Clinical trials: Lung; Disease
Asthma
Sub-Sensitivity to Long-Acting Bronchodilators (LABA)
The purpose of this study is to look at whether Advair® and SYMBICORT® have different effects on airway constriction by means of methacholine challenge testing.
- Trial name
- NCT01117116
- Testing
- fluticasone propionate and salmeterol, budesonide and formoterol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Jewish Health
Lung Neoplasms, Non-Small Cell Lung Cancer
Cisplatin/Irinotecan With Concurrent Radiation for Inoperable NSCLC
This is a prospective, single institution phase II study, whose primary objective is to estimate the median and three year survival rate of non-small lung cancer patients with Stage IIIA and IIIB intra-thoracic disease which is…
- Trial name
- NCT02275806
- Testing
- Irinotecan, Cisplatin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Leo W. Jenkins Cancer Center
Heart Disease, Heart Failure With Preserved Ejection Fraction
Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a major public health problem that has no proven effective treatment. This study assessed the effects of acute nitrite administration on resting and exercise hemodynamics…
- Conditions
- Heart Disease, Heart Failure With Preserved Ejection Fraction, Exercise Intolerance, Pulmonary Hypertension
- Trial name
- NCT01932606
- Testing
- Nitrite
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Barry Borlaug
Ovarian Neoplasms, Colorectal Neoplasms
An Analysis of the Response of Human Tumor Microvascular Endothelium to Ionizing Radiation
Doctors will take some tissue from the tissue removed during surgery in order to study how the blood vessels of the tumor respond to radiation therapy.
- Conditions
- Ovarian Neoplasms, Colorectal Neoplasms, Melanoma, Small Cell Lung Cancer
- Trial name
- NCT00132704
- Testing
- Ionizing radiation (IR) therapy, Ionizing radiation (IR)
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Bronchopulmonary Dysplasia (BPD)
Late Low-Dose Dexamethasone in Preterm Neonates Using DART Protocol
Premature babies, especially those who need breathing support for many days, are at risk of developing a long-term lung condition called bronchopulmonary dysplasia (BPD).
- Trial name
- NCT07904104
- Testing
- Dexamethasone
- Where
- Pakistan
- Volunteers
- 93 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Exercise-induced Pulmonary Arterial Hypertension
An Open-Label Uncontrolled Study of the Safety and Efficacy of Ambrisentan in Participants With Exercise-Induced Pulmonary Arterial Hypertension (PAH)
The purpose of this study is assess whether ambrisentan can help people with exercise- induced pulmonary arterial hypertension (EIPAH).
- Trial name
- EiPAH (NCT01338636)
- Testing
- Ambrisentan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
BRONCHIOLITIS
Comparison of 3% Hypertonic Saline and Salbutamol in Children With Bronchiolitis
Bronchiolitis is a common lower respiratory tract infection that often leads to hospitalization in infants. The use of nebulized 3% hypertonic saline for treating bronchiolitis is being explored as an alternative to Salbutamol.
- Trial name
- NCT06665711
- Testing
- 3% Hypertonic Saline, Intervention: Salbutamol (Ventolin)
- Volunteers
- 100 people
- Sponsor
- University of Health Sciences Lahore
Lung Cancer
Preliminary Efficacy of Different Exercise Training During Immunotherapy in Patients With Lung Cancer: The ENHANCE Trial
The purpose of this study is to examine the feasibility and effects of 12-week exercise training at different intensities among individuals with advanced lung cancer receiving immune checkpoint inhibitors.
- Trial name
- ENHANCE (NCT06026111)
- Testing
- High-Intensity Interval Training (HIIT), Moderate-Intensity Continuous Training (MICT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dana-Farber Cancer Institute
Lung Cancer
Optical Coherence Tomography: An Adjunct to Flexible Bronchoscopy in the Diagnosis of Lung Cancer
Optical coherence tomography will be a feasible adjunct to flexible bronchoscopy, and provide images with good sensitivity and specificity to determine the presence of endobronchial malignancies.
- Trial name
- OCT (NCT01039311)
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Oklahoma
Colorectal Cancer, Non-Small Cell Lung Cancer
A Phase 1 Study of IM-1617 in Participants With Advanced Cancer
This study will test the safety and effectiveness of a drug called IM-1617 in participants with solid tumors. Participants will have solid tumor cancer that has spread through the body (metastatic) or cannot be removed with…
- Conditions
- Colorectal Cancer, Non-Small Cell Lung Cancer, Breast Cancer, Esophageal Cancer
- Trial name
- NCT07578571
- Testing
- IM-1617
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Immunome, Inc.
COVID, Disseminated Intravascular Coagulation
Coagulation Changes Associated With COVID-19 Infection
This study will study the potential utility of the Quantra QPlus System in patients inflicted with COVID-19 disease.
- Conditions
- COVID, Disseminated Intravascular Coagulation, Coagulation Disorder
- Trial name
- NCT04460664
- Testing
- Quantra System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- HemoSonics LLC
Carcinoma, Non-Small-Cell Lung
Gene Mutations in Non-Small Cell Lung Cancer Cells
To compare the frequency of individual genetic abnormality between tumor cells and blood specimens.
- Trial name
- NCT00977509
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Severe Asthma
Tapering of Inhaled Corticosteroids in Tezepelumab-treated Asthma patieNts: Impact on Clinical Outcomes
To evaluate the relationship between starting tezepelumab treatment followed by tapering of inhaled corticosteroid (ICS) and ICS dose, metabolic outcomes, asthma control and exacerbation rate in a real world setting
- Trial name
- TITANIC (NCT07713498)
- Testing
- Tapering of inhaled corticosteroid (ICS) treatment
- Where
- Netherlands
- Volunteers
- 61 people
- Sponsor
- Franciscus Gasthuis
Severe Asthma
ChAracterisation of ItaliaN Severe Uncontrolled Asthmatic patieNts Key Features When Receiving Benralizumab
This is an observational, Italian multi-center, retrospective cohort study with enrollment visit on patients suffering from severe eosinophilic asthma who started benralizumab in the Sampling Program or as per normal clinical…
- Trial name
- ANANKE (NCT04272463)
- Testing
- No intervention
- Where
- 18 sites in Italy
- Volunteers
- 217 people
- Sponsor
- AstraZeneca
Cough, COPD
Cough Monitoring in COPD
This is an observational study designed to learn about symptoms of cough and how changes in cough may be associated with the beginning of a COPD exacerbation (acute worsening of symptoms.
- Conditions
- Cough, COPD, COPD Exacerbation
- Trial name
- NCT07098793
- Testing
- Cough monitoring
- Where
- United Kingdom
- Volunteers
- 39 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Asthma
A Study to Evaluate the Safety, Tolerability and Absorption to the Blood After Administration of Single and Multiple Doses of AZD8154 in Healthy Participants.
This study is a Phase 1, first in human (FiH) study, consisting of 3 parts (Part 1, Part 2, and Part 3) in healthy male and female participants of non-childbearing potential, performed at a single study center.
- Trial name
- NCT03436316
- Testing
- AZD8154
- Where
- Germany
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pulmonary Hypertension
Study of Remodulin® in Pediatric Pulmonary Hypertension With Single Ventricular Physiology After Fontan Surgery
The aim of this study is to determine the safety and efficiency of Remodulin®（Treprostinil Injection）to reduce the pulmonary arterial pressure and prevent pulmonary hypertension (PH) after Fontan operation with univentricular…
- Trial name
- NCT02865733
- Testing
- Remodulin, distilled water
- Volunteers
- 36 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Pulmonary Hypertension
Inspiratory Muscle Training in Pulmonary Hypertension
The aim of this study is to investigate the effective of inspiratory muscle training on respiratory function, exercise capacity, physical activity and quality of life.
- Trial name
- NCT03385733
- Testing
- inspiratory muscle training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University
Alpha1-proteinase Inhibitor Deficiency, Emphysema
Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency
This is a randomized, placebo-controlled, double-blind, multicenter phase III/IV study to compare the efficacy and safety of Zemaira® with placebo in subjects with emphysema due to alpha1-proteinase inhibitor deficiency.
- Trial name
- NCT00261833
- Testing
- Alpha1-proteinase inhibitor
- Where
- 28 sites in United States, Australia and 11 more
- Volunteers
- 180 people
- Sponsor
- CSL Behring
Chronic Disease, Neoplasm Metastasis
Facilitating Communication Study
This study is a randomized clinical trial of an intervention to improve outcomes for patients and their family by using ICU nurse facilitators to support, model, and teach communication strategies that enable patients and their…
- Conditions
- Chronic Disease, Neoplasm Metastasis, Lung Neoplasm, Pulmonary Disease, Chronic Obstructive
- Trial name
- FCS2 (NCT03721952)
- Testing
- Facilitator-Based Intervention
- Where
- 3 sites in United States
- Volunteers
- 977 people
- Sponsor
- University of Washington
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