Clinical trials: Lung Cancer Prevention
Pulmonary Embolism, Deep Vein Thrombosis
Multi-Center Human Alert Trial to Prevent DVT and PE
To evaluate physician response to human alerts that inform the clinician that his/her patient may be eligible for thromboprophylaxis.
- Conditions
- Pulmonary Embolism, Deep Vein Thrombosis, Cancer, Surgery
- Trial name
- NCT00409136
- Testing
- Human Alert
- Where
- 26 sites in United States
- Volunteers
- 2,496 people
- Sponsor
- Brigham and Women's Hospital
Venous Thromboembolism, Lung Neoplasm
Prophylaxis of Venous Thromboembolism in Advanced Lung Cancer (PROVE)
Prospective randomized open multicenter trial with blinded adjudication of endpoints to assess the efficacy of six-month low-dose LMWH (Low Molecular Weight Heparin) for the prevention of symptomatic or incidental VTE in patients…
- Trial name
- PROVE (NCT03090880)
- Testing
- Tinzaparin Sodium
- Where
- 27 sites in France
- Volunteers
- 59 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer-Associated Thrombosis (CAT)
REGN7508 in Adult Participants for Prevention of Cancer-Associated Thrombosis
This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on the prevention of Cancer-Associated Thrombosis (CAT) in participants.
- Trial name
- ROXI-CAT-I (NCT07410117)
- Testing
- REGN7508
- Where
- 23 sites in United States, Georgia and 1 more
- Volunteers
- 1,120 people
- Sponsor
- Regeneron Pharmaceuticals
Venous Thromboembolism, Brain Tumors
Dalteparin Low Molecular Weight Heparin for Primary Prophylaxis of Venous Thromboembolism in Brain Tumour Patients
In patients with malignant glioma, to determine the efficacy of prophylaxis with LMWH (dalteparin) compared to placebo, both commenced beyond the immediate postoperative period, for the prevention of VTE.
- Trial name
- NCT00135876
- Testing
- dalteparin
- Where
- 14 sites in United States, Australia and 2 more
- Volunteers
- 512 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Lung Cancer, Nonsmall Cell, Esophageal Carcinoma
Thalidomide Prevention or Treatment of Camrelizumab-induced Reactive Cutaneous Capillary Endothelial Proliferation (RCCEP)
To explore the dose and safety of thalidomide for the prevention and treatment of camrelizumab-induced reactive cutaneous capillary endothelial proliferation (RCCEP)
- Trial name
- NCT06231680
- Testing
- Camrelizumab, Thalidomide 50mg, Thalidomide 100mg
- Where
- 2 sites in China
- Volunteers
- 132 people
- Sponsor
- Henan Cancer Hospital
Radiation Pneumonitis
Hyperbaric Oxygen in the Prevention of Radiation Pneumonitis
Radiotherapy is one of the important treatments to improve the survival rate of breast cancer patients, but also has the risk of radiation lung injury, which can develop into pulmonary fibrosis.
- Trial name
- NCT05189496
- Testing
- hyperbaric oxygen therapy
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Guangdong Provincial People's Hospital
Lung Cancer (Diagnosis)
Prospective Multicenter Cohort Study for the Development and Evaluation of Risk Stratification Tools for Lung Cancers and Their Postoperative Recurrences Using Multimodal Clinical, Radiological, Tissue and Longitudinal Biological Phenotyping Among People at Risk of Lung Cancer
Interventional study with minimal risks and constraints, involving annual assessment of the prevalence and incidence of lung cancer using low-dose contrast-free thoracic CT scans, immunological, inflammatory, metabolic, blood…
- Trial name
- LUCA-pi COHORT (NCT07042867)
- Testing
- biobanking, low dose scan
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Stomatitis
An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.
This is a multicenter, open-label, single-arm study of prophylaxis for Dato-DXd-related stomatitis in eligible patients with metastatic or inoperable locally recurrent breast cancer or locally advanced or metastatic Epidermal…
- Trial name
- TROPION-SWISH (NCT07357597)
- Testing
- Dexamethasone mouthwash, Datopotamab Deruxtecan (Dato-DXd)
- Where
- 41 sites in United States
- Volunteers
- 100 people
- Sponsor
- AstraZeneca
Head and Neck Cancer
Comparison of AIRVO High Flow Oxygen Therapy With Standard Care for Prevention of PPCs After Major H&N Surgery
Patients undergoing major head and neck surgery often develop breathing difficulties as a result of build up of sputum and difficulty taking deep breaths.
- Trial name
- NCT03828578
- Testing
- High flow oxygen therapy
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Cardiff and Vale University Health Board
Lung Neoplasms, Esophagitis
Study of Epigallocatechin-3-gallate (EGCG) for Esophagus Protection in Patients With Lung Cancer Receiving Radial Radiotherapy
The investigators conducted this phase II study of EGCG therapy protection of the esophagus from damage induced by radiotherapy.
- Conditions
- Lung Neoplasms, Esophagitis, Prevention & Control, Epigallocatechin Gallate
- Trial name
- NCT02577393
- Testing
- EGCG, mLDG
- Volunteers
- 83 people
- Sponsor
- Shandong Cancer Hospital and Institute
Lung Cancer
Comparison of Nicotine Inhaler and/or Bupropion in Helping People to Stop Smoking and Prevent the Recurrence of Smoking
RATIONALE: Use of a nicotine inhaler and/or bupropion may be effective in helping people stop smoking and prevent them from starting smoking again.
- Trial name
- NCT00033592
- Testing
- bupropion hydrochloride, nicotine
- Where
- 25 sites in United States, Canada
- Volunteers
- 1,708 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Cerebral Vein Thrombosis, Deep Vein Thrombosis
Apixaban in Preventing Secondary Cancer Related Venous Thrombosis in Cancer Patients Who Have Completed Anticoagulation Therapy
This randomized phase III trial studies the best dose of apixaban and how well it works in preventing secondary cancer related venous thrombosis in cancer patients who have completed anticoagulation therapy.
- Conditions
- Cerebral Vein Thrombosis, Deep Vein Thrombosis, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT03080883
- Testing
- Apixaban
- Where
- 32 sites in United States
- Volunteers
- 370 people
- Sponsor
- Academic and Community Cancer Research United
Cancer, Deep-vein Thrombosis of the Lower and Upper Extremities
Rivaroxaban Utilization for Treatment and Prevention of Thromboembolism in Cancer Patients: Experience at a Comprehensive Cancer Center
The primary objective of this study is to evaluate the practice patterns of rivaroxaban usage invenous-thromboembolism (VTE) and non-valvular atrial fibrillation (NVAF) in cancer patients.
- Conditions
- Cancer, Deep-vein Thrombosis of the Lower and Upper Extremities, Pulmonary Embolism, Non-valvular Atrial Fibrillation
- Trial name
- NCT02502396
- Testing
- Retrospective Chart Review
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- M.D. Anderson Cancer Center
Limited Stage Small Cell Lung Cancer
Effect of Trilaciclib in the Prevention of Myelosupression in Subjects With Limited-stage Small Cell Lung Cancer
The goal of this clinical trial is to compare the efficacy and safety of trilaciclib versus placebo in subjects with limited stage small cell lung cancer.
- Trial name
- NCT07473128
- Testing
- Trilaciclib, Saline (0.9% NaCl)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Pharmacosmos A/S
Infections, Covid19
Rosmalip® for Cancer Infections Prevention
This study is designed to assess the safety and efficacy of Rosmalip® nutritional supplement compared to placebo in subjects with solid cancer for the prevention of infections including COVID-19.
- Conditions
- Infections, Covid19, Cancer
- Trial name
- OnCOVInf (NCT05080920)
- Testing
- Rosmalip®
- Where
- Spain
- Volunteers
- 109 people
- Sponsor
- Fundación Investigación E Innovación Biomédica Hospital Universitario Infanta Sofia-Henares
Smoking, Cigarette, Breastfeeding
Lung and Breast Cancer Prevention by an Integrated Intervention of Maternal Smoking Cessation and Breastfeeding
This pilot clinical trial aims to integrate maternal smoking cessation and breastfeeding interventions to enhance both cancer prevention behaviors.
- Trial name
- NCT05123118
- Testing
- Integrated intervention of smoking cessation and breastfeeding
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Xiaozhong Wen
Lung Cancer Prevention
High Tea Consumption on Smoking Related Oxidative Stress
The overall objective of this study is to determine the effect of high tea consumption on biological markers of oxidative stress that mediate lung cancer risk.
- Trial name
- NCT02719860
- Testing
- Green tea, Black tea
- Volunteers
- 154 people
- Sponsor
- University of Arizona
Non Small Cell Lung Cancer
Adjuvant Melatonin for Prevention of Lung Cancer Recurrence and Mortality
There is evidence to support the use of melatonin, a natural health product, as an additional treatment aid for cancer patients.
- Trial name
- AMPLCaRe (NCT00668707)
- Testing
- melatonin
- Where
- 8 sites in Canada
- Volunteers
- 709 people
- Sponsor
- The Canadian College of Naturopathic Medicine
Carcinoma, Non-small-cell Lung
Prevention of Radiation Pneumonitis After Three-dimensional Conformal Radiation Therapy (3D-CRT) in Patients With Non-small-cell Lung Cancer
The purpose of this study is to evaluate the interest of breath holding for the prevention of radiation pneumonitis following conformal radiation therapy.
- Trial name
- NCT00349102
- Testing
- Free breathing, Breath holding
- Where
- 7 sites in France
- Volunteers
- 242 people
- Sponsor
- Centre Leon Berard
Metastatic Colorectal Cancer, Non-Small-Cell Lung Carcinoma
Study About Preventive Treatment of Folliculitis Induced by Epidermal Growth Factor Receptor Inhibitors
Patients will receive local prophylactic treatment (Diprosone cream) during 8 weeks from the beginning of the EGF-R inhibitors treatment, on the areas of the body susceptible to be affected by folliculitis.
- Trial name
- DIPROCOL (NCT00910676)
- Testing
- Diprosone
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Oscar Lambret