Clinical trials: Lung Cancer Prevention
Lung Cancer
A Cohort Study on the Prevention of Nausea and Vomiting Induced by Concurrent Chemoradiotherapy for Lung Cancer Using Rolapitant and Palonosetron
This study aims to evaluate the efficacy and safety of a combination regimen based on Rolapitant Palonosetron injection for preventing nausea and vomiting induced by concurrent chemoradiotherapy in lung cancer patients.
- Trial name
- NCT07442890
- Testing
- Rolapitant Palonosetron, Dexamethasone, Olanzapine
- Volunteers
- 238 people
- Sponsor
- Henan Cancer Hospital
Non Small Cell Lung Cancer, Small-cell Lung Cancer
A Study of ALRN-6924 for the Prevention of Chemotherapy-induced Side Effects (Chemoprotection)
This is a Phase 1b, multicenter, 2-part study of ALRN-6924 for the prevention of chemotherapy-induced side effects. Part 1 SCLC is an open-label, multicenter study of ALRN-6924 for the prevention of chemotherapy-induced side…
- Trial name
- NCT04022876
- Testing
- ALRN-6924, Carboplatin, Pemetrexed
- Where
- 28 sites in United States, Bosnia and Herzegovina and 5 more
- Volunteers
- 35 people
- Sponsor
- Aileron Therapeutics, Inc.
Brain Metastases, Small Cell Lung Cancer
Hair-sparing Whole Brain Radiotherapy
Up to 10% of patients with cancer will develop symptomatic brain metastases. Given this limited survival it is important to consider quality of life (QOL) when treating these patients.
- Trial name
- NCT01421316
- Testing
- Whole brain radiotherapy with volumetric arc therapy
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- University Hospital, Ghent
Lung Cancer, Radiation Therapy Complication
Xenon-enhanced Ventilation CT-guided Radiotherapy for Lung Cancer Treatment
The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy.
- Trial name
- NCT05134558
- Testing
- Xenon-enhanced Ventilation CT-guided Radiotherapy
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Chronic Lymphocytic Leukemia, COVID-19 Infection
A Vaccine Booster (GEO-CM04S1) for the Prevention of COVID-19 in Patients With Chronic Lymphocytic Leukemia
This phase II trial compares the effect of the GEO-CM04S1 vaccine with the current standard of care vaccine in preventing COVID-19 infections in patients with chronic lymphocytic leukemia (CLL).
- Trial name
- NCT05672355
- Testing
- Biospecimen Collection, mRNA COVID-19 Vaccine, Synthetic MVA-based SARS-CoV-2 Vaccine COH04S1
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- City of Hope Medical Center
Squamous Cell Lung Cancer, Lung Cancer
Photodynamic Therapy for the Prevention of Lung Cancer
PEARL is a phase III multicentre 2:1 randomised controlled trial, with an incorporated phase II (pilot) component. All patients consented/registered onto the trial will have an autofluorescence bronchoscopy (AFB) to check for the…
- Trial name
- PEARL (NCT03346304)
- Testing
- Photodynamic Therapy (PDT)
- Sponsor
- University College, London
Breast Cancer, Lung Cancer
Feasibility of a Clinical Trial Comparing the Use of Cetirizine to Replace Diphenhydramine in the Prevention of Reactions Related to Paclitaxel
Explore the randomized, controlled, double-blind design targeted for the final clinical trial to assess the acceptability of interventions and clinical outcome measures and to provide data making it possible to estimate the…
- Conditions
- Breast Cancer, Lung Cancer, Ovarian Cancer, Oesophageal Cancer
- Trial name
- PREMED-F1 (NCT04237090)
- Testing
- Diphenhydramine, Cetirizine, Lactose pill
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Bladder Cancer, Cervical Cancer
Motivational Counseling in Preventing Smoking Relapse After Pregnancy in Pregnant Women Who Quit Smoking During Pregnancy
RATIONALE: Motivational counseling may help prevent pregnant women from smoking again after pregnancy. PURPOSE: This randomized clinical trial is studying three different types of counseling to see how well they work in…
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00310115
- Testing
- Smoking Prevention Usual Care, Counseling Intervention
- Where
- United States
- Volunteers
- 469 people
- Sponsor
- M.D. Anderson Cancer Center
Drug Toxicity, Lung Cancer
13-Cis Retinoic Acid With or Without Vitamin E for Prevention of Lung Cancer
RATIONALE: 13 Cis retinoic acid may prevent the development of cancer cells. PURPOSE: Randomized double-blinded phase II trial to study the effectiveness of 13-cis retinoic acid with or without vitamin E for chemoprevention or…
- Trial name
- 13-Cis (NCT00002586)
- Testing
- 13-cis retinoic acid, Tocopherol
- Where
- 4 sites in United States
- Volunteers
- 96 people
- Sponsor
- University of Colorado, Denver
Leukemia, Myelocytic, Acute
Voriconazole or Placebo in the Prophylaxis of Lung Infiltrates in Patients Undergoing Induction Chemotherapy for Acute Myelogenous Leukemia
The purpose of the study is to determine whether voriconazole is as effective as antifungal prophylaxis in patients undergoing chemotherapy for acute myelogenous leukemia (AML).
- Trial name
- NCT00152594
- Testing
- voriconazole
- Where
- 3 sites in Germany
- Volunteers
- 150 people
- Sponsor
- University of Cologne
Non-Small Cell Lung Carcinoma, Compliance Behavior
Patient Navigation for Lung Cancer Screening in an Urban Safety-Net System
The study proposes to evaluate a patient navigation intervention among a sample of 446 individuals referred for CT-based lung cancer screening in an urban safety-net setting.
- Conditions
- Non-Small Cell Lung Carcinoma, Compliance Behavior, Prevention Harmful Effects
- Trial name
- NCT02758054
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 447 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Dementia, Diabetes Mellitus
Impact of Lifestyle Modification on the Development of Dementia, Chronic Kidney Disease, Diabetes, Chronic Obstructive Pulmonary Disease, Cancers and Cardiovascular Disease in a Thai General Population
This is a community-based cluster randomized control trial aimed to investigate the impact of lifestyle modification (diet, physical activity, alcohol drinking and smoking) on the development of dementia, diabetes, chronic kidney…
- Conditions
- Dementia, Diabetes Mellitus, Chronic Kidney Disease, Cardiovascular Diseases
- Trial name
- NCT02967406
- Testing
- 4 x 4 lifestyle modification
- Where
- Thailand
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- Sanpasitthiprasong Hospital
Cryotherapy Effect, Chronic Pain
Intercostal Cryoanalgesia for Chronic Pain After VATS Lung Resection
Intercostal cryoanalgesia is a technique that allows extensive and prolonged analgesia of the hemithorax. The aim of this study is to demonstrate the efficacy of intercostal cryoanalgesia as an adjunct to a single-injection…
- Conditions
- Cryotherapy Effect, Chronic Pain, Lung Cancer, Surgery
- Trial name
- CRYO-VATS-2 (NCT05884099)
- Testing
- Cryoanalgesia AND single-injection paravertebral block, Single-injection paravertebral block
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Lung Cancer
Preventive Effects of Zoledronic Acid on Bone Metastasis in Patients With Stage IIIB and IV Lung Cancer
Bone metastases are common in patients with advanced lung cancer and can have devastating consequences. Preventing or delaying bone metastases may improve outcomes.
- Trial name
- NCT02622607
- Testing
- Zoledronic acid
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tang-Du Hospital
Health Personnel Attitude, Health Knowledge, Attitudes, Practice
Healthcare Provider Human Papillomavirus Education and Professional Skills Intervention
Healthcare providers (HCP) serving the El Paso U.S.-Mexico Border Region will be recruited to compare educational and professional skills interventions focused on the human papillomavirus (HPV).
- Trial name
- NCT05120869
- Testing
- Tailored HPV Education and Professional Skills Intervention Group, General HPV Education and Communication Skills Control Group
- Where
- 2 sites in United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Health Knowledge, Attitudes, Practice
PCORI-CER-1306-03385 Lung Cancer Screening Decision Aid Development and Testing
Objectives: This protocol addresses the first phase of a larger project funded by the Patient-Centered Outcomes Research Institute to help heavy smokers make informed decisions about lung cancer screening with low-dose computed…
- Trial name
- NCT02282969
- Testing
- Interviews, Questionnaires
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Smoking Cessation
Capitalizing on a Teachable Moment to Promote Smoking Cessation
The purpose of this study is to develop and test a self-help smoking cessation treatment for patients receiving a lung cancer screening computed tomography (CT) scan.
- Trial name
- NCT02276664
- Testing
- Self-Help (SHI), Usual Care (UC)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Lung Cancer, Heart Disease
Does Moderate Intensity Exercise Help Prevent Smoking Relapse Among Women?
This study compares the effects of a standard smoking cessation treatment, including one-time brief counseling and provision of nicotine patch plus an 8-week moderate intensity exercise program versus the same standard smoking…
- Conditions
- Lung Cancer, Heart Disease, COPD
- Trial name
- NCT00420160
- Testing
- Smoking cessation treatment plus moderate intensity exercise, Smoking cessation treatment plus health education
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Carcinoma, Non-Small-Cell Lung
Premedication to Reduce Amivantamab Associated Infusion Related Reactions
The purpose of the study is to separately assess the potential of dexamethasone, montelukast and methotrexate administration, prior to amivantamab infusion given through a needle in the vein, to decrease the incidence and/or…
- Trial name
- NCT05663866
- Testing
- Dexamethasone, Montelukast, Methotrexate
- Where
- 36 sites in United States, France and 3 more
- Volunteers
- 68 people
- Sponsor
- Janssen Research & Development, LLC
COVID-19
Tocilizumab for Prevention of Respiratory Failure in Patients With Severe COVID-19 Infection
The purpose of this study is to find out whether the study drug tocilizumab is an effective treatment for COVID-19 infection.
- Trial name
- NCT04377659
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Memorial Sloan Kettering Cancer Center