physical therapy exercise program and hot pack
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Lumbosacral Radicular Pain
Corticosteroid Lumbar Epidural Analgesia for Radiculopathy
This is a research study of SP-102, an experimental medication designed to relieve pain in patients with a specific type of leg pain.
- Trial name
- NCT03372161
- Testing
- SP-102
- Where
- 37 sites in United States
- Volunteers
- 401 people
- Sponsor
- Scilex Pharmaceuticals, Inc.
Lumbosacral Radiculopathy, Lumbar Herniated Nucleus Pulposus
Epidural Contrast Flow Patterns of TESI Using the Inferior-Anterior Position as the Final Needle Tip Position.
The purpose of this study is to describe the contrast flow patterns in the epidural space using the inferior-anterior approach with continuous fluoroscopic guidance, and determine how well this approach correlates with…
- Trial name
- NCT01836770
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- George Washington University
Lumbar Disc Herniation, Lumbosacral Radiculopathy
Comparing Three Epidural Steroid Injection Approaches for Lumbar Radicular Pain
This study will compare three fluoroscopy-guided epidural steroid injection approaches for adults with unilateral lumbosacral radicular pain caused by lumbar disc herniation.
- Trial name
- NCT07813988
- Testing
- High-Volume Parasagittal Interlaminar Epidural Steroid Injection, Low-Volume Parasagittal Interlaminar Epidural Steroid Injection, Transforaminal epidural steroid injection
- Where
- Egypt
- Volunteers
- 99 people
- Sponsor
- Benha University
Pain, Chronic, Lumbosacral Radiculopathy
Focal Microvibration and Chronic Lumbosacral Radicular Pain
The goal of this clinical trial is to investigate the effectiveness of focal microvibration on patients affected by chronic lumbosacral radicular pain.
- Conditions
- Pain, Chronic, Lumbosacral Radiculopathy, Radicular; Neuropathic
- Trial name
- NCT06301061
- Testing
- Equistasi®, Gabapentin; Pregabalin; Duloxetine; Amitriptyline
- Volunteers
- 150 people
- Sponsor
- Federico II University
Lumbosacral Radiculopathy
Treatment of Pain Associated With Lumbosacral Radiculopathy in Adults
This study will evaluate the safety and effectiveness of a new pain medication in development, clonidine micropellet. Participants will receive a single injection of either clonidine micropellet or sham injection for the…
- Trial name
- RePRIEVE-CM (NCT03727100)
- Testing
- Clonidine Micropellets
- Where
- 33 sites in United States
- Volunteers
- 207 people
- Sponsor
- Sollis Therapeutics, Inc.