Clinical trials: Lung; Disease
COPD (Chronic Obstructive Pulmonary Disease)
Photon-counting CT in Chest Imaging
Purpose and objective: This project aims to evaluate photon-counting computed tomography (PCCT) quantitative accuracy using COPDGene subjects.
- Trial name
- NCT07031336
- Testing
- Photon-counting CT, Energy-integrating CT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Carcinoma, Non-Small-Cell Lung
Concomitant Chemo-radiotherapy in Locally Advanced Non Small Cell Lung Cancer
Feasibility of pragmatic concomitant chemo-radiotherapy association with 1 cycle of Induction chemotherapy, weekly chemo-radiotherapy, and consolidation chemotherapy.
- Trial name
- BIB 01 (NCT00210171)
- Testing
- Toxicity : Time to progression, 1 and 2 years survival
- Where
- 7 sites in France
- Sponsor
- Institut Bergonié
Bone and Joint Infection, Treated by Daptomycin
Daptomycin > 6 mg/kg/Day as Salvage Therapy in Patients With Complex Bone and Joint Infection: Cohort Study in a Regionalreference Center
The choice of antimicrobial therapy to treat complex bone and joint infections (BJI) is challenging, requiring consideration of: (i) the problem of bone diffusion; (ii) the necessity of using antimicrobials active against…
- Trial name
- NCT03209934
- Volunteers
- 43 people
- Sponsor
- Hospices Civils de Lyon
BPD - Bronchopulmonary Dysplasia
Randomized Control Trial: Synchronized Non-invasive Positive Pressure Ventilation Versus Non Synchronized Non Invasive Positive Pressure Ventilation in Extremely Low Birth Weight Infants
Infants delivered weighing less than 1 kg at birth (ELBW) are at high risk for the development of bronchopulmonary dysplasia (BPD) and Ventilator-Induced Lung Injury (VILI), in part because of the need for mechanical ventilation…
- Trial name
- NCT03613987
- Testing
- NAVA technology to synchronize NIPPV
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York Medical College
Acute Respiratory Distress Syndrome
To Evaluate The Safety and Initial Efficacy of STSA-1002 Injection in Patients With Acute Respiratory Distress Syndrome
To evaluate the safety and initial efficacy of STSA-1002 injection in patients with acute respiratory distress syndrome.
- Trial name
- NCT06038916
- Testing
- STSA-1002 Injection
- Where
- 30 sites in China
- Volunteers
- 47 people
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd
COPD, Medication Adherence
Medication Adherence Research in COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of death, affects over 24 million people in the US and is the leading cause of disability with projected healthcare costs at almost $50 billion.
- Trial name
- MARC (NCT03174704)
- Where
- 2 sites in United States
- Volunteers
- 314 people
- Sponsor
- Johns Hopkins University
NSCLC, Stage I
Ablative STEreotactic RadiOtherapy wIth Durvalumab (MEDI4736)
This is a randomized multicentre open label phase II study of Durvalumab following Stereotactic Body Radiotherapy (SBRT) in patients with T1-2N0M0 NSCLC.
- Trial name
- ASTEROID (NCT03446547)
- Testing
- Durvalumab
- Where
- 15 sites in Finland, Norway and 1 more
- Volunteers
- 106 people
- Sponsor
- Vastra Gotaland Region
COVID-19
CAP-1002 in Severe COVID-19 Disease
This expanded access protocol will enroll subjects with a clinical diagnosis of COVID-19 confirmed by laboratory testing and who are in critical condition as indicated by life support measurements.
- Trial name
- NCT04338347
- Testing
- CAP-1002 Allogeneic Cardiosphere-Derived Cells
- Where
- United States
- Sponsor
- Capricor Inc.
Atrial Flutter Typical, Heart Failure
Pulmonary Vein Isolation in Typical Atrial Flutter and Heart Failure
This study, called the PVI-AFL-HF Trial, investigates two treatments for patients with typical atrial flutter (AFL) and heart failure (HF).
- Trial name
- PVI-AFL-HF (NCT06817447)
- Testing
- Pulmonary vein isolation plus cavo-tricuspid isthmus ablation, Cavo-tricuspid isthmus ablation
- Volunteers
- 168 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection
Efficacy, Safety, Tolerability of AXA1125 in Fatigue After COVID-19 Infection
This study will compare the effects of AXA1125, an orally active mixture of amino acids, compared to placebo, on improving muscle function (metabolism) following moderate exercise in subjects with fatigue-Predominant Post-Acute…
- Trial name
- NCT05152849
- Testing
- AXA1125
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Axcella Health, Inc
Brain Metastases, Bone Metastases
Dual Energy CT - a Tool for Delineation of Tumor and Organs at Risk in Radiotherapy
The primary aim of this clinical study, 'Dual Energy CT - a tool for delineation of tumor and organs at risk in radiotherapy' (DART) is to evaluate whether dual-energy CT (DECT) is at least as effective as magnetic resonance…
- Conditions
- Brain Metastases, Bone Metastases, Head and Neck Cancer, Lung Cancer
- Trial name
- DART (NCT07185958)
- Testing
- Dual-energy CT (DECT), Iodine-based contrast agent, Magnetic Resonance Imaging (MRI)
- Where
- 3 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- Aalborg University Hospital
COPD, Mechanical Ventilation
Effect of Invasive and Non Invasive Mechanical Ventilation on Feeding Delivery in COPD Elderly Patients
COPD patients requiring ventilation may benefit from invasive or non invasive ventilation. Non invasive ventilation is often incompatible with oral or enteral feding, due to gastric dilatation and full mask therapy.
- Trial name
- NCT00417755
- Volunteers
- 40 people
- Sponsor
- Rabin Medical Center
Asthma
Helping Chicago's Westside Adults Breathe and Thrive
Adults with asthma living in Chicago's West and Southwest side who completed the home-based Community Health Worker (CHW) intervention called Helping Chicago's Westside Adults Breathe and Thrive (HCWABT I) after October 2015 were…
- Trial name
- HCWABT (NCT03489655)
- Testing
- Maintenance Phase Intervention
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Sinai Health System
Asthma
A Pilot Study to Improve Preventive Asthma Care for Urban Adolescents
The goal of this pilot study is to implement directly observed therapy with preventive asthma medications through a partnership with the school nurse (with input and direction from the primary care provider) to assure that the…
- Trial name
- NCT01106326
- Testing
- Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Rochester
COVID-19, SARS-CoV-2
Safety and Immunogenicity of COVI-VAC as a Booster Dose in Adults Previously Vaccinated Against COVID-19
The purpose of this study is to to evaluate the safety and immune response of COVI-VAC given as a single booster dose in healthy adults previously vaccinated against COVID-19 with an authorised mRNA or adenovirus-vectored…
- Trial name
- NCT05233826
- Testing
- COVI-VAC
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Codagenix, Inc
Cachexia; Cancer, Weight Loss
Evaluating the Combined Intervention of Nutritional Supplementation (Remune) and Exercise in Patients With Cancer Cachexia
The main purpose of this research study is to determine if the use of a nutritional supplement and exercise improve or worsen cachexia.
- Conditions
- Cachexia; Cancer, Weight Loss, Lung Cancer, Gastrointestinal Cancer
- Trial name
- NCT04131426
- Testing
- Remune, EXCAP©®
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Rochester
Covid19
Clinical Role of Testosterone and Dihydrotestosterone and Which of Them Should be Inhibited in COVID-19 Patients - A Double-edged Sword?
Clinical Role of Testosterone and Dihydrotestosterone and which of them should be inhibited in COVID-19 patients - A double-edged sword? COVID-19 attacks and affects Males significantly more than females [1], [2].
- Trial name
- NCT04623385
- Testing
- Aerosolized 13 cis retinoic acid plus Inhalation Inhaled testosterone, The standard therapy
- Volunteers
- 1,000 people
- Sponsor
- Kafrelsheikh University
Cystic Fibrosis, Adolescent Behavior
SAFETIM-needs : Exploring Adolescent's and Parent's Needs During Transition in French CF Centers
prospective multicentric study protocol in french CF center, exploring adolescent avec parents needs during transition from pediatric CF center to adult CF center
- Trial name
- SAFETIM-needs (NCT03298685)
- Testing
- semi structured interviews for all adolescents and their parent
- Where
- 4 sites in France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Cigarette Smoker, Current Smoker
18F-FSPG PET/CT in Diagnosing Early Lung Cancer in Patients With Lung Nodules
This phase II trial studies how well 18F-FSPG positron emission tomography (PET)/computed tomography (CT) work in diagnosing early lung cancer in patients with indeterminate lung nodules.
- Conditions
- Cigarette Smoker, Current Smoker, Former Smoker, Multiple Pulmonary Nodules
- Trial name
- NCT03824535
- Testing
- Computed Tomography, Fludeoxyglucose F-18, Fluorine F 18 L-glutamate Derivative BAY94-9392
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Andrei Iagaru
Lung Cancer Non Small Cell
A Study of Lymph Node Metastatic Pattern Based Incorporating Tumor Location, GGO Components and Size for Non-small Cell Lung Cancer
The goal of this observational study is to learn about in invasive non-small cell lung cancer patients who underwent pulmonary resection with systematic lymph node dissection from April 2008 to July 2022 .
- Trial name
- NCT06161935
- Testing
- no intervention
- Volunteers
- 7,067 people
- Sponsor
- Fudan University
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