Clinical trials: Lung; Disease
Lung Cancer, Patient Engagement
Improving Access to Lung Cancer Clinical Trials
There are ~85,000 lung cancer patients (LCPs) in the UK; yet only around 8% were recruited into clinical trials in 2021/22. LCPs need opportunities to take part in clinical trials to access new treatments, increasing their…
- Conditions
- Lung Cancer, Patient Engagement, Research, Communication, Nurse-Patient Relations
- Trial name
- Lung I-ACT (NCT05780164)
- Testing
- Research readiness tool
- Where
- United Kingdom
- Volunteers
- 109 people
- Sponsor
- Oxford Brookes University
Healthy Volunteer, Prostate Cancer
Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors
Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes.
- Conditions
- Healthy Volunteer, Prostate Cancer, Head and Neck Cancer, Esophageal Cancer
- Trial name
- NCT04354064
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Non-small Cell Lung Cancer
Survival Outcome of EGFR-TKI in Uncommon EGFR Mutant Advanced NSCLC
This study aims to explore Survival Outcome of EGFR-TKI in Uncommon EGFR Mutant Advanced Non-small Cell Lung Cancer in China
- Trial name
- NCT04324164
- Testing
- Third-generation EGFR-TKI, EGFR-TKI
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Hunan Province Tumor Hospital
Severe Asthma
Follow-up of Children With Severe Asthma at Adult Age
Most of clinical cohorts focused on the course of asthma over time and on the different phenotypes of asthma have investigated children and adults separately. The passage from childhood to adulthood is scarcely explored.
- Trial name
- S2AEA (NCT05032209)
- Testing
- follow-up of children with severe asthma in adulthood
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tobacco Use, E-Cigarette Use
E-Cigarette Effects on Markers of Cardiovascular and Pulmonary Disease
This study is designed to enhance the understanding of the possible health effects of e-cigarette use by relating the acute and long-term use of e-cigarettes and conventional cigarettes ("products") to well-validated…
- Conditions
- Tobacco Use, E-Cigarette Use, Cardiovascular Diseases, Pulmonary Disease
- Trial name
- NCT03863509
- Testing
- Cigarettes, E-Cigarettes
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Lung Cancer Non-small Cell Stage IV
Survival imProvement in Lung cancEr iNduced by DenOsUmab theRapy
The purpose of this study is to investigate how well the standard treatment (platinum-based doublet chemotherapy) in combination with denosumab works compared with the standard treatment alone in patients with a type of lung…
- Trial name
- SPLENDOUR (NCT02129699)
- Testing
- Denosumab, None, standard chemotherapy only
- Where
- 66 sites in Austria, Belgium and 9 more
- Volunteers
- 595 people
- Sponsor
- ETOP IBCSG Partners Foundation
COPD, Overlap Syndrome
Biomarkers of Dementia in Chronic Sleep and Breathing Disorders
Chronic obstructive pulmonary disease (COPD), obstructive sleep apnoea (OSA) and overlap syndrome are associated with obstructions in breathing and disturbed sleep.
- Conditions
- COPD, Overlap Syndrome, OSA
- Trial name
- ORACLE (NCT06377332)
- Testing
- High density electroencephalogram (HdEEG), Functional near infrared spectroscopy (fNIRS), Magnetic resonance imaging (MRI)
- Where
- Australia
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Woolcock Institute of Medical Research
Ventilator Induced Lung Injury, Cardiac Disease
Intensive Alveolar Recruitment Protocol After Cardiac Surgery
The purpose of this study was to evaluate prospectively the impact of two protective mechanical ventilation strategies, both using low tidal volume ventilation (6 mL/kg/ibw) after cardiac surgery.
- Conditions
- Ventilator Induced Lung Injury, Cardiac Disease, Acute Lung Injury
- Trial name
- NCT01502332
- Testing
- Intensive Alveolar Recruitment, Moderate Alveolar Recruitment
- Where
- Brazil
- Volunteers
- 320 people
- Sponsor
- University of Sao Paulo
Cystic Fibrosis
Intermittent Versus Continuous Infusion Meropenem in Cystic Fibrosis
The purpose of this study is to compare the incidence of nausea and vomiting following short intermittent versus prolonged intermittent infusion of meropenem.
- Trial name
- NCT02048163
- Where
- United States
- Sponsor
- Dayton Children's Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Early Telemedicine Training in Patients With COPD
Chronic obstructive pulmonary disease (COPD) is a widespread disease that can have a major impact on the lives of individuals. An essential element in the treatment of COPD is rehabilitation of which supervised training is an…
- Trial name
- NCT02085187
- Testing
- Telemedicine training and counselling
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Odense University Hospital
Bronchiectasis
Pulmonary Rehabilitation in Non-Cystic Fibrosis Bronchiectasis
The purpose of this study is to assess the effect of pulmonary rehabilitation on the transport of secretions, inflammation and respiratory resistance, and its repercussions on the quality of life in patients with bronchiectasis.
- Trial name
- NCT02823587
- Testing
- Pulmonary Rehabilitation, Control
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Asthma
Trial of Lay-led Individualised Self-management Education for Adults With Asthma
Long term conditions often necessitate long term care. In many cases, giving control of their conditions to the patients themselves produces the best outcomes.
- Trial name
- NCT00129987
- Testing
- Self management education
- Where
- United Kingdom
- Volunteers
- 567 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cognitive Dysfunctions
Neurological Complications - Pulmonary Transplant
A monocentric prospective open study to evaluate the frequency and nature of cognitive complications in the 3rd month post pulmonary transplant.
- Trial name
- NCT01818193
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Hopital Foch
Cystic Fibrosis
Identification of Predictive Epigenetic Biomarkers of Lung Disease Severity in Cystic Fibrosis
The general aims of this project are (i) to identify predictive epigenetic biomarkers of lung disease severity in Cystic Fibrosis, (ii) to characterize a non-invasive cellular model, spontaneous sputum, for the analysis of these…
- Trial name
- MethylBiomark (NCT02976714)
- Testing
- spontaneous sputum
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Non-small Cell Lung Cancer
A Study Comparing BL-B01D1 With Platinum Based Chemotherapy in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer(PANKU-Lung01)
This trial is a registered phase III, randomized, open-label, multicenter study to evaluate the efficacy and safety of BL-B01D1 in patients with locally advanced or metastatic non-squamous non-small cell lung cancer with…
- Trial name
- NCT06382116
- Testing
- BL-B01D1, Pemetrexed+Cisplatin or Carboplatin
- Where
- China
- Volunteers
- 432 people
- Sponsor
- Sichuan Baili Pharmaceutical Co., Ltd.
Aortic Valve Disease, Pulmonary Valve Disease
Artificial Intelligence in New Cardiac MR Markers for Congenital Heart Disease
The goal of this study is to investigate children with aortic and pulmonary valve disease treated or untreated longitudinally. Established CMR measures with additional newly developped, promising, highly refined and clinically…
- Conditions
- Aortic Valve Disease, Pulmonary Valve Disease, Child, Only, Magnetic Resonance Imaging
- Trial name
- AI-CMR (NCT05979870)
- Testing
- Valvuloplasty,
- Where
- Sweden
- Volunteers
- 45 people
- Sponsor
- Sahlgrenska University Hospital
Respiratory Distress Syndrome, Adult
Individualized Positive End-expiratory Pressure Guided by End-expiratory Lung Volume in the Acute Respiratory Distress Syndrome
During the acute respiratory distress syndrome (ARDS), patients' response to positive end-expiratory pressure (PEEP) is variable according to different degrees of lung recruitability.
- Trial name
- IPERPEEP (NCT04012073)
- Testing
- Invasive Mechanical ventilation, Neuromuscular Blocking Agents, Prone positioning
- Where
- 10 sites in Italy
- Volunteers
- 18 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure
Prone Position Assessed by 3D EIT
To investigate global and regional changes in lung ventilation and perfusion induced by prone position in ARDS patients assessed by 3D-EIT. And to investigate the difference between 2D-EIT and 3D-EIT in prone position monitoring.
- Trial name
- NCT07083973
- Testing
- Prone position
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Streptococcal Pneumonia, Nasopharyngeal Diseases
PCV7 in the Prevention of Nasopharyngeal Carriage of Vaccine Serotype (VT) Streptococcus Pneumoniae
A parallel-group, randomized, open-label study will be performed in subjects receiving PCV7 and subjects receiving controlled vaccine Hib vaccine, to claim the efficacy of PCV7 in the prevention of NP carriage of vaccine-serotype…
- Conditions
- Streptococcal Pneumonia, Nasopharyngeal Diseases, Vaccination Adverse Event
- Trial name
- NCT02133469
- Testing
- PCV7 (Pneumococcal 7-Valent Conjugate Vaccine), Hib Vaccine
- Where
- 9 sites in China
- Volunteers
- 3,281 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention, China
Idiopathic Pulmonary Fibrosis (IPF)
Inhaled NAC in Treatment of IPF
This study plans to learn more about the safety and tolerability of inhaled N-Acetylcysteine (NAC) in patients with pulmonary fibrosis.
- Trial name
- NCT03720483
- Where
- United States
- Sponsor
- University of Colorado, Denver
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