Clinical trials: Lung Cancer, completed
Lung Malignancies, Mediastinal Lymphadenopathy
Accuracy of Convex Probe EBUS-TBNA Versus FDG-PET/CT Imaging in Diagnosis and Staging of Lung Malignancies
Lung cancer is a prevalent cause of cancer-related mortality on a global scale. Appropriate staging of lung cancer is of paramount importance, as it customizes treatment and predicts prognosis.
- Trial name
- NCT06479798
- Testing
- Endo bronchial ultrasound transbronchial needle aspiration(EBUS-TBNA)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Lung Cancer
Nivolumab in Combination With Chemotherapy, or Nivolumab in Combination With Ipilimumab, in Advanced EGFR-Mutant or ALK-Rearranged NSCLC
This research study is studying a drug intervention as a possible treatment for lung cancer. The drugs involved in this study are: Nivolumab Carboplatin Pemetrexed Ipilimumab
- Trial name
- NCT03256136
- Testing
- Carboplatin, Nivolumab, pemetrexed
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Massachusetts General Hospital
Small Cell Lung Cancer
AMG 757 and AMG 404 in Subjects With Small Cell Lung Cancer (SCLC)
The main purpose of this study is to evaluate the safety, tolerability, and recommended phase 2 target dose of tarlatamab in combination with AMG 404.
- Trial name
- NCT04885998
- Testing
- Tarlatamab, AMG 404
- Where
- 17 sites in United States, Austria and 4 more
- Volunteers
- 23 people
- Sponsor
- Amgen
Small Cell Lung Cancer
Pembrolizumab and Paclitaxel in Refractory Small Cell Lung Cancer
Patients with refractory SCLC. Patients will be treated with paclitaxel and pembrolizumab.
- Trial name
- MISP-MK3475 (NCT02551432)
- Testing
- pembrolizumab, paclitaxel
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Seoul National University Hospital
COVID-19 Vaccines, Telemedicine
Improving Pediatric COVID-19 Vaccine Uptake Using an mHealth Tool
This study will determine the effectiveness of a vaccine communication mobile health app on parental decisions to vaccinate their children against coronavirus disease 2019 (COVID-19).
- Conditions
- COVID-19 Vaccines, Telemedicine, Vaccine Hesitancy, Pediatric ALL
- Trial name
- MoVeUP (NCT05386355)
- Testing
- COVID-19 Vaccine Uptake App, General Health App
- Where
- 15 sites in United States
- Volunteers
- 1,934 people, healthy volunteers welcome
- Sponsor
- IDeA States Pediatric Clinical Trials Network
Solid Tumor, Breast Cancer
Safety Study of a Liposomal Docetaxel Formulation in Patients With Solid Tumors Who Have Failed Previous Therapies
The purpose of this study is to determine the safety profile, including the maximum tolerated dose (MTD), of ATI-1123 a liposomal formulation of docetaxel, in the treatment of cancer patients with advanced solid tumors.
- Conditions
- Solid Tumor, Breast Cancer, Ovarian Cancer, Pancreatic Cancer
- Trial name
- NCT01041235
- Testing
- ATI-1123 (active drug = docetaxel)
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Azaya Therapeutics, Inc.
Dyspnea, Lung Cancer
Study of Episodic Breathlessness in Patients With Lung Cancer or Other Advanced Disease
RATIONALE: Gathering information about experiences of episodic breathlessness in patients with advanced disease may help doctors learn more about the disease.
- Conditions
- Dyspnea, Lung Cancer, Metastatic Cancer
- Trial name
- NCT01138358
- Testing
- medical chart review, study of socioeconomic and demographic variables, survey administration
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College Hospital NHS Trust
Advanced Cancer
Suberoylanilide Hydroxamic Acid in Advanced Solid Tumors
The purpose of this investigational study is to determine the safety and tolerability of oral suberoylanilide hydroxamic acid when administered in combination with standard doses of pemetrexed and cisplatin for the treatment of…
- Trial name
- NCT00106626
- Testing
- vorinostat (Suberoylanilide Hydroxamic Acid [SAHA]) in combination with Pemetrexed and Cisplatin
- Volunteers
- 52 people
- Sponsor
- Merck Sharp & Dohme LLC
Extensive Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer
Carboplatin and Etoposide With or Without Oblimersen Sodium in Treating Patients With Extensive Stage Small Cell Lung Cancer
This phase II trial studies how well carboplatin and etoposide with or without oblimersen sodium works in treating patients with extensive stage small cell lung cancer.
- Trial name
- NCT00042978
- Testing
- oblimersen sodium, carboplatin, etoposide
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- National Cancer Institute (NCI)
Advanced Solid Malignancies, Non-Small Cell Lung Cancer (NSCLC)
A Phase 1 Clinical Study of AZD4635 in Patients With Advanced Solid Malignancies
This is a Phase 1, open-label, multicenter study of continuous oral dosing of AZD4635 administered to patients with advanced solid malignancies.
- Conditions
- Advanced Solid Malignancies, Non-Small Cell Lung Cancer (NSCLC), Metastatic Castrate-Resistant Prostate Carcinoma (mCRPC), Colorectal Carcinoma (CRC)
- Trial name
- NCT02740985
- Testing
- AZD4635, Durvalumab, Abiraterone Acetate
- Where
- 17 sites in United States
- Volunteers
- 313 people
- Sponsor
- AstraZeneca
Breast Cancer, Lung Cancer
Impact of Geriatrician Interventions on Chemotherapy Delivery in Vulnerable Elderly Oncology Patients
This is a randomized parallel group trial designed to evaluate the impact of implementing geriatrician-prescribed interventions based on the comprehensive geriatric assessment (CGA), on the ability to deliver adequate…
- Conditions
- Breast Cancer, Lung Cancer, Ovarian Cancer, Prostate Cancer
- Trial name
- GIVE (NCT02785887)
- Testing
- Geriatrician review
- Where
- 3 sites in Italy
- Volunteers
- 233 people
- Sponsor
- Azienda USL 4 Prato
Lung Cancer
Fludeoxyglucose F 18 in Detecting Lymph Node Metastasis in Patients With Stage I or Stage II Non-Small Cell Lung Cancer That Can Be Removed by Surgery
RATIONALE: Diagnostic procedures using fludeoxyglucose F 18 and a surgical probe may help find lymph node metastases in patients with early-stage non-small cell lung cancer.
- Trial name
- NCT00732563
- Testing
- chemotherapy, lymphadenectomy, neoadjuvant therapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Roswell Park Cancer Institute
Carcinoma, Non-Small-Cell Lung
A Study of TAK-788 in Adults With Non-Small Cell Lung Cancer
This study is about a medicine called TAK-788, also known as mobocertinib, given to adults with non-small cell lung cancer. The main aims of this study are to check if there are any side effects from TAK-788, to learn how TAK-788…
- Trial name
- NCT02716116
- Testing
- TAK-788
- Where
- 62 sites in United States, China and 8 more
- Volunteers
- 324 people
- Sponsor
- Takeda
Lung; Disease, Fibroid (Chronic)
Ambulatory Oxygen in Fibrotic Lung Disease (FLD) (AmbOx)
The main aim of this project is to establish whether ambulatory oxygen in patients with fibrotic ILD whose oxygen saturation falls ≤ 88% on a 6MWT, leads to a significant improvement in health status.
- Trial name
- AmbOx (NCT02286063)
- Testing
- Ambulatory Oxygen
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Brain Neoplasms, Lung Neoplasms
18F-fluorodeoxyglucose (18F-FDG) Positron Emission Tomography in Oncology
Positron emission tomography (PET) is a nuclear medicine procedure based on the measurement of positron emission from radiolabelled tracer molecules.
- Conditions
- Brain Neoplasms, Lung Neoplasms, Lymphoma, Melanoma
- Trial name
- NCT00207298
- Testing
- Positron Emission Tomography
- Where
- Canada
- Volunteers
- 39,242 people
- Sponsor
- British Columbia Cancer Agency
Cancer
Pilot Study With the Aim to Quantify a Stress Protein in the Blood and in the Urine for the Monitoring and Early Diagnosis of Malignant Solid Tumors
Recent studies shows that extracellular vesicles (named "exosomes") released by cancer cells exhibit at their membrane the stress protein HSP70, contrary to exosomes released by normal cells.
- Trial name
- EXODIAG (NCT02662621)
- Testing
- blood samples, Urine samples
- Where
- France
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Centre Georges Francois Leclerc
Smoking Cessation
Implementation of Smoking Cessation Within NCI Community Oncology Research Program (NCORP) Sites
Evaluate a multi-faceted training program to improve short-term smoking cessation rates (<14 days post-visit) and short (3 months) and sustained abstinence (6 months) among 1,114 enrolled smokers who present for low-dose computed…
- Trial name
- OaSiS (NCT03291587)
- Testing
- Personnel Training and Coaching Calls
- Where
- 49 sites in United States
- Volunteers
- 1,094 people
- Sponsor
- Wake Forest University Health Sciences
Lung Cancer, Pneumothorax
Effect of Lateral Positioning on Bronchial Cuff Pressure of Left-sided Double-lumen Endotracheal Tube During Thoracic Surgery
The investigators evaluate the effect of postural change on the bronchial cuff pressure (BCP) of double-lumen endotracheal tube (DLT) in patients undergoing thoracic surgery, by observing the pressure of the bronchial cuff before…
- Trial name
- NCT03656406
- Testing
- Lateral decubitus positioning, Cuff-manometer
- Where
- South Korea
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Daegu Catholic University Medical Center
Lung Cancer
Non-Invasive Biomarkers For Early Detection Of Lung Cancers
Recent studies have shown that low-dose chest CT scans can detect lung cancers in high-risk populations (age >50yo, >30 pack-years of tobacco use), and can lower cancer mortality.
- Trial name
- ISRUSAL01 (NCT01580332)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Douglas W. Johnson MD, FACR
Urothelial Carcinoma, Carcinoma, Non-Small Cell Lung
A Study of Atezolizumab (Tecentriq®) in Ministry of Food and Drug Safety (MFDS)-Approved Indication(s)
This Phase 4, prospective, multicenter, non-interventional, regulatory post-marketing surveillance study will collect information on the the safety and effectiveness of atezolizumab under the clinical practice, and update the…
- Conditions
- Urothelial Carcinoma, Carcinoma, Non-Small Cell Lung, Small Cell Lung Carcinoma, Triple Negative Breast Carcinoma
- Trial name
- NCT03232593
- Testing
- Atezolizumab
- Where
- 56 sites in South Korea
- Volunteers
- 1,758 people
- Sponsor
- Hoffmann-La Roche
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