Clinical trials: Lumbosacral Radiculopathy
Lumbosacral Radicular Pain
Corticosteroid Lumbar Epidural Analgesia for Radiculopathy
This is a research study of SP-102, an experimental medication designed to relieve pain in patients with a specific type of leg pain.
- Trial name
- NCT03372161
- Testing
- SP-102
- Where
- 37 sites in United States
- Volunteers
- 401 people
- Sponsor
- Scilex Pharmaceuticals, Inc.
Lumbosacral Radiculopathy
Efficacy and Safety of ETX-018810 in Subjects With Lumbosacral Radicular Pain
Efficacy and Safety of ETX 018810 in Subjects with Lumbosacral Radicular Pain
- Trial name
- NCT04778592
- Testing
- ETX-018810
- Where
- 24 sites in United States
- Volunteers
- 149 people
- Sponsor
- Eliem Therapeutics (UK) Ltd.
Radiculopathy
Effect of Neural Mobilization on Lumbosacral Radiculopathy Patients With Peripheral Sensitization
The primary purpose of this study was to investigate the effects of slider and tensioner techniques on pain, hip and knee ROM in lumbosacral radiculopathy patients with peripheral sensitization.
- Trial name
- NCT03621878
- Testing
- Neural mobilization exercises -Tensioner technique, Neural mobilization exercises -Slider technique, Transcutaneous Electrical Nerve Stimulation (TENS)
- Volunteers
- 51 people
- Sponsor
- Mohammed Al-Ghamdi
Lumbar and Other Intervertebral Disc Disorders With Radiculopathy
Epidural Clonidine for Lumbosacral Radiculopathy
This was a randomized, blinded study of transforaminal epidural injection of clonidine versus a similar injection of corticosteroid for acute lumbosacral radiculopathy.
- Trial name
- NCT00588354
- Testing
- Clonidine, Triamcinolone hexacetonide, Lidocaine HCl
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Lumbosacral Radiculopathy
A 3-arm Multi-center, Randomized Controlled Study Comparing Transforaminal Corticosteroid, Transforaminal Etanercept and Transforaminal Saline for Lumbosacral Radiculopathy
Lumbosacral radiculopathy is one of the leading of cause of disability in the U.S. and worldwide. Among recent reviews evaluating epidural steroid injections, some 1 but not all 2 concluded them to be effective in the long-term.
- Trial name
- NCT00733096
- Testing
- etanercept, methylprednisolone, normal saline
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- Johns Hopkins University
Sciatica, Radiculopathy
Steroids Versus Gabapentin
The purpose of this study is to determine whether pharmacotherapy or epidural steroid injections are a better treatment for lumbosacral radicular pain.
- Trial name
- NCT01495923
- Testing
- epidural steroid injection, Gabapentin
- Where
- 3 sites in United States
- Volunteers
- 145 people
- Sponsor
- Johns Hopkins University
Disc Herniation, Lumbosacral Radiculopathy
CT Guided Injection for Low Back Radiculopathy: A Randomized Clinical Trial
Herniated disc sometimes cause back pain radiating down to a leg. This pain can be so severe that it is functionally disabling. The purpose of this randomized clinical trial is to determine if corticosteroid medication, delivered…
- Trial name
- NCT01267825
- Testing
- CT-guided corticosteroid+ bupivicaine, Standard medical care
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Montefiore Medical Center
Lumbar Spine Degeneration
INFUSE®Bone Graft in Transforaminal Lumbar Interbody Fusion for Degenerative Disease of Lumbosacral Spine
This investigation will provide safety and effectiveness information on the use of INFUSE® Bone Graft with the CAPSTONE® Spinal System and CD HORIZON® Spinal System with a Transforaminal Lumbar Interbody Fusion (TLIF) surgical…
- Trial name
- TLIF (NCT01415908)
- Testing
- INFUSE Bone Graft, Iliac Crest Bone Graft
- Where
- 5 sites in United States
- Volunteers
- 15 people
- Sponsor
- Medtronic Spinal and Biologics
Radicular Pain Related to Lumbosacral Disc Disease
Milnacipran for Lumbosacral Radicular Pain
This study investigates whether milnacipran reduces radicular pain ("sciatica") in patients with lumbosacral disc disease.
- Trial name
- NCT01777581
- Testing
- Milnacipran
- Volunteers
- 13 people
- Sponsor
- Duke University
Low Back Pain, Lumbosacral Radiculopathy
A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief
The purpose of this study is to collect information about how patients feel when doctors manage their pain after lumbar spine surgery using a combination of EXPAREL® and bupivacaine injected into the lumbar spine at the end of…
- Conditions
- Low Back Pain, Lumbosacral Radiculopathy, Lumbar Disc Degeneration, Lumbar Disc Herniation
- Trial name
- NCT03514277
- Testing
- Exparel, Bupivacaine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Lumbosacral Radicular Pain
A Research Study to Characterize the Pharmacodynamics and Safety of Repeat Dose SP-102
This is an open-label, single-arm, repeat dose study to characterize the pharmacodynamics and safety/tolerability of SP-102 administered by epidural injection.
- Trial name
- NCT03613662
- Testing
- SP-102
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Semnur Pharmaceuticals, Inc.
Lumbar Radiculopathy
Safety and Efficacy of SX600 Administered by Lumbosacral Transforaminal Epidural Injection for Radicular Pain
This is a Phase I/II, double-blind, parallel-group, randomized, placebo-controlled multi-centre trial in 180 patients randomized 1:1:1 to receive the IMP (Dexamethasone acetate microspheres for extended-release injectable…
- Trial name
- SALIENT (NCT03952377)
- Testing
- SX600
- Where
- 10 sites in Australia
- Volunteers
- 56 people
- Sponsor
- SpineThera Australia PTY LTD